Study of ventilation with different inspired oxygen concentration on lung ischaemia-reperfusion injury in rats

PURPOSE: To evaluate the FiO2 effect at 0,21, 0,40 and 1,00 on the lung ischaemia-reperfusion injury. METHODS: Forty Wistar rats were randomly allocated in 4 groups. The group I was the control one, and in groups II, III, IV rats were ventilated during the ischaemia-reperfusion at 0,21, 0,40 and 1.00 FiO2 respectively. The ischaemia time was 30 minutes and the reperfusion time was 10 minutes. The model used was normothermic ischaemia-reperfusion, in situ. As assessment parameters, the systemic average arterial pressure (PAM), the oxygen arterial partial pressure/ inspired oxygen fraction relation (PO2/FiO2), the level of reduced glutathione (GSH) and barbituric acid substances reactive measure (TBARS) in the lung tissue and the lung wet/dry weight ratio were used. RESULTS: The results showed that the ventilation with FiO2 at 0,21, when compared with the ventilation at 0,40 and 1,00 FiO2 during the ischaemia-reperfusion period, presented lower PAM, better PO2/FiO2 relation, higher values in the reduced glutathione measures, lower production of the TBARS and lower formation of lung edema. CONCLUSION: The ventilation with low FiO2 (0.21) showed better results when compared to those performed with higher FiO2 (0,40 and 1,00) on the lung ischaemia-reperfusion injury.OBJETIVO: Estudar o efeito das frações inspiradas de oxigênio (FiO2) a 0,21, 0,40 e 1,00 na isquemia-reperfusão pulmonar. MÉTODOS: Foram utilizados 40 ratos Wistar, distribuídos aleatoriamente em quatro grupos. O grupo I foi o controle e, nos grupos II, III e IV, os animais foram ventilados durante a isquemia-reperfusão com FiO2 a 0,21, 0,40 e 1,00 respectivamente. O modelo utilizado foi de isquemia-reperfusão normotérmica, in situ. O tempo de isquemia foi de 30 minutos e o de reperfusão, de 10 minutos. Como parâmetros de avaliação, utilizou-se a pressão arterial média sistêmica (PAM), a relação entre a pressão parcial de oxigênio e a fração inspirada de oxigênio (PO2/FiO2), a dosagem da glutationa reduzida (GSH) e das substâncias reativas ao ácido tiobarbitúrico (TBARS) no tecido pulmonar e a relação entre o peso pulmonar úmido e o peso pulmonar seco. RESULTADOS: Os resultados mostraram que a ventilação com FiO2 a 0,21, quando comparada à ventilação com FiO2 a 0,40 e 1,00, durante o período de isquemia-reperfusão, apresentou menor diminuição da PAM, melhor relação PO2/FiO2, maior valor na medida da GSH, menor produção das TBARS e menor formação de edema pulmonar. CONCLUSÃO: A ventilação com baixa FiO2 (0,21) mostrou melhores resultados quando comparada àquelas realizadas com FiO2 mais elevadas (0,40 e 1,00) na isquemia-reperfusão pulmonar.Secretaria Estadual de Saúde de Santa CatarinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade Federal de Santa Catarina Escola Paulista de Medicina Departamento de CirurgiaUniversidade Federal de Santa Catarina Departamento de Clínica CirúrgicaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de CirurgiaUNIFESP, EPMUniversidade Federal de Santa Catarina Escola Paulista de Medicina Depto. de CirurgiaUNIFESP, EPM, Depto. de CirurgiaSciEL

Série histórica da incidência de tuberculose em Santa Catarina: análise de uma década, 2010-2019

Objective: To describe the profile of tuberculosis cases and analyze the temporal trend of the disease incidence in Santa Catarina, according to sex, from 2010 to 2019. Methods: Time series study carried out with data from the Notifiable Diseases Information System (Sinan). The Prais-Winsten regression model was used. Results: There were 16,446 new cases of tuberculosis. Most cases occurred in men (68.5%), people aged 20 to 49 years (70.3%), in Greater Florianópolis (25.1%) and in individuals with incomplete elementary school (40.0%). A decreasing trend was observed in the incidence rates of tuberculosis for men (VPA: -1.86% – 95%CI -2.68;-1.03), women (VPA: -1.92% – 95%CI -2.63;- 1.20) and both sexes (VPA: -1.77% – 95%CI -2.37;-1.17). Conclusion: In the decade analyzed, there was a significant reduction in the incidence rate of tuberculosis in Santa Catarina, in both sexes. A predominantly male profile was observed, of an economically active age and with low education.Objetivo: Describir el perfil de los casos de tuberculosis y analizar la tendencia temporal de la incidencia de la enfermedad en Santa Catarina, según sexo, de 2010 a 2019. Métodos: Estudio de series de tiempo realizado con datos del Sistema de Información de Enfermedades Notificables (Sinan). Se utilizó el modelo de regresión de Prais-Winsten. Resultados: Se registraron 16.446 nuevos casos de tuberculosis. La mayoría de los casos ocurrieron en hombres (68,5%), personas de 20 a 49 años (70,3%), Gran Florianópolis (25,1%) y en individuos con primaria incompleta (40,0%). Se observó una tendencia decreciente en las tasas de incidencia de tuberculosis para hombres (VPA: -1,86% – IC95% -2,68;-1,03), mujeres (VPA: -1,92% – IC95% -2,63;-1,20) y ambos sexos (VPA: -1,77% – IC95% -2,37;-1,17). Conclusión: En la década analizada, hubo una reducción significativa en la tasa de incidencia de tuberculosis en Santa Catarina, en ambos sexos. Se observó un perfil predominantemente masculino, en edad económicamente activa y con baja escolaridad.Objetivo: Descrever o perfil dos casos de tuberculose e analisar a tendência temporal da incidência da doença em Santa Catarina, Brasil, segundo sexo, no período de 2010 a 2019. Métodos: Estudo de série temporal, realizado com dados do Sistema de Informação de Agravos de Notificação (Sinan). Utilizou-se o modelo de regressão de Prais-Winsten. Resultados: Ocorreram 16.446 casos novos de tuberculose, em sua maioria homens (68,5%), pessoas de 20 a 49 anos de idade (70,3%), na Grande Florianópolis (25,1%) e em indivíduos com ensino fundamental incompleto (40,0%). Observou-se tendência de decréscimo nas taxas de incidência de tuberculose para homens (VPA: -1,86% – IC95% - 2,68;-1,03), mulheres (VPA: -1,92% – IC95% -2,63;-1,20) e ambos os sexos (VPA: -1,77%– IC95% -2,37;-1,17). Conclusão: Na década analisada, ocorreu redução significativa na taxa de incidência de tuberculose em Santa Catarina, em ambos os sexos. Observou-se perfil predominantemente masculino, em idade economicamente ativa e com baixa escolaridade

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Measurement of the t(t)over-bar production cross section, the top quark mass, and the strong coupling constant using dilepton events in pp collisions at root s=13TeV

A measurement of the top quark-antiquark pair production cross section sigma(t (t) over bar) in proton-proton collisions at a centre-of-mass energy of 13 TeV is presented. The data correspond to an integrated luminosity of 35.9 fb(-1), recorded by the CMS experiment at the CERN LHC in 2016. Dilepton events (e(+/-) mu(-/+), mu(+) mu(-), e(+) e(-)) are selected and the cross section is measured from a likelihood fit. For a top quark mass parameter in the simulation of m(t)(MC) = 172.5 GeV the fit yields a measured cross section sigma(t (t) over bar) = 803 +/- 2 (stat) +/- 25 (syst) +/- 20 (lumi) pb, in agreement with the expectation from the standard model calculation at next-to-next-to-leading order. A simultaneous fit of the cross section and the top quark mass parameter in the POWHEG simulation is performed. The measured value of m(t)(MC) = 172.33 +/- 0.14 (stat)(-0.72)(+0.66) (syst) GeV is in good agreement with previous measurements. The resulting cross section is used, together with the theoretical prediction, to determine the top quark mass and to extract a value of the strong coupling constant with different sets of parton distribution functions.Peer reviewe

Search for Physics beyond the Standard Model in Events with Overlapping Photons and Jets

Results are reported from a search for new particles that decay into a photon and two gluons, in events with jets. Novel jet substructure techniques are developed that allow photons to be identified in an environment densely populated with hadrons. The analyzed proton-proton collision data were collected by the CMS experiment at the LHC, in 2016 at root s = 13 TeV, and correspond to an integrated luminosity of 35.9 fb(-1). The spectra of total transverse hadronic energy of candidate events are examined for deviations from the standard model predictions. No statistically significant excess is observed over the expected background. The first cross section limits on new physics processes resulting in such events are set. The results are interpreted as upper limits on the rate of gluino pair production, utilizing a simplified stealth supersymmetry model. The excluded gluino masses extend up to 1.7 TeV, for a neutralino mass of 200 GeV and exceed previous mass constraints set by analyses targeting events with isolated photons.Peer reviewe

Calibration of the CMS hadron calorimeters using proton-proton collision data at root s=13 TeV

Methods are presented for calibrating the hadron calorimeter system of theCMSetector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities vertical bar eta vertical bar ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy.Peer reviewe

Measurement of the Jet Mass Distribution and Top Quark Mass in Hadronic Decays of Boosted Top Quarks in pp Collisions at root s=13 TeV

A measurement is reported of the jet mass distribution in hadronic decays of boosted top quarks produced in pp collisions at root s = 13 TeV. The data were collected with the CMS detector at the LHC and correspond to an integrated luminosity of 35.9 fb(-1). The measurement is performed in the lepton + jets channel of t (t) over bar events, where the lepton is an electron or muon. The products of the hadronic top quark decay t -> bW -> bq (q) over bar' are reconstructed as a single jet with transverse momentum larger than 400 GeV. The t (t) over bar cross section as a function of the jet mass is unfolded at the particle level and used to extract a value of the top quark mass of 172.6 +/- 2.5 GeV. A novel jet reconstruction technique is used for the first time at the LHC, which improves the precision by a factor of 3 relative to an earlier measurement. This highlights the potential of measurements using boosted top quarks, where the new technique will enable future precision measurements.Peer reviewe

Search for top squark pair production in a final state with two tau leptons in proton-proton collisions at root s=13 TeV

A search for pair production of the supersymmetric partner of the top quark, the top squark, in proton-proton collision events at s = 13 TeV is presented in a final state containing hadronically decaying tau leptons and large missing transverse momentum. This final state is highly sensitive to high-tan beta or higgsino-like scenarios in which decays of electroweak gauginos to tau leptons are dominant. The search uses a data set corresponding to an integrated luminosity of 77.2 fb(-1), which was recorded with the CMS detector during 2016 and 2017. No significant excess is observed with respect to the background prediction. Exclusion limits at 95% confidence level are presented in the top squark and lightest neutralino mass plane within the framework of simplified models, in which top squark masses up to 1100 GeV are excluded for a nearly massless neutralino.Peer reviewe