5,969 research outputs found
Top Quark Mass Calibration for Monte Carlo Event Generators -- An Update
We generalize and update our former top quark mass calibration framework for
Monte Carlo (MC) event generators based on the hadron-level
2-jettiness distribution in the resonance region for boosted
production, that was used to relate the PYTHIA 8.205 top mass parameter
to the MSR mass and the pole mass . The current most precise direct top mass measurements specifically
determine . The updated framework includes the addition of the
shape variables sum of jet masses and modified jet mass , and
the treatment of two more gap subtraction schemes to remove the renormalon related to large-angle soft radiation. These
generalizations entail implementing a more versatile shape-function fit
procedure and accounting for a certain type of power corrections to
achieve gap-scheme and observable independent results. The theoretical
description employs boosted heavy-quark effective theory (bHQET) at
next-to-next-to-logarithmic order (NLL), matched to soft-collinear
effective theory (SCET) at NLL and full QCD at next-to-leading order (NLO),
and includes the dominant top width effects. Furthermore, the software
framework has been modernized to use standard file and event record formats. We
update the top mass calibration results by applying the new framework to PYTHIA
8.205, HERWIG 7.2 and SHERPA 2.2.11. Even though the hadron-level resonance
positions produced by the three generators differ significantly for the same
top mass parameter value, the calibration shows that these
differences arise from the hadronization modeling. Indeed, we find that
agrees with m_t^{\rm MSR}(1\,\mbox{GeV}) within MeV for
the three generators and differs from the pole mass by to MeV.Comment: 70 pages, 15 figure
A report of Streptococcus pneumoniae serotype 6D in Europe
Serotype 6D of Streptococcus pneumoniae has been reported in Asia and the Fijian islands among nasopharyngeal carriage isolates. We now report a 6D isolate from a Finnish adult with invasive pneumococcal disease. Interestingly, the Finnish isolate and Asian isolate capsule gene loci are almost identical
Thermal and Residual Excited-State Population in a 3D Transmon Qubit
Remarkable advancements in coherence and control fidelity have been achieved in recent years with cryogenic solid-state qubits. Nonetheless, thermalizing such devices to their milliKelvin environments has remained a long-standing fundamental and technical challenge. In this context, we present a systematic study of the first-excited-state population in a 3D transmon superconducting qubit mounted in a dilution refrigerator with a variable temperature. Using a modified version of the protocol developed by Geerlings et al., we observe the excited-state population to be consistent with a Maxwell-Boltzmann distribution, i.e., a qubit in thermal equilibrium with the refrigerator, over the temperature range 35–150 mK. Below 35 mK, the excited-state population saturates at approximately 0.1%. We verified this result using a flux qubit with ten times stronger coupling to its readout resonator. We conclude that these qubits have effective temperature T_{eff}=35 mK. Assuming T[subscript eff] is due solely to hot quasiparticles, the inferred qubit lifetime is 108 μs and in plausible agreement with the measured 80 μs.United States. Dept. of Defense. Assistant Secretary of Defense for Research & Engineering (United States. Air Force Contract FA8721-05-C-0002)United States. Army Research Office (Grant W911NF-14-1-0078)National Science Foundation (U.S.) (Grant PHY-1415514
Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling
Ovarian cancer is the leading cause of gynecological malignancy-related deaths, due to its widespread intraperitoneal metastases and acquired chemoresistance. Mesothelial cells are an important cellular component of the ovarian cancer microenvironment that promote metastasis. However, their role in chemoresistance is unclear. Here, we investigated whether cancer-associated mesothelial cells promote ovarian cancer chemoresistance and stemness in vitro and in vivo. We found that osteopontin is a key secreted factor that drives mesothelial-mediated ovarian cancer chemoresistance and stemness. Osteopontin is a secreted glycoprotein that is clinically associated with poor prognosis and chemoresistance in ovarian cancer. Mechanistically, ovarian cancer cells induced osteopontin expression and secretion by mesothelial cells through TGF-β signaling. Osteopontin facilitated ovarian cancer cell chemoresistance via the activation of the CD44 receptor, PI3K/AKT signaling, and ABC drug efflux transporter activity. Importantly, therapeutic inhibition of osteopontin markedly improved the efficacy of cisplatin in both human and mouse ovarian tumor xenografts. Collectively, our results highlight mesothelial cells as a key driver of ovarian cancer chemoresistance and suggest that therapeutic targeting of osteopontin may be an effective strategy for enhancing platinum sensitivity in ovarian cancer
Effects of inhibition of P2Y1 and P2Y12 on whole blood clotting, coagulum elasticity and fibrinolysis resistance studied with free oscillation rheometry
Suspension High Velocity Oxy-Fuel (SHVOF)-sprayed alumina coatings: microstructure, nanoindentation and wear
Suspension High Velocity Oxy Fuel Spraying (SHVOF) can be used to produce thermally sprayed coatings from powdered feedstocks too small to be processed by mechanical feeders, allowing formation of nanostructured coatings with improved density and mechanical properties. Here, alumina coatings were produced from sub-micron sized feedstock in aqueous suspension, using two flame combustion parameters yielding contrasting microstructures. Both coatings were tested in dry sliding wear conditions with an alumina counterbody. The coating processed with high combustion power of 101 kW contained 74 wt% amorphous phase and 26 wt% crystalline phase (95 wt% gamma and 3 wt% alpha alumina) while the 72 kW coating contained lower 58 wt% amorphous phase and 42 wt% crystalline phases (73 wt% was alpha and 26 wt % gamma). The 101 kW coating had a dry sliding specific wear rate between 4-4.5 x 10-5 mm3/Nm, 2 orders of magnitude higher than the 72 kW coating wear rate of 2-4.2 x 10-7 mm3/Nm. A severe wear regime dominated by brittle fracture and grain pull out of the coating was responsible for the wear of the 101 kW coating, explained by mean fracture toughness three times lower than the 72 kW coating, owing to the almost complete absence of alpha alumina
Nanoscratch Characterization of GaN Epilayers on c- and a-Axis Sapphire Substrates
In this study, we used metal organic chemical vapor deposition to form gallium nitride (GaN) epilayers on c- and a-axis sapphire substrates and then used the nanoscratch technique and atomic force microscopy (AFM) to determine the nanotribological behavior and deformation characteristics of the GaN epilayers, respectively. The AFM morphological studies revealed that pile-up phenomena occurred on both sides of the scratches formed on the GaN epilayers. It is suggested that cracking dominates in the case of GaN epilayers while ploughing during the process of scratching; the appearances of the scratched surfaces were significantly different for the GaN epilayers on the c- and a-axis sapphire substrates. In addition, compared to the c-axis substrate, we obtained higher values of the coefficient of friction (μ) and deeper penetration of the scratches on the GaN a-axis sapphire sample when we set the ramped force at 4,000 μN. This discrepancy suggests that GaN epilayers grown on c-axis sapphire have higher shear resistances than those formed on a-axis sapphire. The occurrence of pile-up events indicates that the generation and motion of individual dislocation, which we measured under the sites of critical brittle transitions of the scratch track, resulted in ductile and/or brittle properties as a result of the deformed and strain-hardened lattice structure
Measurement of the cross-section and charge asymmetry of bosons produced in proton-proton collisions at TeV with the ATLAS detector
This paper presents measurements of the and cross-sections and the associated charge asymmetry as a
function of the absolute pseudorapidity of the decay muon. The data were
collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with
the ATLAS experiment at the LHC and correspond to a total integrated luminosity
of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements
varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the
1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured
with an uncertainty between 0.002 and 0.003. The results are compared with
predictions based on next-to-next-to-leading-order calculations with various
parton distribution functions and have the sensitivity to discriminate between
them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables,
submitted to EPJC. All figures including auxiliary figures are available at
https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13
Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster
Autophagy is a highly conserved mechanism for cellular repair that becomes progressively down-regulated during normal ageing. Hence, manipulations that activate autophagy could increase lifespan. Previous reports show that manipulations to the autophagy pathway can result in longevity extension in yeast, flies, worms and mammals. Under standard nutrition, autophagy is inhibited by the nutrient sensing kinase Target of Rapamycin (TOR). Therefore, manipulations of TOR that increase autophagy may offer a mechanism for extending lifespan. Ideally, such manipulations should be specific and minimise off-target effects, and it is important to discover additional methods for ‘clean’ lifespan manipulation. Here we report an initial study into the effect of up-regulating autophagy on lifespan and fertility in Drosophila melanogaster by dietary addition of Torin1. Activation of autophagy using this selective TOR inhibitor was associated with significantly increased lifespan in both sexes. Torin1 induced a dose-dependent increase in lifespan in once-mated females. There was no evidence of a trade-off between longevity and fecundity or fertility. Torin1-fed females exhibited significantly elevated fecundity, but also elevated egg infertility, resulting in no net change in overall fertility. This supports the idea that lifespan can be extended without trade-offs in fertility and suggest that Torin1 may be a useful tool with which to pursue anti-ageing research
Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector
A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13 TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV
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