The origin of the infrared emission in radio galaxies. III. Analysis of 3CRR objects

We present Spitzer photometric data for a complete sample of 19 low redshift (z<0.1) 3CRR radio galaxies as part of our efforts to understand the origin of the prodigious mid- to far-infrared (MFIR) emission from radio-loud AGN. Our results show a correlation between AGN power (indicated by [OIII] 5007 emission line luminosity) and 24 micron luminosity. This result is consistent with the 24 micron thermal emission originating from warm dust heated directly by AGN illumination. Applying the same correlation test for 70 micron luminosity against [OIII] luminosity we find this relation to suffer from increased scatter compared to that of 24 micron. In line with our results for the higher-radio-frequency-selected 2Jy sample, we are able to show that much of this increased scatter is due to heating by starbursts which boost the far-infrared emission at 70 micron in a minority of objects (17-35%). Overall this study supports previous work indicating AGN illumination as the dominant heating mechanism for MFIR emitting dust in the majority of low to intermediate redshift radio galaxies (0.03<z<0.7), with the advantage of strong statistical evidence. However, we find evidence that the low redshift broad-line objects (z<0.1) are distinct in terms of their positions on the MFIR vs. [OIII] correlations.Comment: 31 pages, 3 figures, accepted for publication to Ap

Polarimetry and Unification of Low-Redshift Radio Galaxies

We have made high-quality measurements of the polarization spectra of 13 FR II radio galaxies and taken polarization images for 11 of these with the Keck telescopes. Seven of the eight narrow-line radio galaxies (NLRG) are polarized, and six of the seven show prominent broad Balmer lines in polarized light. The broad lines are also weakly visible in total flux. Some of the NLRG show bipolar regions with roughly circumferential polarization vectors, revealing a large reflection nebula illuminated by a central source. Our observations powerfully support the hidden quasar hypothesis for some NLRG. Classification as NLRG, broad-line radio galaxy (BLRG), or quasar therefore depends on orientation. However, not all objects fit into this unification scheme. Our sample is biased towards objects known in advance to be polarized, but the combination of our results with those of Hill, Goodrich and DePoy (1996) show that at least 6 out of a complete, volume and flux-limited sample of 9 FR II NLRG have broad lines, seen either in polarization or P_alpha.Comment: To appear in November 1999 Astronomical Journal. 49 pages, 13 figure

Survival of MUTYH-Associated Polyposis Patients With Colorectal Cancer and Matched Control Colorectal Cancer Patients

Background: MUTYH-associated polyposis is a recessively inherited disorder characterized by a lifetime risk of colorectal cancer that is up to 100%. Because specific histological and molecular genetic features of MUTYH-associated polyposis colorectal cancers might influence tumor behavior and patient survival, we compared survival between patients with MUTYH-associated polyposis colorectal cancer and matched control patients with colorectal cancer from the general population. Method:s In this retrospective multicenter cohort study from Europe, 147 patients with MUTYH-associated polyposis colorectal cancer were compared with 272 population-based control patients with colorectal cancer who were matched for country, age at diagnosis, year of diagnosis, stage, and subsite of colorectal cancer. Kaplan–Meier survival and Cox regression analyses were used to compare survival between patients with MUTYH-associated polyposis colorectal cancer and control patients with colorectal cancer. All statistical tests were two-sided. Results: Five-year survival for patients with MUTYH-associated polyposis colorectal cancer was 78% (95% confidence interval [CI] = 70% to 84%) and for control patients was 63% (95% CI = 56% to 69%) (log-rank test, P = .002). After adjustment for differences in age, stage, sex, subsite, country, and year of diagnosis, survival remained better for MUTYH-associated polyposis colorectal cancer patients than for control patients (hazard ratio of death = 0.48, 95% CI = 0.32 to 0.72). Conclusions: In a European study cohort, we found statistically significantly better survival for patients with MUTYH-associated polyposis colorectal cancer than for matched control patients with colorectal cancer

The balance between shocks and AGN photoionization in radio sources and its relation to the radio size

We have analyzed the ultraviolet and optical emission line ratios of a large sample of extragalactic radio sources (QSOs and radio galaxies), with the help of models combining AGN photoionization and shocks. The results strongly suggest that the two ionizing mechanisms frequently coexist. The model sequences obtained by varying the balance between shocks and AGN photoionization account for most emission line data in the 12 line ratio diagrams we have considered. In the frequently used diagrams involving [OIII]5007/Hbeta, [OI]6300/Halpha, [NII]6584/Halpha and [SII]6716,6731, the effect of varying the shock-photoionization balance mimics a variation of the ionization parameter (U) in traditional photoionization sequences. In most of the remaining diagrams, such as [OI]6300/[OIII]5007 vs.[OIII]4363/[OIII]5007, [OIII]5007/H vs. [OIII]4363/[OIII]5007 and CIII]1909/[CII]2326 vs. CIV1549/[CII]2326, the data can only be accounted for if both photoionization and shocks contribute to the line fluxes. The coexistence of shocks and AGN photoionization also provides an explanation for the most extreme objects in the NV1240/HeII1640 vs. NV1240/CIV1549 diagram without requiring largely super-solar metallicities. In addition, we show that there is a relationship between the [OII]3727/[OIII]5007 ratio and the radio size in radio galaxies. This strongly supports the hypothesis that the most compact (< 2kpc) and the largest (> 150 kpc) sources are dominated by photoionization, while intermediate-sized radio galaxies are dominated by shocks. We briefly discuss the possible origin of the relation between the shock-ionization balance and the radio size.Comment: 11 pages, 6 figures, accepted for publication in Astronomy & Astrophysic

Duodenal Adenomas and Cancer in MUTYH-associated Polyposis: An International Cohort Study

Although duodenal adenomas and cancer appear to occur significantly less frequently in autosomal recessive MUTYH-associated polyposis (MAP) than in autosomal dominant familial adenomatous polyposis (FAP),1 current guidelines recommend similar endoscopic surveillance for both disorders.2-4 This involves gastro-duodenoscopy starting at 25 to 35 years of age and repeated at intervals determined by Spigelman staging based on the number, size, histological type and degree of dysplasia of adenomas, and by ampullary staging. Case reports of duodenal cancers in MAP suggest that they may develop in the absence of advanced Spigelman stage benign disease and even without coexisting adenomas.1 Recent molecular analyses suggest thatMAPduodenal adenomashave a higher mutational burden than FAP adenomas and are more likely to harbor oncogenic drivermutations, such as those in KRAS.5 These apparent differences in the biology and natural history of duodenal polyposis in FAP and MAP challenge the assumption that the same surveillance should be applied in both conditions

A framework for the development of a global standardised marine taxon reference image database (SMarTaR-ID) to support image-based analyses

Video and image data are regularly used in the field of benthic ecology to document biodiversity. However, their use is subject to a number of challenges, principally the identification of taxa within the images without associated physical specimens. The challenge of applying traditional taxonomic keys to the identification of fauna from images has led to the development of personal, group, or institution level reference image catalogues of operational taxonomic units (OTUs) or morphospecies. Lack of standardisation among these reference catalogues has led to problems with observer bias and the inability to combine datasets across studies. In addition, lack of a common reference standard is stifling efforts in the application of artificial intelligence to taxon identification. Using the North Atlantic deep sea as a case study, we propose a database structure to facilitate standardisation of morphospecies image catalogues between research groups and support future use in multiple front-end applications. We also propose a framework for coordination of international efforts to develop reference guides for the identification of marine species from images. The proposed structure maps to the Darwin Core standard to allow integration with existing databases. We suggest a management framework where high-level taxonomic groups are curated by a regional team, consisting of both end users and taxonomic experts. We identify a mechanism by which overall quality of data within a common reference guide could be raised over the next decade. Finally, we discuss the role of a common reference standard in advancing marine ecology and supporting sustainable use of this ecosystem

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe