150 research outputs found
Straightforward Inference of Ancestry and Admixture Proportions through Ancestry-Informative Insertion Deletion Multiplexing
- Author
- A Tandon
- AL Price
- AL Price
- António Amorim
- B Devlin
- C Alkan
- C Phillips
- C Phillips
- C Tian
- Carla Santos
- Christopher Phillips
- D Falush
- D Luca
- DF Conrad
- ER Londin
- HM Cann
- I Halder
- J Marchini
- JK Pritchard
- JK Pritchard
- JL Weber
- JM Mullaney
- JN Hirschhorn
- JN Hirschhorn
- JR Gonzalez
- JR Kidd
- L Excoffier
- Leonor Gusmão
- M Jakobsson
- M Kayser
- Manfred Kayser
- MD Shriver
- MF Seldin
- N Yang
- NA Rosenberg
- NA Rosenberg
- NA Rosenberg
- NA Rosenberg
- NA Rosenberg
- NP Santos
- Nádia Pinto
- O Lao
- O Lao
- P Donnelly
- P Kersbergen
- P Paschou
- PH Sudmant
- R Kosoy
- R Nassir
- R Pereira
- R Pereira
- R Redon
- RE Mills
- RE Mills
- Rui Pereira
- S Biswas
- Sidney Emanuel Batista dos Santos
- T Frudakis
- Ángel Carracedo
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Ancestry-informative markers (AIMs) show high allele frequency divergence between different ancestral or geographically distant populations. These genetic markers are especially useful in inferring the likely ancestral origin of an individual or estimating the apportionment of ancestry components in admixed individuals or populations. The study of AIMs is of great interest in clinical genetics research, particularly to detect and correct for population substructure effects in case-control association studies, but also in population and forensic genetics studies
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
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- Abbaneo D
- Abbiendi G
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- Ziebarth EB
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Testing Nonstandard Neutrino Properties with a M\"ossbauer Oscillation Experiment
- Author
- A Aguilar
- A Aguilar-Arevalo
- A Gago
- A Gouvêa de
- AG Cohen
- AY Smirnov
- C Athanassopoulos
- C Giunti
- C Giunti
- C Giunti
- DB Kaplan
- E Lisi
- EK Akhmedov
- EK Akhmedov
- EK Akhmedov
- F Kaether
- F. A. Pereira dos Santos
- G Fogli
- G Fogli
- G Karagiorgi
- G Mention
- G Raffelt
- GL Fogli
- H Davoudiasl
- H Minakata
- H Minakata
- H. Nunokawa
- I Antoniadis
- J Abdurashitov
- J Hamann
- J Kopp
- J Kopp
- J Schiffer
- JN Bahcall
- JR Ellis
- K Abe
- K Abe
- LA Mikaelyan
- M Cirelli
- M Gonzalez-Garcia
- M Maltoni
- M Maltoni
- M Sorel
- MA Acero
- N Arkani-Hamed
- N Arkani-Hamed
- NC Ribeiro
- O Peres
- P Gu
- P Huber
- P Machado
- P. A. N. Machado
- PC Holanda de
- R Barbieri
- R Daudel
- R Fardon
- R Mohapatra
- R Mohapatra
- R Mohapatra
- R Raghavan
- R. Zukanovich Funchal
- RL Mössbauer
- S Bilenky
- S Bilenky
- S Bilenky
- S Bilenky
- S Bilenky
- S Choubey
- S Petcov
- T Mueller
- T Schwetz
- T Schwetz
- U Franca
- V Barger
- W Hampel
- W Kells
- W Potzel
- W Potzel
- W Potzel
- W Potzel
- WM Visscher
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
If the neutrino analogue of the M\"ossbauer effect, namely, recoiless
emission and resonant capture of neutrinos is realized, one can study neutrino
oscillations with much shorter baselines and smaller source/detector size when
compared to conventional experiments. In this work, we discuss the potential of
such a M\"ossbauer neutrino oscillation experiment to probe nonstandard
neutrino properties coming from some new physics beyond the standard model. We
investigate four scenarios for such new physics that modify the standard
oscillation pattern. We consider the existence of a light sterile neutrino that
can mix with \bar \nu_e, the existence of a Kaluza-Klein tower of sterile
neutrinos that can mix with the flavor neutrinos in a model with large flat
extra dimensions, neutrino oscillations with nonstandard quantum decoherence
and mass varying neutrinos, and discuss to which extent one can constrain these
scenarios. We also discuss the impact of such new physics on the determination
of the standard oscillation parameters.Comment: 28 pages, 11 figures, published version in JHE
Prevalência e fatores associados à infecção pelo Mycobacterium tuberculosis entre agentes comunitários de saúde no Brasil, usando-se a prova tuberculínica
- Author
- Amanda Pissinate do Nascimento Sant’anna
- Barros AJ
- Cailleaux CM
- Chermont AB
- Conde MB
- Crispim Cerutti Junior
- Do AN
- Ethel Leonor Noia Maciel
- Fernanda Mattos de Souza
- Ferreira FM
- Franco C
- Jair dos Santos Pinheiro
- Joshi R
- Kassim S
- Kássia Gomes de Jesus
- Larsen NM
- Lien LT
- Maciel EL
- Maciel EL
- Maciel EL
- Maciel EL
- Maciel EL
- Mazurek GH
- Mazurek M
- Menzies D
- Minayo MC
- Moreira TR
- Moreno S
- Muniz JN
- Nunes MO
- Oliveira GP
- Oliveira JS
- Oliveira SM
- Pai M
- Patrícia Marques Rodrigues
- Pereira AL
- Prado TN
- Pôrto A
- Quadros CM
- Rita de Cássia Duarte Lima
- Rodrigues PM
- Rogerio WP
- Roth VR
- Schwartzman K
- Silva JA
- Silva VM
- Silva VMC
- Thiago Nascimento do Prado
- Wesley Pereira Rogerio
- Yushiara EV
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis
- Author
- A.C. Lyra
- Abuzwaida AR
- Bradley DW
- Bryan JP
- C.P. Saraceni
- Chomczynski P
- Clemens SA
- dos Santos JI
- E.L. Braga
- Erker JC
- F.J. Carrilho
- Ferraz ML
- Gimenez-Barcons M
- Goncales NS
- Halasz R
- Hyams KC
- Ikeda H
- J.E. Pereira
- J.R.R. Pinho
- Kanda T
- Kimura M
- Kumar S
- Kwok S
- L. Sousa
- L.C. da Silva
- L.G.C. Lyra
- L.K. Silva
- Leary TP
- Lewis-Ximenez LL
- Loureiro CL
- M.A.S. Zarife
- M.G. Reis
- Mushahwar IK
- Naoumov NV
- Nishizawa T
- Okamoto H
- Pannuti CS
- Parana R
- Parana R
- Paul DA
- Pinho JR
- Reyes GR
- Silva LK
- Simons JN
- Souto FJ
- Tanaka H
- Tanaka Y
- Thompson JD
- Tillmann HL
- Vitral CL
- Williams CF
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
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- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
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- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
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- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
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- Burton J
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- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
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- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
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- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
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- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
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- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
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- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
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- Da Silva O Jr
- Dahlen G
- Dalseg Am
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- Danik J
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- Dave B
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- De Los Rios M
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- Zineldine A.
- Zirlik A
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
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- Adenike O
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
CMS Data Processing Workflows during an Extended Cosmic Ray Run
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
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- Ahmed W
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- Aisa S
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- Akgun B
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- Akin IV
- Alagoz E
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- Alberdi J
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- Altenhofer G
- Altsybeev I
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- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
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- Andelin D
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- Andreev Y
- Anghel IM
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
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- Abolhassani H
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- Abrams EM
- Abreu LG
- Abrigo MRM
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- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
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- Thapar R
- Thomas N
- Thomson AM
- Thrift AG
- Thurston GD
- Titova MV
- Tlou B
- Tohidinik HR
- Tonelli M
- Topor-Madry R
- Topouzis F
- Toroudi HP
- Torre AE
- Touvier M
- Tovani-Palone MR
- Traini E
- Tran BX
- Travillian R
- Trias-Llimos S
- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
- Ullah S
- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
- Uthman OA
- Vacante M
- Vaicekonyte R
- Vakilian A
- Valdez PR
- Valli A
- Van Donkelaar A
- Vardavas C
- Varughese S
- Vasankari TJ
- Vasconcelos AMN
- Vasseghian Y
- Veisani Y
- Velasquez IM
- Venketasubramanian N
- Vidale S
- Violante FS
- Vlassov V
- Vollset SE
- Vongpradith A
- Vos T
- Vu GT
- Vujcic IS
- Vukovic A
- Vukovic R
- Waheed Y
- Wallin MT
- Walters MK
- Wamai RG
- Wang F
- Wang H
- Wang H
- Wang J
- Wang Y
- Wang Y
- Wang Y-P
- Ward JL
- Watson A
- Watson S
- Wei J
- Wei MYW
- Weintraub RG
- Weiss DJ
- Weiss J
- Welay FT
- Weldesamuel GT
- Werdecker A
- West JJ
- Westerman R
- Whisnant JL
- Whiteford HA
- Wiangkham T
- Wickramasinghe ND
- Wiens KE
- Wijeratne T
- Wilner LB
- Wilson S
- Wiysonge CS
- Wojtyniak B
- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
- …