Methods for medical device and equipment procurement in low and middle-income countries

40-70% of medical devices and equipment in low- and middle-income countries (LMICs) are broken, unused or unfit for purpose: ad-hoc, undiscerning and inefficient procurement methods and processes contribute towards this problem. This thesis presents the findings of four original studies on medical device and equipment procurement within LMICs. Chapter I reports findings of a systematic literature review on procurement and prioritization methods; recommendations from reviewed literature are synthesised. Chapter II describes fieldwork conducted in The Gambia and Romania to explore the processes and dynamics behind medical device procurement in contrasting settings. Findings suggest procurement processes are strongly influenced by political/cultural power dynamics; health technology assessment evidence is rarely considered. Chapter III discusses the feasibility of conducting medical device specific economic evaluations for informing procurement planning. A case study on the costeffectiveness of alternative treatment interventions for femur-shaft fracture fixation in Sub-Saharan Africa is presented. Chapter IV consists of a critical appraisal of the medical device specific elements of the One Health Tool for health system planning. The thesis concludes with a discussion contextualizing the findings and suggestions for further research

ASPECTS REGARDING THE PHYSIOLOGICAL PARAMETERS IN SOME LOCAL POPULATIONS OF CAPSICUM ANNUUM SSP. GROSSUM UNDER STRESS CONDITIONS

In this paper are presented results regarding the physiological behavior of some local populations of Capsicum annuum ssp. grossum, cultivated compared to the control variety Cornel on sandy soils from the Research and Development Station for Plant Culture on Sands, Dăbuleni. The researches focused on the effects of thermal stress on the processes of photosynthesis and foliar transpiration, as well as on the productions made in pepper culture. The results obtained underlined the importance of correlating the physiological processes in pepper plants with environmental factors and the yields obtained. Under conditions of heat stress, all local populations analyzed showed values of photosynthesis above the values recorded at the control variant (Cornel variety). The water lost through foliar transpiration was efficiently recovered by the studied local populations, between transpiration and pepper production being established a positive correlation, significant from statistically point of view

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer

According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further is associated with cell growth, proliferation, and survival, but also with activation of glucose metabolism. Mutations of the AKT signaling pathway components (especially PI3KCA and PTEN) have been observed in breast cancer patients, which are associated with resistance to hormonal treatment. Many clinical trials are testing the effect of AKT inhibition in order to block the growth and proliferation of breast cancer cells. The purpose of this review is to present the incidence of this neoplastic disease, to describe AKT signaling pathways activation, mutations that occur at its level, and inhibitors that can block this protein kinase

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Levels of nitrates in groundwater i

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer

According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further is associated with cell growth, proliferation, and survival, but also with activation of glucose metabolism. Mutations of the AKT signaling pathway components (especially PI3KCA and PTEN) have been observed in breast cancer patients, which are associated with resistance to hormonal treatment. Many clinical trials are testing the effect of AKT inhibition in order to block the growth and proliferation of breast cancer cells. The purpose of this review is to present the incidence of this neoplastic disease, to describe AKT signaling pathways activation, mutations that occur at its level, and inhibitors that can block this protein kinase

UMAN – a pluralistic view of uncertainty management

Decisions associated with Radioactive Waste (RW) Management programmes are made in the presence of irreducible and reducible uncertainties. Responsibilities and roles of each actor, the nature of the RW disposal programme and the stage in its implementation influence the preferences of each category of actors in approaching uncertainty management. UMAN (UMAN – Uncertainties Management Multi-Actor Network is a Work Package of the European Radioactive Waste Management Programme – EURAD) carries out a strategic study about the management of uncertainties based on extended exchanges among actors representing Waste Management Organisations, Technical Support Organisations, Research Entities and Civil Society, a review of knowledge generated by past and ongoing R&D projects, and findings of international organisations. UMAN discusses the classification schemes and approaches applied in uncertainty management, and identifies possible actions to be considered in the uncertainty treatment. The relevance for the safety of the uncertainties associated with waste inventory, including spent fuel, near-field, site and geosphere and human aspects, as perceived by each type of actors, and approaches used in their management are explored with the aim to reach either a common understanding on how uncertainties relate to risk and safety and how to deal with them along the programme implementation, or at least arrive at a mutual understanding of each individual view. Finally, uncertainties assessed as highly significant and the associated R&D issues that can be further investigated are being identified

Education, training and mobility: towards a common effort to assure a future workforce in Europe and abroad

The paper highlights the main features of some Euratom projects, which have been running recently in support to education, training and mobility in the nuclear fields. The described projects address various critical aspects of nuclear knowledge management, aiming at maintaining the wealth of nuclear expertise in Europe in an environment characterised by decreased attractiveness of nuclear careers. In an effort to broaden the cooperation and to further extend the opportunities for mobility, some projects ran in parallel with similar initiatives undertaken beyond the European borders. The lesson learnt in terms of successes achieved and critical aspects revealed by the different actions are finally discussed also considering recent recommendations and assessed scenarios by the European Commission for the decarbonisation of the energy sector

Digitalisation for nuclear waste management: predisposal and disposal

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Support for UNRWA's survival

The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides life-saving humanitarian aid for 5·4 million Palestine refugees now entering their eighth decade of statelessness and conflict. About a third of Palestine refugees still live in 58 recognised camps. UNRWA operates 702 schools and 144 health centres, some of which are affected by the ongoing humanitarian disasters in Syria and the Gaza Strip. It has dramatically reduced the prevalence of infectious diseases, mortality, and illiteracy. Its social services include rebuilding infrastructure and homes that have been destroyed by conflict and providing cash assistance and micro-finance loans for Palestinians whose rights are curtailed and who are denied the right of return to their homeland

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements