Innovation in Early music festivals. domains, strategies and outcomes

This chapter takes an in-depth look at innovation in cultural festivals, in particular in early music festivals, which is a type of festival aimed at a generally local and minority audience. It identifies and analyses types of innovations, the strategies used by early music festivals to innovate and the results of these innovations in the framework of a collaboration with the European Early Music Network, whose members, festival directors, agreed to participate in the survey designed for this purpose. Different types of product, production and pre-production process, marketing and communication innovations are identified but also maintain traditional products and communication channels for their most loyal audience. The analysis shows that early music festivals engage in a range of innovations and employ a meaningful combination of innovation strategies with diverse stakeholders. Innovation efforts have led to several intangible and tangible improvements, including increased prestige and bigger and more diverse audiences. Although some of the innovations identified are common to other cultural festivals, many product innovations depend on musicology research; therefore, similar to other science-based sectors, relationships with researchers are very important

Effects of laser-textured on rake face in turning PCD tools for Ti6Al4V

The demand inherent to the aeronautical industry in terms of productivity and quality requirements leads to develop new cutting tools. Hence, PCD tools meet the requirements in productivity while machining low machinability aeronautical alloys such as Ti6Al4V. Tool chipbreakers play a considerable role in terms of tool life. However, due to the extreme conditions (temperature and pressure) required to manufacture PCD tools, any complex geometry on tool rake faces is not viable, so chipbreakers are not possible, except for those external to inserts. This work proposes a groove-type laser engraved chipbreaker design and a manufacturing methodology, with experimental validation on turning a Ti6Al4V workpiece. The so-manufactured chipbreakers achieve titanium alloy chip fragmentation, making easy chip removal from the cutting zone. A set of experiments involving various laser parameters to characterize the PCD depth and surface integrity and experimental validation for those chipbreakers designs were carried out in finishing cutting conditions. The optimum parameters for the engraving of PCD were found, obtaining satisfactory breakage of titanium chips. Chip length was always below 17.29 mm.Authors are grateful to Basque government group IT IT1337- 19, the Ministry of Mineco REF DPI2016-74845-R and PID2019- 109340RB-I00, and the UPV/EHU itself for the financial aid for the pre-doctoral grants PIF 19/96

A virtuous circle? The effects of university-industry relationships in a region with low absorptive capacity

This article examines the effects of university-industry relationships (UIRs) in a Spanish region - Valencian Community - with low absorptive capacity. The analysis considers two effects of UIRs, one on business innovation and the other on the scientific production of academic researchers. The results reveal that UIRs have no significant effects on either firms' technological innovation or academic scientific production. Therefore, these results suggest that, in territories with low absorptive capacity, UIRs, mainly R&D-based, do not produce the effects found in other contexts, which requires some rethinking about these types of territories. © 2020 The Author(s)

Análisis de los resultados de la encuesta sobre innovación en los festivales de música antigua de REMA

En este trabajo se pretende identificar las innovaciones que tienen lugar en los festivales de música antigua y averiguar en qué medida los diversos tipos de interesados, especialmente los patrocinadores, influyen en su consecución

Evolution of innovation policy in Emilia-Romagna and Valencia: Similar reality, similar results?

This is an author's accepted manuscript of an article published in: “European Planning Studies"; Volume 22, Issue 11, 2014; copyright Taylor & Francis; available online at: http://dx.doi.org/10.1080/09654313.2013.831398[EN] This paper examines the evolution of regional innovation policy in Emilia-Romagna and Valencia, two regions with similar economic features that implemented close innovation policies in the 1970s and 1980s. We investigate whether their similarities have led to parallel targets, policy tools and governance developments. We show that innovation policy in both regions suffered from the effects of privatization, budget constraints and changes to manufacturing during the 1990s and we highlight the consequences. Although Emilia-Romagna experienced deeper changes to its innovation policy, privatizations and/or the replacement of public funds promoted commercial approaches and induced market failures in both regions. The worst effects of these policies were the implementation of less-risky innovation projects, the shift towards extraregional projects and markets, and the favouring of large firms.López Estornell, M.; Barberá Tomás, JD.; Garcia Reche, A.; Mas Verdú, F. (2013). Evolution of innovation policy in Emilia-Romagna and Valencia: Similar reality, similar results?. European Planning Studies. 22(11):2287-2304. doi:10.1080/09654313.2013.831398S22872304221

VERY HIGH ENERGY γ-RAYS from the UNIVERSE'S MIDDLE AGE: DETECTION of the z = 0.940 BLAZAR PKS 1441+25 with MAGIC

The flat-spectrum radio quasar PKS 1441+25 at a redshift of z = 0.940 is detected between 40 and 250 GeV with a significance of 25.5σ using the MAGIC telescopes. Together with the gravitationally lensed blazar QSO B0218+357 (z = 0.944), PKS 1441+25 is the most distant very high energy (VHE) blazar detected to date. The observations were triggered by an outburst in 2015 April seen at GeV energies with the Large Area Telescope on board Fermi. Multi-wavelength observations suggest a subdivision of the high state into two distinct flux states. In the band covered by MAGIC, the variability timescale is estimated to be 6.4 ±1.9 days. Modeling the broadband spectral energy distribution with an external Compton model, the location of the emitting region is understood as originating in the jet outside the broad-line region (BLR) during the period of high activity, while being partially within the BLR during the period of low (typical) activity. The observed VHE spectrum during the highest activity is used to probe the extragalactic background light at an unprecedented distance scale for ground-based gamma-ray astronomy

International lower limb collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures

Trauma remains a major cause of mortality and disability across the world1, with a higher burden in developing nations2. Open lower extremity injuries are devastating events from a physical3, mental health4, and socioeconomic5 standpoint. The potential sequelae, including risk of chronic infection and amputation, can lead to delayed recovery and major disability6. This international study aimed to describe global disparities, timely intervention, guideline-directed care, and economic aspects of open lower limb injuries

Supplement: "Localization and broadband follow-up of the gravitational-wave transient GW150914" (2016, ApJL, 826, L13)

This Supplement provides supporting material for Abbott et al. (2016a). We briefly summarize past electromagnetic (EM) follow-up efforts as well as the organization and policy of the current EM follow-up program. We compare the four probability sky maps produced for the gravitational-wave transient GW150914, and provide additional details of the EM follow-up observations that were performed in the different bands

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues