When gravity meets philosophy again: the Gravitas project

Gravity is, by far, one of the scientific themes that have most piqued the curiosity of scientists and philosophers over the centuries. The history of science tells us that when the creative effort of physicists and philosophers to solve the main puzzles of the understanding of our universe met, a new conceptual revolution has started. However, since Einstein's relativistic theories and the subsequent advent of quantum mechanics, physicists and philosophers have taken different paths, both kidnapped by the intrinsic conceptual and mathematical difficulties inherited by their studies. Is it possible to restore a unitary vision of knowledge, overcoming the scientific-humanistic dichotomy that has established itself over time? The answer is certainly not trivial, but we can start from school to experience a new vision of a unified knowledge. From this need, the Gravitas project has born. Gravitas is a multidisciplinary outreach and educational program devoted to high school students (17-19 years old) that mixes contemporary physics and the philosophy of science. Coordinated by the Cagliari Section of the National Institute of Nuclear Physics, in Italy, Gravitas has started on December 2021 with an unconventional online format: two researchers coming from different fields of research meet a moderator and informally discuss about gravity and related phenomena. The public can chat and indirectly interact with them during the YouTube live. The project involved about 250 students from 16 high schools in Sardinia, Italy. Students should also create posts thought for social media whose content is based on the seminars they attended during the project. We present the project and discuss its possible outcomings concerning the introduction of a multidisciplinary approach in teaching physics, philosophy, and the history of contemporary physics in high schools.Comment: To appear in Proceedings of ICHEP 2022 Conference, 6 pages, 8 figures. An extended version of the abstract appears in the pape

Molecular simulations of SSTR2 dynamics and interaction with ligands

The cyclic peptide hormone somatostatin regulates physiological processes involved in growth and metabolism, through its binding to G-protein coupled somatostatin receptors. The isoform 2 (SSTR2) is of particular relevance for the therapy of neuroendocrine tumours for which different analogues to somatostatin are currently in clinical use. We present an extensive and systematic computational study on the dynamics of SSTR2 in three different states: active agonist-bound, inactive antagonist-bound and apo inactive. We exploited the recent burst of SSTR2 experimental structures to perform μs-long multi-copy molecular dynamics simulations to sample conformational changes of the receptor and rationalize its binding to different ligands (the agonists somatostatin and octreotide, and the antagonist CYN154806). Our findings suggest that the apo form is more flexible compared to the holo ones, and confirm that the extracellular loop 2 closes upon the agonist octreotide but not upon the antagonist CYN154806. Based on interaction fingerprint analyses and free energy calculations, we found that all peptides similarly interact with residues buried into the binding pocket. Conversely, specific patterns of interactions are found with residues located in the external portion of the pocket, at the basis of the extracellular loops, particularly distinguishing the agonists from the antagonist. This study will help in the design of new somatostatin-based compounds for theranostics of neuroendocrine tumours

Reliability and Comparison of Some GEANT4-DNA Processes and Models for Proton Transportation: An Ultra-Thin Layer Study

This chapter presents a specific reliability study of some GEANT4-DNA (version 10.02.p01) processes and models for proton transportation considering ultra-thin layers (UTL). The Monte Carlo radiation transport validation is fundamental to guarantee the simulation results accuracy. However, sometimes this is impossible due to the lack of experimental data and, it is then that the reliability evaluation takes an important role. Geant4-DNA runs in an energy range that makes impossible, nowadays, to perform a proper microscopic validation (cross-sections and dynamic diffusion parameters) and allows very limited macroscopic reliability. The chemical damage cross-sections reliability (experiment versus simulation) is a way to verify the consistency of the simulation results which is presented for 2 MeV incident protons beam on PMMA and PVC UTL. A comparison among different Geant4-DNA physics lists for incident protons beams from 2 to 20 MeV, interacting with homogeneous water UTL (2 to 200 nm) was performed. This comparison was evaluated for standard and five other optional physics lists considering radial and depth profiles of deposited energy as well as number of interactions and stopping power of the incident particle

AX-PET: A novel PET concept with G-APD readout

Abstract The AX-PET collaboration has developed a novel concept for high resolution PET imaging to overcome some of the performance limitations of classical PET cameras, in particular the compromise between spatial resolution and sensitivity introduced by the parallax error. The detector consists of an arrangement of long LYSO scintillating crystals axially oriented around the field of view together with arrays of wave length shifter strips orthogonal to the crystals. This matrix allows a precise 3D measurement of the photon interaction point. This is valid both for photoelectric absorption at 511 keV and for Compton scattering down to deposited energies of about 100 keV. Crystals and WLS strips are individually read out using Geiger-mode Avalanche Photo Diodes (G-APDs). The sensitivity of such a detector can be adjusted by changing the number of layers and the resolution is defined by the crystal and strip dimensions. Two AX-PET modules were built and fully characterized in dedicated test set-ups at CERN, with point-like 22 Na sources. Their performance in terms of energy ( R energy ≈ 11.8 % (FWMH) at 511 keV) and spatial resolution was assessed ( σ axial ≈ 0.65 mm ), both individually and for the two modules in coincidence. Test campaigns at ETH Zurich and at the company AAA allowed the tomographic reconstructions of more complex phantoms validating the 3D reconstruction algorithms. The concept of the AX-PET modules will be presented together with some characterization results. We describe a count rate model which allows to optimize the planing of the tomographic scans

First results from the AX-PET demonstrator

The AX-PET demonstrator is based on a new concept in PET detectors, with LYSO crystals aligned along the z coordinate (patient's axis) and WLS (Wave-length shifter) strips placed orthogonal to them. This kind of structure permits to avoid parallax errors due to different depths of interaction of the photons in the crystals, to register the three coordinates of the impinging photon and to reconstruct Compton events. In this way both the spatial resolution and the sensitivity can be highly improved. Moreover, as both the LYSO crystals and the strips are readout via Geiger-mode Avalanche Photo Diodes (G-APDs) the detector is insensitive to magnetic fields and is then suitable to be used in a combined PET/MRI apparatus. A complete Monte Carlo simulation and dedicated reconstruction software, suited to the particular geometry arrangement, have been developed. The two final modules, each composed by 48 crystals and 156 WLS strips have been built and fully characterized in a dedicated test set-up. The results on the performances of the system obtained with a 22Na point source (0.25 mm diameter) are reported

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements