Estudio clinicopatologico de trastornos genito-urinarios en un rebaño ovino del estado de México. México

Con el objeto de evaluar y documentar el caso clínico - patológico de un ovino remitido para diagnostico al CIESA , se realizó una valoración clínica, estudios anatomopatológico e histopatológico y otros complementarios , debido a las co ndiciones y características de presentación de cuatro casos similares en un rebaño ovino , con similitud en los signos clínicos . El principal problema detectado se relacionó a un problema de: U retritis supurativa y a cistitis hemorrágica no supurativa. La importancia del presente caso es la presencia de agentes bacterianos que pueden afectar de manera importante la producción del ganado ovino, a través de lesiones o alteraciones inaparentes que deben considerarse en el manejo y eficiencia reproductiva de u n rebaño

Novel genes and sex differences in COVID-19 severity.

Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥ 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided

Two-pion femtoscopy in p-Pb collisions at sNN=5.02\sqrt{s_{\rm NN}}=5.02 TeV

We report the results of the femtoscopic analysis of pairs of identical pions measured in p-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV. Femtoscopic radii are determined as a function of event multiplicity and pair momentum in three spatial dimensions. As in the pp collision system, the analysis is complicated by the presence of sizable background correlation structures in addition to the femtoscopic signal. The radii increase with event multiplicity and decrease with pair transverse momentum. When taken at comparable multiplicity, the radii measured in p-Pb collisions, at high multiplicity and low pair transverse momentum, are 10-20% higher than those observed in pp collisions but below those observed in A-A collisions. The results are compared to hydrodynamic predictions at large event multiplicity as well as discussed in the context of calculations based on gluon saturation

Centrality dependence of particle production in p-Pb collisions at sNN\sqrt{s_{\rm NN} }= 5.02 TeV

We report measurements of the primary charged particle pseudorapidity density and transverse momentum distributions in p-Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV, and investigate their correlation with experimental observables sensitive to the centrality of the collision. Centrality classes are defined using different event activity estimators, i.e. charged particle multiplicities measured in three disjunct pseudorapidity regions as well as the energy measured at beam rapidity (zero-degree). The procedures to determine the centrality, quantified by the number of participants ($N_{\rm part}$), or the number of nucleon-nucleon binary collisions ($N_{\rm coll}$), are described. We show that, in contrast to Pb-Pb collisions, in p-Pb collisions large multiplicity fluctuations together with the small range of participants available, generate a dynamical bias in centrality classes based on particle multiplicity. We propose to use the zero-degree energy, which we expect not to introduce a dynamical bias, as an alternative event-centrality estimator. Based on zero-degree energy centrality classes, the $N_{\rm part}$ dependence of particle production is studied. Under the assumption that the multiplicity measured in the Pb-going rapidity region scales with the number of Pb-participants, an approximate independence of the multiplicity per participating nucleon measured at mid-rapitity of the number of participating nucleons is observed. Furthermore, at high-$p_{\rm T}$ the p-Pb spectra are found to be consistent with the pp spectra scaled by $N_{\rm coll}$ for all centrality classes. Our results represent valuable input for the study of the event activity dependence of hard probes in p-Pb collision and, hence, help to establish baselines for the interpretation of the Pb-Pb data

Inclusive, prompt and non-prompt J/ψ\psi production at mid-rapidity in Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The transverse momentum ($p_{\rm T}$) dependence of the nuclear modification factor $R_{\rm AA}$ and the centrality dependence of the average transverse momentum $\langle p_{\rm T}\rangle$ for inclusive J/$\psi$ have been measured with ALICE for Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV in the e$^+$e$^-$ decay channel at mid-rapidity ($|y|<0.8$). The $\langle p_{\rm T}\rangle$ is significantly smaller than the one observed for pp collisions at the same centre-of-mass energy. Consistently, an increase of $R_{\rm AA}$ is observed towards low $p_{\rm T}$. These observations might be indicative of a sizable contribution of charm quark coalescence to the J/$\psi$ production. Additionally, the fraction of non-prompt J/$\psi$ from beauty hadron decays, $f_{\rm B}$, has been determined in the region $1.5 < p_{\rm T} < 10$ GeV/c in three centrality intervals. No significant centrality dependence of $f_{\rm B}$ is observed. Finally, the $R_{\rm AA}$ of non-prompt J/$\psi$ is discussed and compared with model predictions. The nuclear modification in the region $4.5 < p_{\rm T} < 10$ GeV/c is found to be stronger than predicted by most models.The transverse momentum (p$_{T}$) dependence of the nuclear modification factor R$_{AA}$ and the centrality dependence of the average transverse momentum 〈p$_{T}$〉 for inclusive J/ψ have been measured with ALICE for Pb-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=2.76$ TeV in the e+e$^{−}$ decay channel at mid-rapidity (|y| < 0.8). The 〈p$_{T}$〉 is significantly smaller than the one observed for pp collisions at the same centre-of-mass energy. Consistently, an increase of R$_{AA}$ is observed towards low p$_{T}$. These observations might be indicative of a sizable contribution of charm quark coalescence to the J/ψ production. Additionally, the fraction of non-prompt J/ψ from beauty hadron decays, f$_{B}$, has been determined in the region 1.5 < p$_{T}$ < 10 GeV/c in three centrality intervals. No significant centrality dependence of f$_{B}$ is observed. Finally, the R$_{AA}$ of non-prompt J/ψ is discussed and compared with model predictions. The nuclear modification in the region 4.5 < p$_{T}$ < 10 GeV/c is found to be stronger than predicted by most models.The transverse momentum ($p_{\rm T}$) dependence of the nuclear modification factor $R_{\rm AA}$ and the centrality dependence of the average transverse momentum $\langle p_{\rm T}\rangle$ for inclusive J/$\psi$ have been measured with ALICE for Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV in the e$^+$e$^-$ decay channel at mid-rapidity ($|y|<0.8$). The $\langle p_{\rm T}\rangle$ is significantly smaller than the one observed for pp collisions at the same centre-of-mass energy. Consistently, an increase of $R_{\rm AA}$ is observed towards low $p_{\rm T}$. These observations might be indicative of a sizable contribution of charm quark coalescence to the J/$\psi$ production. Additionally, the fraction of non-prompt J/$\psi$ from beauty hadron decays, $f_{\rm B}$, has been determined in the region $1.5 < p_{\rm T} < 10$ GeV/c in three centrality intervals. No significant centrality dependence of $f_{\rm B}$ is observed. Finally, the $R_{\rm AA}$ of non-prompt J/$\psi$ is discussed and compared with model predictions. The nuclear modification in the region $4.5 < p_{\rm T} < 10$ GeV/c is found to be stronger than predicted by most models

Centrality dependence of high-pT_{T} D meson suppression in Pb-Pb collisions at sNN=2.76 \sqrt{s_{\mathrm{N}\mathrm{N}}}=2.76 TeV

The nuclear modification factor, $R_{\rm AA}$, of the prompt charmed mesons ${\rm D^0}$, ${\rm D^+}$ and ${\rm D^{*+}}$, and their antiparticles, was measured with the ALICE detector in Pb-Pb collisions at a centre-of-mass energy $\sqrt{s_{\rm NN}} = 2.76$ TeV in two transverse momentum intervals, $5<p_{\rm T}<8$ GeV/$c$ and $8<p_{\rm T}<16$ GeV/$c$, and in six collision centrality classes. The $R_{\rm AA}$ shows a maximum suppression of a factor of 5-6 in the 10% most central collisions. The suppression and its centrality dependence are compatible within uncertainties with those of charged pions. A comparison with the $R_{\rm AA}$ of non-prompt ${\rm J}/\psi$ from B meson decays, measured by the CMS Collaboration, hints at a larger suppression of D mesons in the most central collisions.The nuclear modification factor, R$_{AA}$, of the prompt charmed mesons D$^{0}$, D$^{+}$ and D$^{∗+}$, and their antiparticles, was measured with the ALICE detector in Pb-Pb collisions at a centre-of-mass energy $\sqrt{s_{\mathrm{N}\,\mathrm{N}}}=2.76$ TeV in two transverse momentum intervals, 5 < p$_{T}$ < 8 GeV/c and 8 < p$_{T}$ < 16 GeV/c, and in six collision centrality classes. The R$_{AA}$ shows a maximum suppression of a factor of 5-6 in the 10% most central collisions. The suppression and its centrality dependence are compatible within uncertainties with those of charged pions. A comparison with the R$_{AA}$ of non-prompt J/ψ from B meson decays, measured by the CMS Collaboration, hints at a larger suppression of D mesons in the most central collisions.This is an addendum to the article JHEP 11 (2015) 205 [1]. The figures 3 (right), 4 (right) and 5 are updated with published results on non-prompt J/ψ-meson production from the CMS collaboration [2].The nuclear modification factor, $R_{\rm AA}$, of the prompt charmed mesons ${\rm D^0}$, ${\rm D^+}$ and ${\rm D^{*+}}$, and their antiparticles, was measured with the ALICE detector in Pb-Pb collisions at a centre-of-mass energy $\sqrt{s_{\rm NN}} = 2.76$ TeV in two transverse momentum intervals, $5<p_{\rm T}<8$ GeV/$c$ and $8<p_{\rm T}<16$ GeV/$c$, and in six collision centrality classes. The $R_{\rm AA}$ shows a maximum suppression of a factor of 5-6 in the 10% most central collisions. The suppression and its centrality dependence are compatible within uncertainties with those of charged pions. A comparison with the $R_{\rm AA}$ of non-prompt ${\rm J}/\psi$ from B meson decays, measured by the CMS Collaboration, hints at a larger suppression of D mesons in the most central collisions

(3)(Lambda)Hand (3)((Lambda)over-bar)(H)over-bar production in Pb-Pb collisions at root s(NN)=2.76 TeV

Peer reviewe

Measurement of charm and beauty production at central rapidity versus charged-particle multiplicity in proton-proton collisions at s=7 \sqrt{s}=7 TeV

Prompt D meson and non-prompt J/$\psi$ yields are studied as a function of the multiplicity of charged particles produced in inelastic proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=7$ TeV. The results are reported as a ratio between yields in a given multiplicity interval normalised to the multiplicity-integrated ones (relative yields). They are shown as a function of the multiplicity of charged particles normalised to the average value for inelastic collisions (relative charged-particle multiplicity). D$^0$, D$^+$ and D$^{*+}$ mesons are measured in five $p_{\rm T}$ intervals from 1 to 20 GeV/$c$ and for $|y|1.3$ GeV/$c$ and $|y|0$. The fraction of non-prompt J/$\psi$ in the inclusive J/$\psi$ yields shows no dependence on the charged-particle multiplicity at central rapidity. Charm and beauty hadron relative yields exhibit a similar increase with increasing charged-particle multiplicity. The measurements are compared to PYTHIA 8, EPOS 3 and percolation calculations.Prompt D meson and non-prompt J/ψ yields are studied as a function of the multiplicity of charged particles produced in inelastic proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=7$ TeV. The results are reported as a ratio between yields in a given multiplicity interval normalised to the multiplicity-integrated ones (relative yields). They are shown as a function of the multiplicity of charged particles normalised to the average value for inelastic collisions (relative charged-particle multiplicity). D$^{0}$, D$^{+}$ and D$^{*+}$ mesons are measured in five p$_{T}$ intervals from 1 GeV/c to 20 GeV/c and for |y| 1.3 GeV/c and |y| 0. The fraction of non-prompt J/ψ in the inclusive J/ψ yields shows no dependence on the charged-particle multiplicity at central rapidity. Charm and beauty hadron relative yields exhibit a similar increase with increasing charged-particle multiplicity. The measurements are compared to PYTHIA 8, EPOS 3 and percolation calculations.Prompt D meson and non-prompt J/$\psi$ yields are studied as a function of the multiplicity of charged particles produced in inelastic proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=7$ TeV. The results are reported as a ratio between yields in a given multiplicity interval normalised to the multiplicity-integrated ones (relative yields). They are shown as a function of the multiplicity of charged particles normalised to the average value for inelastic collisions (relative charged-particle multiplicity). D$^0$, D$^+$ and D$^{*+}$ mesons are measured in five $p_{\rm T}$ intervals from 1 to 20 GeV/$c$ and for $|y|1.3$ GeV/$c$ and $|y|0$. The fraction of non-prompt J/$\psi$ in the inclusive J/$\psi$ yields shows no dependence on the charged-particle multiplicity at central rapidity. Charm and beauty hadron relative yields exhibit a similar increase with increasing charged-particle multiplicity. The measurements are compared to PYTHIA 8, EPOS 3 and percolation calculations