Exporting to Europe

What will change under the revised EU Regulation? Impacts for traders and certification bodies in third countries

Binary Fluorescence Labeling for the Recovery of Polymeric Materials for Recycling

Fluorescent perylene derivatives for the invisible digital coding of polymers were reported where a binary combination of fluorescent doping allows the unambiguous identification of the polymers for sorting. The mono-material recovery of the polymeric materials is an important prerequisite for the high-performance application of recycled material and was enabled by the application of optical methods

Рынок розничной торговли в России: современные тенденции развития (на примере ООО «КПК»)

Объектом исследования является: российский рынок розничной торговли: история, текущее состояние и проблемы, перспективные тренды и направления развития. Цель работы – рассмотрение понятия и особенностей российского рынка розничной торговли в целом и на примере действующего торгового предприятия.The subject of the study is: the Russian retail market: history, current state and problems, prospective trends and directions of development. The purpose of the work is to consider the concept and features of the Russian retail market in general and the example of an operating trade enterprise

Spectroscopic binaries among Hipparcos M giants III. The eccentricity-period diagram and mass-transfer signatures

This paper is the third one in a series devoted to studying the properties of binaries involving M giants. We use a new set of orbits to construct the first (e-logP) diagram of an extensive sample of M giant binaries, to obtain their mass-function distribution, and to derive evolutionary constraints for this class of binaries and related systems. The orbital properties of binaries involving M giants were analysed and compared with those of related families of binaries (K giants, post-AGB stars, barium stars, Tc-poor S stars). The orbital elements of post-AGB stars and M giants are not different, which may very indicate that, for the considered sample of post-AGB binaries, the post-AGB star left the AGB at quite an early stage (M4 or so). Neither are the orbital elements of post-mass-transfer binaries like barium stars very different from those of M giants, suggesting that the mass transfer did not alter the orbital elements much, contrary to current belief. Finally, we show that binary systems with e < 0.4 log P - 1 (with periods expressed in days) are predominantly post-mass-transfer systems, because (i) the vast majority of barium and S systems match this condition, and (ii) these systems have companion masses peaking around 0.6 solar mass, as expected for white dwarfs. The latter property has been shown to hold as well for open-cluster binaries involving K giants, for which a lower bound on the companion mass may easily be set.Comment: 14 pages, 12 figures, accepted for publication in A&A, language editing changes onl

A Solvable Regime of Disorder and Interactions in Ballistic Nanostructures, Part I: Consequences for Coulomb Blockade

We provide a framework for analyzing the problem of interacting electrons in a ballistic quantum dot with chaotic boundary conditions within an energy $E_T$ (the Thouless energy) of the Fermi energy. Within this window we show that the interactions can be characterized by Landau Fermi liquid parameters. When $g$, the dimensionless conductance of the dot, is large, we find that the disordered interacting problem can be solved in a saddle-point approximation which becomes exact as $g\to\infty$ (as in a large-N theory). The infinite $g$ theory shows a transition to a strong-coupling phase characterized by the same order parameter as in the Pomeranchuk transition in clean systems (a spontaneous interaction-induced Fermi surface distortion), but smeared and pinned by disorder. At finite $g$, the two phases and critical point evolve into three regimes in the $u_m-1/g$ plane -- weak- and strong-coupling regimes separated by crossover lines from a quantum-critical regime controlled by the quantum critical point. In the strong-coupling and quantum-critical regions, the quasiparticle acquires a width of the same order as the level spacing $\Delta$ within a few $\Delta$'s of the Fermi energy due to coupling to collective excitations. In the strong coupling regime if $m$ is odd, the dot will (if isolated) cross over from the orthogonal to unitary ensemble for an exponentially small external flux, or will (if strongly coupled to leads) break time-reversal symmetry spontaneously.Comment: 33 pages, 14 figures. Very minor changes. We have clarified that we are treating charge-channel instabilities in spinful systems, leaving spin-channel instabilities for future work. No substantive results are change

Designing organometallic compounds for catalysis and therapy

Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation. Electronic and steric effects are used to control both the thermodynamics and kinetics of ligand substitution and redox reactions of metal ions, especially Ru II. Can similar features be incorporated into the design of targeted organometallic drugs? Such complexes offer potential for novel mechanisms of drug action through incorporation of outer-sphere recognition of targets and controlled activation features based on ligand substitution as well as metal- and ligand-based redox processes. We focus here on η 6-arene, η 5-cyclopentadienyl sandwich and half-sandwich complexes of Fe II, Ru II, Os II and Ir III with promising activity towards cancer, malaria, and other conditions. © 2012 The Royal Society of Chemistry

Genome-wide tracking of unmethylated DNA Alu repeats in normal and cancer cells

Methylation of the cytosine is the most frequent epigenetic modification of DNA in mammalian cells. In humans, most of the methylated cytosines are found in CpG-rich sequences within tandem and interspersed repeats that make up to 45% of the human genome, being Alu repeats the most common family. Demethylation of Alu elements occurs in aging and cancer processes and has been associated with gene reactivation and genomic instability. By targeting the unmethylated SmaI site within the Alu sequence as a surrogate marker, we have quantified and identified unmethylated Alu elements on the genomic scale. Normal colon epithelial cells contain in average 25 486 ± 10 157 unmethylated Alu's per haploid genome, while in tumor cells this figure is 41 995 ± 17 187 (P = 0.004). There is an inverse relationship in Alu families with respect to their age and methylation status: the youngest elements exhibit the highest prevalence of the SmaI site (AluY: 42%; AluS: 18%, AluJ: 5%) but the lower rates of unmethylation (AluY: 1.65%; AluS: 3.1%, AluJ: 12%). Data are consistent with a stronger silencing pressure on the youngest repetitive elements, which are closer to genes. Further insights into the functional implications of atypical unmethylation states in Alu elements will surely contribute to decipher genomic organization and gene regulation in complex organisms

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis

Strategies of policy advocacy organizations and their theoretical affinities: Evidence from Q-methodology

Policy advocacy is an increasingly important function for many nonprofit organizations, yet their advocacy activities have largely escaped theoretical grounding. The literature on nonprofits has described how they engage in policy advocacy, without linking them to theories of policy change. The policy studies literature, on the other hand, has explained how various forms of influence result in policy change, but has largely ignored organizational perspectives on those processes. These two literatures remain largely disconnected. Drawing upon interviews with a purposive sample of policy advocacy directors at 31 nonprofit organizations, this study applies Q-methodology to identify and describe six distinct policy advocacy strategies employed by the organizations, and their resonant theoretical views of policy processes. These findings suggest strategic approaches for nonprofits seeking to influence policy processes. They also enhance the academic literature on policy processes by adding the advocates\u27 views and expectations. Implications for further research are also identified

A green fluorescent protein fused to rice prolamin forms protein body-like structures in transgenic rice

Prolamins, a group of rice (Oryza sativa) seed storage proteins, are synthesized on the rough endoplasmic reticulum (ER) and deposited in ER-derived type I protein bodies (PB-Is) in rice endosperm cells. The accumulation mechanism of prolamins, which do not possess the well-known ER retention signal, remains unclear. In order to elucidate whether the accumulation of prolamin in the ER requires seed-specific factors, the subcellular localization of the constitutively expressed green fluorescent protein fused to prolamin (prolamin–GFP) was examined in seeds, leaves, and roots of transgenic rice plants. The prolamin–GFP fusion proteins accumulated not only in the seeds but also in the leaves and roots. Microscopic observation of GFP fluorescence and immunocytochemical analysis revealed that prolamin–GFP fusion proteins specifically accumulated in PB-Is in the endosperm, whereas they were deposited in the electron-dense structures in the leaves and roots. The ER chaperone BiP was detected in the structures in the leaves and roots. The results show that the aggregation of prolamin–GFP fusion proteins does not depend on the tissues, suggesting that the prolamin–GFP fusion proteins accumulate in the ER by forming into aggregates. The findings bear out the importance of the assembly of prolamin molecules and the interaction of prolamin with BiP in the formation of ER-derived PBs