Ghosts in the Academy: historians and historical consciousness in the making of modern Uganda

The public and professional significance of precolonial History as a discipline has declined markedly across much of sub-Saharan Africa over the last forty years: History has been both demonized—depicted as deeply dangerous and the source of savagery and instability—and portrayed as irrelevant when set alongside the needs for economic modernization and “development.” This paper explores this trend in the context of Uganda, with a particular focus on the kingdom of Buganda, chosen for its particularly rich oral and literary heritage and the thematic opportunities offered by its complex and troubled twentieth century. The paper aims to explore how “the past”—with a focus on the precolonial era—has been understood there in several distinct periods. These include the era of imperial partition and the formation of the Uganda Protectorate between the 1880s and the 1910s; competition for political space within colonial society to the 1950s; decolonization and the struggle to create new nationhood in the mid-twentieth century; and political crises and partial recovery since the 1970s. Ultimately, the paper seeks to assess the role of History in a modern African society vis-à-vis the developmental agendas and notions of economic growth against which African “progress” and prospects for “stability” are currently measured

Ghosts in the Academy: historians and historical consciousness in the making of modern Uganda

The public and professional significance of precolonial History as a discipline has declined markedly across much of sub-Saharan Africa over the last forty years: History has been both demonized—depicted as deeply dangerous and the source of savagery and instability—and portrayed as irrelevant when set alongside the needs for economic modernization and “development.” This paper explores this trend in the context of Uganda, with a particular focus on the kingdom of Buganda, chosen for its particularly rich oral and literary heritage and the thematic opportunities offered by its complex and troubled twentieth century. The paper aims to explore how “the past”—with a focus on the precolonial era—has been understood there in several distinct periods. These include the era of imperial partition and the formation of the Uganda Protectorate between the 1880s and the 1910s; competition for political space within colonial society to the 1950s; decolonization and the struggle to create new nationhood in the mid-twentieth century; and political crises and partial recovery since the 1970s. Ultimately, the paper seeks to assess the role of History in a modern African society vis-à-vis the developmental agendas and notions of economic growth against which African “progress” and prospects for “stability” are currently measured

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abundant structural, sensory, and signaling filament in muscle) as a common cause of end-stage dilated cardiomyopathy (DCM) promises new prospects for improving heart failure management. However, realization of this opportunity has been hindered by the burden of TTN-truncating variants (TTNtv) in the general population and uncertainty about their consequences in health or disease. To elucidate the effects of TTNtv, we coupled TTN gene sequencing with cardiac phenotyping in 5267 individuals across the spectrum of cardiac physiology and integrated these data with RNA and protein analyses of human heart tissues. We report diversity of TTN isoform expression in the heart, define the relative inclusion of TTN exons in different isoforms (using the TTN transcript annotations available at http://cardiodb.org/titin), and demonstrate that these data, coupled with the position of the TTNtv, provide a robust strategy to discriminate pathogenic from benign TTNtv. We show that TTNtv is the most common genetic cause of DCM in ambulant patients in the community, identify clinically important manifestations of TTNtv-positive DCM, and define the penetrance and outcomes of TTNtv in the general population. By integrating genetic, transcriptome, and protein analyses, we provide evidence for a length-dependent mechanism of disease. These data inform diagnostic criteria and management strategies for TTNtv-positive DCM patients and for TTNtv that are identified as incidental findings

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

10.1126/scitranslmed.3010134Science Translational Medicine7270270ra