STUDY UNIFORM DISTRIBUTION OF ELEMENTS IN THE OXIDE DISPERSIVE STRENGTHENED STEEL

The distribution of elements in the oxide dispersive strengthened steel at the outputted proton beam into the atmosphere is study. The experiments were performed on an analytical nuclear-physical complex "Sokol" is study. For the analysis of the samples obtained were used vacuum arc melting of steel industry 08Cr18Ni10Ti into which the hardening particles ZrO2 stabilized Y2O3, with a size of 0.1 – 0.5 microns. Mathematical processing of spectral data obtained by mass composition of basic elements and doping impurities studied oxide dispersive strengthened steel. The uniformity of the distribution of elements was studied on entire surface of the sample

Efficacy and safety of diacerein in patients with knee osteoarthritis

Diacerein (D) belongs to a class of symptomatic slow-acting agents, has an original mechanism of action, and is widely used as a diseasemodifying antirheumatic drug to treat osteoarthritis (OA) in Russia and many countries of the world. The ability of the drug to affect the main symptoms and progression of OA has been shown in a number of well-organized clinical trials.Objective: to evaluate the efficacy and safety of D in patients with knee OA.Patients and methods. An open-label trial evaluating the efficacy and safety of D (diaflex) in patients with knee OA was conducted in accordance with the multicenter program «Osteoarthrosis: Assessment of Progression in Real Clinical Practice». The trial included 80 patients of both sexes with Stage II–III knee OA; mean age, 60.8±6.8 years (47–75 years); mean body mass index, 31.8±5.9 kg/m2; disease duration, 10.3±5.7 years (2–30 years). The duration of the trial was 9 months (6 months of therapy and 3 months of follow-up).Results. There was a statistically significant reduction in visual analog scale pain on walking just 1 month after therapy initiation (57.1±9.7 and 44.7±13.9 mm; p<0.0001) and a further significant improvement throughout the 6-month therapy. Pain did not increase after the drug was discontinued (the follow-up period was 3 months). The same pattern was observed in the assessment of the WOMAC index (pain during early therapy, 243.8±73.9; pain at the end of therapy, 137.5±78.9; stiffness, 97.8±41.1 and 57.7±38.6; functional failure, 875.8±250.4 and 525±305.7 respectively; p<0.0001). Statistically significantly improved quality of life indicators measured by EQ-5D were noted throughout the follow-up period: 0.43±0.23 at the beginning of therapy, 0.61±0.14 at its end, and 0.63±0.11 at 3 months following treatment completion (p<0.0001). By the time of therapy completion, 71.3% of the patients completely refused to take nonsteroidal anti-inflammatory drugs (NSAIDs). Both the patient and the physician evaluated the efficiency of treatment identically. By the end of therapy, 87.5% of the patients were observed to have improvement. Adverse reactions (ARs) were recorded in 10 (12.5%) patients and mainly associated with more frequent stools; ARs were not a cause of treatment interruptions or protocol deviations.Conclusion. Diaflex has a good symptomatic and anti-inflammatory effect: the therapy statistically significantly reduces pain, stiffness, and the need for NSAIDs and improves quality of life and joint function. The drug has a good safety profile and after-effects, which is seen at least 3 months after therapy discontinuation

A taxonomic backbone for the global synthesis of species diversity in the angiosperm order caryophyllales

The Caryophyllales constitute a major lineage of flowering plants with approximately 12?500 species in 39 families. A taxonomic backbone at the genus level is provided that reflects the current state of knowledge and accepts 749 genera for the order. A detailed review of the literature of the past two decades shows that enormous progress has been made in understanding overall phylogenetic relationships in Caryophyllales. The process of re-circumscribing families in order to be monophyletic appears to be largely complete and has led to the recognition of eight new families (Anacampserotaceae, Kewaceae, Limeaceae, Lophiocarpaceae, Macarthuriaceae, Microteaceae, Montiaceae and Talinaceae), while the phylogenetic evaluation of generic concepts is still well underway. As a result of this, the number of genera has increased by more than ten percent in comparison to the last complete treatments in the “Families and genera of vascular plants” series. A checklist with all currently accepted genus names in Caryophyllales, as well as nomenclatural references, type names and synonymy is presented. Notes indicate how extensively the respective genera have been studied in a phylogenetic context. The most diverse families at the generic level are Cactaceae and Aizoaceae, but 28 families comprise only one to six genera. This synopsis represents a first step towards the aim of creating a global synthesis of the species diversity in the angiosperm order Caryophyllales integrating the work of numerous specialists around the world. © 2015 BGBM Berlin

PERCEPTION FEATURES OF THE SITUATION OF SIMULATION TRAINING AMONG MEDICAL STUDENTS IN COMPARISON WITH INTERACTION WITH A REAL PATIENT

Within the framework of this study, issues related to the features of simulation training used in the training of medical specialists are considered. The main problems of using high-tech simulators in the educational process are outlined. The tasks of further study of the psychological characteristics of the transfer of acquired knowledge to work with real patients are formulated.В рамках данного исследования рассматриваются вопросы, связанные с особенностями симуляционного обучения, применяющегося в рамках подготовки специалистов-медиков. Обозначены основные проблемы использования высокотехнологичных тренажеров в образовательном процессе. Сформулированы задачи дальнейшего исследования психологических особенностей переноса полученных знаний на работу с реальными пациентами

Опыт применения регионарной анестезии при каротидной эндартерэктомии в НИИ СП им. Н.В. Склифосовского ДЗМ

Acute cerebrovascular accident is one of the major causes of death and disability of patients around the world. In 30-40% of cases, the cause of ischemic stroke is an extracranial lesion of the brachiocephalic vessels. Carotid endarterectomy is the main technique for preventing cerebrovascular accident in carotid artery stenosis. General anesthesia with endotracheal intubation has been the method of choice since the widespread introduction of this type of surgical intervention into clinical practice and in most centers remains so to this day. At the same time, many authors report, that the use of general anesthesia with endotracheal intubation has limitations in a number of patients, namely, in the presence of an embologenic plaque in the operated internal carotid artery, severe coronary artery disease, decompensated aortic and / or mitral stenosis, low ejection fraction, heart rhythm and conduction disorders, severe chronic diseases of the respiratory system, as well as patient refusal for general anesthesia.THE AIM of the study was to show the possibilities of using regional anesthesia for carotid endarterectomy in a high-risk patient.RESULTS The use of regional anesthesia allows surgeons to avoid instability or abrupt changes in hemodynamics in the intraoperative period. Indications for its use are also cases of critical contralateral stenosis of the internal carotid artery when it is necessary to carefully consider the advisability of installing an internal stent.CONCLUSION The use of regional anesthesia made it possible to successfully perform carotid endarterectomy without cardiovascular events, neurological deficit and postoperative complications in a patient with relative contraindications to general anesthesia.Острое нарушение мозгового кровообращения является одной из основных причин смертельных исходов и инвалидицизации пациентов в мире. В 30–40% случаев причиной ишемического инсульта является экстракраниальное поражение брахиоцефальных сосудов. Основным методом профилактики нарушения мозгового кровообращения при стенотическом поражении сонных артерий является каротидная эндартерэктомия. Комбинированная общая анестезия с интубацией трахеи являлась методом выбора с момента широкого внедрения этого вида оперативного вмешательства в клиническую практику и остается таковой до настоящего времени в большинстве центров. В то же время, по мнению многих авторов, применение комбинированной общей анестезии с интубацией трахеи имеет ограничения у целого ряда пациентов, а именно, при наличии эмбологенной бляшки в оперируемой внутренней сонной артерии, тяжелом поражении коронарного русла, декомпенсированном стенозе аортального и/или митрального клапана, низкой фракции сердечного выброса, нарушении ритма и проводимости сердца, тяжелых хронических заболеваниях дыхательной системы, а также при отказе пациента от общей анестезии.В этой связи для обеспечения анестезиологического пособия у пациентов с высоким риском использование регионарной анестезии может быть безопасным альтернативным методом.ЦЕЛЬ Показать возможности использования регионарной анестезии при выполнении каротидной эндартерэктомии у пациента высокого риска.РЕЗУЛЬТАТЫ Применение регионарной анестезии позволяет избежать нестабильности или резких изменений гемодинамики в интраоперационном периоде, а также показаниями к ее использованию являются случаи критического контралатерального стеноза внутренней сонной артерии, когда следует особенно внимательно решать вопрос о целесообразности установки внутреннего шунта.ЗАКЛЮЧЕНИЕ Применение регионарной анестезии позволило успешно провести каротидную эндартерэктомию без осложнений со стороны сердечно-сосудистой системы, а также без неврологического дефицита и послеоперационных осложнений у пациента с относительными противопоказаниями к общей анестезии

Measurement of inclusive D*+- and associated dijet cross sections in photoproduction at HERA

Inclusive photoproduction of D*+- mesons has been measured for photon-proton centre-of-mass energies in the range 130 < W < 280 GeV and a photon virtuality Q^2 < 1 GeV^2. The data sample used corresponds to an integrated luminosity of 37 pb^-1. Total and differential cross sections as functions of the D* transverse momentum and pseudorapidity are presented in restricted kinematical regions and the data are compared with next-to-leading order (NLO) perturbative QCD calculations using the "massive charm" and "massless charm" schemes. The measured cross sections are generally above the NLO calculations, in particular in the forward (proton) direction. The large data sample also allows the study of dijet production associated with charm. A significant resolved as well as a direct photon component contribute to the cross section. Leading order QCD Monte Carlo calculations indicate that the resolved contribution arises from a significant charm component in the photon. A massive charm NLO parton level calculation yields lower cross sections compared to the measured results in a kinematic region where the resolved photon contribution is significant.Comment: 32 pages including 6 figure

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV