An evaluation of the efficacy of the exercise on referral scheme in Northumberland, UK: association with physical activity and predictors of engagement. A naturalistic observation study

Objectives Exercise on referral schemes (ERS) are widely commissioned in the UK but there is little evidence of their association with physical activity levels. We sought to assess the Northumberland exercise on referral scheme in terms of increased levels of physical activity and identify predictors of engagement. Design A naturalistic observational study. Setting 9 local authority leisure sites in Northumberland. Participants 2233 patients referred from primary and secondary care between July 2009 and September 2010. Intervention A 24-week programme including motivational consultations and supervised exercise sessions for participants. Outcome measures Uptake, 12-week adherence, 24-week completion, changes in Godin Leisure-Time Exercise Questionnaire scores after 24-weeks and attendance levels at supervised exercise sessions during the scheme. Three binary logistic regressions were used to examine demographic and referral factors associated with initial uptake, 12-week adherence and 24-week completion. Results Uptake was 81% (n=1811), 12-week adherence was 53.5% (n=968) and 24-week completion was 42.9% (n=777). Participants who completed significantly increased their self-reported physical activity levels at 24-weeks t (638)=−11.55, p<0.001. Completers attended a mean of 22.87 (12.47 SD) of a target 48 supervised sessions. Increasing age, being female and leisure site were associated with uptake, increasing age, Index of Multiple Deprivation and leisure site were associated with 12-week adherence and Body Mass Index and leisure site were associated with 24-week completion. Each regression significantly increased the prediction accuracy of stage of exit (non-starters vs starters 81.5%, dropouts before 12 weeks vs 12-week adherers 66.9%, and dropouts between 13 and 24 weeks 82.2%). Conclusions Completers of the Northumberland ERS increased physical activity at 24 weeks, although the levels achieved were below the current UK guidelines of 150 min of moderate exercise per week. Leisure site was associated with uptake, adherence and completion

Pathogenic Potential to Humans of Bovine Escherichia coli O26, Scotland

Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx&lt;sub&gt;2&lt;/sub&gt; in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26–associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx&lt;sub&gt;2&lt;/sub&gt; phage acquisition

Economic and Market Analysis of CO2 Utilization Technologies – Focus on CO2 derived from North Dakota lignite

AbstractBased on information obtained about the technical aspects of the technologies, several challenges are expected to be faced by any potential CO2 utilization technologies intended for North Dakota lignite plants. The weather, alkaline content of lignite fly ash, and space limitations in the immediate vicinity of existing power plants are challenging hurdles to overcome. Currently, no CO2 utilization option is ready for implementation or integration with North Dakota power plants. Mineralization technologies suffer from the lack of a well-defined product and insufficient alkalinity in lignite fly ash. Algae and microalgae technologies are not economically feasible and will have weather- related challenges

CMBR Weak Lensing and HI 21-cm Cross-correlation Angular Power Spectrum

Weak gravitational lensing of the CMBR manifests as a secondary anisotropy in the temperature maps. The effect, quantified through the shear and convergence fields imprint the underlying large scale structure (LSS), geometry and evolution history of the Universe. It is hence perceived to be an important observational probe of cosmology. De-lensing the CMBR temperature maps is also crucial for detecting the gravitational wave generated B-modes. Future observations of redshifted 21-cm radiation from the cosmological neutral hydrogen (HI) distribution hold the potential of probing the LSS over a large redshift range. We have investigated the correlation between post-reionization HI signal and weak lensing convergence field. Assuming that the HI follows the dark matter distribution, the cross-correlation angular power spectrum at a multipole \ell is found to be proportional to the cold dark matter power spectrum evaluated at \ell/r, where r denotes the comoving distance to the redshift where the HI is located. The amplitude of the ross-correlation depends on quantities specific to the HI distribution, growth of perturbations and also the underlying cosmological model. In an ideal ituation, we found that a statistically significant detection of the cross-correlation signal is possible. If detected, the cross-correlation signal hold the possibility of a joint estimation of cosmological parameters and also test various CMBR de-lensing estimators.Comment: 14 pages, 4 figures, publishe

Reconciling Neutralino Relic Density with Yukawa Unified Supersymmetric Models

Supersymmetric grand unified models based on the gauge group SO(10) are especially attractive in light of recent data on neutrino masses. The simplest SO(10) SUSY GUT models predict unification of third generation Yukawa couplings in addition to the usual gauge coupling unification. Recent surveys of Yukawa unified SUSY GUT models predict an inverted scalar mass hierarchy in the spectrum of sparticle masses if the superpotential mu term is positive. In general, such models tend to predict an overabundance of dark matter in the universe. We survey several solutions to the dark matter problem in Yukawa unified supersymmetric models. One solution-- lowering the GUT scale mass value of first and second generation scalars-- leads to u_R and c_R squark masses in the 90-120 GeV regime, which should be accessible to Fermilab Tevatron experiments. We also examine relaxing gaugino mass universality which may solve the relic density problem by having neutralino annihilations via the Z or h resonances, or by having a wino-like LSP.Comment: 21 page file plus 9 figures; updated version to coincide with published versio

Acute biphenotypic leukaemia: immunophenotypic and cytogenetic analysis

The incidence of acute biphenotypic leukaemia has ranged from less than 1% to almost 50% in various reports in the literature. This wide variability may be attributed to a number of reasons including lack of consistent diagnostic criteria, use of various panels of antibodies, and the failure to recognize the lack of lineage specificity of some of the antibodies used. The morphology, cytochemistry, immunophenotype and cytogenetics of acute biphenotypic leukaemias from our institution were studied. The diagnostic criteria took into consideration the morphology of the analysed cells, light scatter characteristics, and evaluation of antibody fluorescence histograms in determining whether the aberrant marker expression was arising from leukaemic blasts or differentiated bone marrow elements. Fifty-two of 746 cases (7%) fulfilled our criteria for acute biphenotypic leukaemias. These included 30 cases of acute lymphoblastic leukaemia (ALL) expressing myeloid antigens, 21 cases of acute myelogenous leukaemia (AML) expressing lymphoid markers, and one case of ALL expressing both B- and T-cell associated antigens. The acute biphenotypic leukaemia cases consisted of four major immunophenotypic subgroups: CD2± AML (11), CD19± AML (8), CD13 and/or CD33± ALL (24), CD11b± ALL (5) and others (4). Chromosomal analysis was carried out in 42/52 of the acute biphenotypic leukaemia cases; a clonal abnormality was found in 31 of these 42 cases. This study highlights the problems encountered in the diagnosis of acute biphenotypic leukaemia, some of which may be reponsible for the wide variation in the reported incidence of this leukaemia. We suggest that the use of strict, uniform diagnostic criteria may help in establishing a more consistent approach towards diagnosis of this leukaemic entity. We also suggest that biphenotypic leukaemia is comprised of biologically different groups of leukaemia based on immunophenotypic and cytogenetic findings.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73301/1/j.1365-2141.1993.tb03024.x.pd

The Search for the Sidereal and Solar Diurnal Modulations in the Total MACRO Muon Data Set

We have analyzed 44.3M single muons collected by MACRO from 1991 through 2000 in 2,145 live days of operation. We have searched for the solar diurnal, apparent sidereal, and pseudo-sidereal modulation of the underground muon rate by computing hourly deviations of the muon rate from 6 month averages. We find evidence for statistically significant modulations with the solar diurnal and the sidereal periods. The amplitudes of these modulations are <0.1%, and are at the limit of the detector statistics. The pseudo-sidereal modulation is not statistically significant. The solar diurnal modulation is due to the daily atmospheric temperature variations at 20 km, the altitude of primary cosmic ray interactions with the atmosphere; MACRO is the deepest experiment to report this result. The sidereal modulation is in addition to the expected Compton-Getting modulation due to solar system motion relative to the Local Standard of Rest; it represents motion of the solar system with respect to the galactic cosmic rays toward the Perseus spiral arm.Comment: 18 pages, 8 of which are figures, 1 is a table. Accepted by Phys. Rev.

Meta-analysis of type 2 Diabetes in African Americans Consortium

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR)  = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.Peer reviewe

Test beam performance measurements for the Phase I upgrade of the CMS pixel detector

A new pixel detector for the CMS experiment was built in order to cope with the instantaneous luminosities anticipated for the Phase I Upgrade of the LHC. The new CMS pixel detector provides four-hit tracking with a reduced material budget as well as new cooling and powering schemes. A new front-end readout chip mitigates buffering and bandwidth limitations, and allows operation at low comparator thresholds. In this paper, comprehensive test beam studies are presented, which have been conducted to verify the design and to quantify the performance of the new detector assemblies in terms of tracking efficiency and spatial resolution. Under optimal conditions, the tracking efficiency is (99.95 ± 0.05) %, while the intrinsic spatial resolutions are (4.80 ± 0.25) μm and (7.99 ± 0.21) μm along the 100 μm and 150 μm pixel pitch, respectively. The findings are compared to a detailed Monte Carlo simulation of the pixel detector and good agreement is found.Peer reviewe

Studies of Hadronic Event Structure in e+e- Annihilation from 30 GeV to 209 GeV with the L3 Detector

In this Report, QCD results obtained from a study of hadronic event structure in high energy e^+e^- interactions with the L3 detector are presented. The operation of the LEP collider at many different collision energies from 91 GeV to 209 GeV offers a unique opportunity to test QCD by measuring the energy dependence of different observables. The main results concern the measurement of the strong coupling constant, \alpha_s, from hadronic event shapes and the study of effects of soft gluon coherence through charged particle multiplicity and momentum distributions.Comment: To appear in Physics Report