392 research outputs found
Computational Nuclear Physics and Post Hartree-Fock Methods
We present a computational approach to infinite nuclear matter employing
Hartree-Fock theory, many-body perturbation theory and coupled cluster theory.
These lectures are closely linked with those of chapters 9, 10 and 11 and serve
as input for the correlation functions employed in Monte Carlo calculations in
chapter 9, the in-medium similarity renormalization group theory of dense
fermionic systems of chapter 10 and the Green's function approach in chapter
11. We provide extensive code examples and benchmark calculations, allowing
thereby an eventual reader to start writing her/his own codes. We start with an
object-oriented serial code and end with discussions on strategies for porting
the code to present and planned high-performance computing facilities.Comment: 82 pages, to appear in Lecture Notes in Physics (Springer), "An
advanced course in computational nuclear physics: Bridging the scales from
quarks to neutron stars", M. Hjorth-Jensen, M. P. Lombardo, U. van Kolck,
Editor
11β-hydroxysteroid dehydrogenase type I inhibition in solid tumours
Glucocorticoids, key hormonal regulators of the stress response, powerfully influence
inflammation and metabolism. Reducing excessive glucocorticoid exposure is
beneficial in treating metabolic and cognitive disorders, but manipulating systemic
endogenous glucocorticoids risks compromising their beneficial effects. The enzyme
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activates glucocorticoids in
target tissues and thus inhibition of this enzyme presents a clinical opportunity to
reduce tissue-specific glucocorticoid action. Active glucocorticoids also exert potent
angiostatic effects by binding the glucocorticoid receptor (GR), and 11β-HSD1
inhibitors have proven beneficial in models of myocardial infarction by promoting
angiogenesis. The possibility that 11β-HSD1 inhibitors may increase pathological
angiogenesis, such as that seen in solid tumours, remains unaddressed. This project
tested the hypothesis that 11β-HSD1 inhibition promotes tumour growth as a result of
increased angiogenesis, using murine models of squamous cell carcinoma (SCC) and
pancreatic ductal adenocarcinoma (PDAC).
Murine SCC or PDAC cells were injected (1x106 cells/flank) into WT female mice fed
either standard diet, or diet containing the 11β-HSD1 inhibitor UE2316 (175 mg/kg,
N=6/group), or into 11β-HSD1 knockout (Del1) mice fed standard diet. Developing
tumours were measured by callipers over several weeks, before animals were culled
and tissues collected. SCC tumours grew more rapidly in UE2316-treated mice to
reach a significantly (P<0.01) larger final volume (0.158 ± 0.037 cm3) than in control
mice (0.051 ± 0.007 cm3). PDA tumours were unaffected by 11β-HSD1 inhibition or
deletion. Immunofluorescent co-staining of tumour sections for CD31/α-smooth
muscle actin revealed no differences in vessel density, and RT-qPCR showed no
difference in angiogenic factor expression, after 11β-HSD1 inhibition/deletion in
either tumour type. GR and 11β-HSD1 RNA expression were greater in SCC vs PDAC
tumours (P<0.001), as was 11β-HSD1 activity (P<0.0001).
In studies using the aortic ring assay of ex vivo angiogenesis, 11β-HSD1 deletion, but
not inhibition with UE2316, was shown to prevent glucocorticoid-mediated
angiostasis. The growth/viability of tumour cell lines was not affected by UE2316 or
corticosterone, as assessed by live cell imaging using the Incucyte imaging system.
RNA-sequencing of SCC tumours revealed that multiple factors involved in the innate
immune/inflammatory response were reduced in UE2316-treated tumours, and that
extracellular matrix regulation was also altered by UE2316. Imaging of tumour
sections using Second Harmonic Generation microscopy confirmed that UE2316
altered Type I collagen deposition in SCC (P<0.001) but not PDAC.
11β-HSD1 inhibition can increase tumour growth, possibly via suppression of
inflammatory/immune cell signalling and alteration of the extracellular matrix, and
tumours with higher GR and 11β-HSD1 content, such as SCC, may be more at risk.
Interestingly this investigation found no evidence of increased angiogenesis in vivo or
ex vivo after UE2316 treatment, suggesting that 11β-HSD1 inhibition does not
promote angiogenesis in all ischaemic environments. Future work must focus on the
effects of 11β-HSD1 inhibition on the immune and extracellular matrix component of
the tumour microenvironment. While promotion of pathological angiogenesis does not
appear to pose a major threat, 11β-HSD1 inhibitors may still interact with the immune
and inflammatory environment in tumours to the detriment of health
Perturbative and nonperturbative contributions to the strange quark asymmetry in the nucleon
There are two mechanisms for the generation of an asymmetry between the
strange and anti-strange quark distributions in the nucleon: nonperturbative
contributions originating from nucleons fluctuating into virtual baryon-meson
pairs such as and , and perturbative contributions
arising from gluons splitting into strange and anti-strange quark pairs. While
the nonperturbative contributions are dominant in the large- region, the
perturbative contributions are more significant in the small- region. We
calculate this asymmetry taking into account both nonperturbative and
perturbative contributions, thus giving a more accurate evaluation of this
asymmetry over the whole domain of . We find that the perturbative
contributions are generally a few times larger in magnitude than the
nonperturbative contributions, which suggests that the best region to detect
this asymmetry experimentally is in the region . We find that
the asymmetry may have more than one node, which is an effect that should be
taken into account, e.g. for parameterizations of the strange and anti-strange
quark distributions used in global analysis of parton distributions.Comment: 14 pages, 4 figures, figures comparing theoretical calculations with
NNPDF global analysis added, accepted for publication in EPJ
Non-standard Hamiltonian effects on neutrino oscillations
We investigate non-standard Hamiltonian effects on neutrino oscillations,
which are effective additional contributions to the vacuum or matter
Hamiltonian. Since these effects can enter in either flavor or mass basis, we
develop an understanding of the difference between these bases representing the
underlying theoretical model. In particular, the simplest of these effects are
classified as ``pure'' flavor or mass effects, where the appearance of such a
``pure'' effect can be quite plausible as a leading non-standard contribution
from theoretical models. Compared to earlier studies investigating particular
effects, we aim for a top-down classification of a possible ``new physics''
signature at future long-baseline neutrino oscillation precision experiments.
We develop a general framework for such effects with two neutrino flavors and
discuss the extension to three neutrino flavors, as well as we demonstrate the
challenges for a neutrino factory to distinguish the theoretical origin of
these effects with a numerical example. We find how the precision measurement
of neutrino oscillation parameters can be altered by non-standard effects alone
(not including non-standard interactions in the creation and detection
processes) and that the non-standard effects on Hamiltonian level can be
distinguished from other non-standard effects (such as neutrino decoherence and
decay) if we consider specific imprint of the effects on the energy spectra of
several different oscillation channels at a neutrino factory.Comment: 30 pages, 6 figures, LaTeX, final version, published in Eur.Phys.J.
Reassessment of the NuTeV determination of the Weinberg angle
In light of the recent discovery of the importance of the isovector EMC
effect for the interpretation of the NuTeV determination of sin^2 theta_W, it
seems timely to reassess the central value and the errors on this fundamental
Standard Model parameter derived from the NuTeV data. We also include earlier
work on charge symmetry violation and the recent limits on a possible asymmetry
between s and \bar{s} quarks. With these corrections we find a revised NuTeV
result of sin^2 theta_W = 0.2232 \pm 0.0013(stat) \pm 0.0024(syst), which is in
excellent agreement with the running of sin^2 theta_W predicted by the Standard
Model.Comment: 4 pages, one figur
Relic Neutrino Absorption Spectroscopy
Resonant annihilation of extremely high-energy cosmic neutrinos on big-bang
relic anti-neutrinos (and vice versa) into Z-bosons leads to sizable absorption
dips in the neutrino flux to be observed at Earth. The high-energy edges of
these dips are fixed, via the resonance energies, by the neutrino masses alone.
Their depths are determined by the cosmic neutrino background density, by the
cosmological parameters determining the expansion rate of the universe, and by
the large redshift history of the cosmic neutrino sources. We investigate the
possibility of determining the existence of the cosmic neutrino background
within the next decade from a measurement of these absorption dips in the
neutrino flux. As a by-product, we study the prospects to infer the absolute
neutrino mass scale. We find that, with the presently planned neutrino
detectors (ANITA, Auger, EUSO, OWL, RICE, and SalSA) operating in the relevant
energy regime above 10^{21} eV, relic neutrino absorption spectroscopy becomes
a realistic possibility. It requires, however, the existence of extremely
powerful neutrino sources, which should be opaque to nucleons and high-energy
photons to evade present constraints. Furthermore, the neutrino mass spectrum
must be quasi-degenerate to optimize the dip, which implies m_{nu} >~ 0.1 eV
for the lightest neutrino. With a second generation of neutrino detectors,
these demanding requirements can be relaxed considerably.Comment: 19 pages, 26 figures, REVTeX
The Nucleon's Virtual Meson Cloud and Deep Inelastic Lepton Scattering
We address the question whether the nucleon's antiquark sea can be attributed
entirely to its virtual meson cloud and, in essence, whether there exists a
smooth transition between hadronic and quark-gluon degrees of freedom. We take
into account contributions from and mesons and compare with the
nucleon's antiquark distributions which serve as a non-perturbative input to
the QCD evolution equations. We elucidate the different behavior in the flavor
singlet and non-singlet channels and study the dependence of our results on the
scale . The meson-nucleon cut-offs that we determine give not only an
indication on the size of the region within which quarks are confined in a
nucleon, but we find that the scale of these form factors is closely related to
the four-momentum transfer, , where gluons are resolved by a high energy
probe, and that large meson loop momenta, GeV,
contribute significantly to the sea quark distributions. While the agreement of
our calculations with data-based parametrizations is satisfactory and scale
independent for the flavor breaking share of the nucleon's antiquark sea, the
flavor singlet component is quite poorly described. This hints the importance
of gluon degrees of freedom.Comment: 34 pages, RevTeX, 6 figures optionally included using epsfig.st
Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation
The current status of electric dipole moments of diamagnetic atoms which
involves the synergy between atomic experiments and three different theoretical
areas -- particle, nuclear and atomic is reviewed. Various models of particle
physics that predict CP violation, which is necessary for the existence of such
electric dipole moments, are presented. These include the standard model of
particle physics and various extensions of it. Effective hadron level combined
charge conjugation (C) and parity (P) symmetry violating interactions are
derived taking into consideration different ways in which a nucleon interacts
with other nucleons as well as with electrons. Nuclear structure calculations
of the CP-odd nuclear Schiff moment are discussed using the shell model and
other theoretical approaches. Results of the calculations of atomic electric
dipole moments due to the interaction of the nuclear Schiff moment with the
electrons and the P and time-reversal (T) symmetry violating
tensor-pseudotensor electron-nucleus are elucidated using different
relativistic many-body theories. The principles of the measurement of the
electric dipole moments of diamagnetic atoms are outlined. Upper limits for the
nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained
combining the results of atomic experiments and relativistic many-body
theories. The coefficients for the different sources of CP violation have been
estimated at the elementary particle level for all the diamagnetic atoms of
current experimental interest and their implications for physics beyond the
standard model is discussed. Possible improvements of the current results of
the measurements as well as quantum chromodynamics, nuclear and atomic
calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for
EPJ
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS
The chi_b(nP) quarkonium states are produced in proton-proton collisions at
the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS
detector. Using a data sample corresponding to an integrated luminosity of 4.4
fb^-1, these states are reconstructed through their radiative decays to
Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks
corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new
structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is
also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes.
This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table,
corrected author list, matches final version in Physical Review Letter
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