45 research outputs found
Characterisation of human saliva as a platform for oral dissolution medium development
Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develop an in vitro dissolution medium to best represent human saliva. In this study, the pH, buffer capacity, surface tension, viscosity and flow rate of both unstimulated (US) and stimulated (SS) human saliva were investigated in order to provide a platform of reference for future dissolution studies using simulated salivary fluids. Age and gender related differences in a sample size of 30 participants for each parameter were investigated. Significant differences were established between US and SS for all characteristics except surface tension. Therefore, the requirement for using two simulated salivary fluids should be considered when developing an oral dissolution model
Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics : an UNGAP review
The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populations (age- and disease-dependent), drug and formulation properties, or food-drug interactions. Clinical evidence for the impact of some of these factors on drug pharmacokinetic variability is mounting: e.g. gastric pH and emptying time, small intestinal fluid properties, differences in pediatrics and the elderly, and surgical changes in gastrointestinal anatomy. However, the link of colonic factors variability (transit time, fluid composition, microbiome), sex differences (male vs. female) and gut-related diseases (chronic constipation, anorexia and cachexia) to drug absorption variability has not been firmly established yet. At the same time, a way to decrease oral drug pharmacokinetic variability is provided by the pharmaceutical industry: clinical evidence suggests that formulation approaches employed during drug development can decrease the variability in oral exposure. This review outlines the main drivers of oral drug exposure variability and potential approaches to overcome them, while highlighting existing knowledge gaps and guiding future studies in this area
An experimental approach in conceptualizing typographic signals of documents by eight-dot and six-dot braille code
The main research aim of the present study focuses on issues of reading comprehension, when users with blindness receive typographic meta-data by touch through a braille display. Levels of reading comprehension are investigated by the use of 6-dot and 8-dot braille code in matched texts for the cases of bold and italic meta-data. The results indicated a slight superiority of the 8-dot braille code in reading time and scorings. The discussion considered the practical implications of the findings such as issues regarding education as well as the development of suitable design of tactile rendition of typographic signals through 6-dot or 8-dot braille code in favor of better perception and comprehension. © 2014 Springer International Publishing
Estimation of intragastric drug solubility in the fed state: comparison of various media with data in aspirates
Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy
Gastrointestinal characterisation and drug solubility determination in animals
OBJECTIVES:
To characterise the gastrointestinal (GI) environment in rat, rabbit and pig for the purpose of determining their utility as animal models for drug delivery in humans.
METHODS:
GI fluid samples were characterised for osmolality, surface tension, pH and buffer capacity. The solubility of two model drugs, mesalazine (ionisable) and prednisolone (unionisable), were also measured and the results were correlated to the physicochemical fluid data.
KEY FINDINGS:
The solubility of the ionisable drug mesalazine was positively correlated to the GI pH in all three species and was significantly influenced by the pH difference. In contrast, the solubility of the unionisable compound prednisolone was not correlated significantly to the changes in pH, buffer capacity, osmolality or surface tension. In general, the solubility of prednisolone was constant irrespective of the location of the sample in the gut from rabbit and pig; however, an unusual trend was observed for the solubility of prednisolone in rats.
CONCLUSIONS:
The results suggest that solubility of ionisable drugs or pH-responsive formulations is significantly influenced by the differences in pH along the GI tract and inter-species differences. It was also found that the data on the GI solubility of prednisolone (a neutral compound) in rats might overestimate its true value in humans