Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.

Funder: All funders per study are acknowledged in the Supplementary FileA new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the genetic correlation of traits, which reflects the number of pleiotropic loci, i.e. genetic loci influencing multiple traits. Here, we applied new meta-analyses of optic nerve head (ONH) related traits implicated in primary open-angle glaucoma (POAG); intraocular pressure and central corneal thickness using Haplotype reference consortium imputations. We performed a multi-trait analysis of ONH parameters cup area, disc area and vertical cup-disc ratio. We uncover new variants; rs11158547 in PPP1R36-PLEKHG3 and rs1028727 near SERPINE3 at genome-wide significance that replicate in independent Asian cohorts imputed to 1000 Genomes. At this point, validation of these variants in POAG cohorts is hampered by the high degree of heterogeneity. Our results show that multi-trait analysis is a valid approach to identify novel pleiotropic variants for ONH

Water Resources and the Historic Wells of Barbuda: Tradition, Heritage and Hope for a Sustainable Future

The island of Barbuda has a relatively unique history, land tenure and geography. Unlike its Caribbean counterparts, the island is not suited to large-scale agriculture due to its arid climate and relatively thin soils. Instead, the enslaved and eventually free people of Barbuda developed a complex herding ecology centered on common land ownership. As a result, carefully designed historic wells are strategically located around the island. With the challenges brought about by climate change, an interdisciplinary, international team led by the Barbuda Research Complex is investigating the state of existing water and food resources and examining how the availability and quality of water resources have influenced local cultural practices. Barbudans and international scientists are working together to improve their resilience and live more sustainably in this new era of climatic adversity

Water resources and the historic wells of Barbuda: tradition, heritage and hope for a sustainable future

The island of Barbuda has a relatively unique history, land tenure and geography. Unlike its Caribbean counterparts, the island is not suited to large-scale agriculture due to its arid climate and relatively thin soils. Instead, the enslaved and eventually free people of Barbuda developed a complex herding ecology centered on common land ownership. As a result, carefully designed historic wells are strategically located around the island. With the challenges brought about by climate change, an interdisciplinary, international team led by the Barbuda Research Complex is investigating the state of existing water and food resources and examining how the availability and quality of water resources have influenced local cultural practices. Barbudans and international scientists are working together to improve their resilience and live more sustainably in this new era of climatic adversity