In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins

Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method. We studied the absorption property of ACGs in rat's intestine, which showed there was a good absorption and uptake percentages with solid dispersion. The study on uptake percentage in different regions of rat's intestine attested that the duodenum had the best permeability, followed by jejunum, ileum, and colon in order with no significant differences. So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins

Calibration of the Timing Performance of GECAM-C

As a new member of the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) after GECAM-A and GECAM-B, GECAM-C (originally called HEBS), which was launched on board the SATech-01 satellite on July 27, 2022, aims to monitor and localize X-ray and gamma-ray transients from $\sim$ 6 keV to 6 MeV. GECAM-C utilizes a similar design to GECAM but operates in a more complex orbital environment. In this work, we utilize the secondary particles simultaneously produced by the cosmic-ray events on orbit and recorded by multiple detectors, to calibrate the relative timing accuracy between all detectors of GECAM-C. We find the result is 0.1 $\mu \rm s$, which is the highest time resolution among all GRB detectors ever flown and very helpful in timing analyses such as minimum variable timescale and spectral lags, as well as in time delay localization. Besides, we calibrate the absolute time accuracy using the one-year Crab pulsar data observed by GECAM-C and Fermi/GBM, as well as GECAM-C and GECAM-B. The results are $2.02\pm 2.26\ \mu \rm s$ and $5.82\pm 3.59\ \mu \rm s$, respectively. Finally, we investigate the spectral lag between the different energy bands of Crab pulsar observed by GECAM and GBM, which is $\sim -0.2\ {\rm \mu s\ keV^{-1}}$.Comment: submitte

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Born for fairness: evidence of genetic contribution to a neural basis of fairness intuition

Human beings often curb self-interest to develop and enforce social norms, such as fairness, as exemplified in the ultimatum game (UG). Inspired by the dual-system account for the responder&#39;s choice during the UG, we investigated whether the neural basis of psychological process induced by fairness is under genetic control using a twin fMRI study (62 monozygotic, 48 dizygotic; mean age: 19.32 +/- 1.38years). We found a moderate genetic contribution to the rejection rate of unfair proposals (24%-35%), independent of stake size or proposer type, during the UG. Using a voxel-level analysis, we found that genetic factors moderately contributed to unfairness-evoked activation in the bilateral anterior insula (AI), regions representing the intuition of fairness norm violations (mean heritability: left 37%, right 40%). No genetic contributions were found in regions related to deliberate, controlled processes in the UG. This study provides the first evidence that evoked brain activity by unfairness in the bilateral AI is influenced by genes and sheds light on the genetic basis of brain processes underlying costly punishment.</p

One-step hydrothermal synthesis of 2D WO3 nanoplates@ graphene nanocomposite with superior anode performance for lithium ion battery

The WO3 nanosheet@reduced graphene oxide (WO3 nanosheet@rGO) square particles have been synthesized successfully by a hydrothermal method. The structure and polymorphy of the particle are well characterized by XRD, FT-IR, XPS, SEM, TEM, HRTEM, Raman spectra and BET analysis. The electrochemical behaviors are researched by using CV, galvanostatic cycle and EIS. The results indicate that the special combination about the two-dimension WO3 nanoplate and graphene scales can promote the electrochemical properties of the metallic oxide effectively. Compared with the pure WO3, a higher initial discharge capacity of the WO3 nanosheet@rGO composite is 1143 mA h g(-1), the reversible capacity can also maintain in 1005.7 mA h g(-1) after 150 cycles in the condition of 100 mA g(-1) and 0.01-3 V. The outstanding electrochemical performances composite demonstrates that WO3 nanosheet@rGO synthesized by this method is feasible and could be used as a promising anode material for LIBs. (C) 2019 Elsevier Ltd. All rights reserved