?????? ????????? ?????? ????????? ?????? ?????? ?????? ????????? ????????? ??????: ????????? ???????????? ????????????

Department of Urban and Environmental Engineering (Urban Infrastructure Engineering)This study analyzes the impact of housing prices on nearby houses by phase of housing reconstruction. Existing prior studies have analyzed the effect of fundamental changes in neighborhood prices, such as housing redevelopment or ???New Town??? project. Also, the prior papers related to housing reconstruction did not carry out generalizable analyses, they are based on case studies. This study classified the 16th phase of housing reconstruction into 4th phase through the operational definition. Subsequent steps were followed by an analysis of how residential prices in the neighborhood were affected. The analysis method used a hierarchy-linear hedonic model. This study was analyzed based on the prices of apartments that are common to houses, especially Seoul. Therefore, the model was used to control the effects of the apartment complex. The finding of this study is as follows. 1) The role of the reconstruction apartment stage is different, and the effects of each stage are also different. 2) Depending on the extent of the surrounding neighborhood like neighborhoods in 400m or 800m, the impact of changes in the housing reconstruction is different. 3) Differences in impact are related to the classification of neighboring housing markets. The effect of the sale is different on the basis of the 20 years of construction. This is related to the progress of nearby reconstruction on the grounds that it can determine expectations of possible reconstruction. This may have affected the market with expectations of possible reconstruction and the possibility of replacement by new housing. In the case of Rent Market, the market is affected by physical changes, such as Move-in to apartments where migration demand and reconstruction have been completed as the reconstruction process progresses. However, the study was conducted only on Songpa-gu in Seoul. Therefore, it is difficult to draw up implications for the overall Seoul reconstruction market. Also, it is difficult to derive a clear understanding of whether the peripheral effects of reconstruction are short-term or long-term.ope

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

A first update on mapping the human genetic architecture of COVID-19

peer reviewe