A radiação ionizante como forma de tratamento nas mulheres com cancer de colo de útero em Araguaína-TO, nos anos de 2000 a 2015 / Ionizing radiation as a treatment for women with cervical cancer in Araguaína-TO, from 2000 to 2015

Introdução: O câncer está se apresentando como um grave problema de saúde pública em todo o mundo como sociedades globais, especialmente em países subdesenvolvidos. (10,3% do total), excluídos por causas indeterminadas. Este é o segundo câncer mais comum entre as mulheres em todo o mundo. Radioterapia, que é uma das formas de tratamento dos estágios da IA2. Nos EUA IB2-IIA-IIB-IIIA-IIIB e IVA, o tratamento com radiação é quimioterapia concomitante. O tratamento concomitante com quimioterapia aumenta a probabilidade de sobrevivência de 40% para 52% no final do primeiro ano de tratamento.Metodologia: Estudo descritivo, retrospectivo, quantitativo-interpretativo, com análise de dados para o período de 2000 a 2015, do Registro Hospitalar de Atenção à Saúde (SIS-RHC), vinculado ao Hospital Regional de Araguaína. Os dados foram tabulados em planilhas para análise das variáveis analisadas.Resultados: Foram analisadas 2.664 mulheres com câncer de colo de útero no Hospital Regional de Araguaína. O consumo de 37,8% das mulheres sem diagnóstico e sem tratamento é de 45,0%, com diagnóstico e sem tratamento. A radioterapia apresentou 53,6% do total de tratamentos.Conclusões: A radioterapia é considerada um dos principais diagnósticos tardios, assim como a radioterapia é considerada a principal forma de tratamento. 

Variabilidade espacial da resistência à penetração e da umidade do solo em Neossolo Flúvico

The penetration resistance is a variable of great importance for agricultural management. The study was conductedto evaluate the spatial variability of soil resistance to penetration (RP) and water content of Fluvent cultivated with carrotand irrigated by micro sprinkler system, in Pesqueira, Pernambuco, under severe water stress scenario. The evaluations wereperformed in the 0-0.20 and 0.20-0.40 m layer, at 49 points, a grid mesh with 7 m × 7 m on two consecutive days, called sample1 and sample 2. The Normal distribution was verified in the variables penetration resistance, water content and texture. Forwater content it was observed a nugget effect, while for the penetration resistance spherical model (0.00-0.20 m) was fitted, insampling 1, and the Gaussian model for the sampling 2. The kriging maps of the two samplings show reduced RP, probably dueto the increase in the water content, although it has not been observed a strong correlation between the two variables.A resistência à penetração é uma variável de grande importância para o manejo agrícola. O estudo foi realizadocom o objetivo de investigar a variabilidade espacial da resistência do solo à penetração (RP) e da umidade de um NeossoloFlúvico cultivado com cenoura e irrigado por microaspersão, em Pesqueira, PE, sob condição de elevado estresse hídrico. Asavaliações foram feitas nas camadas de 0-0,20 e 0,20-0,40 m, em 49 pontos, em uma malha com grid 7 m × 7 m, após irrigaçãoem dois dias consecutivos, denominados amostragem 1 e amostragem 2. A distribuição normal foi verificada nas variáveisresistência à penetração, umidade e textura. Para a umidade do solo observou-se efeito pepita puro; enquanto que para aresistência à penetração, ajustaram-se os modelos esférico (0,00-0,20 m), na amostragem 1, e gaussiano para a amostragem2. Os mapas de krigagem realizados mostram redução da RP, provavelmente devido ao acréscimo da umidade, embora não setenha observado forte correlação entre as duas variáveis

Método de remoção e prevenção da formação de biofilme de bactérias redutoras de sulfato (BRS)

DepositadaA presente invenção propõe o uso do óleo de capim limão ou do seu principal constituinte monoterpênico, o citral, no controle do processo de biocorrosão e acidulação biogênica causada pelo crescimento e formação de biofilme de bactérias redutoras de sulfato (BRS)

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Many Labs 2: Investigating Variation in Replicability Across Samples and Settings

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP

To which world regions does the valence–dominance model of social perception apply?

Over the past 10 years, Oosterhof and Todorov’s valence–dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We addressed this question by replicating Oosterhof and Todorov’s methodology across 11 world regions, 41 countries and 11,570 participants. When we used Oosterhof and Todorov’s original analysis strategy, the valence–dominance model generalized across regions. When we used an alternative methodology to allow for correlated dimensions, we observed much less generalization. Collectively, these results suggest that, while the valence–dominance model generalizes very well across regions when dimensions are forced to be orthogonal, regional differences are revealed when we use different extraction methods and correlate and rotate the dimension reduction solution.C.L. was supported by the Vienna Science and Technology Fund (WWTF VRG13-007); L.M.D. was supported by ERC 647910 (KINSHIP); D.I.B. and N.I. received funding from CONICET, Argentina; L.K., F.K. and Á. Putz were supported by the European Social Fund (EFOP-3.6.1.-16-2016-00004; ‘Comprehensive Development for Implementing Smart Specialization Strategies at the University of Pécs’). K.U. and E. Vergauwe were supported by a grant from the Swiss National Science Foundation (PZ00P1_154911 to E. Vergauwe). T.G. is supported by the Social Sciences and Humanities Research Council of Canada (SSHRC). M.A.V. was supported by grants 2016-T1/SOC-1395 (Comunidad de Madrid) and PSI2017-85159-P (AEI/FEDER UE). K.B. was supported by a grant from the National Science Centre, Poland (number 2015/19/D/HS6/00641). J. Bonick and J.W.L. were supported by the Joep Lange Institute. G.B. was supported by the Slovak Research and Development Agency (APVV-17-0418). H.I.J. and E.S. were supported by a French National Research Agency ‘Investissements d’Avenir’ programme grant (ANR-15-IDEX-02). T.D.G. was supported by an Australian Government Research Training Program Scholarship. The Raipur Group is thankful to: (1) the University Grants Commission, New Delhi, India for the research grants received through its SAP-DRS (Phase-III) scheme sanctioned to the School of Studies in Life Science; and (2) the Center for Translational Chronobiology at the School of Studies in Life Science, PRSU, Raipur, India for providing logistical support. K. Ask was supported by a small grant from the Department of Psychology, University of Gothenburg. Y.Q. was supported by grants from the Beijing Natural Science Foundation (5184035) and CAS Key Laboratory of Behavioral Science, Institute of Psychology. N.A.C. was supported by the National Science Foundation Graduate Research Fellowship (R010138018). We acknowledge the following research assistants: J. Muriithi and J. Ngugi (United States International University Africa); E. Adamo, D. Cafaro, V. Ciambrone, F. Dolce and E. Tolomeo (Magna Græcia University of Catanzaro); E. De Stefano (University of Padova); S. A. Escobar Abadia (University of Lincoln); L. E. Grimstad (Norwegian School of Economics (NHH)); L. C. Zamora (Franklin and Marshall College); R. E. Liang and R. C. Lo (Universiti Tunku Abdul Rahman); A. Short and L. Allen (Massey University, New Zealand), A. Ateş, E. Güneş and S. Can Özdemir (Boğaziçi University); I. Pedersen and T. Roos (Åbo Akademi University); N. Paetz (Escuela de Comunicación Mónica Herrera); J. Green (University of Gothenburg); M. Krainz (University of Vienna, Austria); and B. Todorova (University of Vienna, Austria). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.https://www.nature.com/nathumbehav/am2023BiochemistryGeneticsMicrobiology and Plant Patholog

To which world regions does the valence–dominance model of social perception apply?

Over the past 10 years, Oosterhof and Todorov’s valence–dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We addressed this question by replicating Oosterhof and Todorov’s methodology across 11 world regions, 41 countries and 11,570 participants. When we used Oosterhof and Todorov’s original analysis strategy, the valence–dominance model generalized across regions. When we used an alternative methodology to allow for correlated dimensions, we observed much less generalization. Collectively, these results suggest that, while the valence–dominance model generalizes very well across regions when dimensions are forced to be orthogonal, regional differences are revealed when we use different extraction methods and correlate and rotate the dimension reduction solution