El consumo de revista electrónicas Modalidades de acceso y pautas de uso

Trabajo de Fin de Máster del Máster de Sistemas de Información Digital, curso 2010 - 2011[ES] El presente estudio presenta los resultados de una encuesta sobre los hábitos de uso y de consumo de revistas electrónicas realizada entre el profesorado de la Facultad de Traducción y Documentación de la Universidad de Salamanca. La encuesta intenta recabar datos sobre conocimiento y utilización de las revistas electrónicas, cuales son los hábitos de búsqueda de artículos de los investigadores, cuales son los distribuidores que prefieren o cuales son aquellas revistas que consultan con gran asiduidad. El estudio tiene en cuenta variables como la disciplina, la edad, la categoría profesional y el sexo de los encuestados Los resultados revelan un elevado grado de conocimiento y utilización de las revistas electrónicas, además de la preferencia de los encuestados por la lectura en formato electrónico. Asimismo, se expresa la valoración de las revistas electrónicas por su fácil uso y por el ahorro de tiempo que estas suponen a su labor investigadora. [EN] The current study contains the results of a survey about the habits, use and consume of electronics journals among teaching staff of Translation and Documentation Faculty of the Salamanca University. This survey tries to obtain data about the knowledge and the use of electronic journals by the researchers, who the distributors are, the investigators preferences, or which journals they consult more often. The survey is concerned with factors like the discipline, the age, the professional class, and the sex of people polled. The results reveal high degree of knowledge and a high utilization of the electronic journals, furthermore the preference of the people polled for the electronic reading. The survey expressed the evaluation of the electronic journals because of the easy use and the save of a lot of time to the investigators

Effect of particle size on the hydration kinetics and microstructural development of tricalcium silicate

Impure tricalcium silicate (Alite, C3S) is the most important and abundant phase of Portland cement. It reacts quickly with water to give calcium hydroxide (CH) and calcium silicate hydrate (C-S-H) which is the most important phase for strength development. It is well known that the C3S particle size distribution plays an important role on the hydration kinetics, microstructural development and final properties of hydrated cement pastes. The general aim of the present investigation was to gain insight on the effect of particle size on the hydration kinetics and microstructural development of alite pastes. In this study, alite was synthesized and separated into different gradations. The hydration kinetics was investigated by means of isothermal calorimetry and chemical shrinkage. The microstructural developments of the different gradations of alite were studied and compared using different techniques such as: SEM, TEM, XRD, He pycnometry, N2 adsorption, etc. The hydration kinetics during the different stages of the hydration was observed to be dependent on the initial particle size of the grains and also related with the defect concentration on the surface of the grains. Higher rates of reaction were observed for powders with higher specific surface area. A linear relationship between the rate constant and the specific surface area was observed. Further, it was observed that the hydration kinetics of multi-sized system during the nucleation and growth process can be modeled as the linear addition of individual particles. The microstructural development of C3S pastes at later ages was found to be poorly affected by the initial particle size; the nature of the hydration products is the same. The only differences concern the capillary porosity and the C-S-H density. Slightly higher values of capillary porosity and C-S-H density were measured for smaller particles. The most likely explanation can be related with a different initial arrangement of the grains

Dynamic downscaling of wind speed over the North Atlantic Ocean using CMIP6 projections: implications for offshore wind power density

Offshore wind energy is an important agent to fight climate change. However, it is simultaneously very sensitive to climate change. This study analyzes the future changes in wind speed of 10 m above sea surface (V10) in the North Atlantic Ocean and how these variations may affect offshore wind energy resources for three potential subregions (the United States (US) East Coast, western Iberian Peninsula, and the Caribbean Sea). Dynamic downscaling of three different future scenarios of the CESM2 global climate model (CMIP6 project) was performed using the WRF-ARW atmospheric model. V10 is expected to decrease in the winter and spring seasons but increase in summer and autumn, mainly in tropical regions up to 30 °N. Annually, it shows the maximum increase in the tropical region. For the Iberian Peninsula subregion, significant increases in summer are expected for wind power density (WPD) along the 21st century, but there is uncertainty for the other seasons. A WPD decrease in winter and increases in summer and autumn are expected along the 21st century for the US subregion. No significant changes were observed at annual scale. Finally, for the Caribbean Sea, a decrease is projected in the Yucatan Basin and considerable increases are foreseen for the Colombia and Venezuela basins.Xunta de Galicia | Ref. ED481A-2020/193Xunta de Galicia | Ref. ED431C 2021/44Agencia Estatal de Investigación | Ref. JC2020-043745-IAgencia Estatal de Investigación | Ref. PID2021-22314OB-I00Universidade de Vigo/CISU

Inhibiting HER3 Hyperphosphorylation in HER2‐Overexpressing Breast Cancer through Multimodal Therapy with Branched Gold Nanoshells

Treatment failure in breast cancers overexpressing human epidermal growth factor receptor 2 (HER2) is associated mainly to the upregulation of human epidermal growth factor receptor 3 (HER3) oncoprotein linked to chemoresitence. Therefore, to increase patient survival, here a multimodal theranostic nanoplatform targeting both HER2 and HER3 is developed. This consists of doxorubicin-loaded branched gold nanoshells functionalized with the near-infrared (NIR) fluorescent dye indocyanine green, a small interfering RNA (siRNA) against HER3, and the HER2-specific antibody Transtuzumab, able to provide a combined therapeutic outcome (chemo- and photothermal activities, RNA silencing, and immune response). In vitro assays in HER2+/HER3+ SKBR-3 breast cancer cells have shown an effective silencing of HER3 by the released siRNA and an inhibition of HER2 oncoproteins provided by Trastuzumab, along with a decrease of the serine/threonine protein kinase Akt (p-AKT) typically associated with cell survival and proliferation, which helps to overcome doxorubicin chemoresistance. Conversely, adding the NIR light therapy, an increment in p-AKT concentration is observed, although HER2/HER3 inhibitions are maintained for 72 h. Finally, in vivo studies in a tumor-bearing mice model display a significant progressively decrease of the tumor volume after nanoparticle administration and subsequent NIR light irradiation, confirming the potential efficacy of the hybrid nanocarrierE.V.-A. and I.G.-C. contributed equally to this work. This work was sup ported by the Agencia Estatal de Investigación (AEI) through Project No. PID2019-109517RB-I00) and from the Xunta de Galicia, Project No. ED431C2022/18. European Regional Development Funds are also ac knowledged. A.A.-M. and P.T. also thank the International Scientific Part nership Program ISSP at King Saud University for additional funding of this research through Grant No. ISPP-144. This work also received fi nancial support from the ISCIII, Ministerio de Economía y Competitivi dad (Grant No. PI15/01129; J.A.C.), and the AEI (Grant No. PID2020- 113501RB-I00; J.A.C.). I.-G.C. thanks for financial support through Grant No. PRE/2011/131, and the Centro Singular de Investigación de Galicia accreditation Grant No. 2016–2019 ED431G/05)S

Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System

The endocrine system coordinates a wide array of body functions mainly through secretion of hormones and their actions on target tissues. Over the last decades, a collective effort between developmental biologists, geneticists, and stem cell biologists has generated a wealth of knowledge related to the contribution of stem/progenitor cells to both organogenesis and self-renewal of endocrine organs. This review provides an up-to-date and comprehensive overview of the role of tissue stem cells in the development and self-renewal of endocrine organs. Pathways governing crucial steps in both development and stemness maintenance, and that are known to be frequently altered in a wide array of endocrine disorders, including cancer, are also described. Crucially, this plethora of information is being channeled into the development of potential new cell-based treatment modalities for endocrine-related illnesses, some of which have made it through clinical trials

Perceptions of teachers and directors about the factors that promote or constrain environmental education in schools of Metropolitan Area of Buenos Aires, Argentina

El trabajo aborda las percepciones de docentes y directores de escuelas acerca delos factores que promueven u obstaculizan una educación ambiental compleja, generadora de conocimientos, con dispositivos participativos y orientados a la equidad en instituciones educativas del Área Metropolitana de Buenos Aires (Argentina). Como resultado se observaron experiencias heterogéneas y voluntad de instalar nuevas prácticas, pero con factores que limitan el cambio: pautas culturales arraigadas; deficiencias en la capacitación docente, en cuanto a las políticas públicas; poca claridad en las definiciones sobre los objetivos de la educación ambiental, su abordaje curricular y los dispositivos pedagógicos. Prevalecen enfoques fragmentados, naturalistas y la ausencia de una visión crítica. A nivel institucional, se discute lapertinencia de implementar prácticas sustentables en el aula. Las propias percepciones también operan como obstáculos. Todo esto dificulta la adopción de nuevas acciones de educación ambiental con el ímpetu necesario para sostenerlas en el tiempo.The paper examines the perceptions of teachers and directors regarding the factors that promote or constrain complex environmental education, which generates knowledge, with participatory devices and oriented to equity in educational institutions in Metropolitan Area of Buenos Aires (Argentina). As result, we detected heterogeneous experiences and willingness to set new practices up. But there are factors limiting the change: deep-rooted cultural customs; shortcomings in terms of teacher training; in public policies a lack of clarity about environmental education objectives, curricular approach and pedagogical devices. Fragmented and naturalists approaches, and lack of a critical perspective prevail. At the institutional level, the relevance of implementing sustainable practices in classroom is discussed. Perceptions also operate as obstacles. All this hinders the adoption of new environmental education actions and the momentum needed to sustain them over time.Fil: Saidon, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Claverie, Julieta Andrea. Universidad Nacional de Tres de Febrero. Nucleo Interd de Formación y Est P/e/des D/l/educ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Dynamic downscaling of wind speed over the North Atlantic Ocean using CMIP6 projections: Implications for offshore wind power density

Offshore wind energy is an important agent to fight climate change. However, it is simultaneously very sensitive to climate change. This study analyzes the future changes in wind speed of 10 m above sea surface (V10) in the North Atlantic Ocean and how these variations may affect offshore wind energy resources for three potential subregions (the United States (US) East Coast, western Iberian Peninsula, and the Caribbean Sea). Dynamic downscaling of three different future scenarios of the CESM2 global climate model (CMIP6 project) was performed using the WRF-ARW atmospheric model. V10 is expected to decrease in the winter and spring seasons but increase in summer and autumn, mainly in tropical regions up to 30 °N. Annually, it shows the maximum increase in the tropical region. For the Iberian Peninsula subregion, significant increases in summer are expected for wind power density (WPD) along the 21st century, but there is uncertainty for the other seasons. A WPD decrease in winter and increases in summer and autumn are expected along the 21st century for the US subregion. No significant changes were observed at annual scale. Finally, for the Caribbean Sea, a decrease is projected in the Yucatan Basin and considerable increases are foreseen for the Colombia and Venezuela basins

Empirical Comparison of Graph-based Recommendation Engines for an Apps Ecosystem

Recommendation engines (RE) are becoming highly popular, e.g., in the area of e-commerce. A RE offers new items (products or content) to users based on their profile and historical data. The most popular algorithms used in RE are based on collaborative filtering. This technique makes recommendations based on the past behavior of other users and the similarity between users and items. In this paper we have evaluated the performance of several RE based on the properties of the networks formed by users and items. The RE use in a novel way graph theoretic concepts like edges weights or network flow. The evaluation has been conducted in a real environment (ecosystem) for recommending apps to smartphone users. The analysis of the results allows concluding that the effectiveness of a RE can be improved if the age of the data, and if a global view of the data is considered. It also shows that graph-based RE are effective, but more experiments are required for a more accurate characterization of their properties

Temporal Stability of Dominant Frequency as Predictor of Atrial Fibrillation Recurrence

[EN] Catheter ablation is one of the main therapies for restoring sinus rhythm in patients with atrial fibrillation (AF), yet AF termination ratios are far from satisfactory. The goal of this work is to study if temporal stability of dominant frequencies (DFs) of electrograms (EGMs) can be used as predictor of AF recurrence. EGMs were recorded from 29 AF patients using 64- pole basket catheters during the ablation procedure. DFs before ablation were obtained for 4-second overlapping fragments of EGM recordings with a 0.4 s shift, and their temporal stability was evaluated for short-term (between 8 and 12 s) and long-term time intervals (>5 min). Patients were classified as AF (N=15) if sinus rhythm was not maintained in a 12-month post-ablation followup, and AF free otherwise (N=14). Significant differences were found in the short-term analysis between AF free and AF patients for the difference between the mode value in DFs (p=0.045), as well as for the long-term analysis for the normalized average between DFs (p=0.028) and the average between DFs (p=0.043). More stable values were found for AF free patients for all statistically significant metrics. Short- and long-term temporal stability of DF values of EGM signals were found to be associated with the 12- month success rate of ablative therapies of AF patients.This work was supported by the Instituto de Salud Carlos III FEDER (DTS16/00160; PI16/01123; PI17/01059; PI17/01106), the EIT-HEALTH 19600 AFFINE and the Valencian Regional Government (AICO2018).Costoya-Sánchez, A.; Climent, AM.; Hernández-Romero, I.; Liberos, A.; Fernández-Avilés, F.; Narayan, SM.; Atienza, F.... (2019). Temporal Stability of Dominant Frequency as Predictor of Atrial Fibrillation Recurrence. IEEE. 1-4. https://doi.org/10.22489/CinC.2019.360S1