Breast papillomas: current management with a focus on a new diagnostic and therapeutic modality

Breast papilloma is a term that describes an intraductal papillary configuration of the mammary epithelium on macroscopic or microscopic examination. It includes solitary intraductal papillomas, multiple papillomas, papillomatosis, and juvenile papillomatosis (JP). Recent advances in mammary ductoscopy (MD) have raised new possibilities in the diagnosis and treatment of breast papillomas. This technique represents an important diagnostic adjunct in patients with pathological nipple discharge (PND) by allowing direct visualisation and biopsy of intraductal lesions and guiding duct excision surgery. Treatment of breast papillomas often entails surgical duct excision for symptomatic relief and histopathological examination. Recently, more conservative approach has been adapted. MD-assisted microdochectomy should be considered the procedure of choice for a papilloma-related single duct discharge. Furthermore, there is increasing evidence that MD has the potential to reduce the number of duct excision procedures and minimise the extent of surgical resection. Imaging-guided vacuum-assisted core biopsy can be diagnostic and therapeutic for papillomas seen on mammography and/or ultrasound. Patients with multiple papillomas do have an increased risk of developing cancer and should be kept under annual review with regular mammography (preferably digital mammography) if treated conservatively. Magnetic resonance (MR) can be also used in surveillance in view of its high sensitivity. Because the risk is small, long term and affects both breasts, long-term follow-up is more appropriate than prophylactic mastectomy. Patients who prove to have solitary duct papilloma have insufficient increase in the risk of subsequent malignancy to justify routine follow-up

Spontaneous breaking of SU(3) to finite family symmetries: a pedestrian's approach

Non-Abelian discrete family symmetries play a pivotal role in the formulation of models with tri-bimaximal lepton mixing. We discuss how to obtain symmetries such as A4, semidirect product of Z7 and Z3, and Delta(27) from an underlying SU(3) gauge symmetry. Higher irreducible representations are required to achieve the spontaneous breaking of the continuous group. We present methods of identifying the required vacuum alignments and discuss in detail the symmetry breaking potentials.Comment: 21 page

Symbolic Analysis of Identity-Based Protocols

International audienceWe show how the Tamarin tool can be used to model and reason about security protocols using identity-based cryptography, including identity-based encryption and signatures. Although such protocols involve rather different primitives than conventional public-key cryptography , we illustrate how suitable abstractions and Tamarin's support for equational theories can be used to model and analyze realistic industry protocols, either finding flaws or gaining confidence in their security with respect to different classes of adversaries. Technically, we propose two models of identity-based cryptography. First, we formalize an abstract model, based on simple equations, in which verification of realistic protocols is feasible. Second, we formalize a more precise model, leveraging Tamarin's support for bilinear pairing and exclusive-or. This model is much closer to practical realizations of identity-based cryptography, but deduction is substantially more complex. Along the way, we point out the limits of precise modeling and highlight challenges in providing support for equational reasoning. We evaluate our models on an industrial protocol case study, where we find and fix flaws

Generalised CP and Δ(6n2)\Delta (6n^2) Family Symmetry in Semi-Direct Models of Leptons

We perform a detailed analysis of $\Delta (6n^2)$ family symmetry combined with a generalised CP symmetry in the lepton sector, breaking to different remnant symmetries $G_{\nu}$ in the neutrino and $G_{l}$ in the charged lepton sector, together with different remnant CP symmetries in each sector. We discuss the resulting mass and mixing predictions for $G_{\nu}=Z_2$ with $G_{l}=K_4,Z_p,p>2$ and $G_{\nu}=K_4$ with $G_{l}=Z_2$. All cases correspond to the preserved symmetry smaller than the full Klein symmetry, as in the semi-direct approach, leading to predictions which depend on a single undetermined real parameter, which mainly determines the reactor angle. We focus on five phenomenologically allowed cases for which we present the resulting predictions for the PMNS parameters as a function of $n$, as well as the predictions for neutrinoless double beta decay.Comment: 65 pages, 19 figures, and the predictions for neutrinoless double beta decay are update

Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector

This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}$and correspond to an integrated luminosity of$4.6\;{\rm f}{{{\rm b}}^{-1}}$. The measurement is performed by reconstructing the boosted W or Z bosons in single jets. The reconstructed jet mass is used to identify the W and Z bosons, and a jet substructure method based on energy cluster information in the jet centre-of-mass frame is used to suppress the large multi-jet background. The cross-section for events with a hadronically decaying W or Z boson, with transverse momentum${{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}$and pseudorapidity$|\eta |\lt 1.9$, is measured to be${{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques

Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb^-1. The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b-hadrons in jets are reconstructed using information from the tracking detectors, or a muon-based method where the presence of a muon is used to identify semileptonic decays of b-hadrons inside jets. The inclusive b-jet cross-section is measured as a function of transverse momentum in the range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet cross-section is measured as a function of the dijet invariant mass in the range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets and the angular variable chi in two dijet mass regions. The results are compared with next-to-leading-order QCD predictions. Good agreement is observed between the measured cross-sections and the predictions obtained using POWHEG + Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet cross-section. However, it does not reproduce the measured inclusive cross-section well, particularly for central b-jets with large transverse momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final version published in European Physical Journal