Nonlocal Equation of State in Anisotropic Static Fluid Spheres in General Relativity

We show that it is possible to obtain credible static anisotropic spherically symmetric matter configurations starting from known density profiles and satisfying a nonlocal equation of state. These particular types of equation of state describe, at a given point, the components of the corresponding energy-momentum tensor not only as a function at that point, but as a functional throughout the enclosed configuration. To establish the physical plausibility of the proposed family of solutions satisfying nonlocal equation of state, we study the constraints imposed by the junction and energy conditions on these bounded matter distributions. We also show that it is possible to obtain physically plausible static anisotropic spherically symmetric matter configurations, having nonlocal equations of state\textit{,}concerning the particular cases where the radial pressure vanishes and, other where the tangential pressures vanishes. The later very particular type of relativistic sphere with vanishing tangential stresses is inspired by some of the models proposed to describe extremely magnetized neutron stars (magnetars) during the transverse quantum collapse.Comment: 21 pages, 1 figure, minor changes in the text, references added, two new solutions studie

Glucagon-like peptide-1 receptor controls exocytosis in chromaffin cells by increasing full-fusion events

Agonists for glucagon-like-peptide-1 receptor (GLP-1R) are currently used for the treatment of type 2 diabetes and obesity. Their benefits have been centered on pancreas and hypothalamus, but their roles in other organ systems are not well understood. We studied the action of GLP-1R on secretions of adrenal medulla. Exendin-4, a synthetic analog of GLP-1, increases the synthesis and the release of catecholamines (CAs) by increasing cyclic AMP (cAMP) production, without apparent participation of cAMP-regulated guanine nucleotide exchange factor (Epac). Exendin-4, when incubated for 24 h, increases CA synthesis by promoting the activation of tyrosine hydroxylase. Short incubation (20 min) increases the quantum size of exocytotic events by switching exocytosis from partial to full fusion. Our results give a strong support to the role of GLP-1 in the fine control of exocytosis

Stability and collapse of localized solutions of the controlled three-dimensional Gross-Pitaevskii equation

On the basis of recent investigations, a newly developed analytical procedure is used for constructing a wide class of localized solutions of the controlled three-dimensional (3D) Gross-Pitaevskii equation (GPE) that governs the dynamics of Bose-Einstein condensates (BECs). The controlled 3D GPE is decomposed into a two-dimensional (2D) linear Schr\"{o}dinger equation and a one-dimensional (1D) nonlinear Schr\"{o}dinger equation, constrained by a variational condition for the controlling potential. Then, the above class of localized solutions are constructed as the product of the solutions of the transverse and longitudinal equations. On the basis of these exact 3D analytical solutions, a stability analysis is carried out, focusing our attention on the physical conditions for having collapsing or non-collapsing solutions.Comment: 21 pages, 14 figure

LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS

Oncogene-induced senescence (OIS), provoked in response to oncogenic activation, is considered an important tumor suppressor mechanism. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nt without a protein-coding capacity. Functional studies showed that deregulated lncRNA expression promote tumorigenesis and metastasis and that lncRNAs may exhibit tumor-suppressive and oncogenic function. Here, we first identified lncRNAs that were differentially expressed between senescent and non-senescent human fibroblast cells. Using RNA interference, we performed a loss-function screen targeting the differentially expressed lncRNAs, and identified lncRNA-OIS1 (lncRNA#32, AC008063.3 or ENSG00000233397) as a lncRNA required for OIS. Knockdown of lncRNA-OIS1 triggered bypass of senescence, higher proliferation rate, lower abundance of the cell-cycle inhibitor CDKN1A and high expression of cell-cycle-associated genes. Subcellular inspection of lncRNA-OIS1 indicated nuclear and cytosolic localization in both normal culture conditions as well as following oncogene induction. Interestingly, silencing lncRNA-OIS1 diminished the senescent-associated induction of a nearby gene (Dipeptidyl Peptidase 4, DPP4) with established role

Measurements of differential production cross sections for a Z boson in association with jets in pp collisions at root s=8 TeV

Peer reviewe

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Charged-particle nuclear modification factors in PbPb and pPb collisions at √=sNN=5.02 TeV

The spectra of charged particles produced within the pseudorapidity window |η| < 1 at √ sNN = 5.02 TeV are measured using 404 µb −1 of PbPb and 27.4 pb−1 of pp data collected by the CMS detector at the LHC in 2015. The spectra are presented over the transverse momentum ranges spanning 0.5 < pT < 400 GeV in pp and 0.7 < pT < 400 GeV in PbPb collisions. The corresponding nuclear modification factor, RAA, is measured in bins of collision centrality. The RAA in the 5% most central collisions shows a maximal suppression by a factor of 7–8 in the pT region of 6–9 GeV. This dip is followed by an increase, which continues up to the highest pT measured, and approaches unity in the vicinity of pT = 200 GeV. The RAA is compared to theoretical predictions and earlier experimental results at lower collision energies. The newly measured pp spectrum is combined with the pPb spectrum previously published by the CMS collaboration to construct the pPb nuclear modification factor, RpA, up to 120 GeV. For pT > 20 GeV, RpA exhibits weak momentum dependence and shows a moderate enhancement above unity

Perisylvian Syndrome: Report Of One Brazilian Family With Focus On The Genetic Mode Of Inheritance And Clinical Spectrum [síndrome Peri-sylviana: Estudo De Uma Família Brasileira Com ênfase Na Modalidade De Transmissäo Genética E Espectro Clinico]

Perisylvian syndrome (PS) refers to a variety of clinical manifestations associated with lesions in the perisylvian or opercular region. Acquired lesions such as cerebrovascular diseases or virus encephalitis and congenital lesions such as polymicrogyria (PMG) may be implied as etiological factors. The onset of the PS may occur in early childhood. The aim of this study was to report one family with PS in order to draw attention to this rarely diagnosed entity. Our family has five affected patients, three children and two male adults. All of them had developmental language disorder. Epilepsy, motor deficit and pseudobulbar signs (such as drooling) were detected in one child who had diffuse PMG along the Sylvian fissure. Subtle clinical manifestations correlated with either subtle MRI findings or normal MRI. Most reported families provide evidence suggestive of X-linked transmission. However, the most likely mode of inheritance in our family is autosomal dominant, since a male to male transmission was documented.632 B459463Guerreiro, M.M., Hage, S.R.V., Guimarães, C.A., Developmental language disorder associated with polymicrogyria (2002) Neurology, 59, pp. 245-250Guerreiro, M.M., Andermann, E., Guerrini, R., Familial perisylvian polymicrogyria: A new familial syndrome of cortical maldevelopment (2000) Ann Neurol, 48, pp. 39-48Hage, S.R.V., Guerreiro, M.M., Distúrbio específico de linguagem: Aspectos lingüísticos e neurobiológicos (2004) Tratado de Fono-Audiologia, pp. 977-986. , Ferreira LP, et al. (eds)Wechsler, D., (1991) Test de Inteligencia para Preescolares, , Buenos Aires: PaidosWechsler, D., (2002) Escala de Inteligência para Crianças, 3a. Edição, , São Paulo: Casa do PsicólogoWechsler, D., (1981) Intelligence Scale for Adults - Revised, , New York: The Psychological CorporationYavas, M., Hernandorena, C.L.M., Lamprecht, R.R., (1992) Avaliação Fonológica da Criança: Reeducação e Terapia, , Porto Alegre: Artes ḾdicasAndrade, C.R.F., Befi-Lopes, D.M., Fernandes, F.D.M., Wertzner, H.F., (2000) ABFW-Teste de Linguagem Infantil, , Carapicuíba: Pró-FonoCapovilla, F.C., Capovilla, A.G.S., Desenvolvimento lingüístico na criança brasileira dos dois aos seis anos: Tradução e estandardização do peabody picture vocabulary test e da language development survey de Rescorla (1997) Ciência Cognitiva: Teoria, Pesquisa e Aplicação, pp. 353-380Capovilla, F.C., Nunes, L.R.O.P., Nogueira, D., Desenvolvimento do vocabulário receprivo-auditivo da pŕ-escola à oitava śrie: Normatizaçatild;o fluminense baseada em aplicação coletiva da tradução brasileira do Pea-body picture vocabulary test (1997) Ciência Cognitiva: Teoria, Pesquisa e Aplicação, pp. 381-440Hage, S.R.V., (2000) Distúrbio Específico Do Desenvolvimento Da Linguagem: Subtipos e Correlações Neuroanatômicas, , Tese, UNICAMP, CampinasCapovilla, A.G., Capovilla, F.C., Prova de consciência fonológica: Desenvolvimento de dez habilidades da pŕ-escola à segunda série (1998) Temas Sobre Desenvolvimento, 37, pp. 14-20Stein, L.M., (1994) Teste de Desempenho Escolar, , São PauloKuzniecky, R., Andermann, F., Guerrini, Congenital bilateral perisylvian syndrome: Study of 31 patients (1993) Lancet, 341, pp. 608-612Gropman, A.L., Barkovich, A.J., Vezina, L.G., Conry, J.A., Dubovsky, E.C., Packer, R.J., Pediatric congenital bilateral perisylvian syndrome: Clinical and MRI features en 12 patients (1997) Neuropediatrics, 28, pp. 198-203Montenegro, M.A., Guerreiro, M.M., Lopes-Cendes, I., Cendes, F., Bilateral posterior parietal polymicrogyria: A mild form of congenital bilateral perisylvian syndrome? (2001) Epilepsia, 42, pp. 845-84