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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
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- Campbell Lewis
- Camsooksai Julie
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- Carrier Marc
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- Castro Ferreira Ricardo Manuel
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- Cathcart Susanne
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- Cazzola Federica
- Centofanti John
- Chablani Manish
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- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
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- Clermont Giles
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- Codreanu Daniel
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- Cutler Sean
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- Day Christopher
- De Beaux Fiona
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- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
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- de Man Angelique
- De Waele Jan
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- Derde Lennie
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- Everitt Robert
- Evers Mirjam
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- Fitzgerald Mark
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- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
- Gardiner-Hill Caroline
- Garrard Hywel
- Garrard William
- Gates Simon
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- Gellamucho Minerva
- Gendall Emma
- Genetu Roman Mary
- Geng Wenli
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- Ghamraoui Ali
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- Gibson Charly
- Girard Timothy
- Girijadevi Dinu
- Gledhill Lisa
- Godement Mathieu
- Golden David
- Goligher Ewan
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- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
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- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
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- Green Cameron
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- Gresha Rebecca
- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
- Haidar Ghady
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- Hall Kathryn
- Hamilton David Oliver
- Hamilton-Davies Colin
- Hamlyn Vincent
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- Haniffa Rashan
- Haniffa Rashan
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- Henderson Steven
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- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
- Hills Tom
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- Hoff Uwe
- Hoiting Oscar
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- Horvat Christopher
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- Hullegie Sebastiaan J
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- Hulme Jonathan
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- Labbe Vincent
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- Lawler Patrick R
- Lawless Patrick
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- Seymour Christopher
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- Thomson Nicola
- Thrush Jessica
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- Tinmouth Alan
- Tong Steve
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- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
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- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija Brajković Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
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- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
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- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
How to manage independent contractors effectively
- Author
- Publication venue
- 'Emerald'
- Publication date
- Field of study
Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope
- Author
- Agostini
- Allen
- Ashley Tetlow
- Berger
- Buehler
- Champion
- Cheryl Champion
- Ciraci
- David M. Ojcius
- Duncan
- Gale Boxx
- Gopinath
- Haggerty
- Halle
- Heinonen
- Ito
- Janina Jiang
- Kar
- Karunakaran
- Kathleen A. Kelly
- Kayagaki
- Kedersha
- Kickhoefer
- Kickhoefer
- Kickhoefer
- Kim
- Kolli
- Kowalski
- Leonard H. Rome
- Mariathasan
- Martinon
- Martinon
- Martinon
- Maxion
- Moayeri
- Morrison
- Morrison
- Morrison
- Munoz-Planillo
- Mócsai
- Najwane Said-Sadier
- Ng
- Ogura
- Poderycki
- Ramsey
- Saïd-Sadier
- Scheffer
- Scheffer
- Shimada
- Steiner
- Stephen
- Su
- Sutterwala
- Taylor
- Thornberry
- Valerie A. Kickhoefer
- Westrom
- Westrom
- Wiesenfeld
- Xu
- Ye Zhu
- Yi
- Yu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
The full potential of vaccines relies on development of effective delivery systems and adjuvants and is critical for development of successful vaccine candidates. We have shown that recombinant vaults engineered to encapsulate microbial epitopes are highly stable structures and are an ideal vaccine vehicle for epitope delivery which does not require the inclusion of an adjuvant. We studied the ability of vaults which were engineered for use as a vaccine containing an immunogenic epitope of C. trachomatis, polymorphic membrane protein G (PmpG), to be internalized into human monocytes and behave as a “natural adjuvant”. We here show that incubation of monocytes with the PmpG-1-vaults activates caspase-1 and stimulates IL-1β secretion through a process requiring the NLRP3 inflammasome and that cathepsin B and Syk are involved in the inflammasome activation. We also observed that the PmpG-1-vaults are internalized through a pathway that is transiently acidic and leads to destabilization of lysosomes. In addition, immunization of mice with PmpG-1-vaults induced PmpG-1 responsive CD4(+) cells upon re-stimulation with PmpG peptide in vitro, suggesting that vault vaccines can be engineered for specific adaptive immune responses. We conclude that PmpG-1-vault vaccines can stimulate NLRP3 inflammasomes and induce PmpG-specific T cell responses
Beta Carotene: From Biochemistry to Clinical Trials
- Author
- Acevedo
- Albanes
- Albanes
- Astorg
- Astorg
- Astorg
- Azzi
- Azzi
- Beecher
- Ben-Amotz
- Bendich
- Bendich
- Benedetto
- Bertram
- Block
- Blot
- Boscoboinik
- Bowen
- Budunova
- Burton
- Burton
- Campbell
- Carpenter
- Castenmiller
- Chambon
- Chandra
- Cheryl L. Rock
- Christen
- Chug-Ahuja
- Cooper
- Dallongeville
- DeMaio
- Donaldson
- Dugas
- Edge
- Eichholzer
- Erdman
- Flagg
- Furukawa
- Furukawa
- Garewal
- Gaziano
- Gerber
- Gey
- Gey
- Giovannucci
- Goodenough
- Gradelet
- Gradelet
- Greenberg
- Greenberg
- Greenberg
- Grolier
- Gärtner
- Handelman
- Handelman
- Hanusch
- Heinonen
- Heinonen
- Hennekens
- Hennekens
- Hennekens
- Hughes
- Iannone
- Ingold
- International Agency for Research on Cancer (IARC)
- Jialal
- Jialal
- Johnson
- Katsumura
- Kaugars
- Kennedy
- Key
- Khopde
- Kostic
- Krinsky
- Krinsky
- Krinsky
- Kritchevsky
- Krutovskikh
- Levy
- Levy
- Liebler
- Lin
- Luca
- Manetta
- Manson
- Marchand
- Mathews-Roth
- Mathews-Roth
- Mathews-Roth
- Mayne
- Mayne
- Mayne
- McClure
- McLarty
- Meydani
- Mills
- Mortensen
- Nebert
- Nierenberg
- Nishino
- Olson
- Omaye
- Omenn
- Omenn
- Omenn
- Omenn
- Paetau
- Palozza
- Palozza
- Palozza
- Palozza
- Paolini
- Paolisso
- Pastori
- Peto
- Poppel
- Poppel
- Poppel
- Prakash
- Princen
- Pryor
- Pryor
- Pryor
- Pryor
- Pryor
- Pryor
- Pryor
- Pryor
- Riemersma
- Rimm
- Rock
- Romney
- Salgo
- Schwartz
- Sharoni
- Shivapurkar
- Sies
- Singh
- Smigel
- Stacker
- Stahelin
- Stahl
- Stahl
- Stahl
- Stampfer
- Stampfer
- Steinberg
- Steinmetz
- Stephens
- Stich
- Stock
- Stone
- Stone
- Swartz
- Swartz
- Tang
- Tsubono
- Tsuchiya
- Verlangieri
- Vet
- Vliet
- Wahlquist
- Wang
- Wang
- Whyatt
- Wilhelm Stahl
- William A. Pryor
- Wrighton
- Yamasaki
- Yamauchi
- Yeum
- Yeum
- Zang
- Zaridze
- Ziegler
- Ziegler
- Ziegler
- Zurcher
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Prunes: Are they Functional Foods?
- Author
- Ames
- Anderson
- Arjmandi
- Arjmandi
- Arjmandi
- Arjmandi
- Basu
- Bolin
- Bradbury
- Brand-Miller
- Bu
- Bureau National Interprofessionnel du Pruneau (BIP)
- California Prune Board
- California Prune Board
- California Prune Board
- California Prune Board
- California Prune Board
- California Prune Board
- California Prune Board
- California Prune Board
- California Prune Board
- California Prune Board
- Chan
- Chapin
- Cheryl
- Cinquanta
- Del Caro
- Dikeman
- Dismore
- Donovan
- Dornberger
- Dreher
- Ellis
- Fang
- Fernandez-Flores
- Ford
- Forni
- Fung
- Fusi
- Gallaher
- Gaworski
- Giacco
- Gottshall
- Groh
- Gross
- Gryglewsky
- Hansmann
- Heinonen
- Hemmerle
- Holmes
- Hooshmand
- Iron
- Ishii
- Iwamoto
- Jouret
- Kayano
- Kayano
- Kayano
- Kikuzaki
- Kimura
- Kline
- Korobkina
- Kristl
- Labavitch
- Lucas
- Luft
- Luh
- Mathew
- Mc Bride
- Meyer
- Mori
- Moutounet
- Mozaffarian
- Naghii
- Naghii
- Nakatani
- Nardini
- Naumann
- Nergiz
- Nielsen
- Nuñez de Gonzalez
- Osburn
- Piga
- Prosky
- Raynal
- Raynal
- Renard
- Ryley
- Sabarez
- Salvini
- Sanders
- Sauter
- Schafer
- Shin
- Souci
- Stacewicz-Sapuntzakis
- Tinker
- Tinker
- USDA
- Usenik
- van Gorsel
- Vinson
- Vinson
- Wehmeyer
- Welsch
- Wilford
- Wrolstad
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.
- Author
- A. Mesut Erzurumluoglu
- Abbas Dehghan
- Adele M. Taylor
- Afshan N. Malik
- Aldi T. Kraja
- Alexander Teumer
- Alison Pattie
- Allan Linneberg
- Altshuler-Keylin
- Amit Patki
- Andre G. Uitterlinden
- Anna E. Jonsson
- Anne B. Newman
- Anne E. Justice
- Aravinda Chakravarti
- Ashar
- Ashar
- Astrid Petersmann
- Audrey Y. Chu
- Aulchenko
- Bambace
- Battle
- Beasley
- Bernardo L. Horta
- Berndt
- Bernhard
- Bharat Thyagarajan
- Boyle
- Brown
- Bruce S. Weir
- Buzaglo-Azriel
- Byerly
- Calvo
- Caroline Hayward
- Castellana
- Chanda
- Chang
- Charles Gu
- Chen
- Cheryl D. Cropp
- Chow
- Christian Theil Have
- Christian Torp-Pedersen
- Christine Williams
- Chunyu Liu
- Claudia Langenberg
- Cramer Christensen
- Craven
- Cunningham
- D.C. Rao
- Dan E. Arking
- Daniel I. Chasman
- Daniel Levy
- Daniel R. Witte
- De Pauw
- Delaneau
- Delaneau
- Dennis O. Mook-Kanamori
- Dhananjay Vaidya
- Diana van Heemst
- Diane M. Becker
- Donald W. Bowden
- Donglin Zeng
- Donna K. Arnett
- Dukes
- Dupuis
- Dörner
- E. Warwick Daw
- Ehret
- El-Hattab
- Eliana P. Fernandez
- Ellen A. Nohr
- Eppinga
- Ernster
- Esteras
- Evie Stergiakouli
- Febbo
- Fernando P. Hartwig
- Fernando Rivadeneira
- Fetterman
- Fimia
- Fimia
- Fish
- Francis
- Franco Giulianini
- Frazier
- Frits R. Rosendaal
- Gail Davies
- Gavin Hudson
- Georg Homuth
- Gibran Hemani
- Go
- Graff
- Guo
- Guo
- Haag-Liautard
- He Gao
- Heard
- Heid
- Heinonen
- Hemant K. Tiwari
- Henrik Vestergaard
- Heymann
- Hinds
- Hinney
- Hongsheng Wu
- Howie
- Huang
- Hugoline G. de Haan
- Ian J. Deary
- Ilegems
- Ioanna Tzoulaki
- Ivan Brandslund
- James A. Perry
- James B. Meigs
- James G. Wilson
- James Pankow
- Janie Corley
- Jelinek
- Jerome I. Rotter
- Jessica L. Fetterman
- Jian’an Luan
- Jie Yao
- John M. Starr
- Joseph H. Lee
- Justice
- Kaare Christensen
- Kari E. North
- Kathleen A. Ryan
- Kearse
- Ken K. Ong
- Keng-Hung Lin
- Kent D. Taylor
- Kevin Sandow
- Klaus Bonnelykke
- Kraja
- Kristiansson
- Kristin Young
- Lai
- Lang
- Latisha D. Love-Gregory
- Lee
- Lee
- Leslie S. Emery
- Li
- Li
- Lihua Wang
- Lin
- Lisa de las Fuentes
- Lisa R. Yanek
- Liu
- Locke
- Lu
- M. Arfan Ikram
- MacDonald
- MacDonald
- Malik
- Malik
- Manning
- Mao Fu
- Marguerite R. Irvin
- Maria Argos
- Mariaelisa Graff
- Marit E. Jørgensen
- Mariza de Andrade
- Mark O. Goodarzi
- Mary F. Feitosa
- Mary K. Wojczynski
- Matthias Nauck
- McDermott-Roe
- Mengel-From
- Meyre
- Michael A. Province
- Middelberg
- Mohsen Ghanbari
- Monda
- Montgomery
- Mozaffarian
- Nakamoto
- Neiman
- Nelson
- Ng
- Nicholas B. Larson
- Nicholas J. Timpson
- Nicholas J. Wareham
- Nicola D. Kerrison
- Niels Grarup
- Nita G. Forouhi
- Nóbrega-Pereira
- Oluf Pedersen
- Oscar H. Franco
- Pagliarini
- Pattin
- Paul Elliott
- Paul M. Ridker
- Peter E. Weeke
- Ping An
- Pott
- Prasai
- Prokopenko
- Pruim
- Purcell
- Qibin Qi
- Randall
- Rasika A. Mathias
- Rasmus Ribel-Madsen
- Raymond Noordam
- Rebecca Rohde
- Renée de Mutsert
- Ridler
- Robert A. Scott
- Ruifang Li-Gao
- Ruteja A. Barve
- Ruth J.F. Loos
- Sabater-Lleal
- Saha
- Samuels
- Santiago Rodriguez
- Sané
- Sarah E. Harris
- Saxena
- Schaefer
- Schleinitz
- Scott
- Sebastian M. Armasu
- Semenkovich
- Sepe
- Sharon L.R. Kardia
- Shiow J. Lin
- Shungin
- Simon R. Cox
- Smith
- Soranzo
- Speliotes
- Spracklen
- Stefan Weiss
- Stephen T. Turner
- Steven C. Hunt
- Strawbridge
- Suzette J. Bielinski
- Symen Ligthart
- Szendroedi
- Szklarczyk
- Taanman
- Tamar Sofer
- Taniguchi
- Tarunveer S. Ahluwalia
- Theresia M. Schnurr
- Thomas
- Thomas J. Baranski
- Thomas T. Perls
- Thorkild I.A. Sørensen
- Tin
- Tom G. Richardson
- Torben Hansen
- Torben Jørgensen
- Tuomas O. Kilpeläinen
- Ulrich Broeckel
- Unoki
- van der Harst
- van der Wijst
- Vernochet
- Victor G. Davila-Roman
- Voight
- W. David Hill
- Walford
- Wang
- Wang
- Wang
- Ward
- Warren
- Wayne Huey-Herng Sheu
- Wei Yang
- Wen-Jane Lee
- West
- Wheeler
- Wiklund
- Willer
- Willer
- Winkler
- Winkler
- Woś
- Xiuqing Guo
- Yang
- Yang Hai
- Yasuda
- Yasuno
- Yeo
- Yii-Der Ida Chen
- Yuasa
- Yujie Wang
- Zhang
- Zhao
- Zhenglong Gu
- Publication venue
- Am J Hum Genet
- Publication date
- 06/12/2018
- Field of study
Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the CHARGEmtDNA+ Consortium, we studied genetic associations of mtDNA and MT-nDNA associations with body mass index (BMI), waist-hip-ratio (WHR), glucose, insulin, HOMA-B, HOMA-IR, and HbA1c. This 45-cohort collaboration comprised 70,775 (insulin) to 170,202 (BMI) pan-ancestry individuals. Validation and imputation of mtDNA variants was followed by single-variant and gene-based association testing. We report two significant common variants, one in MT-ATP6 associated (p ≤ 5E-04) with WHR and one in the D-loop with glucose. Five rare variants in MT-ATP6, MT-ND5, and MT-ND6 associated with BMI, WHR, or insulin. Gene-based meta-analysis identified MT-ND3 associated with BMI (p ≤ 1E-03). We considered 2,282 MT-nDNA candidate gene associations compiled from online summary results for our traits (20 unique studies with 31 dataset consortia's genome-wide associations [GWASs]). Of these, 109 genes associated (p ≤ 1E-06) with at least 1 of our 7 traits. We assessed regulatory features of variants in the 109 genes, cis- and trans-gene expression regulation, and performed enrichment and protein-protein interactions analyses. Of the identified mtDNA and MT-nDNA genes, 79 associated with adipose measures, 49 with glucose/insulin, 13 with risk for type 2 diabetes, and 18 with cardiovascular disease, indicating for pleiotropic effects with health implications. Additionally, 21 genes related to cholesterol, suggesting additional important roles for the genes identified. Our results suggest that mtDNA and MT-nDNA genes and variants reported make important contributions to glucose and insulin metabolism, adipocyte regulation, diabetes, and cardiovascular disease
Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19
- Author
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Aguilar-Dano April
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Amri Ali
- Al Enezi Farhan
- Al Qasim Eman
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderink Bashar
- Alderman Meera
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Farisha
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Alqahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Amatya Sameena
- Ambrosino Richard
- Anders Jeanette
- Anderson Thomas
- Andreae Mark
- Andric Zdravko
- Angus Derek
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Apte Yogesh
- Arabi Yaseen
- Arachchige Malka
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Aryal Diptesh
- Asif Namra
- Aspinwall Angelique
- Attanayaka Udara
- Attokaran Antony
- Attwood Ben
- Au Carly
- Austin Karen
- Austin Pauline
- Avard Bronwyn
- Awan Sidra
- Azaiz Amine
- Azergui Nora
- Azzaui Harun
- Babel Jakša
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Baillie Kenneth
- Bain William
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barbazza Leanne
- Barber Russell
- Barbier François
- Barge Deborah
- Bari Sara
- Bariola Ryan
- Barker Gareth
- Barnes Nicky
- Baron Rebecca
- Barreau Amelie
- Bart Robert
- Bartholdy Roland
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastola Sirjana
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bean Sarah
- Beane Abi
- Beard Gregory
- Beasley Richard
- Beavis Sarah
- Bedford Caroline
- Beer Deborah
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Beltran Mercedes
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Benyon Sarah
- Benzekri Dalila
- Berdaguer Fernando
- Bergin Colin
- Berry Lindsay
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bhattarai Binita
- Bhimani Zahra
- Bhonagiri Deepak
- Biddie Simon
- Bihari Shailesh
- Binnie Alexandra
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Bland Yvonne
- Blank Elisabeth
- Bloos Frank
- Board Jasmin
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Hélène
- Bojunga Jörg
- Bone Allison
- Bonner Stephen
- Bonten Marc
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brajković Ana
- Brakké Karen
- Brant Emily
- Breen Patrick
- Bremmer Pamela
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brieger Klaus-Gerd
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Louise
- Browne Troy
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank
- Brunskill Nigel
- Bryan-Morris Kayla
- Buchanan Philip
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Bélteczki János
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callender Owen
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Lewis
- Campbell Ryan
- Campisi Josie
- Campos Sara
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Frédérick
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Brittney
- Carter David
- Carter Jay
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Cecconi Maurizio
- Centofanti John
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Marianne
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
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- de Bus Liesbet
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- de Jong Menno
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- de Neef Mark
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- Ebenezer R
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- Golden David
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- Kremling Julius
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- Krishnamurthy Vinodh
- Krishnaoorthy S
- Kruger Peter
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- Raithatha Ajay
- Raj Ashok
- Ramakrishnan N
- Ramali Mohamed
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- Ranganathan Lakshmi
- Rao Deepak
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- Ratnam Valli
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- Reschreiter Henrik
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- Rhodes Jonathan
- Richards Carol
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- Richards-Belle Alvin
- Richardson Aaron
- Richardson Angus
- Richecoeu Jack
- Riches Joanne
- Ricketts Dan
- Ricketts Daniel
- Riepe Ansgar
- Rietveld Ilse
- Rimmer Dominic
- Ristimäki Sanna
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- Roberts David
- Roberts Eilir
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- Robertson Debra
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- Robinson Matt
- Roche Lisa
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- Roebers Harald
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- Shah Asim
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- Shaw David
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- Shimabukuro-Vornhagen Alexander
- Shovelton Charmaine
- Shree Madhu
- Shrestha Tapaswi
- Shuker Karen
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- Williams Alexandra
- Williams Angharad
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- Willson Jayne
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- Winters Lauren
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- Wood Hannah
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- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
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- Wright Chris
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yang Yang
- Yarad Elizabeth
- Yates David
- Yealy Donald
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Đimoti Renata
- Publication venue
- American Medical Association
- Publication date
- 05/04/2022
- Field of study
International audienc
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Acera Gil Maria Angeles
- Ackermann Oda
- Adarmes Astrid
- Agarwal Veena
- Agosti Chiara
- Akhtar Shahbana
- Alaerts Nick
- Alarcón María Dolores
- Albanese Alberto (ORCID:0000-0002-5864-0006)
- Allain Philippe
- Almagro Carmen Antúnez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrews Thomasin
- Andrich Jürgen
- Anheim Mathieu
- Anjum Uruj
- Anna Bryl Jacek Anioła
- Annic Agnès
- Antczak Jakub
- Antequera Torres María Martirio
- Antonova Victoria
- Arbelo José Matías
- Arkuszewski Michał
- Armstrong Richard
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-Lévi Anne-Catherine
- Bachoud-Lévi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barlati Sergio
- Barral Verónica Mañanes
- Barrero Francisco
- Barrett Wendy
- Barth Katrin
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Becanovic Kristina
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benaminov Stanislav
- Benito Dolors Moragues
- Bentivoglio Anna Rita (ORCID:0000-0002-9663-095X)
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund Måns
- Berglund Peter
- Bergmann Ulrike
- Bernal-Escudero Maravilla
- Bernard Tomáš
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bezdíček Ondřej
- Bijlsma Emilia K.
- Bioux Sandrine
- Biunno Ida
- Björnsson Elisabeth
- Bjørgo Kathrine
- Bjørnevoll Inga
- Bled Déborah
- Bliaux Evangeline
- Blin Stéphanie
- Blinkenberg Ellen Økland
- Blondeau Leily
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boissé Marie-Françoise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borgerød Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boster Sarah
- Boudali Lotfi
- Bove Francesco
- Boćwińska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brown Pauline
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bruun Anu
- Buchanan Lindsay
- Buck Andrea
- Buongiorno María Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bárcenas Antonio Herranz
- Böringer Regina
- Bürk Katrin
- Błaszczyk Magdalena
- Cabaret Maryline
- Calado Ana
- Calandra-Buonaura Giovanna
- Caldentey Juan García
- Caldentey Juan García
- Caldentey Juan García
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- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
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- Calvas Fabienne
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- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
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- Cardoso Helena
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- Carrillo Fátima
- Carrière Nicolas
- Carruesco Gemma Tome
- Casado Rocío Villagrán
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
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- Cavaco Sara
- Cação Gonçalo
- Charles Perrine
- Charpentier Sébastien
- Chen Simone
- Cheriet Samia
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- Chu Elvina
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- Corrales Koldo Berganzo
- Cortelli Pietro
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- Costa Andreia
- Costa Cristina
- Coulthard Elizabeth
- Couttier Julien
- Craufurd David
- Craven Janet
- Craven Janet
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D'Alessio Barbara
- Damásio Joana
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bruycker Christelle
- de Die-Smulders Christine EM.
- De Gregorio Francesca
- De Michele Giuseppe
- De Nicola Annunziata
- de Raedt Sylvie
- de Souza (Keylock) Jenny
- de Tommaso Marina
- Debilly Bérengère
- Debruxelles Sabrina
- Dec Małgorzata
- Decorte Eric
- Dedichá Nadia Rodríguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Delabaere Helène
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Delvaux Isabelle
- Demonet Jean-François
- Depelchin Alizé
- Derost Philippe
- Descals Asunción Martínez
- Destee Alain
- Dewulf-Pasz Nelly
- Di Bella Daniela
- Di Donato Stefano
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- Dias Margarida
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- Difruscolo Olimpia
- Dipple Heather
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- Dixon Kathryn
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- Dose Matthias
- Dougherty Andrew
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- Dumas Eve M.
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- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J.
- Ferreira Joaquim J.
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- Ganos Christos
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- Held Christine
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- Herranhof Brigitte
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- Heywood Melanie
- Hidding Ute
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- Hjermind Lena
- Ho Aileen
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- Møller Anette Torvin
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- Müller Christoph
- Müller Nicole
- Münchau Alexander
- Münkel Kristina
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- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Neumann Christian
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- Nevitt Louise
- Nguyen Karine
- Nielsen Jørgen
- Nielsen Jørgen E.
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- Nikolai Tomáš
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- Oehmen Martin
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- Olivier Audrey
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- Olofsson Carina
- Oosterloo Mayke
- Oosterloo Mayke
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- Orth Michael
- Orth Michael
- Ossig Christiana
- Otti Daniela
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- Periañez Juan Manuel
- Peter Mireille
- Petersen Jens A.
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- Petracca Martina
- Petrollini Martina
- Peña José Chacón
- Phillipps Clélie
- Phillips Michelle
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- Pinter Bernadette
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- Purkayastha Debasish Das
- Päivärinta Markku
- Pålhagen Sven
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- Quaranta Davide
- Quarrell Oliver
- Quarrell Oliver
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria
- Ramos-Arroyo Maria Antonia
- Redondo Luis
- Reetz Kathrin
- Regeur Lisbeth
- Reilmann Ralf
- Reimer Jan
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- Reiter Eva-Magdalena
- Retterstøl Lars
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- Robertson Dene
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- Romero Irene
- Romero Sandra Gutierrez
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- Rose Sarah
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- Rowett Liz
- Rowett Liz
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- Valentine Ruth
- van de Wyngaerde Françoise
- van den Bogaard Simon J. A.
- van Hout Monique S. E.
- van Kuijk Sander MJ.
- van Oostrom Joost
- Van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vargas-González Laura
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- Verstraelen (formerly Ritchie) Nichola
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- Weekes Rebecca
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- Wenning Gregor
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- Werner Cornelius J.
- Westman Laila
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- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witjes-Ané Marie-Noëlle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wiśniewski Bartłomiej
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- Wolz Martin
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- Zalyalova Zuleykha
- Zaremba
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Zea Sevilla Maria Ascension
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zouitina Yassine
- Zucker Birgit
- Åman Jaana
- Østern Rune
- Šašinková Pavla
- Šenkárová Zuzana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients