204 research outputs found
A Simple Model of Epidemics with Pathogen Mutation
We study how the interplay between the memory immune response and pathogen
mutation affects epidemic dynamics in two related models. The first explicitly
models pathogen mutation and individual memory immune responses, with contacted
individuals becoming infected only if they are exposed to strains that are
significantly different from other strains in their memory repertoire. The
second model is a reduction of the first to a system of difference equations.
In this case, individuals spend a fixed amount of time in a generalized immune
class. In both models, we observe four fundamentally different types of
behavior, depending on parameters: (1) pathogen extinction due to lack of
contact between individuals, (2) endemic infection (3) periodic epidemic
outbreaks, and (4) one or more outbreaks followed by extinction of the epidemic
due to extremely low minima in the oscillations. We analyze both models to
determine the location of each transition. Our main result is that pathogens in
highly connected populations must mutate rapidly in order to remain viable.Comment: 9 pages, 11 figure
Automatic structures for semigroup constructions
We survey results concerning automatic structures for semigroup
constructions, providing references and describing the corresponding automatic
structures. The constructions we consider are: free products, direct products,
Rees matrix semigroups, Bruck-Reilly extensions and wreath products.Comment: 22 page
Ergodic properties of a model for turbulent dispersion of inertial particles
We study a simple stochastic differential equation that models the dispersion
of close heavy particles moving in a turbulent flow. In one and two dimensions,
the model is closely related to the one-dimensional stationary Schroedinger
equation in a random delta-correlated potential. The ergodic properties of the
dispersion process are investigated by proving that its generator is
hypoelliptic and using control theory
The first multi-wavelength campaign of AXP 4U 0142+61 from radio to hard X-rays
For the first time a quasi-simultaneous multi-wavelength campaign has been
performed on an Anomalous X-ray Pulsar from the radio to the hard X-ray band.
4U 0142+61 was an INTEGRAL target for 1 Ms in July 2005. During these
observations it was also observed in the X-ray band with Swift and RXTE, in the
optical and NIR with Gemini North and in the radio with the WSRT. In this paper
we present the source-energy distribution. The spectral results obtained in the
individual wave bands do not connect smoothly; apparently components of
different origin contribute to the total spectrum. Remarkable is that the
INTEGRAL hard X-ray spectrum (power-law index 0.79 +/- 0.10) is now measured up
to an energy of ~230 keV with no indication of a spectral break. Extrapolation
of the INTEGRAL power-law spectrum to lower energies passes orders of magnitude
underneath the NIR and optical fluxes, as well as the low ~30 microJy (2 sigma)
upper limit in the radio band.Comment: 6 pages, 1 figure. To be published in the proceedings of the
conference "Isolated Neutron Stars: from the Interior to the Surface" (April
24-28, 2006, London, UK), eds. S. Zane, R. Turolla and D. Pag
Quantum phase transitions from topology in momentum space
Many quantum condensed matter systems are strongly correlated and strongly
interacting fermionic systems, which cannot be treated perturbatively. However,
physics which emerges in the low-energy corner does not depend on the
complicated details of the system and is relatively simple. It is determined by
the nodes in the fermionic spectrum, which are protected by topology in
momentum space (in some cases, in combination with the vacuum symmetry). Close
to the nodes the behavior of the system becomes universal; and the universality
classes are determined by the toplogical invariants in momentum space. When one
changes the parameters of the system, the transitions are expected to occur
between the vacua with the same symmetry but which belong to different
universality classes. Different types of quantum phase transitions governed by
topology in momentum space are discussed in this Chapter. They involve Fermi
surfaces, Fermi points, Fermi lines, and also the topological transitions
between the fully gapped states. The consideration based on the momentum space
topology of the Green's function is general and is applicable to the vacua of
relativistic quantum fields. This is illustrated by the possible quantum phase
transition governed by topology of nodes in the spectrum of elementary
particles of Standard Model.Comment: 45 pages, 17 figures, 83 references, Chapter for the book "Quantum
Simulations via Analogues: From Phase Transitions to Black Holes", to appear
in Springer lecture notes in physics (LNP
Climate resilience in marine protected areas and the âProtection Paradoxâ
Restricting human activities through Marine Protected Areas (MPAs) is assumed to create more resilient biological communities with a greater capacity to resist and recover following climate events. Here we review the evidence linking protection from local pressures (e.g., fishing and habitat destruction) with increased resilience. Despite strong theoretical underpinnings, studies have only rarely attributed resilience responses to the recovery of food webs and habitats, and increases in the diversity of communities and populations. When detected, resistance to ocean warming and recovery after extreme events in MPAs have small effect sizes against a backdrop of natural variability. By contrast, large die-offs are well described from MPAs following climate stress events. This may be in part because protection from one set of pressures or drivers (such as fishing) can select for species that are highly sensitive to others (such as warming), creating a âProtection Paradoxâ. Given that climate change is overwhelming the resilience capacity of marine ecosystems, the only primary solution is to reduce carbon emissions. High-quality monitoring data in both space and time can also identify emergent resilience signals that do exist, in combination with adequate reference data to quantify the initial system state. This knowledge will allow networks of diverse protected areas to incorporate spatial refugia against climate change, and identify resilient biological components of natural systems. Sufficient spatial replication further offers insurance against losses in any given MPA, and the possibility for many weak signals of resilience to accumulate
Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.In this multicenter study, we investigated the kinetics of neutrophil recovery in relation to acuity and survival among 125 children undergoing allogeneic hematopoietic cell transplantation (allo-HCT) who required invasive mechanical ventilation (IMV). Recovery of neutrophils, whether prior to or after initiation of IMV, was associated with a significantly decreased risk of death relative to never achieving neutrophil recovery. A transient increase in acuity (by oxygenation index and vasopressor requirements) occurred among a subset of the patients who achieved neutrophil recovery after initiation of IMV; 61.5% of these patients survived to discharge from the intensive care unit (ICU). Improved survival among patients who subsequently achieved neutrophil recovery on IMV was not limited to those with peri-engraftment respiratory distress syndrome. The presence of a respiratory pathogen did not affect the risk of death while on IMV but was associated with an increased length of IMV (pâ<â0.01). Among patients undergoing HCT who develop respiratory failure and require advanced therapeutic support, neutrophil recovery at time of IMV and/or presence of a respiratory pathogen should not be used as determining factors when counseling families about survival
Rigorous QCD-Potential for the -System at Threshold
Recent evidence for the top mass in the region of 160 for the first
time provides an opportunity to use the full power of relativistic quantum
field theoretical methods, available also for weakly bound systems. Because of
the large decay width \G of the top quark individual energy-levels in
"toponium" will be unobservable. However, the potential for the
system, based on a systematic expansion in powers of the strong coupling
constant \a_s can be rigorously derived from QCD and plays a central role in
the threshold region. It is essential that the neglect of nonperturbative
(confining) effects is fully justified here for the first time to a large
accuracy, also just {\it because} of the large \G. The different
contributions to that potential are computed from real level corrections near
the bound state poles of the -system which for \G \ne 0 move into
the unphysical sheet of the complex energy plane. Thus, in order to obtain the
different contributions to that potential we may use the level corrections at
that (complex) pole. Within the relevant level shifts we especially emphasize
the corrections of order O(\a_s^4 m_t) and numerically comparable ones to
that order also from electroweak interactions which may become important as
well.Comment: 36 pages (mailer uncorrupted version), TUW-94-1
Measurement of the cross section for isolated-photon plus jet production in pp collisions at âs=13 TeV using the ATLAS detector
The dynamics of isolated-photon production in association with a jet in protonâproton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fbâ1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photonâjet invariant mass and the scattering angle in the photonâjet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements
A search for resonances decaying into a Higgs boson and a new particle X in the XH â qqbb final state with the ATLAS detector
A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fbâ1 of protonâproton collision data at collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle X is assumed to decay to a pair of light quarks, and the fully hadronic final state is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the resonance
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