18 research outputs found
Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial
- Author
- Antoniadou Anastasia
- Arlinda Dona
- Arnoczy Gretchen S
- Babiker Abdel G
- Baker Jason V
- Benfield Thomas
- Bhagani Sanjay
- Canario Daniel
- Cao Huyen
- Chang Christina C
- Cummings Matthew J
- Dewar Robin
- Doyle Mittie K
- Eriobu Nnakelu
- Fernández-Cruz Eduardo
- Frosch Anne EP
- Gerry Norman
- Grund Birgit
- Hadi Usman
- Hall Christine
- Hariadi Prasetyo
- Helleberg Marie
- Higgs Elizabeth
- Highbarger Helene
- Holbrook Michael R
- Holley Horace P
- Hudson Fleur
- Jain Mamta K
- Jensen MD Tomas O
- Jensen Jens Ulrik Stæhr
- Johansen Isik S
- Kalomenidis Ioannis
- Kan Virginia L
- Koulouris Nikolaos G
- Kwaghe Vivian
- Lallemand Perrine
- Lane H Clifford
- Lazarte Susana M
- Liu Sean TH
- Lloyd Kathryn M
- Losso Marcelo H
- Lundgren Jens D
- Lübbert Christoph
- Malin Jakob J
- Mateu Lourdes
- McBride Natalie A
- McNay Laura A
- Meegada Sreenath
- Metallidis Simeon
- Mondou Elsa
- Morales-Rull Jose Luis
- Murray Daniel D
- Muñoz Jose
- Narang Rajeev
- Neaton James D
- Nordwall Jacqueline
- Paredes Roger
- Pett Sarah L
- Phillips Andrew
- Podlekareva Daria
- Polizzotto Mark N
- Popik Sharon
- Poulakou Garyfallia
- Ramachandruni Srikanth
- Ramanathan Roshan
- Rehman Tauseef
- Robinson Philip A
- Røge Birgit Thorup
- Saito Sho
- Sakurai Aki
- Sarafian Farjad
- Shah Amish
- Shaughnessy Megan
- Shaw-Saliba Kathryn
- Smolskis Mary C
- Susilo Adityo
- Sweerus Kelly
- Syrigos Konstantinos N
- Taha Hassan S
- Thakuria Joseph V
- Touloumi Giota
- Trotman Robin
- Turner Dan
- Vock David M
- Weintrob Amy C
- Willis Todd
- Wright Mary E
- Yel Leman
- Publication venue
- 'Elsevier BV'
- Publication date
- 05/02/2022
- Field of study
BACKGROUND:
Passive immunotherapy using hyperimmune intravenous immunoglobulin (hIVIG) to SARS-CoV-2, derived from recovered donors, is a potential rapidly available, specific therapy for an outbreak infection such as SARS-CoV-2. Findings from randomised clinical trials of hIVIG for the treatment of COVID-19 are limited.
METHODS:
In this international randomised, double-blind, placebo-controlled trial, hospitalised patients with COVID-19 who had been symptomatic for up to 12 days and did not have acute end-organ failure were randomly assigned (1:1) to receive either hIVIG or an equivalent volume of saline as placebo, in addition to remdesivir, when not contraindicated, and other standard clinical care. Randomisation was stratified by site pharmacy; schedules were prepared using a mass-weighted urn design. Infusions were prepared and masked by trial pharmacists; all other investigators, research staff, and trial participants were masked to group allocation. Follow-up was for 28 days. The primary outcome was measured at day 7 by a seven-category ordinal endpoint that considered pulmonary status and extrapulmonary complications and ranged from no limiting symptoms to death. Deaths and adverse events, including organ failure and serious infections, were used to define composite safety outcomes at days 7 and 28. Prespecified subgroup analyses were carried out for efficacy and safety outcomes by duration of symptoms, the presence of anti-spike neutralising antibodies, and other baseline factors. Analyses were done on a modified intention-to-treat (mITT) population, which included all randomly assigned participants who met eligibility criteria and received all or part of the assigned study product infusion. This study is registered with ClinicalTrials.gov, NCT04546581.
FINDINGS:
From Oct 8, 2020, to Feb 10, 2021, 593 participants (n=301 hIVIG, n=292 placebo) were enrolled at 63 sites in 11 countries; 579 patients were included in the mITT analysis. Compared with placebo, the hIVIG group did not have significantly greater odds of a more favourable outcome at day 7; the adjusted OR was 1·06 (95% CI 0·77–1·45; p=0·72). Infusions were well tolerated, although infusion reactions were more common in the hIVIG group (18·6% vs 9·5% for placebo; p=0·002). The percentage with the composite safety outcome at day 7 was similar for the hIVIG (24%) and placebo groups (25%; OR 0·98, 95% CI 0·66–1·46; p=0·91). The ORs for the day 7 ordinal outcome did not vary for subgroups considered, but there was evidence of heterogeneity of the treatment effect for the day 7 composite safety outcome: risk was greater for hIVIG compared with placebo for patients who were antibody positive (OR 2·21, 95% CI 1·14–4·29); for patients who were antibody negative, the OR was 0·51 (0·29–0·90; pinteraction=0·001).
INTERPRETATION:
When administered with standard of care including remdesivir, SARS-CoV-2 hIVIG did not demonstrate efficacy among patients hospitalised with COVID-19 without end-organ failure. The safety of hIVIG might vary by the presence of endogenous neutralising antibodies at entry.
FUNDING:
US National Institutes of Health
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
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- Herruzo-Aviles A
- Heunks LM
- Hewitt H
- Heyne T
- Hickey S
- Hidalgo C
- Hikasa Y
- Hillier SD
- Himmel Y
- Himpe D
- Hinojosa-Perez R
- Hirata A
- Hirayama T
- Hirohata S
- Hodgson LE
- Hodgson LE
- Hofmeijer J
- Hollands S
- Hom H
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- Hopkins PA
- Hoppu S
- Hoppu S
- Horkan CM
- Horstmann C
- Horton A
- Horvat A
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- Houzé S
- Houzé S
- Howes D
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- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
- Irazabal JM
- Ishimatsu S
- Itenov TS
- Iwamoto M
- Izawa M
- Izdes S
- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
- Jeong WY
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- Jian Z
- Jiao LR
- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
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- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katabami K
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- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
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- Keep J
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- Kellner F
- Kelly JM
- Kenardy J
- Keough E
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- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
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- Kim KS
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- Kim MH
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- Kim W
- Kimmoun A
- King HS
- Kinnear J
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- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
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- Klaus DA
- Kleinpell R
- Kluge S
- Knafelj R
- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
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- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
- Ku NS
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- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
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- Kwon HM
- Kwon HM
- Kwon WY
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- Kye YC
- Kyle UG
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Latini R
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- Latini R
- Latorre J
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- Laureys S
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- Legrand M
- Legrand M
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- Leitao AL
- Leite RT
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- Leone M
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- Lerma FA
- Lesmes SP
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- Li SH
- Liao X
- Lichtenstein D
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- Limuti R
- Lin KC
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- Lin WC
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- Lischinsky A
- Lissonde F
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- Litchfield K
- Liu CP
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- Liu D
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- Llorente B
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- Lobato MS
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- Loizou C
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- Longhi L
- Lopes JA
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- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
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- Lotay R
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- Louf-Durier A
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- Louis B
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- Lukaszewicz AC
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- MacKay A
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- Macrì M
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- Maekawa K
- Maekawa K
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- Magnoni S
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- Maistry N
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- Mengelle C
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- Mezidi M
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Simón JM
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- Singer M
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- Sirisena N
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- Siu K
- Sjövall F
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- Smekal D
- Snelson C
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- Sobhanian S
- Soeffker G
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- Sokolova E
- Solanki S
- Soler EA
- Solligård E
- Solé-Violán J
- Somhorst P
- Son Y
- Song I
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- Sonneville R
- Sosa M
- Sossou A
- Sousa SC
- Soussi S
- Souza VA
- Spadaro S
- Spadaro S
- Spahn DR
- Spatenkova V
- Spazzadeschi A
- Spijkstra JJ
- Spronk PE
- Spronk PE
- Sprung CL
- St George’s University of London
- Stamm J
- Stamouli M
- Stanić R
- Starczewska M
- Staszewsky L
- Stauffert N
- Stella A
- Stephens T
- Stiphout C
- Stocchetti N
- Stocchetti N
- Stougianni M
- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- Stümpfle R
- Stümpfle R
- Su F
- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
- Suh GY
- Suh JW
- Sullivan E
- Sun WZ
- Sun XM
- Sung D
- Suwanpasu S
- Suzuki S
- Suzuki T
- Swart M
- Sy O
- Sydow K
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- Sáez VC
- Sánchez B
- Sánchez B
- Sánchez EC
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez PC
- Sánchez PC
- Sánchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taggu A
- Taggu A
- Takahashi H
- Takaki S
- Takaki S
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- Takeda M
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- Tapponnier R
- Tapponnier R
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- Tarabrin P
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- Temprano-Gómez I
- Tena SA
- Tencé N
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- Theodorakopoulou M
- Thies P
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- Timsit JF
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- Tirumala S
- Tjepkema-Cloostermans MC
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- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
- Tomic I
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- Tomás MA
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- Tormos P
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- Vanhuyse F
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- Vaquerizo C
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- Varas JL
- Varea MM
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- Vazquez D
- Vedage D
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- Viera MA
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- Villard I
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- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
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- Wood CA
- Wood D
- Wood M
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- Xie Z
- Xini A
- Xini A
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- Xu M
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- Yaguchi A
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- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
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- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
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- Zhou JX
- Zhovnir V
- Zibandah N
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- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
- Adisa AO
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguado Suarez N
- Aguilar-Jimenez J
- Aguilera M
- Aguilera ML
- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed S
- Ahmed S
- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
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- Al-Saqqa SW
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- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
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- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
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- Amin J
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- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
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- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
- Asal M
- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
- Augestad KM
- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
- Basir ERM
- Bassem M
- Bassit KA
- Basso SMM
- Basson S
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- Beamon M
- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
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- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
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- Blackwell J
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- Blencowe N
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- Blower E
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- Boal M
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- Elhusseiny AAE
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- Lim G
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- Madrid Barrientos LA
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- Mirza A
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- Mogan YP
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- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
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- Mohammed MMH
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- Montoya Botero JA
- Montrimaite M
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- Mosalum O
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- Mostafa M
- Mostafa M
- Mousa M
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- Samaraweera DI
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- Smedley A
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- Snyder E
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
- Solar Garcia L
- Soldevila-Verdeguer C
- Soley R
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- Soliman N
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- Soltani N
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- Stefanopoulos A
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- Summerour V
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- Sundstrom SM
- Suresh S
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- Sutton P
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- Suyadi A
- Swann J
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- Szeto CCL
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- Taddei A
- Tade A
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- Taha EMS
- Tahboub H
- Taher AA
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- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
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- Talukder S
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- Talving P
- Talving P
- Tammam A
- Tan C
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- Tan CY
- Tan JJ
- Tan JK
- Tan KSK
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Zhu B
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- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC):a double-blind, placebo-controlled, phase 3, randomised trial
- Author
- Antoniadou Anastasia
- Arnoczy Gretchen S.
- Babiker Abdel G.
- Baker Jason V.
- Benfield Thomas
- Bhagani Sanjay
- Canario Daniel
- Eriobu Nnakelu
- Fernández-Cruz Eduardo
- Frosch Anne E.P.
- Hadi Usman
- Hariadi Prasetyo
- Helleberg Marie
- Jain Mamta K.
- Jensen MD Tomas O.
- Jensen Jens Ulrik Stæhr
- Johansen Isik S.
- Kalomenidis Ioannis
- Koulouris Nikolaos G.
- Kwaghe Vivian
- Lazarte Susana M.
- Liu Sean T.H.
- Lloyd Kathryn M.
- Lundgren Jens D.
- Mateu Lourdes
- McBride Natalie A.
- Meegada Sreenath
- Metallidis Simeon
- Morales-Rull Jose Luis
- Muñoz Jose
- Narang Rajeev
- Nordwall Jacqueline
- Paredes Roger
- Phillips Andrew
- Podlekareva Daria
- Polizzotto Mark N.
- Poulakou Garyfallia
- Ramachandruni Srikanth
- Robinson Philip A.
- Røge Birgit Thorup
- Saito Sho
- Sakurai Aki
- Sarafian Farjad
- Shah Amish
- Susilo Adityo
- Syrigos Konstantinos N.
- Taha Hassan S.
- Trotman Robin
- Vock David M.
- Weintrob Amy C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Measurement of charged particle spectra in minimum-bias events from proton-proton collisions at root s =13 TeV
- Author
- Aarrestad Thea Klaeboe
- Abad David Romero
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adzic Petar
- Agapitos Antonis
- Agaras Merve Nazlim
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akbiyik Melike
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albajar Carmen
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Allen Brandon
- Almond John
- Alonso Andrea Garc�a
- Alunni Solestizi Luisa
- Alvarez Jos� David Ruiz
- Alverson George
- Alves F�bio L�cio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Ambrogi Federico
- Amendola Chiara
- Amin Nick
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arndt Till
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Atakisi Ismail Okan
- Atay Serhat
- Ather Mohsan Waseem
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avila Carlos
- Ayala Edy
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babaev Anton
- Babounikau Illia
- Bacchetta Nicola
- Bachiller Irene
- Bachtis Michail
- Backhaus Malte
- Baden Drew
- Baginyan Andrey
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Ball Austin
- Ball Fionn
- Ban Yong
- Band Reyer
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bart�k M�rton
- Baselga Marta
- Baskakov Alexey
- Bat Ayse
- Battilana Carlo
- Baty Austin
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baur Sebastian
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Beghin Diego
- Behera Prafulla Kumar
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Bell Ken W.
- Bellan Riccardo
- Belloni Alberto
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benecke Anna
- Benelli Gabriele
- Beni Noemi
- Benussi Luigi
- Benvenuti Alberto
- Beretvas Andrew
- Bergauer Thomas
- Berger Pirmin
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernet Colin
- Berry Douglas
- Berryhill Jeffrey
- Bertl Willi
- Bertsche David
- Besancon Marc
- Beschi Andrea
- Betts Russell Richard
- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhardwaj Rishika
- Bharti Monika
- Bhat Muzamil Ahmad
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhattacharya Soham
- Bhawandeep Bhawandeep
- Bheesette Srinidhi
- Bhopatkar Vallary
- Bhowmik Debabrata
- Bhowmik Sandeep
- Bi Ran
- Bialkowska Helena
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Michele
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bin Anuar Afiq Aizuddin
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- Bitioukov Sergei
- Blekman Freya
- Blinov Vladimir
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
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- Bocci Andrea
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- Boletti Alessio
- Bolla Gino
- Bonacorsi Daniele
- Bondu Olivier
- Boos Edouard
- Boran Fatma
- Boren Samuel
- Borg Johan
- Borgonovi Lisa
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bose Tulika
- Botta Cristina
- Botta Valeria
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- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bouza V�ctor Rodr�guez
- Bowen James
- Bradmiller-Feld John
- Bragagnolo Alberto
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brainerd Christopher
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G.
- Bravo Cameron
- Breedon Richard
- Breeze Shane
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brito Lucas
- Brivio Francesco
- Brochero Cifuentes Javier Andres
- Brochet S�bastien
- Brodski Michael
- Brom Jean-Marie
- Brondolin Erica
- Brooke James John
- Brown Robert M.
- Brun Hugues
- Bruno Giacomo
- Brzhechko Danyyl
- Bucci Rachael
- Buccilli Andrew
- Buchanan James
- Buchmuller Oliver
- Bundock Aaron
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burkett Kevin
- Burns Douglas
- Burns Dustin
- Burt Kira
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H.
- Butz Erik
- Bylinkin Alexander
- Bylsma Ben
- Byszuk Adrian
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- Cabrillo Iban Jose
- Cadamuro Luca
- Caillol C�cile
- Cakir Altan
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- Calderon Alicia
- Cali Ivan Amos
- Call Kenneth
- Calligaris Luigi
- Caminada Lea
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Canepa Anadi
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- Capiluppi Paolo
- Caputo Claudio
- Carlin Roberto
- Carlsmith Duncan
- Carnes Andrew
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Antunes de Oliveira Alexandra
- Carvalho Wagner
- Carver Matthew
- Casarsa Massimo
- Casasso Stefano
- Caspart Ren�
- Castaldi Rino
- Castaneda Hernandez Alfredo
- Castilla-Valdez Heriberto
- Castle James
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- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceballos Guillelmo Gomez
- Cecchi Claudia
- Celik Ali
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- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chang Paoti
- Chang Yu-Hsiang
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Chapon Emilien
- Charaf Otman
- Charlot Claude
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chatterjee Suman
- Chauhan Shubhanshu
- Chauhan Sushil
- Chaves Jorge
- Chawla Ridhi
- Chazin Quero Barbara
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- Chekhovsky Vladimir
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- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Mingshui
- Chen Po-Hsun
- Chen Xuan
- Chen Ye
- Chen Yi
- Chen Zhenyu
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- Cheng Tongguang
- Cheng Yangyang
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- Chernyavskaya Nadezda
- Chertok Maxwell
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- Chierici Roberto
- Chinellato Jose
- Chistov Ruslan
- Chlebana Frank
- Cho Sungwoong
- Choi Suyong
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Somnath
- Chu Jennifer
- Chudasama Ruchi
- Chwalek Thorsten
- Ciangottini Diego
- Cieri Davide
- Ciocci Maria Agnese
- Cipriani Marco
- Ciriolo Vincenzo
- Cirkovic Predrag
- Citron Matthew
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- CMS Collaboration
- Cockerill David J. A.
- Cocoros Alice
- Codispoti Giuseppe
- Coelho Eduardo
- Colafranceschi Stefano
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- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Colombo Fabio
- Connor Patrick
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Conway John
- Conway Rylan
- Cooper Seth
- Cooperstein Stephane
- Cornelis Tom
- Corpe Louie
- Correia Silva Gilson
- Cossutti Fabio
- Costa Marco
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- Coubez Xavier
- Couderc Fabrice
- Coughlan John A.
- Courbon Benoit
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremonesi Matteo
- Cristella Leonardo
- Cruz Sergio Sanchez
- Csanad Mate
- Cucciati Giacomo
- Cuevas Javier
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- Cumalat John Perry
- Curry David
- Cussans David
- Cutts David
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- Da Silveira Gustavo Gil
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- Daci Nadir
- Dalchenko Mykhailo
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- Dallavalle Gaetano-Marco
- Damarseckin Serdal
- Damgov Jordan
- Damiani Daniela Dom�nguez
- Danilov Vladyslav
- Daponte Vincenzo
- Das Pallabi
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- Daskalakis Georgios
- Dasu Sridhara
- Datta Abhisek
- Dauncey Paul
- David Tinoco Mendes Andre
- David Pieter
- Davies Gavin
- Davignon Olivier
- de Barbaro Pawel
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- De Clercq Jarne
- De Cosa Annapaola
- De Filippis Nicola
- De Guio Federico
- De Jesus Damiao Dilson
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- De La Cruz-Burelo Eduard
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- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
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- De Wit Adinda
- De Wolf Eddi A.
- Deelen Nikkie
- Defranchis Matteo Maria
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- Dejardin Marc
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- Del Re Daniele
- Delaere Christophe
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- Delannoy Hugo
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- Delgado Andrea
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- Della Ricca Giuseppe
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- Demina Regina
- Demiragli Zeynep
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- Depasse Pierre
- Derdzinski Mark
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- Deroover Kevin
- Dev Nabarun
- Devetak Damir
- Dewanjee Ram Krishna
- Dey Sourav
- Dhingra Nitish
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- Di Croce Davide
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- Di Maria Riccardo
- Di Mattia Alessandro
- Diemoz Marcella
- Dierlamm Alexander
- Diez Pardos Carmen
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- Dishaw Adam
- Dissertori G�nther
- Dittmann Jay
- Dittmar Michael
- Dittmer Susan
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- Duchardt Deborah
- Dudenas Vytautas
- Dudero Phillip Russell
- Dugad Shashikant
- Duh Yi-ting
- Dulemba Joseph Lynn
- Dupont Niels
- Duran-Osuna Cecilia
- Durgut S�leyman
- Duric Senka
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- Eckerlin Guenter
- Ecklund Karl Matthew
- Eerola Paula
- Ehataht Karl
- Eichhorn Thomas
- El Mamouni Houmani
- Elliott-Peisert Anna
- Elmer Peter
- Elumakhov Dmitry
- Elvira Victor Daniel
- Elwood Adam
- Eminizer Nicholas
- Endres Matthias
- Eno Sarah Catherine
- Epshteyn Vladimir
- Erbacher Robin
- Erdmann Martin
- Erdmann Wolfram
- Eren Engin
- Erice Carlos
- Errico Filippo
- Ershov Alexander
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- Escalante Del Valle Alberto
- Esch Thomas
- Eskandari Tadavani Esmaeel
- Eskut Eda
- Espinosa Tirso Alejandro G�mez
- Estrada Cecilia Uribe
- Etesami Seyed Mohsen
- Eusebi Ricardo
- Evangelou Ioannis
- Evans Andrew
- Evdokimov Olga
- Everaerts Pieter
- Eysermans Jan
- Fabbri Fabrizio
- Fabbri Franco
- Fabozzi Francesco
- Faccioli Pietro
- Fagot Alexis
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- Fang Wenxing
- Fangmeier Caleb
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- Fasanella Giuseppe
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- Favart Laurent
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- Fernandez Bedoya Cristina
- Fernandez Menendez Javier
- Fernandez Marcos
- Fern�ndez Adrian �lvarez
- Fern�ndez Juan Rodrigo Gonz�lez
- Ferraioli Charles
- Ferri Federico
- Ferro Fabrizio
- Field Richard D.
- Fienga Francesco
- Figueiredo Diego Matos
- Filipovic Nicolas
- Finco Linda
- Finger Michael, Jr.
- Finger Miroslav
- Fiore Luigi
- Fiorendi Sara
- Fischer Robert
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- Flechl Martin
- Flix Jose
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- Flores Chad
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- Flouris Giannis
- Flowers Sean
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- Focardi Ettore
- Folgueras Santiago
- Fonseca De Souza Sandro
- Fontaine Jean-Charles
- Ford William T.
- Foudas Costas
- Fouz Maria Cruz
- Francis Brian
- Franco Sevilla Manuel
- Francois Brieuc
- Franzoni Giovanni
- Freed Sarah
- Freeman Jim
- Freer Chad
- Freund Benedikt
- Frueboes Tomasz
- Fruehwirth Rudolf
- Fulcher Jonathan
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- Funk Wolfgang
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- Galanti Mario
- Galati Giuliana
- Galinhas Bruno
- Gallinaro Michele
- Gallo Elisabetta
- Galloni Camilla
- Gandrajula Reddy Pratap
- Ganjour Serguei
- Gao Xuyang
- Garcia-Bellido Aran
- Garcia-Ferrero Juan
- Garg Rocky Bala
- Garutti Erika
- Gary J. William
- Gascon Susan
- Gasparini Fabrizio
- Gasparini Ugo
- Gastler Daniel
- Gavrilov Vladimir
- Gecse Zoltan
- Geiser Achim
- Gelli Simone
- Gelmi Andrea
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- Gennai Simone
- Geralis Theodoros
- Gerber Cecilia Elena
- Gerosa Raffaele
- Gershtein Yuri
- Geurts Frank J. M.
- Ghete Vasile Mihai
- Ghezzi Alessio
- Ghiasi Shirazi Seyyed Mohammad Amin
- Ghosh Saranya
- Ghosh Shamik
- Giacomelli Paolo
- Giammanco Andrea
- Gianneios Paraskevas
- Giannini Leonardo
- Giassi Alessandro
- Giffels Manuel
- Gigi Dominique
- Gilbert Andrew
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- Gill Karl
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- Givernaud Alain
- Glege Frank
- Gleyzer Sergei V.
- Gninenko Sergei
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- Godshalk Andrew
- Goerlach Ulrich
- Goh Junghwan
- Gokbulut Gul
- Gola Mohit
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- Goldstein Joel
- Golf Frank
- Golovtsov Victor
- Golubev Nikolai
- Golutvin Igor
- Gomber Bhawna
- Gomez Gervasio
- Goncharov Maxim
- Gonzalez Caballero Isidro
- Gonzalez Lopez Oscar
- Gonzalez Suarez Rebeca
- Gonzalez Daniel
- Gonzalez Juan Suarez
- Gottschalk Erik
- Gouskos Loukas
- Gouzevitch Maxime
- Govoni Pietro
- Goy Lopez Silvia
- Gozzelino Andrea
- Grab Christoph
- Grados Luyando Juan Manuel
- Grandi Claudio
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- Grebenyuk Anastasia
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- Grippo Maria Teresa
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- Grohsjean Alexander
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- Hadjiiska Roumyana
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- Hajdu Csaba
- Hakala John
- Halkiadakis Eva
- Hall Geoffrey
- Haller Johannes
- Hamel de Monchenault Gautier
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- Hangal Dhanush Anil
- Hanlon Jim
- Hansen Peter
- Hanson Gail
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- Hardenbrook Joshua
- Harder Kristian
- Harper Sam
- Harr Robert
- Harrendorf Marco Alexander
- Harrington Charles
- Harris Philip
- Harris Robert M.
- Hart Andrew
- Hartmann Frank
- Hasegawa Satoshi
- Hashemi Bobak
- Hassan Qamar
- Hatakeyama Kenichi
- Hauk Johannes
- Hauser Jay
- Havukainen Joona
- Haytmyradov Maksat
- Heath Greg P.
- Heath Helen F.
- Hebbeker Thomas
- Hebda Philip
- Hegde Vinay
- Hegeman Jeroen
- Heidegger Constantin
- Heideman Joseph
- Heidemann Carsten
- Heikkil� Jaana Kristiina
- Heindl Maximilian
- Heindl Stefan Michael
- Heintz Ulrich
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- Hernandez Jose M.
- Herndon Matthew
- Hern�ndez Alberto S�nchez
- Hern�ndez Carlos Felipe Gonz�lez
- Herv� Alain
- Higginbotham Samuel
- Hildreth Michael
- Hill Christopher
- Hindrichs Otto
- Hinzmann Andreas
- Hirosky Robert
- Hirschauer James
- Hits Dmitry
- Hlushchenko Olena
- Hobson Peter R.
- Hoepfner Kerstin
- Hoffmann Malte
- Hofman David Jonathan
- Hogan Julie Managan
- Hohlmann Marcus
- Hollar Jonathan
- Holzner Andr�
- Hong Byung-Sik
- Hoorani Hafeez R.
- Horisberger Roland
- Hortiangtham Apichart
- Horvath Dezso
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- Hreus Tomas
- Hrubec Josef
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- Hughes Elliot
- Hung Wai Ting
- Hunyadi �d�m
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- Husemann Ulrich
- Hussain Usama
- Hwang Chanwook
- Iaselli Giuseppe
- Iashvili Ia
- Iaydjiev Plamen
- Ibarguen Humberto Antonio Salazar
- Ibrahim Zainol Abidin
- Iglesias Lara Lloret
- Ignatenko Mikhail
- Iiyama Yutaro
- Iles Gregory
- Ille Bernard
- Incandela Joe
- Ingram Quentin
- Innocente Vincenzo
- Innocenti Gian Michele
- Iorio Alberto Orso Maria
- Isildak Bora
- Ivanov Andrew
- Ivanov Yury
- Jabeen Shabnam
- Jafari Abideh
- Jain Sandhya
- Jain Shilpi
- James Thomas
- Janjam Ravi
- Janot Patrick
- Jansov� Mark�ta
- Janssen Xavier
- Jarry Patrick
- Jarvinen Terhi
- Jayatilaka Bodhitha
- Jeitler Manfred
- Jeng Geng-Yuan
- Jensen Frank
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- Jha Vishwajeet
- Ji Weifeng
- Jiang Chun-Hua
- Jindariani Sergo
- Jo Youngkwon
- Johns Willard
- Johnson Andrew
- Johnson Kurtis F.
- Johnson Marvin
- Jones Matthew
- Josa Maria Isabel
- Joshi Bhargav Madhusudan
- Joshi Umesh
- Joshi Yagya Raj
- Joyce Matthew
- Jung Andreas Werner
- Jung Hannes
- Jung Kurt
- Juodagalvis Andrius
- Kaadze Ketino
- Kachanov Vassili
- Kadastik Mario
- Kadija Kreso
- Kaestli Hans-Christian
- Kalafut Sean
- Kalinin Alexey
- Kalinowski Artur
- Kalogeropoulos Alexis
- Kalsi Amandeep Kaur
- Kamalieddin Rami
- Kamin Jason
- Kamon Teruki
- Kangal Evrim Ersin
- Kaplan Steven
- Kapoor Anshul
- Kara Ozgun
- Karacheban Olena
- Karancsi J�nos
- Karapinar Guler
- Karapostoli Georgia
- Karathanasis George
- Karavdina Anastasia
- Karchin Paul Edmund
- Kardapoltsev Leonid
- Kargoll Bastian
- Karim�ki Veikko
- Karjavine Vladimir
- Karmgard Daniel John
- Karneyeu Anton
- Kasemann Matthias
- Kashunin Ivan
- Kasieczka Gregor
- Kassel Florian
- Katkov Igor
- Katsoulis Panagiotis
- Kaur Amandeep
- Kaur Anterpreet
- Kaur Manjit
- Kaur Sandeep
- Kaya Mithat
- Kaya Ozlem
- Kazana Malgorzata
- Keaveney James
- Kellams Nathan
- Keller Henning
- Kellogg Richard G.
- Kennedy Elizabeth
- Keshri Sumit
- Kesisoglou Stilianos
- Khakzad Mohsen
- Khalil Sadia
- Khan Akram
- Khan Wajid Ali
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- Khatiwada Ajeeta
- Khein Lev
- Khristenko Viktor
- Khukhunaishvili Aleko
- Khurana Raman
- Khvastunov Illia
- Khvedelidze Arsen
- Kiani Bilal
- Kiesel Maximilian Knut
- Kieseler Jan
- Kilminster Benjamin
- Kilpatrick Matthew
- Kim Dong Hee
- Kim Doyeong
- Kim Gui Nyun
- Kim Hyunchul
- Kim Hyunsoo
- Kim Hyunyong
- Kim Jae Sung
- Kim Ji Hyun
- Kim Junho
- Kim Min Suk
- Kim Tae Jeong
- Kim Victor
- Kiminsu Ugur
- Kinnunen Ritva
- Kirakosyan Martin
- Kirsanov Mikhail
- Kirschenmann Henning
- Klabbers Pamela
- Klanner Robert
- Klein Daniel
- Klein Katja
- Kleinwort Claus
- Klijnsma Thomas
- Klima Boaz
- Klute Markus
- Klyukhin Vyacheslav
- Knolle Joscha
- Knutzen Simon
- Kn�nz Valentin
- Ko Winston
- Kodolova Olga
- Kogler Roman
- Kokkas Panagiotis
- Kolberg Ted
- Kole Gouranga
- Komaragiri Jyothsna Rani
- Komm Matthias
- Komurcu Yildiray
- Konecki Marcin
- Konigsberg Jacobo
- Konstantinov Dmitri
- Kontaxakis Pantelis
- Korenkov Vladimir
- Kornmayer Andreas
- Kortelainen Matti J.
- Korytov Andrey
- Kothekar Kunal
- Kotlinski Danek
- Kousouris Konstantinos
- Kovac Marko
- Kovalchuk Nataliia
- Kovalskyi Dmytro
- Kozlov Guennady
- Krammer Manfred
- Krammer Natascha
- Krasnikov Nikolai
- Kravchenko Ilya
- Kreczko Lukasz
- Kreis Benjamin
- Kress Thomas
- Krintiras Georgios
- Krofcheck David
- Krohn Michael
- Krolikowski Jan
- Kropivnitskaya Anna
- Krutelyov Vyacheslav
- Kr�cker Dirk
- Kr�tschmer Ilse
- Kubota Yuichi
- Kucher Inna
- Kudella Simon
- Kukral Ota
- Kumar Arun
- Kumar Ashok
- Kumar Ramandeep
- Kumar Sanjeev
- Kumar Vineet
- Kumari Priyanka
- Kunkle Joshua
- Kunnawalkam Elayavalli Raghav
- Kunori Shuichi
- Kuo Chia-Ming
- Kurz Simon
- Kutzner Viktor
- Kuznetsova Ekaterina
- Kwok Ka Hei Martin
- Kyberd Paul
- Kyriacou Savvas
- Kyriakis Aristotelis
- K�nsken Andreas
- La Cruz Ivan Heredia-De
- Lacaprara Stefano
- Lacroix Florent
- Lagarde Francois
- Laird Edward
- Laktineh Imad Baptiste
- Lamichhane Kamal
- Lammel Stephan
- Lamp�n Tapio
- Lanaro Armando
- Lander Richard
- Landsberg Greg
- Laner Christian
- Lanev Alexander
- Lange Clemens
- Lange David
- Lange Johannes
- Lange Wolfgang
- Langenegger Urs
- Lannon Kevin
- Lariccia Paolo
- Lassila-Perini Kati
- Lath Amitabh
- Latino Giuseppe
- Lattaud Hugues
- Laurila Santeri
- Lauwers Jasper
- Lawhorn Jay Mathew
- Le Bihan Anne-Catherine
- Lecoq Paul
- Ledovskoy Alexander
- Lee Haneol
- Lee Jangbae
- Lee Jason Sang Hun
- Lee Jeongeun
- Lee Jongseok
- Lee Kisoo
- Lee Kyeongpil
- Lee Kyong Sei
- Lee Sangeun
- Lee Seh Wook
- Lee Songkyo
- Lee Sung Won
- Lee Yen-Jie
- Leggat Duncan
- Lehti Sami
- Lelas Damir
- Lelek Aleksandra
- Leloup Cl�ment
- Lemaitre Vincent
- Lenz Teresa
- Lenzi Piergiulio
- Lenzi Thomas
- Leonardo Nuno
- Leontsinis Stefanos
- Lesko Zachary
- Lethuillier Morgan
- Letts James
- Levchenko Petr
- Levchuk Leonid
- Levin Andrew
- Levine Aaron
- Lezki Samet
- Li Hengne
- Li Jing
- Li Linwei
- Li Qiang
- Li Wei
- Li Wenzhao
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- Liao Hongbo
- Ligabue Franco
- Liko Dietrich
- Lim Jaehoon
- Lin Willis
- Linacre Jacob
- Lincoln Don
- Lind�n Tomas
- Ling Ta-Yung
- Linn Stephan
- Lipinski Martin
- Lipka Katerina
- Lipton Ron
- Lisniak Stanislav
- Lista Luca
- Litov Leander
- Liu Hongxuan
- Liu Miaoyuan
- Liu Tiehui
- Liu Zhenan
- Lo Kin Ho
- Lobanov Artur
- Locci Elizabeth
- Lohan Manisha
- Lohmann Wolfgang
- Lokhtin Igor
- Long Kenneth
- Long Owen Rosser
- Longo Egidio
- Lontkovskyi Denys
- Lopez-Fernandez Ricardo
- Loukas Demetrios
- Loukas Nikitas
- Lourenco Carlos
- Loveless Richard
- Lowette Steven
- Lu Rong-Shyang
- Lucchini Marco Toliman
- Luckey Paul David
- Luetic Jelena
- Lujan Paul
- Lukina Olga
- Luo Jingyu
- Luo Sifu
- Luo Wuming
- Lustermann Werner
- Luukka Panja-Riina
- Lychkovskaya Natalia
- Lykken Joseph
- Lyons Louis
- Ma Peisen
- MacDonald Emily
- Mackay Catherine Kirsty
- Madlener Thomas
- Madrid Christopher
- Maeshima Kaori
- Maggi Giorgio
- Maggi Marcello
- Magitteri Alessio
- Magnan Anne-Marie
- Magnani Alice
- Maguire Charles
- Mahakud Bibhuprasad
- Mahmoud Mohammed
- Maier Benedikt
- Maity Manas
- Major P�ter
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- Majumder Gobinda
- Makovec Alajos
- Maksimovic Petar
- Mal Prolay
- Malakhov Alexander
- Malberti Martina
- Malbouisson Helena
- Malcles Julie
- Malgeri Luca
- Malhotra Shivali
- Malik Sarah
- Malik Sudhir
- Mallios Stavros
- Malvezzi Sandra
- Manca Elisabetta
- Mandal Koushik
- Mandorli Giulio
- Mandrik Petr
- Manganote Edmilson Jos� Tonelli
- Mankel Rainer
- Mannelli Marcello
- Manoni Elisa
- Mans Jeremy
- Manteca Pedro Jos� Fern�ndez
- Manthos Nikolaos
- Mantovani Giancarlo
- Manzoni Riccardo Andrea
- Mao Yajun
- Mao Zaixing
- Maravin Yurii
- Marcellini Stefano
- Marchesini Ivan
- Marco Jesus
- Marconi Daniele
- Margoni Martino
- Mariani Valentina
- Marinelli Nancy
- Marini Andrea Carlo
- Marinov Andrey
- Marionneau Matthieu
- Mariotti Chiara
- Marlow Daniel
- Marraffino John Michael
- Martelli Arabella
- Martin Blanco Javier
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- Martinez German
- Mart�nez Armando Berm�dez
- Marzocchi Badder
- Masciovecchio Mario
- Maselli Silvia
- Masetti Gianni
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- Massironi Andrea
- Mastrolorenzo Luca
- Matchev Konstantin
- Matorras Francisco
- Matveev Viktor
- Mavromanolakis Georgios
- Mazumdar Kajari
- Mcbrayer William
- McBride Patricia
- Mccoll Nickolas
- Mcdermott Kevin
- Mcginn Christopher
- Mclean Christine
- McMaster Brooks
- Md Ali Mohd Adli Bin
- Mehta Ankita
- Mei Hualin
- Mei Kelvin
- Meijers Frans
- Meinhard Maren Tabea
- Meister Daniel
- Mejia Guisao Jhovanny
- Melo Da Costa Eliza
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- Melo Andrew
- Melzer-Pellmann Isabell-Alissandra
- Menasce Dario
- Mendis Dalath Rachitha
- Meneguzzo Anna Teresa
- Meng Fanbo
- Mengke Tielige
- Menichelli Mauro
- Meola Sabino
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- Merkel Petra
- Merlin Jeremie Alexandre
- Merlo Jean-Pierre
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- Mersi Stefano
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- Meschi Emilio
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- Meyer Andreas Bernhard
- Meyer Arnd
- Meyer Mareike
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- Micheli Francesco
- Michlin Benjamin
- Migliore Ernesto
- Mignerey Alice
- Mikulec Ivan
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- Millet Philipp
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- Mirman Nathan
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- Mitra Soureek
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- Mittag Gregor
- Mnich Joachim
- Modak Atanu
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- Mohamad Idris Faridah
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- Mondal Kuntal
- Monroy Jose
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- Moon Dong Ho
- Moortgat Filip
- Moortgat Seth
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- Morelos Pineda Antonio
- Moroni Luigi
- Morse David Michael
- Morton Alexander
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- Mozer Matthias Ulrich
- Mrenna Stephen
- Mucia Nicholas
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- Mueller Ryan
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- Mulhearn Michael
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- Murray Michael
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- M�ller Thomas
- M�ller Thomas
- Nachtman Jane
- Nagy Marton Imre
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- Nam Kyungwook
- Nandan Saswati
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- Narayanan Siddharth
- Naseri Mohsen
- Nash Jordan
- Nash Kevin
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- Nawrocki Krzysztof
- Nayak Aruna
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- Nehrkorn Alexander
- Nemallapudi Mythra Varun
- Nessi-Tedaldi Francesca
- Netrakanti Pawan Kumar
- Neu Christopher
- Neugebauer Hannes
- Neumeister Norbert
- Neutelings Izaak
- Newbold Dave M.
- Newman Harvey B.
- Ngadiuba Jennifer
- Nguyen Duong
- Nguyen Matthew
- Nguyen Thong
- Ni Hong
- Nicolaou Charalambos
- Niedziela Marek
- Nikitenko Alexander
- Niu Xinmei
- Nogima Helio
- Noonan Daniel
- Norberg Scarlet
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- Novaes Sergio F.
- Nowack Andreas
- Nowatschin Dominik
- Nuzzo Salvatore
- O'Dell Vivian
- Obertino Maria Margherita
- Obraztsov Stepan
- Ochando Christophe
- Odell Nathaniel
- Oglakci Mehmet
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- Ojalvo Isabel
- Olaiya Emmanuel
- Oliveros Sandra
- Olivito Dominick
- Olmedo Negrete Manuel
- Olsen James
- Olszewski Michal
- Onel Yasar
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- Organtini Giovanni
- Orimoto Toyoko
- Oropeza Barrera Cristina
- Orsini Luciano
- Ortona Giacomo
- Osherson Marc
- Ovcharova Ana
- Ozdemir Kadri
- Ozok Ferhat
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- Pacher Luca
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- Padula Sandra
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- Palichik Vladimir
- Palla Fabrizio
- Palladino Vito
- Palmer Christopher
- Panagiotou Apostolos
- Pandey Shubham
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- Paolucci Pierluigi
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- Paramatti Riccardo
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- Pastrone Nadia
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- Pozdnyakov Ivan
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- Preiato Federico
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- Rahatlou Shahram
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- Rander John
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- Rauch Max Philip
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- Rebello Teles Patricia
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- Reinsvold Allison
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- Reyes-Almanza Rogelio
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- Riccardi Cristina
- Ricci-Tam Francesca
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- Richman Jeffrey
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- Roskes Jeffrey
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- Ruckstuhl Nicole
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- Rumerio Paolo
- Rusack Roger
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- Ruspa Marta
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- Ryutin Roman
- Sacchi Roberto
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- Salerno Roberto
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- Saltzberg David
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- Sandeep Kaur
- Sanders Stephen
- Sandoval Gonzalez Irving Daniel
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- Santanastasio Francesco
- Santocchia Attilio
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- Santra Arka
- Sanz Becerra Diego Alejandro
- Saoulidou Niki
- Sarica Ulascan
- Sarkar Subir
- Sarkar Tanmay
- Sauvan Jean-Baptiste
- Savin Alexander
- Savitskyi Mykola
- Savoy-Navarro Aurore
- Savrin Viktor
- Saxena Pooja
- Scharf Christian
- Scheuch Florian
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- Schmitz Erich
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- Schr�der Matthias
- Schulte Jan-Frederik
- Schulz Johannes
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- Schweiger Korbinian
- Schwick Christoph
- Sch�fbeck Robert
- Sch�fer Christoph
- Sch�nenberger Myriam
- Sch�tze Paul
- Sciacca Crisostomo
- Scodellaro Luca
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- Segura Delgado Manuel Alejandro
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- Seitz Claudia
- Seixas Joao
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- Selvaggi Giovanna
- Selvaggi Michele
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- Sexton-Kennedy Elizabeth
- Sguazzoni Giacomo
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- Shah Mehar Ali
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- Skatchkov Nikolai
- Skhirtladze Nikoloz
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- Smirnov Vitaly
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- Smith Dominic
- Smith Geoffrey
- Smith Nicholas
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- Smith Wesley H.
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- Spiridonov Alexander
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- Topakli Huseyin
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- Wright Jack
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- Yetkin Elif Asli
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- Yzquierdo Antonio Mar�a P�rez-Calero
- Zabel James
- Zabi Alexandre
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- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zeinali Maryam
- Zenaiev Oleksandr
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Aobo
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Sijing
- Zhang Zhicai
- Zhao Jingzhou
- Zhaozhong Shi
- Zhemchugov Evgenii
- Zhiltsov Victor
- Zhokin Alexander
- Zhu De Hua
- Zhu Ren-Yuan
- Zhukov Valery
- Zientek Margaret
- Zito Giuseppe
- Zobec Joze
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zucchetta Alberto
- Zumerle Gianni
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Pseudorapidity, transverse momentum, and multiplicity distributions are measured in the pseudorapidity range vertical bar eta vertical bar 0.5 GeV in proton-proton collisions at a center-of-mass energy of root s = 13 TeV. Measurements are presented in three different event categories. The most inclusive of the categories corresponds to an inelastic pp data set, while the other two categories are exclusive subsets of the inelastic sample that are either enhanced or depleted in single diffractive dissociation events. The measurements are compared to predictions from Monte Carlo event generators used to describe high-energy hadronic interactions in collider and cosmic-ray physics.Peer reviewe
Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial.
- Author
- Antoniadou Anastasia
- Arlinda Dona
- Arnoczy Gretchen S
- Babiker Abdel G
- Baker Jason V
- Benfield Thomas
- Bhagani Sanjay
- Canario Daniel
- Cao Huyen
- Chang Christina C
- Cummings Matthew J
- Dewar Robin
- Doyle Mittie K
- Eriobu Nnakelu
- Fernández-Cruz Eduardo
- Frosch Anne EP
- Gerry Norman
- Grund Birgit
- Hadi Usman
- Hall Christine
- Hariadi Prasetyo
- Helleberg Marie
- Higgs Elizabeth
- Highbarger Helene
- Holbrook Michael R
- Holley Horace P
- Hudson Fleur
- Jain Mamta K
- Jensen MD Tomas O
- Jensen Jens Ulrik Stæhr
- Johansen Isik S
- Kalomenidis Ioannis
- Kan Virginia L
- Koulouris Nikolaos G
- Kwaghe Vivian
- Lallemand Perrine
- Lane H Clifford
- Lazarte Susana M
- Liu Sean TH
- Lloyd Kathryn M
- Losso Marcelo H
- Lundgren Jens D
- Lübbert Christoph
- Malin Jakob J
- Mateu Lourdes
- McBride Natalie A
- McNay Laura A
- Meegada Sreenath
- Metallidis Simeon
- Mondou Elsa
- Morales-Rull Jose Luis
- Murray Daniel D
- Muñoz Jose
- Narang Rajeev
- Neaton James D
- Nordwall Jacqueline
- Paredes Roger
- Pett Sarah L
- Phillips Andrew
- Podlekareva Daria
- Polizzotto Mark N
- Popik Sharon
- Poulakou Garyfallia
- Ramachandruni Srikanth
- Ramanathan Roshan
- Rehman Tauseef
- Robinson Philip A
- Røge Birgit Thorup
- Saito Sho
- Sakurai Aki
- Sarafian Farjad
- Shah Amish
- Shaughnessy Megan
- Shaw-Saliba Kathryn
- Smolskis Mary C
- Susilo Adityo
- Sweerus Kelly
- Syrigos Konstantinos N
- Taha Hassan S
- Thakuria Joseph V
- Touloumi Giota
- Trotman Robin
- Turner Dan
- Vock David M
- Weintrob Amy C
- Willis Todd
- Wright Mary E
- Yel Leman
- Publication venue
- eScholarship, University of California
- Publication date
- 05/02/2022
- Field of study
BACKGROUND: Passive immunotherapy using hyperimmune intravenous immunoglobulin (hIVIG) to SARS-CoV-2, derived from recovered donors, is a potential rapidly available, specific therapy for an outbreak infection such as SARS-CoV-2. Findings from randomised clinical trials of hIVIG for the treatment of COVID-19 are limited. METHODS: In this international randomised, double-blind, placebo-controlled trial, hospitalised patients with COVID-19 who had been symptomatic for up to 12 days and did not have acute end-organ failure were randomly assigned (1:1) to receive either hIVIG or an equivalent volume of saline as placebo, in addition to remdesivir, when not contraindicated, and other standard clinical care. Randomisation was stratified by site pharmacy; schedules were prepared using a mass-weighted urn design. Infusions were prepared and masked by trial pharmacists; all other investigators, research staff, and trial participants were masked to group allocation. Follow-up was for 28 days. The primary outcome was measured at day 7 by a seven-category ordinal endpoint that considered pulmonary status and extrapulmonary complications and ranged from no limiting symptoms to death. Deaths and adverse events, including organ failure and serious infections, were used to define composite safety outcomes at days 7 and 28. Prespecified subgroup analyses were carried out for efficacy and safety outcomes by duration of symptoms, the presence of anti-spike neutralising antibodies, and other baseline factors. Analyses were done on a modified intention-to-treat (mITT) population, which included all randomly assigned participants who met eligibility criteria and received all or part of the assigned study product infusion. This study is registered with ClinicalTrials.gov, NCT04546581. FINDINGS: From Oct 8, 2020, to Feb 10, 2021, 593 participants (n=301 hIVIG, n=292 placebo) were enrolled at 63 sites in 11 countries; 579 patients were included in the mITT analysis. Compared with placebo, the hIVIG group did not have significantly greater odds of a more favourable outcome at day 7; the adjusted OR was 1·06 (95% CI 0·77-1·45; p=0·72). Infusions were well tolerated, although infusion reactions were more common in the hIVIG group (18·6% vs 9·5% for placebo; p=0·002). The percentage with the composite safety outcome at day 7 was similar for the hIVIG (24%) and placebo groups (25%; OR 0·98, 95% CI 0·66-1·46; p=0·91). The ORs for the day 7 ordinal outcome did not vary for subgroups considered, but there was evidence of heterogeneity of the treatment effect for the day 7 composite safety outcome: risk was greater for hIVIG compared with placebo for patients who were antibody positive (OR 2·21, 95% CI 1·14-4·29); for patients who were antibody negative, the OR was 0·51 (0·29-0·90; pinteraction=0·001). INTERPRETATION: When administered with standard of care including remdesivir, SARS-CoV-2 hIVIG did not demonstrate efficacy among patients hospitalised with COVID-19 without end-organ failure. The safety of hIVIG might vary by the presence of endogenous neutralising antibodies at entry. FUNDING: US National Institutes of Health
Anisotropic larval connectivity and metapopulation structure driven by directional oceanic currents in a marine fish targeted by small-scale fisheries
- Author
- A Metaxas
- A Munguia-Vega
- A Munguia-Vega
- A Piñon
- A Rocha-Olivares
- Adrian Munguia-Vega
- AL Green
- AL Green
- Alfredo Giron-Nava
- Amy Hudson Weaver
- AW Visser
- B Eldon
- B Erisman
- BY Benjamini
- C Lodeiros
- C Oosterhout Van
- CC D’Aloia
- D Hedgecock
- D Hedgecock
- D Hedgecock
- D Ottmann
- DA Paz-García
- David A. Paz-Garcia
- DC Queller
- E Sala
- E Sala
- EA Treml
- EA Treml
- Francisco J. García-Rodriguez
- G Soria
- G Soria
- GP Jones
- GR Almany
- GR Almany
- Hector Reyes-Bonilla
- HM Galindo
- I Paz-Vinas
- JA Proehl
- JG Diaz-Uribe
- JL Jensen
- JM Leis
- JM Pringle
- JM Yearsley
- JO Backhaus
- JO Irisson
- JR Watson
- JR Watson
- JT Kool
- JT Nichols
- JW White
- KA Selkoe
- KA Selkoe
- KA Selkoe
- KJ Nickols
- L Jost
- M Dubois
- M Iacchei
- M Pascual
- M Raymond
- MD Spalding
- ME Zarate-Becerra
- MEJ Newman
- MR Christie
- MS Johnson
- MS Johnson
- N Ryman
- O Aburto-Oropeza
- OJ Luiz
- Ollin Gonzalez-Cuellar
- P Beerli
- P Beerli
- PF Sale
- PG Meirmans
- PR Teske
- PR Teske
- R Beldade
- R Peakall
- RJ Dyer
- RJ Dyer
- RK Cowen
- RK Cowen
- S. Guido Marinone
- SC Burgess
- SC Burgess
- SG Marinone
- SG Marinone
- SG Marinone
- SG Marinone
- SG Marinone
- SG Marinone
- SG Marinone
- ST Kalinowski
- Tomas Plomozo-Lugo
- W Amos
- W Watson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The dispersal during the planktonic larval period is a key feature to understand the metapopulation structure of marine fishes, and is commonly described by four general models: (1) lack of population structure due to extensive larval dispersal; (2) isolation by geographic distance, where larval connectivity decreases with increasing distance between sites in all directions (isotropy); (3) population structure without any clear geographic trend (chaotic); and (4) population structure explained by seascape approaches that explicitly incorporate the spatial and temporal variations in the direction and strength of oceanic currents via oceanographic modeling. We tested the four models in the Pacific red snapper Lutjanus peru, a key commercial species in the Gulf of California (GC), Mexico. We genotyped 15 microsatellite loci in 225 samples collected during 20152016 from 8 sites, and contrasted the observed empirical genetic patterns against predictions from each model. We found low but significant levels of population structure among sites. Only the seascape approach was able to significantly explain levels of genetic structure and diversity, but exclusively within spring and summer, suggesting that this period represents the spawning season for L. peru. We showed that in the GC, the strong asymmetry in the oceanic currents causes larval connectivity to show different values when measured in distinct directions (anisotropy). Management tools, including marine reserves, could be more effective if placed upstream of the predominant flow. Managers should consider that oceanographic distances describing the direction and intensity of currents during the spawning period are significant predictors of larval connectivity between sites, as opposed to geographic distances.CONACYT fellowship [250126]; Walton Family Foundation [2011-1235]; David and Lucile Packard Foundation [2013-39359, 2013-39400, 2015-62798]; Fondo Institucional CONACYT-Fronteras de la Ciencia [26/2016]12 month embargo; published online: 22 November 2017This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Anisotropic larval connectivity and metapopulation structure driven by directional oceanic currents in a marine fish targeted by small-scale fisheries
- Author
- A Metaxas
- A Munguia-Vega
- A Munguia-Vega
- A Piñon
- A Rocha-Olivares
- Adrian Munguia-Vega
- AL Green
- AL Green
- Alfredo Giron-Nava
- Amy Hudson Weaver
- AW Visser
- B Eldon
- B Erisman
- BY Benjamini
- C Lodeiros
- C Oosterhout Van
- CC D’Aloia
- D Hedgecock
- D Hedgecock
- D Hedgecock
- D Ottmann
- DA Paz-García
- David A. Paz-Garcia
- DC Queller
- E Sala
- E Sala
- EA Treml
- EA Treml
- Francisco J. García-Rodriguez
- G Soria
- G Soria
- GP Jones
- GR Almany
- GR Almany
- Hector Reyes-Bonilla
- HM Galindo
- I Paz-Vinas
- JA Proehl
- JG Diaz-Uribe
- JL Jensen
- JM Leis
- JM Pringle
- JM Yearsley
- JO Backhaus
- JO Irisson
- JR Watson
- JR Watson
- JT Kool
- JT Nichols
- JW White
- KA Selkoe
- KA Selkoe
- KA Selkoe
- KJ Nickols
- L Jost
- M Dubois
- M Iacchei
- M Pascual
- M Raymond
- MD Spalding
- ME Zarate-Becerra
- MEJ Newman
- MR Christie
- MS Johnson
- MS Johnson
- N Ryman
- O Aburto-Oropeza
- OJ Luiz
- Ollin Gonzalez-Cuellar
- P Beerli
- P Beerli
- PF Sale
- PG Meirmans
- PR Teske
- PR Teske
- R Beldade
- R Peakall
- RJ Dyer
- RJ Dyer
- RK Cowen
- RK Cowen
- S. Guido Marinone
- SC Burgess
- SC Burgess
- SG Marinone
- SG Marinone
- SG Marinone
- SG Marinone
- SG Marinone
- SG Marinone
- SG Marinone
- ST Kalinowski
- Tomas Plomozo-Lugo
- W Amos
- W Watson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abbas A
- Abbasy J
- Abbo O
- Abbott T
- Abbouch M
- Abd El-Sameea A
- Abd Elkhalek E
- Abd Elmoen Elhusseiny A
- Abd-Elmawla M
- Abd-Elrazek A
- Abdallah E
- Abdalmageed Kasem E
- Abdel Gawad Shakshouk H
- Abdel Sabour F
- Abdel-Aty A
- Abdel-Hameed N
- Abdelaal A
- Abdelaty M
- Abdelaty Mohamed M
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- Abdelfatah Ibraheem A
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader O
- Abdelkhalek M
- Abdellatif Elsherif F
- Abdelmageed E
- Abdelmotaleb I
- Abdelraouf AM
- Abdelshakour M
- Abdul Aziz Amin H
- Abdul Aziz DN
- Abdul Bassit K
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdullah N
- Abdullah Soliman N
- Abdullahi L
- Abdurrazzaaq A
- Abem OE
- Abiola O
- Abo El Dahab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Abouzaid A
- Abozed Abdullah M
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abushamleh S
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebola O
- Adedeji A
- Adel Awad S
- Adel BE
- Adel Elsharkawy A
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa O
- Adenekan B
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adeyeye A
- Adhitama N
- Adil M
- Adisa AO
- Adiyaman C
- Adu-Aryee N
- Afana S
- Agalianos C
- Agarwal A
- Agbedinu K
- Aglan A
- Aguado Suárez N
- Aguilera ML
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed Bahaa Eldin M
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed Reda Elsayed N
- Ahmed S
- Ahmed S
- Ahounou EYS
- Ait Kaci A
- Ajah J
- Ajai O
- Ajao A
- Ajiboye A
- Akatibo E
- Akoto E
- Akpenyi O
- Al Amin S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faqawi M
- Al-Farram H
- Al-Marakby D
- Al-saqqa S
- Al-Saqqa SW
- Al-Slaibi I
- Al-taher T
- Alaa El-Din R
- Alaa El-Din S
- Alaael-Dein S
- Alada M
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Albiety A
- Alcca Ticona W
- Alexander P
- Alexandre C
- Alghamdi A
- Alghamdi MSA
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alherz M
- Ali A
- Ali E
- Ali FM
- Ali Mahmoud M
- Ali S
- Ali Samuel S
- Ali THA
- Ali W
- Alihonou T
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Alkaaki A
- Alkelani M
- Alkhatib A
- Allam M
- Allam Y
- Alm Eldeen E
- Almanon CL
- Alnusairat A
- Alqahtani S
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Altibi A
- Altinel Y
- Altwijri A
- Alvi AR
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alzahrani A
- Aman NF
- Amandito R
- Ambrona-Zafra D
- Amjad MA
- Amoah M
- Amoako J
- Amoako-Boateng M
- Amole I
- Amr Mohamed Farouk S
- Amreia M
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Antezana D
- Anthoulakis C
- Antoniozzi A
- Anwar N
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aquilino F
- Arafa O
- Arafa S
- Arcudi C
- Armellini A
- Arnaud A
- Arnaud AP
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Aruldas N
- Asare-Bediako K
- Ashour A
- Ashour K
- Ashtari M
- Asi F
- Asilah SMD
- Assal A
- Asturias S
- Asumah H
- Ata A
- Ata AY
- Atiyeh A
- Atkins ET
- Attia A
- Augestad KM
- Aviles S
- Avoka A
- Awad I
- Awadallah S
- Ayandipo O
- Aydin MC
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Bahar S
- Baillie K
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Balducci G
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baquero Suarez AA
- Baraka H
- Barendegere V
- Barkolias C
- Barmayehvar B
- Barrios E
- Basilicò S
- Bassem M
- Basso SM
- Bayram S
- Beamon M
- Bediako-Bowan A
- Bekhet AH
- Bekhet NM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Bennai RM
- Bentounsi Z
- Benyaiche C
- Bermúdez YEA
- Berti S
- Bertuello I
- Beuran M
- Bhangu A
- Bhatnagar A
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Birindelli A
- Bisset C
- Björklund I
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Bliksøen M
- Bluelle R
- Bocchetti T
- Bode C
- Bodur S
- Boggon A
- Bonavia K
- Bonavina L
- Bond-Smith G
- Bondin J
- Bondurri A
- Boni S
- Bonney W
- Borda-Luque G
- Borg E
- Bortolasi L
- Bottini C
- Bougard H
- Boukhal K
- Bowabsak A
- Bowling K
- Bradulskis S
- Bratu M
- Bratu MR
- Breistrand M
- Breslin R
- Brincat SD
- Broch A
- Brunoni B
- Bréaud J
- Bsisu I
- Bucci L
- Buisson P
- Bunting D
- Burger S
- Burmistrovas A
- Bustangi N
- Butt MT
- Caliman C
- Callan R
- Calua AC
- Camilleri GM
- Camilleri-Brennan J
- Campagnaro T
- Capito C
- Carabott K
- Cardozo JT
- Cardozo RAM
- Carmona JM
- Carpio J
- Carrasco N
- Cassar K
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cevik M
- Chabok A
- Chai C-A
- Chai FY
- Chan L
- Chan T-YK
- Chan XW
- Charles A
- Cheah AEZ
- Chean Khun Ng J
- Chen KY
- Chen T-L
- Cheong YJ
- Chetta N
- Cheung YHE
- Chibuye C
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Choi P
- Chong CS
- Chong H-Y
- Choudhry A
- Chow CYN
- Chowdhury D
- Chu K
- Chung KJ
- Chungui Bravo JA
- Ciccioli E
- Ciubotaru C
- Claire R
- Clarissa A
- Clegg-Lampety J-N
- Clegg-Lamptey J-N
- Clerico G
- Coccolini F
- Cocorullo G
- Cohen DM
- Cohen F
- Cole S
- Coletta D
- Coletti M
- Collado MV
- Cona C
- Conci S
- Confalonieri G
- Conlon KC
- Connor K
- Contreras E
- Contreras-Vergara AL
- Coompson CL
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
- Corral Moreno S
- Correa JC
- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costas-Chavarri A
- Courboin E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Craus-Miguel A
- Cullen F
- Curletti G
- Currow C
- D'Amours S
- D'Souza MS
- Dabboor M
- Dabbour K
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dalli J
- Dally C
- Dambrauskas Z
- Daniyan M
- Danys D
- Dao W
- Dar W
- Dardenne S
- Darwish AK
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davies R
- Davor A
- Dawood K
- Dayie M
- De Boni D
- De Franciscis S
- de Luca E
- De Marco P
- Deal R
- Deane C
- Debrah S
- Dedekind B
- Dedey F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Denewer A
- Depalma N
- Der Y
- Deutschmann P
- Deva Tata M
- Dhillon D
- Di Martino N
- Di Saverio S
- Diaconescu B
- Diaz Vico T
- Diaz-Jover P
- Dick L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Donnelly P
- Dorismé A
- Dossou F
- Dousset B
- Dragatas D
- Drake TM
- Drungilas M
- du Plooy F
- Du Toit F
- Duane T
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dénakpo M
- Ebidy M
- Ebidy MM
- Ekow M
- El Halawany E
- El Halawany M
- El Jamassi A
- El Kashash A
- El-Gizawy E
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Taher E
- Elashry R
- Elazab A
- Elbe P
- Eldafrawy M
- Eldosouky Mohammed A
- Elebute O
- Elfarargy A
- Elfeki H
- Elfiky M
- Elfouly N
- Elfouly Y
- Elgendy AH
- Elgheriany M
- Elhadad A
- Elhadry S
- Elhamouly S
- Elhendawy A
- Elhoseny G
- Ellison Q
- Elmashala A
- Elmasry M
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elsabbagh N
- Elsawy A
- Elsayed Moghazy M
- Elsemelawy R
- Elshaar M
- Elshaer M
- Elshami M
- Elsherbiney S
- Elwy E
- Elzahed N
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Ern Tze RG
- erson F
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Etchill E
- Etienne S
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Ezzat E
- Ezzat T
- Faboya O
- Fahim M
- Fairfield C
- Falaschi F
- Falco N
- Falzon M
- Farag A
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- Zakaria Y
- Zaki A
- Zaki Eldeeb A
- Zammit S
- Zampitis N
- Zani A
- Zanini N
- Zapata F
- Zarb C
- Zdanyte Sruogiene E
- Zielinski M
- Zilinskas J
- Zohair A
- Zorrilla CD
- Zuber M
- Zuk G
- Zulkifli A
- Zumbühl L
- Çakaloğlu HC
- Žilinskas J
- Žilinskienė R
- Žiubrytė G
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58\ub75%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31\ub72%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10\ub72%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12\ub73%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9\ub74%] of 7339 patients), middle (549 [14\ub70%] of 3918 patients), and low (298 [23\ub72%] of 1282) HDI (p<0\ub7001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17\ub78%] of 574 patients in high-HDI countries; 74 [31\ub74%] of 236 patients in middle-HDI countries; 72 [39\ub78%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1\ub760, 95% credible interval 1\ub705\u20132\ub737; p=0\ub7030). 132 (21\ub76%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16\ub76%) of 295 patients in high-HDI countries, in 37 (19\ub78%) of 187 patients in middle-HDI countries, and in 46 (35\ub79%) of 128 patients in low-HDI countries (p<0\ub7001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication. Funding: DFID-MRC-Wellcome Trust Joint Global Health Trial Development Grant, National Institute of Health Research Global Health Research Unit Grant