80 research outputs found

    Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at āˆšs=8 Tev

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    Measurement of Higgs boson production and properties in the WW decay channel with leptonic final states

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    Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial

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    Aimsā€ƒ The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisinā€“kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18Ā 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (ā‰„1.8ā€‰mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and resultsā€ƒ Median follow-up was 2.8ā€‰years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (nā€‰=ā€‰2) or Type 5 (nā€‰=ā€‰5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77ā€“0.95; Pā€‰=ā€‰0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77ā€“0.99; Pā€‰=ā€‰0.032) and Type 2 (0.77, 0.61ā€“0.97; Pā€‰=ā€‰0.025), but not Type 4 MI. Conclusionā€ƒ After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p

    Measurements of the ttĀÆ charge asymmetry using the dilepton decay channel in pp collisions at āˆšs=7 TeV

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