High Energy Coprecipitate of Nonoxynol Oligomer, PVP and Iodine Having Contraceptive and Potent Anti-HIV Properties

A composition which is a contraceptive with potent anti-HIV activity. The composition is a high energy coprecipitate of nonoxynol-9 oligomers, polyvinylpyrrolidone (PVP) and iodine or PVP-I and shows a pronounced synergistic, anti-HIV effect between the compounds of the composition. A method of obtaining a contraceptive and anti-HIV environment in a female comprising administering to said female an effective amount of a high energy coprecipitate

Coated-Products with Potent Anti-HIV and Antimicrobial Properties

A composition which has potent anti-HIV activity. The composition is a high energy coprecipitate of nonoxynol-9 oligomers, polyvinyl-pyrrolidone (PVP) and iodine or PVP-I and shows a pronounced synergistic, anti-HIV effect between the compounds of the composition. The invention also includes paper and plastic products coated with the composition of the invention

Multicompartment Hard Capsule with Control Release Properties

The present invention relates to a hard capsule made from a material such as gelatin, starch or a hydrophilic polymer. The capsule of the present invention is formulated into a delivery system which incorporates pharmacologically active components in three or more distinct compartments. When three compartments are utilized in the capsule, the outer compartment incorporates a drug and excipients into a layer which coats the outer part of the capsule. This layer represents the rapid release portion of the delivery system. The intermediate compartment comprises a powder formulation comprised of a drug and excipients which represents the intermediary speed release portion of the delivery system. The innermost compartment incorporates the active ingredient or ingredients in a multiparticulate form, such as small pellets, and represents the slow release component of the delivery system

Methods of Treating Eye Conditions with Human Leukocyte Elastase (HLE) Inhibitory Agents

A method of reducing corneal scarring or fibroblast proliferation comprises applying to an area of a subject\u27s eye afflicted with the condition a corneal scar-fibroblast proliferation-reducing amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect. A method of reducing neovascularization of corneal scar tissue comprises applying to an area of a subject\u27s eye afflicted with the condition a neovascularization-inhibitory amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect

Low Molecular Weight Thiocarbamates as Inhibitors of Elastase, Uses and Method of Synthesis

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Novel Peptidyl Carbamate Inhibitors of the Enzyme Elastase

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Tobacco Smoke Filter Material

A tobacco smoke filter comprising a imidazole-containing polymer, the imidazole groups being chemically bound to said polymer

A Multiple Methods Research Program Examining Enhanced Recovery Care with Next-Day Discharge for Elective Caesarean Section

Enhanced recovery care for surgery has been increasingly applied for caesarean section. Programs of enhanced recovery aim to ‘fast-track’ convalescence by including antenatal preparation and education, and improved intrapartum and postnatal care such as encouraging mobility, early cessation of fasting and criteria-led hospital discharge. Given this improved care, enhanced recovery is associated with or includes an early discharge. A health service in South Australia is the first to implement an enhanced recovery care pathway for caesarean section in Australia called Enhanced Recovery after Elective Caesarean Section (EREC). EREC includes a next-day discharge with home midwifery and Mothercarer support. This program of research used multiple methods to better understand enhanced recovery care with next-day discharge after elective caesarean section. The results are discussed in terms of implications for future similar programs in this and other clinical contexts. Study 1 was a mixed methods systematic review synthesising women’s experiences and psychosocial outcomes with early discharge after caesarean section. Eight studies were identified reporting on: satisfaction, mental well-being, infant feeding, and pain. This study found no clear negative impact on women’s psychosocial outcomes and experiences. Several characteristics of care such as home midwifery were associated with more positive outcomes. Study 2 was a qualitative paper examining the experiences and perspectives of 11 women on the EREC pathway who had an early discharge. Using thematic analysis, major themes identified were: women’s general experience of an enhanced recovery care pathway, their experiences at home, and support at home. All women interviewed were satisfied with the EREC pathway and home recovery. Certain aspects of care were essential to a positive experience such as social support, support from staff, and home midwifery care; well managed pain relief, information, and reassurance of longer hospitalisation if required. Study 3 addressed anecdotal reports from midwives who reported that a large percentage of women assessed as eligible for EREC were not discharging the next-day, and therefore not completing the pathway as expected. This was suggested to be primarily due to psychosocial reasons. A prospective cohort study was developed and found that 62% of women did not go home the next-day, and identified that the two most common factors were for medical and obstetric reasons rather than psychosocial reasons. This study also identified antenatal demographic and biopsychosocial characteristics of women on the EREC pathway and described women’s antenatal satisfaction with preparation for EREC, preferences for postnatal care, and perception of support for EREC by hospital staff and family. Finally study 4, was a qualitative study applying thematic analysis to explore the experiences and perspectives of 23 healthcare providers (5 doctors and 18 midwives) who had occupational experience with the EREC pathway. Major themes identified were: EREC is more than just early discharge; experiences with the EREC process; woman-centred care; staff engagement with EREC, and the impact of EREC within the health system. This qualitative study found that staff were generally accepting of enhanced recovery care. Although, staff identified specific challenges such as early discharge, and the perceived lack of choice for women, as all eligible women were automatically included on the EREC pathway. Staff identified components that assisted with the integration and acceptance of EREC such as education, communication of the evidence, the inclusion of home support, and clinical flexibility. Organisational considerations such as having enough clinical time, clear guidelines and protocols, and clear staff roles were also discussed. Overall, the findings indicated that implementing enhanced recovery care with nextday discharge should be thoughtfully considered in other maternity services, given the benefits of this model of care. However, a combined package of care similar to the one included in the EREC pathway is required. This package of care should include appropriate screening and eligibility criteria, preparation and antenatal education, well-defined discharge processes, and home support. This work has also identified that staff require support to integrate change into practice.Thesis (Ph.D.) -- University of Adelaide, School of Psychology, 202

Peptide Elastase Inhibitors and Methods

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Iodo-Nonoxynol-9-Derivatives and Methods for Their Use

Mono- and di-iodinated nonoxynol-9-derivatives and methods for their use are disclosed