Evaluation of ibuprofen prescriptions into a Psychiatric Hospital: regarding safety, indication, and dose.

Introduction: non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are widely used throughout the world. In the psychiatric hospital, where this study was conducted, drugs such as selective serotonin reuptake inhibitors (SSRI) and lithium are widely used and may interact with ibuprofen (IBU). The literature also shows that ibuprofen may lead to changes in the central nervous system, which may trigger the imbalance of psychiatric disorders. Objective: to evaluate whether both the frequency of use and the prescriptions of ibuprofen are in agreement with the information contained in the literature regarding safety, indication, and dose. Methodology: retrospective observational cross-sectional study to evaluate the use of ibuprofen on patients from a psychiatric hospital. The prescriptions were evaluated for a 10-month period. Results: of the total number of prescriptions, 43 contained ibuprofen 600 mg. Note that in most cases, the drug was being prescribed according to the literature. However, in some cases there were divergences in the literature regarding: i) safety – information about the absence or presence of ulcers (1; 2.3%), gastrointestinal events (0; 0%) and absence of dyspepsia, abdominal pain and discomfort gastrointestinal (11; 25.5%) – ii) and the dose, in which in 19 cases (44%) it was higher than recommended by the literature. In addition, in 2 prescriptions (4.7%), the concomitant use of IBU and SSRI was observed and in 5 (11.6%) of IBU and lithium. Conclusion: the use of this drug often escaped safety and dosage criteria concerning scientific literature

NPK combinations mitigate the deleterious effects of salt stress on the morphophysiology of West Indian Cherry

Under salt stress, plant growth and development are negatively affected due to physiological changes,requiring strategies such as fertilization management to minimize these effects. In this scenario, this study aimedto evaluate the effect of combinations of nitrogen, phosphorus, and potassium on the growth, leaf waterstatus, electrolyte leakage, and gas exchange of West Indian Cherry grown under water stress in the secondyear of production. The experiment was conducted in a protected environment in Campina Grande - PB.The treatments were distributed in a randomized block design with a 2 × 10 factorial arrangement with threereplications corresponding to two electrical conductivity levels of irrigation water– ECw (0.6 and 4.0 dS m-1)and ten combinations of fertilization with nitrogen, phosphorus, and potassium (80-100-100; 100-100-100; 120-100-100; 140-100-100; 100-80-100; 100-120-100; 100-140-100; 100-100-80; 100-100-120, and 100-100-140% of therecommendation in the second year of production). Irrigation with the ECw of 4.0 dS m-1 negatively affectedplant growth, the leaf water status, electrolyte leakage, and the leaf gas exchange of West Indian Cherry.However, the 40% increase (C4 -140-100-100% of the recommended N-P2O5-K2O level) in the nitrogen levelmitigated the deleterious effects of salt stress on the relative water content, internal CO2 concentration, and theCO2 assimilation rate of West Indian Cherry plants in the second year of production.Under salt stress, plant growth and development are negatively affected due to physiological changes,requiring strategies such as fertilization management to minimize these effects. In this scenario, this study aimedto evaluate the effect of combinations of nitrogen, phosphorus, and potassium on the growth, leaf waterstatus, electrolyte leakage, and gas exchange of West Indian Cherry grown under water stress in the secondyear of production. The experiment was conducted in a protected environment in Campina Grande - PB.The treatments were distributed in a randomized block design with a 2 × 10 factorial arrangement with threereplications corresponding to two electrical conductivity levels of irrigation water– ECw (0.6 and 4.0 dS m-1)and ten combinations of fertilization with nitrogen, phosphorus, and potassium (80-100-100; 100-100-100; 120-100-100; 140-100-100; 100-80-100; 100-120-100; 100-140-100; 100-100-80; 100-100-120, and 100-100-140% of therecommendation in the second year of production). Irrigation with the ECw of 4.0 dS m-1 negatively affectedplant growth, the leaf water status, electrolyte leakage, and the leaf gas exchange of West Indian Cherry.However, the 40% increase (C4 -140-100-100% of the recommended N-P2O5-K2O level) in the nitrogen levelmitigated the deleterious effects of salt stress on the relative water content, internal CO2 concentration, and theCO2 assimilation rate of West Indian Cherry plants in the second year of production.

Impacto da quarentena do Covid-19 na qualidade de vida e nos aspectos psicológicos dos pacientes com doenças respiratórias crônicas / Impact of Covid-19 quarantine on quality of life and psychological aspects of patients with chronic respiratory diseases

As doenças respiratórias crônicas são alterações presentes tanto nas vias aéreas superiores como nas inferiores, como principais estão: Asma e Doença Pulmonar Obstrutiva Crônica (DPOC). Uma das alternativas de tratamento é o Programa de Reabilitação Pulmonar (PRP), que gera benefícios aos pacientes, observando melhoras nos aspectos funcionais, sociais e psicológicos.Uma alternativa viável e eficaz aos atendimentos presenciais é o PRP não supervisionado (RPNS), que tem como objetivo principal exercitar pacientes sob supervisão indireta. Os indivíduos são encorajados a utilizarem estratégias que aprenderam no Programa de Reabilitação Pulmonar Supervisionada (RPS) e realizarem os exercícios físicos nos seus domicílios. A mais recente ameaça à saúde global tem sido o surto em curso da doença infecciosa causada por um Coronavírus recém descoberto. Este novo Coronavírus denominado SARS-Cov-2, causador da doença COVID-19. Os objetivos desta pesquisa são avaliar o impacto do isolamento pela quarentena do COVID -19 na qualidade de vida, na capacidade funcional e nos aspectos psicológicos recorrentes em pacientes com doenças respiratórias crônicas e observar estes aspectos associados ao RPNS

Comparação do desempenho no teste de caminhada de seis minutos com o uso de concentrador portátil e oxigênio cilindro em pacientes com DPOC: Projeto piloto

Objetivo: Comparar o desempenho dos pacientes com DPOC no Teste de Caminhada de 6’, com a utilização do concentrador Portátil (pulsado/ contínuo) e Cilindro. Métodos: Trata-se de um estudo piloto observacional, foram recrutados 20 pacientes com DPOC, participantes do Ambulatório de Reabilitação Pulmonar do Centro Universitário FMABC. Os participantes foram submetidos à avaliação, realizaram o Questionário COPD Assessment Test  e o teste de caminhada de seis minutos com uso do cilindro de oxigênio e com concentrador portátil Concentrador De Oxigênio Portátil SimplyGo - Philips Respironics®  em modo contínuo (CPC) e concentrador portátil de modo pulsado (CPP). Foram verificadas a saturação de oxigênio (SpO2) e a frequência cardíaca (FC) por meio de um oxímetro portátil.  Os parâmetros aferidos antes e depois do teste foram os seguintes: (I) Pressão Arterial (PA), (II) FC, (III) SpO2 e (IV) Escala de Borg. Resultados: Quando comparadas as variáveis (SatO2, FC, Borg dispneia e MMII) em todos os momentos dos TC6’ nas diferentes formas de fornecimento, não houve diferença significativa, o que sugere que as fontes de O2 têm equiparidade no uso em pacientes com DPOC. Conclusões: o presente estudo sugere que os diferentes dispositivos de oxigênio CPC, CPP, C utilizados no TC6’, se mostraram equivalentes no desempenho e na performance física dos pacientes com DPOC

International Society of Human and Animal Mycology (ISHAM)-ITS reference DNA barcoding database - the quality controlled standard tool for routine identification of human and animal pathogenic fungi

Human and animal fungal pathogens are a growing threat worldwide leading to emerging infections and creating new risks for established ones. There is a growing need for a rapid and accurate identification of pathogens to enable early diagnosis and targeted antifungal therapy. Morphological and biochemical identification methods are time-consuming and require trained experts. Alternatively, molecular methods, such as DNA barcoding, a powerful and easy tool for rapid monophasic identification, offer a practical approach for species identification and less demanding in terms of taxonomical expertise. However, its wide-spread use is still limited by a lack of quality-controlled reference databases and the evolving recognition and definition of new fungal species/complexes. An international consortium of medical mycology laboratories was formed aiming to establish a quality controlled ITS database under the umbrella of the ISHAM working group on "DNA barcoding of human and animal pathogenic fungi." A new database, containing 2800 ITS sequences representing 421 fungal species, providing the medical community with a freely accessible tool at http://www.isham.org and http://its.mycologylab.org/ to rapidly and reliably identify most agents of mycoses, was established. The generated sequences included in the new database were used to evaluate the variation and overall utility of the ITS region for the identification of pathogenic fungi at intra-and interspecies level. The average intraspecies variation ranged from 0 to 2.25%. This highlighted selected pathogenic fungal species, such as the dermatophytes and emerging yeast, for which additional molecular methods/genetic markers are required for their reliable identification from clinical and veterinary specimens.This study was supported by an National Health and Medical Research Council of Australia (NH&MRC) grant [#APP1031952] to W Meyer, S Chen, V Robert, and D Ellis; CNPq [350338/2000-0] and FAPERJ [E-26/103.157/2011] grants to RM Zancope-Oliveira; CNPq [308011/2010-4] and FAPESP [2007/08575-1] Fundacao de Amparo Pesquisa do Estado de So Paulo (FAPESP) grants to AL Colombo; PEst-OE/BIA/UI4050/2014 from Fundacao para a Ciencia e Tecnologia (FCT) to C Pais; the Belgian Science Policy Office (Belspo) to BCCM/IHEM; the MEXBOL program of CONACyT-Mexico, [ref. number: 1228961 to ML Taylor and [122481] to C Toriello; the Institut Pasteur and Institut de Veil le Sanitaire to F Dromer and D Garcia-Hermoso; and the grants from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and the Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG) to CM de Almeida Soares and JA Parente Rocha. I Arthur would like to thank G Cherian, A Higgins and the staff of the Molecular Diagnostics Laboratory, Division of Microbiology and Infectious Diseases, Path West, QEII Medial Centre. Dromer would like to thank for the technical help of the sequencing facility and specifically that of I, Diancourt, A-S Delannoy-Vieillard, J-M Thiberge (Genotyping of Pathogens and Public Health, Institut Pasteur). RM Zancope-Oliveira would like to thank the Genomic/DNA Sequencing Platform at Fundacao Oswaldo Cruz-PDTIS/FIOCRUZ [RPT01A], Brazil for the sequencing. B Robbertse and CL Schoch acknowledge support from the Intramural Research Program of the NIH, National Library of Medicine. T Sorrell's work is funded by the NH&MRC of Australia; she is a Sydney Medical School Foundation Fellow.info:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio