51 research outputs found
Radio Emissions from Solar Active Regions
- Author
- A. Lara
- A. Nindos
- A. Nindos
- A. Nindos
- A. Vourlidas
- A. Vourlidas
- A. Vourlidas
- A.E. Covington
- A.E. Covington
- A.N. McClymont
- A.O. Benz
- B.C. Low
- B.C. Low
- B.C. Low
- B.I. Ryabov
- B.I. Ryabov
- B.I. Ryabov
- C.E. Alissandrakis
- C.E. Alissandrakis
- C.E. Alissandrakis
- C.E. Alissandrakis
- C.E. Alissandrakis
- C.U. Keller
- D.B. Melrose
- D.B. Melrose
- D.B. Melrose
- D.E. Gary
- D.E. Gary
- D.E. Gary
- D.E. Gary
- D.F. Webb
- D.R. Hartree
- D.W. Longcope
- E.G. Harris
- E.J. Schmahl
- E.J. Schmahl
- E.N. Parker
- E.R. Priest
- E.V. Appleton
- E.Y. Zlotnik
- E.Y. Zlotnik
- E.Y. Zlotnik
- F. Chiuderi-Drago
- F. Chiuderi-Drago
- F. Chiuderi-Drago
- F. Chiuderi-Drago
- G. Rybicki
- G.A. Dulk
- G.A. Dulk
- G.A. Gary
- G.B. Gelfreikh
- G.B. Gelfreikh
- G.B. Gelfreikh
- G.B. Gelfreikh
- G.D. Holman
- H. Lin
- H. Song
- H. Zirin
- H.S. Hudson
- J. Lee
- J. Lee
- J. Lee
- J. Lee
- J. Lee
- J. Lee
- J. Zhang
- J.A. Klimchuk
- J.A. Ratcliffe
- J.H. Piddington
- J.M. Laming
- J.M. Wilcox
- J.T. Schmelz
- J.T. Schmelz
- J.T. Schmelz
- J.W. Brosius
- J.W. Brosius
- J.W. Brosius
- J.W. Brosius
- J.W. Brosius
- J.W. Brosius
- J.W. Brosius
- J.W. Dungey
- Jeongwoo Lee
- K. Shibasaki
- K. Shibasaki
- K.R. Lang
- K.R. Lang
- K.R. Lang
- K.T. Strong
- L. Jiao
- M.H. Cohen
- M.J. Aschwanden
- M.J. Aschwanden
- M.J. Aschwanden
- M.J. Aschwanden
- M.R. Kundu
- M.R. Kundu
- M.R. Kundu
- N. Gopalswamy
- N. Gopalswamy
- N. Gopalswamy
- N. Gopalswamy
- P. Lantos
- P.V. Foukal
- R. Bandiera
- R. Rosner
- R.A. Kopp
- R.K. Shevgaonkar
- R.W. Komm
- S. Krucker
- S. Krucker
- S.-C. Bong
- S.-C. Bong
- S.-C. Bong
- S.B. Akhmedov
- S.M. White
- S.M. White
- S.M. White
- S.M. White
- S.M. White
- S.T. Suess
- T. Amari
- T. Kakinuma
- T. Sakurai
- T. Sakurai
- T.H. Stix
- T.R. Metcalf
- T.S. Bastian
- U. Feldman
- U. Feldman
- V. Domingo
- V. Yurchyshyn
- V.M. Bogod
- V.M. Nakariakov
- V.M. Nakariakov
- V.V. Zheleznyakov
- V.V. Zheleznyakov
- V.V. Zheleznyakov
- V.V. Zheleznyakov
- V.V. Zheleznyakov
- Y. Mok
- Y. Nakagawa
- Y.-K. Ko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.
- Author
- A Fatica
- A Hamvas
- AC Ferguson-Smith
- Alison Male
- Alison Yeung
- Amy S. Lay
- Anne Loccufier
- Annelies de Klein
- Ashley L. Wilson
- AV Dharmadhikari
- Avinash V. Dharmadhikari
- Björn Menten
- BL Black
- Brian Hon-Yin Chung
- C Galambos
- C Gregg
- C Langston
- Carlos A. Bacino
- Carol L. Wagner
- CC Warzecha
- Charles Shaw-Smith
- Claire Langston
- D Chu
- David A. Bateman
- David Francis
- David R. Kelly
- Dawn English
- Daynna J. Wolff
- Denise A. Hayes
- DG Lupiåñez
- Diane J. Payton
- Dick Tibboel
- DP Barlow
- E Araujo JĂșnior
- Edwina Popek
- Eileen McKay
- Eitan Kerem
- Elfride De Baere
- Elizabeth K. Fiorino
- Elizabeth R. Roeder
- Erwin Brosens
- F Zufferey
- Fernando Santos-Simarro
- Frances Elmslie
- Gael E. Phillips
- Gary Tsz Kin Mok
- Girvan Malcolm
- Glenda Hendson
- GR Handrigan
- Gregory Peters
- H Oyanagi
- I Tasha
- Ilse Feenstra
- IM Campbell
- IM Campbell
- IM Kim
- Isabelle Maystadt
- J Kohlhase
- James R. Lupski
- Janet Lioy
- Jasneek Chawla
- Jason Pinner
- Jennifer L. Kussmann
- Jennifer Schuette
- Jessica Sebastian
- Jill Slamon
- Joel Reiter
- Joseph Shieh
- Joyce Fox
- JR Dixon
- JuliĂĄn Nevado
- Kadir Caner Akdemir
- Kamilla Schlade-Bartusiak
- KM Lai
- Kristin Scheible
- Laurie Steiner
- Liesbeth Spruijt
- Lieve Vanwalleghem
- M Iascone
- M Kagoshima
- M Mahlapuu
- M Sauvageau
- M. Anwar Iqbal
- Margaret L. McKinnon
- Martina Owens
- MarĂa Palomares
- Maya Chopra
- Melinda H. Markham
- Melissa Lees
- MJ Garabedian
- Morris Edelman
- MS Bartolomei
- Namasivayam Ambalavanan
- NB Bishop
- Neil Sebire
- Nicole de Leeuw
- Nihal Godiwala
- NJ Brand
- Oliver Quarrell
- P Dello Russo
- P Grote
- P Sen
- P Sen
- P Sen
- P Sen
- P Stankiewicz
- P Szafranski
- P Szafranski
- P Szafranski
- Pablo Lapunzina
- Partha Sen
- PaweĆ Stankiewicz
- Philippe Moerman
- PJ Hastings
- PJ Yong
- PP Luedi
- Przemyslaw Szafranski
- PĂ Jacques
- Rebecca Okashah Littlejohn
- Richard Fisher
- Richard Sayers
- Rosanna G. Abellar
- S Gu
- S Joza
- S Yu
- Sandra Janssens
- Sara Jane Hamilton
- Scott A. Anderson
- Shalini N. Jhangiani
- SL Prothro
- Suneeta Madan-Khetarpal
- Susan Arbuckle
- Svetlana A. Yatsenko
- T Parris
- Taryn C. Rosenthal
- Thomas S. DeNapoli
- Timothy Thiruchelvam
- Tomasz Gambin
- Urvashi Surti
- VV Kalinichenko
- VW Chang
- Wai-Lap Wong
- Y Guo
- Yoyo Wing Yiu Chu
- Yves Sznajer
- Zoe Mead
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or genomic deletion copy-number variants (CNVs) of FOXF1 or its upstream enhancer involving fetal lung-expressed long noncoding RNA genes LINC01081 and LINC01082. Using custom-designed array comparative genomic hybridization, Sanger sequencing, whole exome sequencing (WES), and bioinformatic analyses, we studied 22 new unrelated families (20 postnatal and two prenatal) with clinically diagnosed ACDMPV. We describe novel deletion CNVs at the FOXF1 locus in 13 unrelated ACDMPV patients. Together with the previously reported cases, all 31 genomic deletions in 16q24.1, pathogenic for ACDMPV, for which parental origin was determined, arose de novo with 30 of them occurring on the maternally inherited chromosome 16, strongly implicating genomic imprinting of the FOXF1 locus in human lungs. Surprisingly, we have also identified four ACDMPV families with the pathogenic variants in the FOXF1 locus that arose on paternal chromosome 16. Interestingly, a combination of the severe cardiac defects, including hypoplastic left heart, and single umbilical artery were observed only in children with deletion CNVs involving FOXF1 and its upstream enhancer. Our data demonstrate that genomic imprinting at 16q24.1 plays an important role in variable ACDMPV manifestation likely through long-range regulation of FOXF1 expression, and may be also responsible for key phenotypic features of maternal uniparental disomy 16. Moreover, in one family, WES revealed a de novo missense variant in ESRP1, potentially implicating FGF signaling in the etiology of ACDMPV
Implementation of corticosteroids in treating COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK:prospective observational cohort study
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Allen Sam
- Andrikopoulos Petros
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin WA
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Richard
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- da Silva Filipe Ana
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donegan Cara
- Donegan Cara
- Donelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gon alo
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fawkes Angie
- Fegan Chrisopher
- Finch Lorna
- Finn Adam
- Fisher Lewis WS
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Gilchrist Tammy
- Girvan Michelle
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Griffin Julian
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Hafezi Katarzyna
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
- Hiscox Julian A
- Ho Antonia
- Ho Antonia YW
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
- Jones Trevor R
- Kaliappan Agilan
- Kasipandian Vidya
- Keating SeĂĄn
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Say
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Leeming Gary
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lewis Matthew
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A
- Lyttle Mark
- MacGillivray Louise
- Maclean Alan
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A
- Meda Manjula
- Mentzer Alexander J
- Merson Laura
- Metelmann Soeren
- Meynert Alison M
- Miah Nahida S
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moonesinghe S Ramani
- Moore Elinoor
- Moore Shona C
- Moore Shona C
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulholland Rachel H
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Nguyen-Van-Tam Jonathan S
- Norman Lisa
- Norris Lillian
- Noursadeghi Mahdad
- NĂ€rhi Fiina
- O'Shea Matthew K
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter JM
- Openshaw Peter JM
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P Matthew
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D
- Russell Clark D
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline
- Sarah Sarah
- Saviciute Egle
- Schmid Matthias
- Scott Janet T
- Scott-Brown James
- Semple Malcolm G
- Semple Malcolm G
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A
- Shaw Catherine A
- Shaw Victoria
- Shaw Victoria E
- Shawcross Anna
- Shears Rebecca K
- Shenkin Susan D
- Sigfrid Louise
- Singh Pooni Jagtur
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G
- Spencer Rebecca G
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S
- Subudhi Pradeep
- Summers Charlotte
- Swann Olivia V
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S
- Thomas Jo
- Thomas Jordan
- Thompson AA Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C
- Thwaites Ryan S
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance
- Turtle Lance CW
- Twagira Mary
- Vallotton Nick
- van Tonder Libby
- Vancheeswaran Rama
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zhang J Eunice
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on June 16, 2020, and to identify discrepancies in care. METHODS: We did an audit of clinical implementation of corticosteroids in a prospective, observational, cohort study in 237 UK acute care hospitals between March 16, 2020, and April 14, 2021, restricted to patients aged 18 years or older with proven or high likelihood of COVID-19, who received supplementary oxygen. The primary outcome was administration of dexamethasone, prednisolone, hydrocortisone, or methylprednisolone. This study is registered with ISRCTN, ISRCTN66726260. FINDINGS: Between June 17, 2020, and April 14, 2021, 47â795 (75·2%) of 63â525 of patients on supplementary oxygen received corticosteroids, higher among patients requiring critical care than in those who received ward care (11â185 [86·6%] of 12â909 vs 36â415 [72·4%] of 50â278). Patients 50 years or older were significantly less likely to receive corticosteroids than those younger than 50 years (adjusted odds ratio 0·79 [95% CI 0·70â0·89], p=0·0001, for 70â79 years; 0·52 [0·46â0·58], p80 years), independent of patient demographics and illness severity. 84 (54·2%) of 155 pregnant women received corticosteroids. Rates of corticosteroid administration increased from 27·5% in the week before June 16, 2020, to 75â80% in January, 2021. INTERPRETATION: Implementation of corticosteroids into clinical practice in the UK for patients with COVID-19 has been successful, but not universal. Patients older than 70 years, independent of illness severity, chronic neurological disease, and dementia, were less likely to receive corticosteroids than those who were younger, as were pregnant women. This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered. FUNDING: UK National Institute for Health Research and UK Medical Research Council
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
- Author
- Abrams Simon
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W A
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Cox Helen
- Cupitt Jason
- Cutino-moguel Maria-teresa
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- De Silva Thushan
- De Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donnison Phil
- Donohue Chloe
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Dunn Chris
- Dunning Jake
- Durand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Eunice Zhang J
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fegan Christopher
- Filipe Ana Da Silva
- Finch Lorna
- Finn Adam
- Fisher Lewis W S
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Girvan Michelle
- Gkrania-klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Greenhalf William
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
- Hiscox Julian A
- Ho Antonia
- Ho Antonia Ying Wai
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
- Jones Trevor R
- Kaliappan Agilan
- Kasipandian Vidya
- Keating SeĂĄn
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-langham Lara
- Law Andrew
- Law Andrew
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A
- Lyons Ruth
- Lyttle Mark
- Maclean Alan
- Macmahon Michael
- Macnaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Matthew Ridley P
- Maziere Nicole
- Mccafferty Sarah
- Mccullough Katherine
- Mcdonald Sara
- Mcdonald Sarah
- Mcevoy Laurence
- Mcewen Ruth
- Mclauchlan John
- Mclean Kenneth A
- Meda Manjula
- Mentzer Alexander J
- Merson Laura
- Metelmann Soeren
- Meynert Alison M
- Miah Nahida S
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C
- Moore Shona C
- Moore Shona C
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Norman Lisa
- Noursadeghi Mahdad
- Oosthuyzen Wilna
- Oosthuyzen Wilna
- Openshaw Peter J M
- Openshaw Peter J M
- Ostermann Marlies
- Otahal Igor
- Oâshea Matthew K
- Pais Mark
- Palmarini Massimo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A
- Penrice-randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Pollakis Georgios
- Pooni Jagtur Singh
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Relph Katharine A
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L
- Roger Thompson A A
- Rose Alistair
- Rousseau Guy
- Russell Clark D
- Russell Clark D
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-shimizu Vanessa
- Saviciute Egle
- Scott Janet T
- Scott-brown James
- Semple Malcolm G
- Semple Malcolm G
- Shah Aarti
- Shankar-hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A
- Shaw Victoria
- Shaw Victoria E
- Shawcross Anna
- Shears Rebecca K
- Sigfrid Louise
- Siggins Matthew K
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S
- Subudhi Pradeep
- Summers Charlotte
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Tanianis-hughes Jolanta
- Tatham Kate
- Tedder Richard S
- Thomas Jo
- Thomas Jordan
- Thompson Chris
- Thompson Robert
- Thomson Emma C
- Thwaites Ryan S
- Thwaites Ryan S
- Tridente Ascanio
- Trochu Erwan
- Tupper-carey Darell
- Turtle Lance
- Turtle Lance C W
- Twagira Mary
- Ustianowski Andrew
- Vallotton Nick
- Van Tonder Libby
- Vincent-smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/04/2022
- Field of study
Abstract Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11â1.70] ng/mL vs 0.24 [0.10â0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51â.60]).</jats:p
The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
- Author
- Aawsaj Yousif
- Abayomi Michael
- Acharya Vikas
- Aggarwal Smeer Kumar
- Ahmad Anwar
- Ahmed Irfan
- Ahmed Jamil
- Ahmed Javed
- Ahmed Talat
- Ainley Paul
- Akhtar Mansoor
- Al Amari Khalid
- Al-Abed Yahya A.
- Al-Akash Musallam
- Al-Bahrani Ahmed Z.
- Al-Khyatt Waleed
- Al-Muhktar Ahmed
- Al-Sarireh Bilal
- Al-Taan Omer
- Alagaratnam Swethan
- Alam Imran
- Alberts Justin
- Alderson Derek
- Aldridge Roland C.
- Aleksandrov Danail
- Ali Haythem
- Ali Shahda
- Amin Khalid
- Andrew David R.
- Appleton Shaun
- Arhi Chanpreet
- Aroori Somaiah
- Aryal Kamal
- Asad Mehek
- Aseem Rabiya
- Asprou Fotini M.
- Awan Altaf
- Ayaani Soofiyah
- Aymon null
- Babu Benoy I.
- Bajwa Dalvir S.
- Bajwa Farrukh M.
- Baker Andrew L.
- Balfe Paul
- Ball William R.
- Ballance Laura
- Banwell Victoria
- Barnes James
- Barrie Jenifer
- Bartlett Francis
- Basheer Mohammed
- Bashir Gareth
- Basra Melvinder
- Basu Sanjoy
- Basynat Pradeep
- Batt Jeremy
- Bausbacher Harald
- Bawa Sadiq
- Beasley William D.
- Belding Rowena
- Bellini Maria Irene
- Bennett Stephen P.
- Bhandari Santosh
- Bharamgoudar Reshma
- Bhattacharya Vish
- Blane Christine
- Blazeby Jane M.
- Boal Matthew
- Boddy Alexander
- Boland Michael
- Bond-Smith Giles
- Booth Michael I.
- Borowski David W.
- Bowen Laura
- Boyce Kathryn M.
- Boyd Alan T.
- Bradley Donal
- Bradley Neil
- Brennan Stephen
- Brett Daniel
- Broadhurst Jack
- Brooke Eleanor
- Brown Timothy H.
- Bryant Alice
- Buchan Joanna
- Bullen Naomi
- Bunnell Catherine
- Bunting David M.
- Burke Paul
- Byrne James P.
- Byrnes Colman K.
- Campbell William
- Carney Kate
- Carney Kate
- Carroll Paul
- Carter C. Ross
- Carter Nicholas C.
- Carty Nick
- Cassidy John T.
- Chambers Adam
- Chambers Alice
- Chambers Alice
- Chan Wei Ming
- Chang Jessica
- Charalabopoulos Alexandros
- Chauhan Neal
- Cheung Melanie
- Chhabra Alok
- Chishti Imran A.
- Chitre Vivek
- Choy Alfred
- Cieplucha Krzysztos
- Clements Joshua M.
- Coats Maria
- Cockbain Andrew J.
- Coe Peter O.
- Connelly Martin
- Cooke Fiachra
- Courtney Michael J.
- Cowley Jonathan B.
- Cross Keith S.
- Cuming Tamzin
- Cunha Pedro
- Dalgaty Faith
- Dar Farooq
- Date Ravindra
- Dave Rajiv V.
- Davey Phil
- Davies James
- Dawson Suzanne
- De Marchi Joshua A.
- de Siqueira Jonathan
- Deguara Jean
- Delisle Theo G.
- Dennison A. R.
- Derbyshire Laura
- Devoto Laurence
- Dhillon Ajit
- Diamond Tom
- Dickson-Lowe Richard
- Digney Ruairi
- Dindyal Shiva
- Dobbins Brian
- Doe Matthew
- Dorrian Emmet
- Doulias Triantafyllos
- Downing Justine
- Drake Benjamin
- Driscoll Peter J.
- Duke Diana
- Durkin Damien
- Dwerryhouse Simon J.
- DâCosta Conrad
- Ebdewi Hamdi
- Ebied Husam
- Eisawi Abdalla
- El-Dhuwaib Yesar
- El-Hasani Shamsi S.
- Elkheir Natalie
- Elmasry Mohamed
- Elsayed Mohammed
- Elshaer Mohamed
- Emesih Sophie
- Farag Sameh F.
- Farooq Ansar
- Farouk Marwan
- Fasih Tani
- Fawole Adeshina S.
- Fenwick Stephen
- Ferguson Graeme
- Ferris Paul
- Finch David
- Finch J. G.
- Finlay Ian
- Fleming Katie
- Fletcher Ted
- Fordham Imogen J.
- Forouzanfar Amir
- Forrest Craig R.
- Forster Luke
- Fothergill Laura
- Frame Richard J.
- Francombe James
- Frank Lucinda
- Fusai Guiseppe
- Galanopoulos Giorgios
- Gallagher Paul V.
- Garcea Giuseppe
- Gardner-Thorpe James
- Geoghegan Justin G.
- Geogloma Ileana
- Gerakopoulos Stratos
- Ghareeb Essam
- Ghazanfar Mudassar A.
- Gibson Simon
- Giles Mathew
- Giovinazzo Francesco
- Giwa Lola
- Goh Yan Li
- Gopalswamy Sivakumar
- Goscimski Andrzej
- Gossage James A.
- Gough Martin
- Gould Laura
- Gould Laura
- Grant Alan J.
- Gravante Gianpiero
- Griffiths Ewen
- Griffiths Ewen A.
- Gull Sadaf
- Gunasekera Rohan T.
- Gurung Kabita
- Guthrie Graeme J. K.
- Guy Finch J.
- Hafiz Shazia
- Halkias Constantine
- Hall Claire
- Hamady Zayed
- Hamdan Alhafidz
- Hamdan Mohammed F.
- Hamilton Emma
- Hancorn Kate
- Haque Manzarul
- Haque Samer Ul
- Hardy Thomas J.
- Hargreaves Anita
- Harilingam Mohan
- Harris Andrew
- Harrison Ewen
- Hawkins Helen
- Heath Jonathan
- Hebbar Madhusoodhana
- Henderson Lucy T.
- Henley Natasha
- Heshaishi Mohamed
- Hewes James
- Hewes James C.
- Heywood Nick
- Higgs Simon M.
- Hill Arnold D. K.
- Hindley Caroline
- Hirst Natalie A.
- Hisham Elzanati
- Ho Wei-Min
- Hoban Jennifer R.
- Hodgkins Kathryn A.
- Hodson James
- Holroyd David J.
- Hooks Gareth
- Hopwood Benjamin
- Hornby Steve T.
- Hornsby Jane
- Hosie Kenneth B.
- Hosie Kenneth B.
- Hossack Martin R.
- Hossain Tanvir
- Hoti Emir
- Hou David
- Hrycaiczuk Alex
- Hughes Michael
- Hunter David I.
- Hussain Abdulzahra A.
- Hussain Adnan
- Hussain Anwar
- Hussain Najam
- Iftikhar Syed Yusuf
- Iqbal Nusrat
- Iskandar Edrin
- Issa Eyad
- Ivanovski Ivan
- Jackson Andrew
- Jackson Claire
- Jafferbhoy Sadaf F.
- Jambulingam Periyathambi
- Jamdar Saurabh
- Jamel Sara
- Janeczko Adam
- Jaunoo Shameen
- Jayanthi Naga V. G.
- Jelley Clare
- Jennings Neil A.
- Joel Abraham
- Johnpulle Michelle A.
- Johnston Dorothy
- Johnstone Marianne
- Johnstone Marianne
- Joji Nikita
- Jones Claire
- Jones Elinor
- Jones Gareth H.
- Jones M. Angharad
- Jones Michael J.
- Jones Robert P.
- Jones Steven M.
- Kadhim Abbas
- Kadirkamanathan Sritharan
- Kallaway Charlotte
- Kanakala Venkatesh
- Kanavati Osama
- Kansal Nisheeth
- Kaptanis Sarantos
- Karavadra Babu
- Karim Lawen
- Karunakaran Priyadarssini
- Kaur Parminder
- Kausar Ambareen
- Kelly Michael E.
- Kendal Chris
- Kennedy David
- Kenny Ross
- Keogh Ken
- Khalil Ahmed M.
- Khan Amarah
- Khan Mohammad A.
- Khan Muhammad A. S.
- Khan Raja Basit
- Khan Shabuddin
- Khan Shahab
- Khawaja Amir
- Khawaja Zechan
- Khogali Elmoataz
- Kimble Adam
- Kinghorn Alison
- Kirkham Amanda J.
- Knight Benjamin
- Knight Katrina
- Kourkulos Michail
- Krysztopik Richard
- Kumar Pradeep
- Kynaston James
- Kyriakidis Dimitrios
- Lalla Kushik
- Lambert Joel
- Lammy Simon
- Lane Risha
- Larkin David
- Law Jennifer
- Lawther Roger
- Lazim Taha
- Lee Kathryn
- Lee Matthew
- Leeder Paul
- Lennon Hannah
- Lewis Michael
- Lim Henry C. C.
- Lim Pei J.
- Lindsay David
- Lloyd David
- Lo Christina
- Lodhia Joshil
- Longbotham David A.
- Loughlin Paula
- Lovett Bryony
- Luhmann Andreas
- Luther Ali Alison
- Lyons Emma M.
- Macano Christina A. W.
- MacArtney Matthew
- Macdonald Andrew
- Madanipour Suroosh
- Madbak Khaliel
- Madurska Marta
- Magee Conor J.
- Maguire Donal
- Maharaj Geta
- Majeed Ali
- Malcolm Cathy
- Malde Deep
- Malik Nabeela S.
- Mallik Mekhlola
- Mansour Sami
- Manu Mangta
- Manzelli Antonio
- Marriott Paul
- Martin Jack
- Martin Sean T.
- Martin Serena
- Marudanayagam Ravi
- Mason Denise
- Mathur Pawan
- Mawhinney Abi
- Mbuvi James
- McAree Barry
- McCain Stephen
- McCallum Iain J. D.
- McClarey Andrew
- McCune Ken
- McDermott Frank
- McEntee Gerry P.
- McGlone Emma R.
- McGuigan Andrew
- McIlmunn Colin
- McKay Damian
- McKenzie Stephen
- McNair Angus G. K.
- Mealy Ken
- Menzies Donald
- Mercer Stuart J.
- Milburn James
- Mirza Ahmed K.
- Mirza Darius
- Miu Victor
- Mockford Justine Downing Katherine A.
- Mohamed Sarah
- Mohan Helen M.
- Mok Kam Wa Jessica
- Monk David
- Morcous Paul
- Morrison Tamsin E. M.
- Mothe Bhavani Sidhartha
- Mowbray Nicholas
- Mozolowski Kirsty L.
- Mukherjee Dipankar
- Murphy James O.
- Murtaza Ghulam
- Nally Deirdre M.
- Napetti Sara
- Nassar Ahmad H.
- Naumann David
- Nedujchelyn Yuwaraja
- Needham Paul J.
- Newton Katy
- Newton Richard C.
- Ngu Wee Sing
- Nicholson Gary A.
- Nicholson James
- Nicholson James A.
- Nicol Laura
- Nicolay Christopher R.
- Nieto Tom
- Nijjar Rajwinder S.
- Nilsen-Nunn April
- Nilsson Frida
- Noble Fergus
- Nofal Emma
- Noor Nigel
- Nunes Quentin M.
- Obeidallah Mohd Rami
- Ogedegbe Arikoge
- Old Oliver J.
- Orchard Philippa
- Orizu Mavis N.
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- OâNeill Maeve A.
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- OâReilly Derek A.
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- Packer Jessica R.
- Padwick Robert
- Pannu Arslan
- Panteleimonitis Sofoklis
- Parappally Ciny P.
- Parmar J.
- Pasquali Sandro
- Patel Abhilasha
- Patel Krashna
- Patel Shakira
- Pati Pradeep
- Pearce Belinda
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- Peirce Colin
- Pellen Mike
- Peter Mark B.
- Peterson Mark
- Pezzuto Roberto
- Photi Evangelos
- Phull Manraj
- Pinho-Gomes Ana C.
- Pollock Sarah
- Popplewell Matthew
- Pore Naresh
- Porter Jonathan
- Prasad Abheesh R.
- Prasad Raj
- Preston Shaun R.
- Preziosi Giuseppe
- Prince Sarah
- Psica Alicja
- Puig Sonia
- Puntis Daniel J.
- Puri Yogesh
- Qandeel Haitham
- Rabie Mohamed
- Radwan Rami
- Rae David M.
- Rahman Saquib
- Rajaganeshan Rajasundaram
- Rajendran Ilayaraja
- Ramage Michael I.
- Rao Sudhindra T. V.
- Rate Anthony J.
- Raza Soulat
- Read Edward
- Reddy Marcus
- Reece-Bolton Obuobi
- Reed Joanna
- Reid Alistair
- Rengifo Carla
- Rhys Thomas
- Richards Colin H.
- Riera Manel
- Ritchie Judith
- Robb William
- Roberts Geoffrey P.
- Robinson Sarah
- Robinson Steven J.
- Robinson Stuart
- Rodriguez Dan
- Rodriguez Daniel Urriza
- Roebuck Amanda
- Rogers Paul N.
- Rolph Rachel C.
- Roy Sudipta
- Rutherford Claire L.
- Sadat Mohammed M.
- Sakai Naomi
- Sampat Keerthika
- Samuel Nehemiah
- Sarmah Piyush B.
- Sarvananthan Kas
- Sarveswaran Janahan
- Satheesan Steve
- Saunders Michael
- Sayegh Mazin
- Segaran Ashvina
- Sekhar Hema
- Sen Gourab
- Seymour Keith
- Shabo Wael
- Shah Nayab
- Shah Reena
- Shahin Yousef
- Sheel Andrea R. G.
- Shenoy Hrishikesh
- Shetty Vinutha
- Shier David
- Shingler Guy M.
- Shiwani Muhammad Hanif
- Shrestha Ashish Kiran
- Siddiqi Najaf
- Siddiqui Midhat N.
- Siddiqui Zohaib
- Sillo Toritseju O.
- Silva Michael
- Simpson Duncan J.
- Singh Shailendra
- Singh-Ranger Deepak
- Sinha Sidhartha
- Skelly Brendan L.
- Slavin John P.
- Slawinski Corinna
- Sloane Jake
- Smith Stella R.
- Smith Stella R.
- Sonsale Aniket
- Spearman John
- Spence Gary
- Spreadborough Philip
- Spreadborough Philip
- Starmer Benjamin Z.
- Stevenson Thomas E. J.
- Stewart Duncan J.
- Stirland E.
- Subramanium Dhivya
- Sufi Pratik A.
- Sukha Anisha
- Sutcliffe Robert
- Suttie Stuart
- Sutton Cherith M. L. R.
- Szentpali Karoly
- Tang Cheuk-Bong
- Tanner Nicola
- Tate Sophie
- Tayeh Salim
- Taylor Christopher
- Taylor Greg W.
- Teasdale Rebecca L.
- Templeton Alexa
- Terrace John
- Thakkar Rohan
- Thomas George
- Thompson Ronald L. E.
- Tilston Michael P.
- Toh Simon K. C.
- Tolofari Sotonye
- Tomlinson Mark A.
- Trevatt Alexander E. J.
- Trotter Martin
- Tsang Andrew
- Tsavellas George
- Tuck Liz
- Turner Paul
- Tutton Matthew G.
- Ullah Muhammad Fahad
- Upchurch Emma A.
- Urbonas Tomas
- Varghase Joseph
- Vass David G.
- Vaughan Elizabeth M.
- Vijay Vardhini
- Vijayan Deepak
- Vijayanand Dhakshinamoorthy
- Villatoro Eduardo
- Virupaksha Suvi
- Vitone Louis J.
- Vohra Ravinder S.
- Wadley Martin
- Wainwright Denise
- Wajed Saj
- Wallace Tom
- Wardle Stacy
- Warren Conor
- Watkin Helen
- Watson Angus J. M.
- Watson Nicholas F.
- Wayman John
- Weaver Simon
- Weber Beatrix
- Weber Beatrix
- Weerasinghe Chamindri
- Welbourn Hannah
- Wheatley Kevin
- White Timothy J.
- Wijetunga Imeshi
- Wild Jonathan R. L.
- Wilkinson Marc D.
- Williams Sophie V.
- Williamson Tracey K.
- Willson Peter D.
- Wilson Michael S. J.
- Wilson Timothy R.
- Winter Des C.
- Winter Hannah
- Wood Christopher P. J.
- Wood Peter
- Wood Simon
- Woodman Thomas
- Yahya Salama
- Yao Caroline
- Yeldham Geoffrey
- Yoganathan Thusidaran
- Youssef Haney
- Zafar Sara
- Zafrani Zakhi
- Zarsadias Prizzi
- Zeeshan Saquib
- Zhang Catherine
- Ziprin Paul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations.
Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (>â90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves.
Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45â85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations >â90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SEâ=â0.013, pââ90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score.
Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care
Analysis of shared heritability in common disorders of the brain
- Author
- Adams Hieab H.H.
- Air Tracy
- Al-Chalabi Ammar
- Alda Martin
- Alegret Montserrat
- Alfredsson Lars
- Amouyel Philippe
- Andlauer Till F.M.
- Andreassen Ole A.
- Anjorin Adebayo
- Anney Richard
- Anttila Verneri
- Arias Vasquez Alejandro
- Arking Dan
- Arnold Paul
- Arranz Maria JesĂșs
- Artto Ville
- Aschauer Harald
- Attia John
- Avbersek Andreja
- Bacchelli Elena
- Bailey Anthony
- Baker Jessica H.
- Bal Vanessa
- Banaschewski Tobias
- Barnes Lisa L.
- Barr Cathy L.
- Battaglia Agatino
- Battey Thomas
- Bau Claiton H.D.
- Bauer Michael
- Baum Larry
- Baune Bernhard T.
- Bayer Anthony
- Beach Thomas G.
- Becker Felicitas
- Bedoya-Berrio Gabriel
- Beekman Aartjan TF
- Beiser Alexa
- Belin Andrea C.
- Bergen Andrew W.
- Bergen Sarah E
- Berkovic Samuel
- Berr Claudine
- Betancur Catalina
- Bevan Steve
- Bienvenu O. Joseph
- Bis Joshua C
- Blackwood Douglas
- Boada MercĂš
- Boland Anne
- Bolton Patrick
- Boncoraglio Giorgio
- Boomsma Dorret
- Boraska Perica Vesna
- Borck Guntram
- Bradfield Jonathan
- Bramon Elvira
- Bras Jose
- Breen Gerome
- Brentani Helena
- Buccola Nancy
- Buitelaar Jan K.
- Bulik Cynthia M.
- Bulik-Sullivan Brendan
- Buono Russell
- Buring Julie E.
- Burton Christie
- BĂžrglum Anders D.
- Cahn Wiepke
- Cairns Murray
- Camarena Beatriz
- Cantor Rita
- Cappi Carolina
- Casas Miguel
- Catarino Claudia B.
- Cath Danielle
- Cavallini Maria
- Celestino-Soper PatrĂcia
- Chasman Daniel I.
- Chen Wei-Min
- Cheng Wei
- Chong Siow A.
- Chouraki Vincent
- Churchhouse Claire
- Cichon Sven
- Clementi Maurizio
- Cloninger Robert
- Cohen David
- Cohen-Woods Sarah
- Cook Edwin
- Cormand Bru
- Corvin Aiden
- Cossette Patrick
- Cotsapas Chris
- Craddock Nick
- Crespo-Facorro Benedicto
- Crosbie Jennifer
- Crowley James
- Cruceanu Cristiana
- Cruchaga Carlos
- Cuenca-Leon Ester
- Curtis David
- Cusi Daniele
- Czerski Piotr M.
- Dalsgaard Soeren
- Daly Mark
- Danner Unna N.
- Darrow Sabrina
- Davidson Michael
- Davis Oliver S. P.
- Dawson Geraldine
- de Geus Eco
- De Jager Philip L.
- De Jonghe Peter
- De Rubeis Silvia
- De-Luca Daniel Moreno-
- Degenhardt Franziska
- Deleuze Jean-François
- DeLisi Lynn
- Delorme Richard
- Demirci F. Yesim
- Dempfle Astrid
- Denys Damiaan
- Depienne Christel
- Depondt Chantal
- Derks Eske M.
- Dichgans Martin
- Dick Danielle M.
- Dietrich Andrea
- Dinan Timothy
- Dlugos Dennis
- Docampo Elisa
- Donohoe Gary
- Doyle Alysa E.
- Drapeau Elodie
- Duan Jubao
- Duncan Laramie
- Dunn Erin
- Duque Frederico
- Duron Emmanuelle
- Edenberg Howard J.
- Ehrlich Stefan
- Elia Josephine
- Eriksson Nicholas
- Escott-Price Valentina
- Espeseth Thomas
- Falcone Guido J.
- Faraone Stephen V.
- Farh Kai-How
- Farrer Lindsay A.
- Fernandez Thomas
- Ferrari Michel D.
- Ferraro Thomas N.
- Ferrier I. Nicol
- Figee Martijn
- Finucane Hilary K.
- Fischer Sascha B.
- Forstner Andreas J.
- Forzan Monica
- Fox Nick C.
- Franke Barbara
- Freilinger Tobias
- Freimer Nelson
- Freitag Christine
- French Jacqueline
- Fullerton Janice M.
- Furlotte Nicholas
- Gasser Thomas
- Gejman Pablo V.
- Gerber Gloria
- Gershon Elliot S.
- Geschwind Daniel H.
- Gibbs Raphael
- Goate Alison M.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott D.
- Gormley Padhraig
- Grabe Hans-Jorgen
- Grados Marco
- Gratacos Monica
- Green Andrew
- Greenberg Erica
- Grenier-Boley Benjamin
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Guerreiro Rita
- Guzman-Parra José
- Göbel Hartmut
- Haan Lieuwe
- Haavik Jan
- Hakonarson Hakon
- Halmi Katherine A.
- Hampel Harald
- Hanna Gregory L.
- Hannequin Didier
- Hansen Thomas
- Harold Denise
- Hartmann Andreas
- Hauser Joanna
- Head Elizabeth
- Heinzen Erin L.
- Helder Sietske G.
- Henskens Frans
- Herms Stefan
- Herpertz-Dahlmann Beate
- Hervas Amaia
- Heutink Peter
- Hickie Ian
- Hirschtritt Matthew E.
- Hjalgrim Helle
- Hoekstra Pieter J.
- Hoffmann Per
- Holliday Elizabeth
- Holmans Peter
- Homuth Georg
- Hottenga Jouke-Jan
- Hougaard David
- Hrafnsdottir Maria
- Huang Alden
- Huang Hailiang
- Huang Jie
- Huckins Laura M.
- Hudson James I.
- Huentelman Matthew J.
- Hulette Christine M.
- Huyser Chaim
- Hyman Bradley T.
- HÀmÀlÀinen Eija
- Illmann Cornelia
- Jamain Stéphane
- Jamnadas-Khoda Jennifer
- Jansen Rick
- Jenike Michael
- Jicha Gregory A.
- Johansson Stefan
- Jones Ian R.
- JuliĂ Antonio
- Kamatani Yoichiro
- Kamboh M. Ilyas
- Kaprio Jaakko
- Karachanak-Yankova Sena
- Karwautz Andreas
- Kaunisto Mari
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- Sander Thomas
- Sanders Alan R.
- Sandin Sven
- Sandor Cynthia
- Sandor Paul
- Santangelo Susan
- Saykin Andrew J.
- Schachar Russell
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- Schall Ulrich
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- Scharf Jeremiah
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- Schneider Lon S.
- Schoch Susanne
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- Schulze Thomas G.
- Schumacher Johannes
- Schwab Sibylle G.
- SchĂŒrks Markus
- Scott Rodney
- Seshadri Sudha
- Sharma Manu
- Sharma Pankaj
- Silliman Scott
- Sim Kang
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- Sisodiya Sanjay M.
- Sklar Pamela
- Smit Johannes H.
- Smith Amanda G.
- Smith Philip
- Smoller Jordan W.
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- Subramaniam Mythily
- Sudlow Cathie
- Sullivan Patrick
- Surges Rainer
- Szatkiewicz Jin Peng
- SĂĄnchez-Mora Cristina
- Terwindt Gisela M.
- The Brainstorm Consortium
- Thijs Vincent
- Thomas G. Neil
- Thompson Robert C.
- Thornton Laura M.
- Toncheva Draga
- Tortorella Alfonso
- Trace Sara E.
- Tsetsos Fotis
- Tsolaki Magda
- Turecki Gustavo
- Turley Patrick
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- Valencia-Duarte Ana
- Van Deerlin Vivianna M.
- van den Maagdenberg Arn M.J.M.
- van der Lee Sven J.
- van Elburg Annemarie A.
- Van Eldik Linda J.
- Van Nieuwerburgh Filip
- van Os Jim
- Vardarajan Badri N.
- VepsÀlÀinen Salli
- Vicente Astrid
- Viktorin Alexander
- Visscher Frank
- Vorstman Jacob
- Waddington John
- Wagner Gudrun
- Waldman Irwin
- Walters James
- Walters Raymond K.
- Wassink Thomas
- Weatherall Sarah
- Webb Bradley
- Webber Caleb
- Wedenoja Juho
- Wei Zhi
- Weiser Mark
- Weiss Lauren A.
- Wendland Jens R.
- Werge Thomas
- Whelan Christopher D.
- Wijsman Ellen
- William Rayner N.
- Williams Julie
- Williams Nigel
- Wilmot Beth
- Winsvold Bendik
- Witt Stephanie H.
- Wolanczyk Tomasz
- Wood Nicholas W.
- Worbe Yulia
- Wray Naomi R.
- Yilmaz Zeynep
- Yu Dongmei
- Zai Gwyneth
- Zandi Peter P.
- Zara Federico
- Zayats Tetyana
- Zimprich Fritz
- Zwart John-Anker
- Publication venue
- American Association for the Advancement of Science
- Publication date
- 01/01/2018
- Field of study
ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders
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- A. B. Galvin
- A. Ciaravella
- A. Gary
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- A. Llebaria
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- A. W. Sandman
- A. Warmuth
- A.A. Vedenov
- A.J. Tylka
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- A.R. Winebarger
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- Field of study
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
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- Zhao Yuhang
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- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
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- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- çè°š
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
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- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
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- Aronson Scott
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- Karki Sudarshan
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- Lin Chien-Yu
- Lin Chun-Yu
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- Washimi Tatsuki
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- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zahoor Jan Aasim
- Zannelli A. J.
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- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
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- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
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- Attadio Francesca
- Aubin Florian
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- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
- âŠ