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BPA uptake in rat tissues after partial hepatectomy
In boron neutron capture therapy (BNCT), boron given as boronophenylalanine (BPA) accumulates transiently not only in tumors but also in normal tissues. Average boron concentrations in transplanted 9L gliosarcoma tumors of 20 rats were 2.5 to 3.7 times concentrations found in blood. Although boron levels in a variety of tissues were also higher than blood the concentrations were less than the lowest found in the tumor. Further note than although BPA is a structural analogue of phenylalanine (Phe), the pathway of BPA uptake into regenerating liver may not be linked to Phe uptake mechanisms
Non-compact Groups, Coherent States, Relativistic Wave Equations and the Harmonic Oscillator II: Physical and Geometrical Considerations
The physical meaning of the particularly simple non-degenerate supermetric,
introduced in the previous part by the authors, is elucidated and the possible
connection with processes of topological origin in high energy physics is
analyzed and discussed. New possible mechanism of the localization of the
fields in a particular sector of the supermanifold is proposed and the
similarity and differences with a 5-dimensional warped model are shown. The
relation with gauge theories of supergravity based in the group is
explicitly given and the possible original action is presented. We also show
that in this non-degenerate super-model the physic states, in contrast with the
basic states, are observables and can be interpreted as tomographic projections
or generalized representations of operators belonging to the metaplectic group
. The advantage of geometrical formulations based on non-degenerate
super-manifolds over degenerate ones is pointed out and the description and the
analysis of some interesting aspects of the simplest Riemannian superspaces are
presented from the point of view of the possible vacuum solutions.Comment: Stile of the text improved in Journa
Inflationary Perturbations: the Cosmological Schwinger Effect
This pedagogical review aims at presenting the fundamental aspects of the
theory of inflationary cosmological perturbations of quantum-mechanical origin.
The analogy with the well-known Schwinger effect is discussed in detail and a
systematic comparison of the two physical phenomena is carried out. In
particular, it is demonstrated that the two underlying formalisms differ only
up to an irrelevant canonical transformation. Hence, the basic physical
mechanisms at play are similar in both cases and can be reduced to the
quantization of a parametric oscillator leading to particle creation due to the
interaction with a classical source: pair production in vacuum is therefore
equivalent to the appearance of a growing mode for the cosmological
fluctuations. The only difference lies in the nature of the source: an electric
field in the case of the Schwinger effect and the gravitational field in the
case of inflationary perturbations. Although, in the laboratory, it is
notoriously difficult to produce an electric field such that pairs extracted
from the vacuum can be detected, the gravitational field in the early universe
can be strong enough to lead to observable effects that ultimately reveal
themselves as temperature fluctuations in the Cosmic Microwave Background.
Finally, the question of how quantum cosmological perturbations can be
considered as classical is discussed at the end of the article.Comment: 49 pages, 6 figures, to appear in a LNP volume "Inflationary
Cosmology
Nucleon superfluidity versus thermal states of isolated and transiently accreting neutron stars
The properties of superdense matter in neutron star (NS) cores control NS thermal states by affecting the efficiency of neutrino emission from NS interiors. To probe these properties we confront the theory of thermal evolution of NSs with observations of their thermal radiation. Our observational basis includes cooling isolated NSs (INSs) and NSs in quiescent states of soft X-ray transients (SXTs). We find that the data on SXTs support the conclusions obtained from the analysis of INSs: strong proton superfluidity with T_{cp,max} >= 10^9 K should be present, while mild neutron superfluidity with T_{cn,max} =(2*10^8 -- 2*10^9) K is ruled out in the outer NS core. Here T_{cn,max} and T_{cp,max} are the maximum values of the density dependent critical temperatures of neutrons and protons. The data on SXTs suggest also that: (i) cooling of massive NSs is enhanced by neutrino emission more powerful than the emission due to Cooper pairing of neutrons; (ii) mild neutron superfluidity, if available, might be present only in inner cores of massive NSs. In the latter case SXTs would exhibit dichotomy, i.e. very similar SXTs may evolve to very different thermal states
Report from the OECI Oncology Days 2014
The 2014 OECI Oncology Days was held at the ‘Prof. Dr. Ion Chiricuta’ Oncology Institute in Cluj, Romania, from 12 to 13 June. The focus of this year’s gathering was on developments in personalised medicine and other treatment advances which have made the cost of cancer care too high for many regions throughout Europe
Nuclear Alpha-Particle Condensates
The -particle condensate in nuclei is a novel state described by a
product state of 's, all with their c.o.m. in the lowest 0S orbit. We
demonstrate that a typical -particle condensate is the Hoyle state
( MeV, state in C), which plays a crucial role for
the synthesis of C in the universe. The influence of antisymmentrization
in the Hoyle state on the bosonic character of the particle is
discussed in detail. It is shown to be weak. The bosonic aspects in the Hoyle
state, therefore, are predominant. It is conjectured that -particle
condensate states also exist in heavier nuclei, like O,
Ne, etc. For instance the state of O at MeV
is identified from a theoretical analysis as being a strong candidate of a
condensate. The calculated small width (34 keV) of ,
consistent with data, lends credit to the existence of heavier Hoyle-analogue
states. In non-self-conjugated nuclei such as B and C, we discuss
candidates for the product states of clusters, composed of 's,
triton's, and neutrons etc. The relationship of -particle condensation
in finite nuclei to quartetting in symmetric nuclear matter is investigated
with the help of an in-medium modified four-nucleon equation. A nonlinear order
parameter equation for quartet condensation is derived and solved for
particle condensation in infinite nuclear matter. The strong qualitative
difference with the pairing case is pointed out.Comment: 71 pages, 41 figures, review article, to be published in "Cluster in
Nuclei (Lecture Notes in Physics) - Vol.2 -", ed. by C. Beck,
(Springer-Verlag, Berlin, 2011
Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease.
Alzheimer's disease (AD) is a neurodegenerative condition for which there is currently no available medication that can stop its progression. Previous studies suggest that mild cognitive impairment (MCI) is a phase that precedes the disease. Therefore, a better understanding of the molecular mechanisms behind MCI conversion to AD is needed.
Here, we propose a machine learning-based approach to detect the key metabolites and proteins involved in MCI progression to AD using data from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Study. Proteins and metabolites were evaluated separately in multiclass models (controls, MCI and AD) and together in MCI conversion models (MCI stable vs converter). Only features selected as relevant by 3/4 algorithms proposed were kept for downstream analysis.
Multiclass models of metabolites highlighted nine features further validated in an independent cohort (0.726 mean balanced accuracy). Among these features, one metabolite, oleamide, was selected by all the algorithms. Further in-vitro experiments in rodents showed that disease-associated microglia excreted oleamide in vesicles. Multiclass models of proteins stood out with nine features, validated in an independent cohort (0.720 mean balanced accuracy). However, none of the proteins was selected by all the algorithms. Besides, to distinguish between MCI stable and converters, 14 key features were selected (0.872 AUC), including tTau, alpha-synuclein (SNCA), junctophilin-3 (JPH3), properdin (CFP) and peptidase inhibitor 15 (PI15) among others.
This omics integration approach highlighted a set of molecules associated with MCI conversion important in neuronal and glia inflammation pathways
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC
Measurements of inclusive jet suppression in heavy ion collisions at the LHC
provide direct sensitivity to the physics of jet quenching. In a sample of
lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated
luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with
a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the
transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the
anti-kt algorithm with values for the distance parameter that determines the
nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of
the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp.
Jet production is found to be suppressed by approximately a factor of two in
the 10% most central collisions relative to peripheral collisions. Rcp varies
smoothly with centrality as characterized by the number of participating
nucleons. The observed suppression is only weakly dependent on jet radius and
transverse momentum. These results provide the first direct measurement of
inclusive jet suppression in heavy ion collisions and complement previous
measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables,
submitted to Physics Letters B. All figures including auxiliary figures are
available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02
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