Application of multifractal wavelet analysis to spontaneous fermentation processes

An algorithm is presented here to get more detailed information, of mixed culture type, based exclusively on the biomass concentration data for fermentation processes. The analysis is performed with only the on-line measurements of the redox potential being available. It is a two-step procedure which includes an Artificial Neural Network (ANN) that relates the redox potential to the biomass concentrations in the first step. Next, a multifractal wavelet analysis is performed using the biomass estimates of the process. In this context, our results show that the redox potential is a valuable indicator of microorganism metabolic activity during the spontaneous fermentation. In this paper, the detailed design of the multifractal wavelet analysis is presented, as well as its direct experimental application at the laboratory levelComment: 12 pages, 3 figures, Physica A, to appea

Scintillation-only Based Pulse Shape Discrimination for Nuclear and Electron Recoils in Liquid Xenon

In a dedicated test setup at the Kamioka Observatory we studied pulse shape discrimination (PSD) in liquid xenon (LXe) for dark matter searches. PSD in LXe was based on the observation that scintillation light from electron events was emitted over a longer period of time than that of nuclear recoil events, and our method used a simple ratio of early to total scintillation light emission in a single scintillation event. Requiring an efficiency of 50% for nuclear recoil retention we reduced the electron background to 7.7\pm1.1(stat)\pm1.2 0.6(sys)\times10-2 at energies between 4.8 and 7.2 keVee and to 7.7\pm2.8(stat)\pm2.5 2.8(sys)\times10-3 at energies between 9.6 and 12 keVee for a scintillation light yield of 20.9 p.e./keV. Further study was done by masking some of that light to reduce this yield to 4.6 p.e./keV, the same method results in an electron event reduction of 2.4\pm0.2(stat)\pm0.3 0.2(sys)\times10-1 for the lower of the energy regions above. We also observe that in contrast to nuclear recoils the fluctuations in our early to total ratio for electron events are larger than expected from statistical fluctuations.Comment: 25 pages, 15 figure

Heavy quarkonium: progress, puzzles, and opportunities

A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b}, and b\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K. Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D. Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A. Petrov, P. Robbe, A. Vair

Effects of sleep deprivation on neural functioning: an integrative review

Sleep deprivation has a broad variety of effects on human performance and neural functioning that manifest themselves at different levels of description. On a macroscopic level, sleep deprivation mainly affects executive functions, especially in novel tasks. Macroscopic and mesoscopic effects of sleep deprivation on brain activity include reduced cortical responsiveness to incoming stimuli, reflecting reduced attention. On a microscopic level, sleep deprivation is associated with increased levels of adenosine, a neuromodulator that has a general inhibitory effect on neural activity. The inhibition of cholinergic nuclei appears particularly relevant, as the associated decrease in cortical acetylcholine seems to cause effects of sleep deprivation on macroscopic brain activity. In general, however, the relationships between the neural effects of sleep deprivation across observation scales are poorly understood and uncovering these relationships should be a primary target in future research

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

BACKGROUND: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. METHOD: We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/ ), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. RESULTS: Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06-1.12; P = 3 × 10(-9)), rs805510 (OR = 1.08, 95 % CI = 1.04-1.12, P = 2 × 10(-5)), and rs1871152 (OR = 1.04, 95 % CI = 1.02-1.06; P = 2 × 10(-4)) identified in the general populations, and rs113824616 (P = 7 × 10(-5)) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers. Of the six variants with the strongest evidence of potential functionality, rs11049453 was statistically significantly associated with the expression of PTHLH and its nearby gene CCDC91 at P < 0.05. CONCLUSION: This study identified four independent association signals at 12p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.UK funding includes Cancer Research UK and NIH.This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s13058-016-0718-

Measurement of \chi_{c2} Production in Two-Photon Collisions

The production of the \chi_{c2} charmonium state in two-photon collisions has been measured with the Belle detector at the KEKB e^+e^- collider. A clear signal for \chi_{c2} --> \gamma J/\psi, J/\psi --> l^+l^- is observed in a 32.6fb^{-1} data sample accumulated at center-of-mass energies near 10.6GeV, and the product of its two-photon decay width and branching fraction is determined to be \Gamma_{\gamma\gamma}(\chi_{c2})B(\chi_{c2} --> \gamma J/\psi) B(J/\psi --> l^+l^-)= 13.5 +/- 1.3(stat.) +/- 1.1(syst.)eV.Comment: 16 pages, 5 figures, to be submitted to Phys. Lett.

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFb signaling, p53 and beta-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy

Energy Saving Study in Hotel HVAC System

Energy conservation is one of the key issues for environmental protection and sustainable development. Currently, about 17% of the total energy is being consumed for heating, ventilation, air conditioning (HVAC) and refrigeration in Hong Kong. Therefore, energy saving in the HVAC systems of buildings is an important topic. In this paper, a study on the energy saving in a hotel HVAC system was carried out. The cooling load features of the hotel were analyzed. Retrofitting strategy of the HVAC system in the hotel was then designed. It included replacement of the chillers and pumps followed by adopting a newly designed control scheme based on the pattern of the cooling load. The control scheme consisted of controls of the chillers, pumps and cooling towers. An intelligent algorithm was developed to ensure the chillers work at the highest COP under different conditions. It was found that with the new system, about 63% to 74% of the chiller/pump system energy could be saved in that hotel. The result shows that for buildings such as hotels, a good control on the operation of the chillers and pumps is crucial