332 research outputs found
Lynx X-Ray Observatory: Response to the First Astro 2020 Decadal Survey Request for Information
This document serves as the Lynx Teams response to the first Request For Information (RFI) from the 2020 Decadal Survey in Astronomy and Astrophysics. Detailed answers to all of the questions asked in this RFI can be found in the Lynx Concept Study Report, Supplementary Technology Roadmaps, and the Lynx Cost Book
Processing TES Level-1B Data
TES L1B Subsystem is a computer program that performs several functions for the Tropospheric Emission Spectrometer (TES). The term "L1B" (an abbreviation of "level 1B"), refers to data, specific to the TES, on radiometric calibrated spectral radiances and their corresponding noise equivalent spectral radiances (NESRs), plus ancillary geolocation, quality, and engineering data. The functions performed by TES L1B Subsystem include shear analysis, monitoring of signal levels, detection of ice build-up, and phase correction and radiometric and spectral calibration of TES target data. Also, the program computes NESRs for target spectra, writes scientific TES level-1B data to hierarchical- data-format (HDF) files for public distribution, computes brightness temperatures, and quantifies interpixel signal variability for the purpose of first-order cloud and heterogeneous land screening by the level-2 software summarized in the immediately following article. This program uses an in-house-developed algorithm, called "NUSRT," to correct instrument line-shape factors
Neighborhood poverty and early transition to sexual at
This study examined how the link between neighborhood poverty and the timing of sexual initiation varies as a function of age, gender, and background characteristics. A sample of N 5 2,596 predominately White Canadian adolescents from the National Longitudinal Survey of Children and Youth was used. Sexual initiations occurring between 12 and 15 years old were considered. Results showed that younger adolescent females who lived in poor neighborhoods and who had a history of conduct problems were more likely to report early sexual activity. Peer characteristics partly accounted for this susceptibility. Among adolescent males, no direct neighborhood effects were found, but those who had combined risks at multiple levels appeared more vulnerable. The theoretical and practical implications of these findings are discussed
Two novel human NUMB isoforms provide a potential link between development and cancer
We previously identified four functionally distinct human NUMB isoforms. Here, we report the identification of two additional isoforms and propose a link between the expression of these isoforms and cancer. These novel isoforms, NUMB5 and NUMB6, lack exon 10 and are expressed in cells known for polarity and migratory behavior, such as human amniotic fluid cells, glioblastoma and metastatic tumor cells. RT-PCR and luciferase assays demonstrate that NUMB5 and NUMB6 are less antagonistic to NOTCH signaling than other NUMB isoforms. Immunocytochemistry analyses show that NUMB5 and NUMB6 interact and complex with CDC42, vimentin and the CDC42 regulator IQGAP1 (IQ (motif) GTPase activating protein 1). Furthermore, the ectopic expression of NUMB5 and NUMB6 induces the formation of lamellipodia (NUMB5) and filopodia (NUMB6) in a CDC42- and RAC1-dependent manner. These results are complemented by in vitro and in vivo studies, demonstrating that NUMB5 and NUMB6 alter the migratory behavior of cells. Together, these novel isoforms may play a role in further understanding the NUMB function in development and cancer
The Role of the Lactate Dehydrogenase and the Effect of Prone Position during Ventilator-induced Lung Injury
To examine the impact of lactate dehydrogenase (LDH) as an early marker of ventilator-induced lung injury (VILI) and the effect of prone position during the VILI, we ventilated 28 normal white rabbits (10 supine, 10 prone, 8 controls) for 6 hr or until PaO2/FIO2 ratio was <200 mmHg. We applied an identical injurious ventilatory pattern (peak inspiratory pressure of 35 cmH2O with a PEEP of 3 cmH2O, I:E ratio of 1:2, and FIO2 of 0.40) in the supine and prone group. VILI was assessed by oxygenation, gravimetric analysis and histologic grading. Serum levels of LDH progressively increased significantly during the VILI (supine and prone groups) as compared with controls. There was a significant negative correlation between oxygenation and LDH levels (r=-0.619, p<0.001). Wet weight/dry weight ratios (WW/DW) and histologic scores for dependent regions were significantly higher in the supine than the prone group. There were no differences in WW/DW and histologic scores for nondependent regions between the supine and prone group. These findings suggest that serum LDH levels might be an early marker of severity of lung injury. The prone position resulted in a less severe and more homogenous distribution of VILI
Kinematic properties of early-type galaxy haloes using planetary nebulae
We present new planetary nebulae (PNe) positions, radial velocities, and
magnitudes for 6 early-type galaxies obtained with the Planetary Nebulae
Spectrograph, their two-dimensional velocity and velocity dispersion fields. We
extend this study to include an additional 10 early-type galaxies with PNe
radial velocity measurements available from the literature, to obtain a broader
description of the outer-halo kinematics in early-type galaxies. These data
extend the information derived from stellar kinematics to typically up to ~8
Re. The combination of photometry, stellar and PNe kinematics shows: i) good
agreement between the PNe number density and the stellar surface brightness in
the region where the two data sets overlap; ii) good agreement between PNe and
stellar kinematics; iii) that the mean rms velocity profiles fall into two
groups: with of the galaxies characterized by slowly decreasing profiles and
the remainder having steeply falling profiles; iv) a larger variety of velocity
dispersion profiles; v) that twists and misalignments in the velocity fields
are more frequent at large radii, including some fast rotators; vi) that outer
haloes are characterised by more complex radial profiles of the specific
angular momentum-related lambda_R parameter than observed within 1Re; vii) that
many objects are more rotationally dominated at large radii than in their
central parts; and viii) that the halo kinematics are correlated with other
galaxy properties, such as total luminosity, isophotal shape, total stellar
mass, V/sigma, and alpha parameter, with a clear separation between fast and
slow rotators.Comment: 36 pages, 21 figures, revised version for MNRA
Mass-to-light ratio gradients in early-type galaxy haloes
Since the near future should see a rapidly expanding set of probes of the
halo masses of individual early-type galaxies, we introduce a convenient
parameter for characterising the halo masses from both observational and
theoretical results: \dML, the logarithmic radial gradient of the mass-to-light
ratio. Using halo density profiles from LCDM simulations, we derive predictions
for this gradient for various galaxy luminosities and star formation
efficiencies . As a pilot study, we assemble the available \dML\
data from kinematics in early-type galaxies - representing the first unbiassed
study of halo masses in a wide range of early-type galaxy luminosities - and
find a correlation between luminosity and \dML, such that the brightest
galaxies appear the most dark-matter dominated. We find that the gradients in
most of the brightest galaxies may fit in well with the LCDM predictions, but
that there is also a population of fainter galaxies whose gradients are so low
as to imply an unreasonably high star formation efficiency .
This difficulty is eased if dark haloes are not assumed to have the standard
LCDM profiles, but lower central concentrations.Comment: 17 pages, 13 figures. Accepted for publication on MNRA
Lynx X-Ray Observatory: An Overview
Lynx, one of the four strategic mission concepts under study for the 2020 Astrophysics Decadal Survey, provides leaps in capability over previous and planned x-ray missions and provides synergistic observations in the 2030s to a multitude of space- and ground-based observatories across all wavelengths. Lynx provides orders of magnitude improvement in sensitivity, on-axis subarcsecond imaging with arcsecond angular resolution over a large field of view, and high-resolution spectroscopy for point-like and extended sources in the 0.2- to 10-keV range. The Lynx architecture enables a broad range of unique and compelling science to be carried out mainly through a General Observer Program. This program is envisioned to include detecting the very first seed black holes, revealing the high-energy drivers of galaxy formation and evolution, and characterizing the mechanisms that govern stellar evolution and stellar ecosystems. The Lynx optics and science instruments are carefully designed to optimize the science capability and, when combined, form an exciting architecture that utilizes relatively mature technologies for a cost that is compatible with the projected NASA Astrophysics budget
Genetic regulation of pituitary gland development in human and mouse
Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s pouch. These factors dictate organ commitment, cell differentiation, and cell proliferation within the anterior pituitary. Abnormalities in these processes are associated with congenital hypopituitarism, a spectrum of disorders that includes syndromic disorders such as septo-optic dysplasia, combined pituitary hormone deficiencies, and isolated hormone deficiencies, of which the commonest is GH deficiency. The highly variable clinical phenotypes can now in part be explained due to research performed over the last 20 yr, based mainly on naturally occurring and transgenic animal models. Mutations in genes encoding both signaling molecules and transcription factors have been implicated in the etiology of hypopituitarism, with or without other syndromic features, in mice and humans. To date, mutations in known genes account for a small proportion of cases of hypopituitarism in humans. However, these mutations have led to a greater understanding of the genetic interactions that lead to normal pituitary development. This review attempts to describe the complexity of pituitary development in the rodent, with particular emphasis on those factors that, when mutated, are associated with hypopituitarism in humans
Early Science from POSSUM: Shocks, turbulence, and a massive new reservoir of ionised gas in the Fornax cluster
We present the first Faraday rotation measure (RM) grid study of an
individual low-mass cluster -- the Fornax cluster -- which is presently
undergoing a series of mergers. Exploiting commissioning data for the
POlarisation Sky Survey of the Universe's Magnetism (POSSUM) covering a
square degree sky area using the Australian Square Kilometre Array
Pathfinder (ASKAP), we achieve an RM grid density of RMs per square
degree from a 280 MHz band centred at 887 MHz, which is similar to expectations
for forthcoming GHz-frequency all-sky surveys. We thereby probe the extended
magnetoionic structure of the cluster in unprecedented detail. We find that the
scatter in the Faraday RM of confirmed background sources is increased by
rad m within 1 degree (360 kpc) projected distance to the
cluster centre, which is 2--4 times more extended than the presently-detectable
X-ray-emitting intracluster medium (ICM). The Faraday-active plasma is more
massive than the X-ray-emitting ICM, with an average density that broadly
matches expectations for the Warm-Hot Intergalactic Medium. The morphology of
the Faraday depth enhancement exhibits the classic morphology of an
astrophysical bow shock on the southwest side of the main Fornax cluster, and
an extended, swept-back wake on the northeastern side. Our favoured explanation
is an ongoing merger between the main cluster and a sub-cluster to the
southwest. The shock's Mach angle and stand-off distance lead to a
self-consistent transonic merger speed with Mach 1.06. The region hosting the
Faraday depth enhancement shows a decrement in both total and polarised
intensity. We fail to identify a satisfactory explanation for this; further
observations are warranted. Generally, our study illustrates the scientific
returns that can be expected from all-sky grids of discrete sources generated
by forthcoming all-sky radio surveys.Comment: Accepted for publication in PASA. 27 pages, 14 figures, 1 tabl
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