Improving Services for Students with Disabilities at Community Colleges

The purpose of this qualitative case study was to discover ways in which community college faculty and administrators can better facilitate learning for students with disabilities. Semi-structured interviews, preinterview questionnaires, and a review of relevant documents were used to gain an understanding of how community college faculty perceive the challenges of teaching students with disabilities. Additional research goals included an exploration of strategies community college faculty have found effective in assisting students with disabilities to be successful, actions community college administrators have taken that effectively address issues related to success for students with disabilities, and approaches community college administrators use to enhance their support of faculty who teach students with disabilities. The primary findings were constraints on funding and staffing negatively effecting support for students with disabilities. In addition, participants felt faculty and administrators lack sufficient knowledge concerning specific disabilities and need to learn new ways to work with students with disabilities in and out of the classroom. Other findings included faculty participants’ frustration with a variety of issues students bring to the classroom such as high levels of immaturity and overly intrusive parents intervening with faculty. Faculty participants also expressed dissatisfaction with a variety of erroneous beliefs; for example, some students expect services identical to those they received in high school. Moreover, faculty were dissatisfied with inadequate skills exhibited by colleagues when working with students with disabilities, such as providing excessive assistance to students and thereby setting unrealistic standards for future faculty. Administrators also reported students often experience inconsistent intervention strategies in working with different faculty members. Exploration of effective intervention methods used by faculty and administrators revealed the application of specific behavioral strategies, relationship focused communication, and individual creativity in teaching and communication strategies. Many of these strategies do not involve a large cost to the institution, but faculty and administrator training is needed to make better use of current campus resources. Conclusions drawn from the research suggest that administrators need to clarify the responsibilities both faculty and administrators have in working with students with disabilities. Moreover, faculty and administrators need to take greater responsibility in serving these students, and not rely solely on the college’s Disability Services office to provide all of the support. In order to accomplish this transition, more disability specific training for faculty and administrators is necessary. Finally, a pedagogical paradigm shift should be examined at the institution to better address the needs of students with disabilities, particularly in view of the current funding environment. Also, the needs of students should be included in short term operational and long term strategic planning at the college

Rearing the bay scallop, Aequipecten irradians

Bay scallops, Acquipcctcn irradians, collected from various bays along the Eastern Shore of Virginia and from Bogue Sottnd, North Carolina, were conditoned and spawned in the laboratory, out of their normal spawning period. A thermal stimulus of 21-2100 was used to stimulate spawning, and larvae set in 10-19 days using cultured algae as food. Juvenile scallops were held in plastic trays in the laboratory for one week, then moved to outdoor tanks with flowing, unfiltered seawater. They remained there until they were about 2 mm in width, then moved to plastic screened wooden floats in the field where they reached an average minimum market size (50 mm) in 12·13 months. Mortality of larvae, early post-set scallops and adults is described. The bay scallop appears to be amenable to mariculture. The biological feasibility of rearing bay scallops from egg to market size has been established

Lentivirus-mediated gene therapy for Fabry disease

Enzyme and chaperone therapies are used to treat Fabry disease. Such treatments are expensive and require intrusive biweekly infusions; they are also not particularly efficacious. In this pilot, single-arm study (NCT02800070), five adult males with Type 1 (classical) phenotype Fabry disease were infused with autologous lentivirus-transduced, CD34+-selected, hematopoietic stem/progenitor cells engineered to express alpha-galactosidase A (α-gal A). Safety and toxicity are the primary endpoints. The non-myeloablative preparative regimen consisted of intravenous melphalan. No serious adverse events (AEs) are attributable to the investigational product. All patients produced α-gal A to near normal levels within one week. Vector is detected in peripheral blood and bone marrow cells, plasma and leukocytes demonstrate α-gal A activity within or above the reference range, and reductions in plasma and urine globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) are seen. While the study and evaluations are still ongoing, the first patient is nearly three years post-infusion. Three patients have elected to discontinue enzyme therapy

Dynamic Coupling of Pattern Formation and Morphogenesis in the Developing Vertebrate Retina

In this Research Article, Picker et al. show how cells in the retina get their spatial coordinates

Discovery of common and rare genetic risk variants for colorectal cancer.

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.Goncalo R Abecasis has received compensation from 23andMe and Helix. He is currently an employee of Regeneron Pharmaceuticals. Heather Hampel performs collaborative research with Ambry Genetics, InVitae Genetics, and Myriad Genetic Laboratories, Inc., is on the scientific advisory board for InVitae Genetics and Genome Medical, and has stock in Genome Medical. Rachel Pearlman has participated in collaborative funded research with Myriad Genetics Laboratories and Invitae Genetics but has no financial competitive interest

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

In the version of this article initially published, the author affiliations incorrectly listed “Candiolo Cancer Institute FPO-IRCCS, Candiolo (TO), Italy” as “Candiolo Cancer Institute, Candiolo, Italy.” The change has been made to the HTML and PDF versions of the article

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

BACKGROUND: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk. METHODS: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided. RESULTS: The discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0. CONCLUSIONS: This study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screenin

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio