Análisis de la expresión de los transportadores de fructosa en cáncer de próstata

Tesis (Tecnólogo Médico)El cáncer de próstata corresponde a la segunda causa de muerte por cáncer en Chile, la cual ha aumentado progresivamente durante la última década. Esta neoplasia es de etiología multifactorial, entre ellas la dieta, debido a que el consumo de azúcar per cápita se ha incrementado en los últimos 20 años. El azúcar ampliamente utilizado en la dieta moderna es la fructosa, debido a sus variadas formas de presentación. Se ha correlacionado fuertemente el aumento del consumo de azúcar y el cáncer prostático en el continente americano y asiático, siendo este último el que presenta menor aumento en el consumo de azúcares y a su vez el que posee menor incidencia de esta patología. Muchos tumores dependen únicamente de glucosa para su sobrevida, sin embargo la próstata no posee este comportamiento, por lo que podría estar utilizando otros azúcares como fructosa que son ingresados a la célula neoplásica a través de transportadores específicos de esta y aumentando la expresión de la enzima fructoquinasa, que es específica para esta hexosa. Debido a lo anterior se tiene como hipótesis que la carcinogénesis y/o progresión de cáncer prostático se asocia con un aumento de la expresión de transportadores de fructosa y/o la expresión de fructoquinasa. El objetivo de este estudio es analizar la expresión de los transportadores de fructosa y enzima fructoquinasa in vitro y además la expresión de los transportadores en muestras clínicas, como también sus posibles consecuencias metabólicas analizando las enzimas clave α-KGD y PDH en respiración celular y metabolismo de hexosas respectivamente. Esto se llevó a cabo a través de qRT-PCR lo que mostró un aumento de los transportadores de fructosa GLUT-5, GLUT-7 y GLUT-11, como de la enzima fructoquinasa en líneas celulares malignas. Por otra parte Western Blot y Citometría de Flujo mostró un aumento de la expresión de las enzimas anteriormente descritas. En muestras clínicas tumorales se mostró una alta expresión de GLUT-5, GLUT-9 y GLUT-11 con respecto a muestras no tumorales. Finalmente, este estudio sugiere que la fructosa es utilizada de manera imperativa en células de cáncer prostático. Lo que se refleja a nivel tisular y transcripcional en modelos in vitro. Este trabajo aporta una visión innovadora de la biología del cáncer de próstata desde un enfoque metabólico

Investigación pedagógica en Bogotá : horizontes desde el programa Maestros y Maestras que Inspiran 2021

251 páginasPublicación resultado de la sistematización de experiencias de docentes participantes en el programa Maestros y Maestras que Inspiran, 2021. «Si quisiéramos mejorar la educación deberíamos mejorar la calidad de sus docentes […] Esto implica cultivar la curiosidad, la mirada crítica y buscarle significado al mundo que nos rodea, apreciando dónde está lo importante y siendo capaces de entender y describir por qué es importante. Los textos —de este compilado— dan cuenta de esas búsquedas y aquellos encuentros […] los autores nos dicen, de diferentes maneras, que la educación es la gran oportunidad, que una nueva escuela es necesaria y posible» Agustín Porre

Saber pedagógico en Interculturalidad, ciudadanía global y cultura de paz

198 p. Libro electronicoprimera ediciónPublicación resultado del programa Maestros y Maestras que Inspiran, una apuesta para la educación del siglo XXI, adelantada desde la línea Interculturalidad, Ciudadanía Global y Cultura de Paz, por los autores de este texto, con el acompañamiento del siguiente equipo: Mentor Jairzinho Francisco Panqueba Cifuentes Asistente de línea Vanessa Julieth Cabrales Parr

Envejecimiento de la población

•Actividades básicas de la vida diaria en personas mayores y factores asociados •Asociación entre depresión y posesión de mascotas en personas mayores •Calidad de vida en adultos mayores de Santiago aplicando el instrumento WHOQOL-BREF •Calidad de vida en usuarios con enfermedad de Parkinson, demencia y sus cuidadores, comuna de Vitacura •Caracterización de egresos hospitalarios de adultos mayores en Puerto Natales (2007-2009) •Comportamiento de las patologías incluidas como GES para el adulto mayor atendido en un Cesfam •Contribución de vitaminas y minerales a las ingestas recomendadas diarias en ancianos institucionalizados de Madrid •Estado de salud oral del paciente inscrito en el Programa de Visita Domiciliaria •Evaluación del programa de discapacidad severa en Casablanca con la matriz de marco lógico •Factores asociados a satisfacción vital en una cohorte de adultos mayores de Santiago, Chile •Pauta instrumental para la identificación de riesgos para el adulto mayor autovalente, en su vivienda •Perfil farmacológico del paciente geriátrico institucionalizado y posibles consecuencias en el deterioro cognitivo •Programa de cuidados paliativos y alivio del dolor en Puerto Natales •Rehabilitación mandibular implantoprotésica: efecto en calidad de vida relacionada con salud bucal en adultos mayores •Salud bucodental en adultos mayores autovalentes de la Región de Valparaíso •Transición epidemiológica y el estudio de carga de enfermedad en Brasi

Strategies to reengage patients lost to follow up in HIV care in high income countries, a scoping review

Background: Despite remarkable achievements in antiretroviral therapy (ART), losses to follow-up (LTFU) might prevent the long-term success of HIV treatment and might delay the achievement of the 90-90-90 objectives. This scoping review is aimed at the description and analysis of the strategies used in high-income countries to reengage LTFU in HIV care, their implementation and impact. Methods: A scoping review was done following Arksey & O'Malley's methodological framework and recommendations from Joanna Briggs Institute. Peer reviewed articles were searched for in Pubmed, Scopus and Web of Science; and grey literature was searched for in Google and other sources of information. Documents were charted according to the information presented on LTFU, the reengagement procedures used in HIV units in high-income countries, published during the last 15 years. In addition, bibliographies of chosen articles were reviewed for additional articles. Results: Twenty-eight documents were finally included, over 80% of them published in the United States later than 2015. Database searches, phone calls and/or mail contacts were the most common strategies used to locate and track LTFU, while motivational interviews and strengths-based techniques were used most often during reengagement visits. Outcomes like tracing activities efficacy, rates of reengagement and viral load reduction were reported as outcome measures. Conclusions: This review shows a recent and growing trend in developing and implementing patient reengagement strategies in HIV care. However, most of these strategies have been implemented in the United States and little information is available for other high-income countries. The procedures used to trace and contact LTFU are similar across reviewed studies, but their impact and sustainability are widely different depending on the country studied

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass