Reducing smoking in adolescents: cost-effectiveness results from the cluster randomized ASSIST (A Stop Smoking In Schools Trial)

Introduction: School-based smoking prevention programmes can be effective, but evidence on cost-effectiveness is lacking. We conducted a cost-effectiveness analysis of a school-based “peer-led” intervention.<p></p> Methods: We evaluated the ASSIST (A Stop Smoking In Schools Trial) programme in a cluster randomized controlled trial. The ASSIST programme trained students to act as peer supporters during informal interactions to encourage their peers not to smoke. Fifty-nine secondary schools in England and Wales were randomized to receive the ASSIST programme or usual smoking education. Ten thousand seven hundred and thirty students aged 12–13 years attended participating schools. Previous work has demonstrated that the ASSIST programme achieved a 2.1% (95% CI = 0%–4.2%) reduction in smoking prevalence. We evaluated the public sector cost, prevalence of weekly smoking, and cost per additional student not smoking at 24 months.<p></p> Results: The ASSIST programme cost of £32 (95% CI = £29.70–£33.80) per student. The incremental cost per student not smoking at 2 years was £1,500 (95% CI = £669–£9,947). Students in intervention schools were less likely to believe that they would be a smoker at age 16 years (odds ratio [OR] = 0.80; 95% CI = 0.66–0.96).<p></p> Conclusions: A peer-led intervention reduced smoking among adolescents at a modest cost. The intervention is cost-effective under realistic assumptions regarding the extent to which reductions in adolescent smoking lead to lower smoking prevalence and/or earlier smoking cessation in adulthood. The annual cost of extending the intervention to Year 8 students in all U.K. schools would be in the region of £38 million and could result in 20,400 fewer adolescent smokers.<p></p&gt

Riparian buffer strips influence nitrogen losses as nitrous oxide and leached N from upslope permanent pasture

Riparian buffer strips can have a significant role in reducing nitrogen (N) transfers from agricultural land to freshwater primarily via denitrification and plant uptake processes, but an unintended trade-off can be elevated nitrous oxide (N2O) production rates. Against this context, our replicated bounded plot scale study investigated N2O emissions from un-grazed ryegrass pasture served by three types of riparian buffer strips with different vegetation, comprising: (i) grass riparian buffer with novel deep-rooting species, (ii) willow (young trees at establishment phase) riparian buffer, and (iii) deciduous woodland (also young trees at establishment phase) riparian buffer. The experimental control was ryegrass pasture with no buffer strip. N2O emissions were measured at the same time as total oxidized N in run-off, and soil and environmental characteristics in the ri parian buffer strips and upslope pasture between 2018 and 2019. During most of the sampling days, the no-buffer control treatment showed significantly (P < 0.05) greater N2O fluxes and cumulative N2O emissions compared to the remainder of the treatments. Our results also showed that the grass riparian buffer strip is a sink of N2O equivalent to − 2310.2 g N2O-N ha− 1 day− 1 (95% confidence interval:− 535.5 to 492). Event-based water quality results obtained during storms (12 November 2018 and 11 February 2019) showed that the willow riparian buffer treatment had the highest flow-weighted mean N concentrations (N-FWMC) of 0.041 ± 0.022 and 0.031 ± 0.015 mg N L− 1, when compared to the other treatments. Our 9-month experiment therefore, shows that ri parian buffer strips with novel deep-rooting grass can therefore potentially address emissions to both water and air. The results imply that over a shorter timeline similar to the current study, the grass riparian buffer strip can potentially address N emission to both air and water, particularly when serving a permanent pasture in similar settings as the current experiment.Fil: Dlamini, J.C. Crop and Climate Sciences. Departament of Soil; Sudáfrica. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido. University of Pretoria. Department of Plant and Soil Sciences; SudáfricaFil: Cardenas, L.M. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido.Fil: Tesfamarian, E.H. University of Pretoria. Department of Plant and Soil Sciences; SudáfricaFil: Dunn, R.M. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido.Fil: Loick, N. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido.Fil: Charteris, A.F. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido.Fil: Cocciaglia, L. Università degli Studi di Perugia. Dipartimento di Scienze Agrarie, Alimentari e Ambientali; ItaliaFil: Vangeli, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Ingeniería Agrícola y Uso de la Tierra. Cátedra de Manejo y Conservación de Suelo; ArgentinaFil: Blackwell, M.S.A. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido.Fil: Upadhayay, H.R. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido.Fil: Hawkins, J.M.B. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido.Fil: Evans, J. Rothamsted Research. Computational and Analytical Sciences; Reino UnidoFil: Collins, A.L. Rothamsted Research. Sustainable Agriculture Sciences; Reino Unido

Yet Another Extension of the Standard Model: Oases in the Desert?

We have searched for conceptually simple extensions of the standard model, and describe here a candidate model which we find attractive. Our starting point is the assumption that off-diagonal CKM mixing matrix elements are directly related by lowest order perturbation theory to the quark mass matrices. This appears to be most easily and naturally implemented by assuming that all off-diagonal elements reside in the down-quark mass matrix. This assumption is in turn naturally realized by introducing three generations of heavy, electroweak-singlet down quarks which couple to the Higgs sector diagonally in flavor, while mass-mixing off-diagonally with the light down-quarks. Anomaly cancellation then naturally leads to inclusion of electroweak vector-doublet leptons. It is then only a short step to completing the extension to three generations of fundamental representations of E(6). Assuming only that the third generation B couples to the Higgs sector at least as strongly as does the top quark, the mass of the B is roughly estimated to lie between 1.7 TeV and 10 TeV, with lower-generation quarks no heavier. The corresponding guess for the new leptons is a factor two lower. Within the validity of the model, flavor and CP violation are ``infrared'' in nature, induced by semi-soft mass mixing terms, not Yukawa couplings. If the Higgs couplings of the new quarks are flavor symmetric, then there necessarily must be at least one ``oasis'' in the desert, induced by new radiative corrections to the top quark and Higgs coupling constants, and roughly at 1000 TeV.Comment: LaTex, 40 page

Disparate MgII Absorption Statistics towards Quasars and Gamma-Ray Bursts : A Possible Explanation

We examine the recent report by Prochter et al. (2006) that gamma-ray burst (GRB) sight lines have a much higher incidence of strong MgII absorption than quasar sight lines. We propose that the discrepancy is due to the different beam sizes of GRBs and quasars, and that the intervening MgII systems are clumpy with the dense part of each cloudlet of a similar size as the quasars, i.e. < 10^16 cm, but bigger than GRBs. We also discuss observational predictions of our proposed model. Most notably, in some cases the intervening MgII absorbers in GRB spectra should be seen varying, and quasars with smaller sizes should show an increased rate of strong MgII absorbers. In fact, our prediction of variable MgII lines in the GRB spectra has been now confirmed by Hao et al. (2007), who observed intervening FeII and MgII lines at z=1.48 to be strongly variable in the multi-epoch spectra of z=4.05 GRB060206.Comment: 12 pages, 2 figures; substantially revised model calculation; accepted for publication in Astrophysics & Space Science as a Lette

Noncommutative Spheres and Instantons

We report on some recent work on deformation of spaces, notably deformation of spheres, describing two classes of examples. The first class of examples consists of noncommutative manifolds associated with the so called $\theta$-deformations which were introduced out of a simple analysis in terms of cycles in the $(b,B)$-complex of cyclic homology. These examples have non-trivial global features and can be endowed with a structure of noncommutative manifolds, in terms of a spectral triple (\ca, \ch, D). In particular, noncommutative spheres $S^{N}_{\theta}$ are isospectral deformations of usual spherical geometries. For the corresponding spectral triple (\cinf(S^{N}_\theta), \ch, D), both the Hilbert space of spinors \ch= L^2(S^{N},\cs) and the Dirac operator $D$ are the usual ones on the commutative $N$-dimensional sphere $S^{N}$ and only the algebra and its action on $\ch$ are deformed. The second class of examples is made of the so called quantum spheres $S^{N}_q$ which are homogeneous spaces of quantum orthogonal and quantum unitary groups. For these spheres, there is a complete description of $K$-theory, in terms of nontrivial self-adjoint idempotents (projections) and unitaries, and of the $K$-homology, in term of nontrivial Fredholm modules, as well as of the corresponding Chern characters in cyclic homology and cohomology.Comment: Minor changes, list of references expanded and updated. These notes are based on invited lectures given at the ``International Workshop on Quantum Field Theory and Noncommutative Geometry'', November 26-30 2002, Tohoku University, Sendai, Japan. To be published in the workshop proceedings by Springer-Verlag as Lecture Notes in Physic

Nucleotide variation, haplotype structure, and association with end-stage renal disease of the human interleukin-1 gene cluster

A dense gene-based SNP map was constructed across a 360-kb region containing the interleukin-1 gene cluster (IL1A, IL1B, and IL1RN), focusing on IL1RN. In total, 95 polymorphisms were confirmed or identified primarily by direct sequencing. Polymorphisms were precisely mapped to completed BAC and genomic sequences spanning this region. The polymorphisms were typed in 443 case-control subjects from Caucasian and African American groups. Consecutive pair-wise marker linkage disequilibrium was not strictly correlated with distance and ranged from D′ = 0.0079 to 1.000 and D′ = 0.0521 to 1.0000 in Caucasians and African Americans, respectively. Single markers and haplotypes in IL1 cluster genes were evaluated for association with end-stage renal disease (ESRD). Eleven SNPs show some evidence of association with ESRD, with the strongest associations in two IL1A variants, one SNP, rs1516792-3, in intron 5 (p = 0.0015) and a 4-bp insertion/deletion within the 3′UTR, rs16347-2 (p = 0.0024), among African Americans with non-T2DM-associated ESRD

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02