Miocene paleoaltimetry of the Mt. Everest region

Abstract HKT-ISTP 2013 A

Efficacy and safety of blonanserin transdermal patch in patients with schizophrenia: A 6-week randomized, double-blind, placebo-controlled, multicenter study

© 2019 The Authors Background: Blonanserin is a second-generation antipsychotic used for the treatment of schizophrenia. This study determined the efficacy, safety and pharmacokinetics of a blonanserin transdermal patch in patients with acutely exacerbated schizophrenia. Methods: This double-blind, multicenter, phase 3 study consisted of a 1-week observation period during which patients were treated with two patches of placebo, followed by a 6-week double-blind period where patients were randomized (1:1:1) to receive once-daily blonanserin 40 mg, blonanserin 80 mg, or placebo patches. The primary endpoint was the change from baseline in the total Positive and Negative Symptom Scale (PANSS) score. Safety assessments included treatment-emergent adverse events (TEAEs). Results: Between December 2014 and October 2018, patients were recruited and randomly assigned to blonanserin 40 mg (n = 196), blonanserin 80 mg (n = 194), or placebo (n = 190); of these, 77.2% completed the study. Compared with placebo, blonanserin significantly improved PANSS total scores at 6 weeks (least square mean [LSM] difference vs placebo: −5.6 with blonanserin 40 mg; 95% confidence interval [CI] −9.6, −1.6; adjusted p = 0.007, and − 10.4 with blonanserin 80 mg; 95% CI −14.4, −6.4; adjusted p \u3c 0.001). Blonanserin was well tolerated; the most common TEAEs reported were application-site erythema and pruritus, akathisia, tremor, and insomnia. Conclusions: Blonanserin transdermal patch improved the symptoms of acute schizophrenia with acceptable tolerability

A statistical gap-filling method to interpolate global monthly surface ocean carbon dioxide data

We have developed a statistical gap-filling method adapted to the specific coverage and prop-erties of observed fugacity of surface ocean CO2(fCO2). We have used this method to interpolate the Sur-face Ocean CO2Atlas (SOCAT) v2 database on a 2.5832.58 global grid (south of 708N) for 1985–2011 atmonthly resolution. The method combines a spatial interpolation based on a ‘‘radius of influence’’ to deter-mine nearby similar fCO2values with temporal harmonic and cubic spline curve-fitting, and also fits long-term trends and seasonal cycles. Interannual variability is established using deviations of observations fromthe fitted trends and seasonal cycles. An uncertainty is computed for all interpolated values based on thespatial and temporal range of the interpolation. Tests of the method using model data show that it performsas well as or better than previous regional interpolation methods, but in addition it provides a near-globaland interannual coverage

Eocene and Miocene extension, meteoric fluid infiltration, and core complex formation in the Great Basin (Raft River Mountains, Utah)

Metamorphic core complexes (MCCs) in the North American Cordillera reflect the effects of lithospheric extension and contribute to crustal adjustments both during and after a protracted subduction history along the Pacific plate margin. While the Miocene-to-recent history of most MCCs in the Great Basin, including the Raft River-Albion-Grouse Creek MCC, is well documented, early Cenozoic tectonic fabrics are commonly severely overprinted. We present stable isotope, geochronological (40Ar/39Ar), and microstructural data from the Raft River detachment shear zone. Hydrogen isotope ratios of syntectonic white mica (δ2Hms) from mylonitic quartzite within the shear zone are very low (-90‰ to -154‰, Vienna SMOW) and result from multiphase synkinematic interaction with surface-derived fluids. 40Ar/39Ar geochronology reveals Eocene (re)crystallization of white mica with δ2Hms ≥ -154‰ in quartzite mylonite of the western segment of the detachment system. These δ2Hms values are distinctively lower than in localities farther east (δ2Hms ≥ -125‰), where 40Ar/39Ar geochronological data indicate Miocene (18-15 Ma) extensional shearing and mylonitic fabric formation. These data indicate that very low δ2H surface-derived fluids penetrated the brittle-ductile transition as early as the mid-Eocene during a first phase of exhumation along a detachment rooted to the east. In the eastern part of the core complex, prominent top-to-the-east ductile shearing, mid-Miocene 40Ar/39Ar ages, and higher δ2H values of recrystallized white mica, indicate Miocene structural and isotopic overprinting of Eocene fabrics

A multi-decade record of high quality fCO2 data in version 3 of the Surface Ocean CO2 Atlas (SOCAT)

The Surface Ocean CO2 Atlas (SOCAT) is a synthesis of quality-controlled fCO2 (fugacity of carbon dioxide) values for the global surface oceans and coastal seas with regular updates. Version 3 of SOCAT has 14.7 million fCO2 values from 3646 data sets covering the years 1957 to 2014. This latest version has an additional 4.6 million fCO2 values relative to version 2 and extends the record from 2011 to 2014. Version 3 also significantly increases the data availability for 2005 to 2013. SOCAT has an average of approximately 1.2 million surface water fCO2 values per year for the years 2006 to 2012. Quality and documentation of the data has improved. A new feature is the data set quality control (QC) flag of E for data from alternative sensors and platforms. The accuracy of surface water fCO2 has been defined for all data set QC flags. Automated range checking has been carried out for all data sets during their upload into SOCAT. The upgrade of the interactive Data Set Viewer (previously known as the Cruise Data Viewer) allows better interrogation of the SOCAT data collection and rapid creation of high-quality figures for scientific presentations. Automated data upload has been launched for version 4 and will enable more frequent SOCAT releases in the future. High-profile scientific applications of SOCAT include quantification of the ocean sink for atmospheric carbon dioxide and its long-term variation, detection of ocean acidification, as well as evaluation of coupled-climate and ocean-only biogeochemical models. Users of SOCAT data products are urged to acknowledge the contribution of data providers, as stated in the SOCAT Fair Data Use Statement. This ESSD (Earth System Science Data) “living data” publication documents the methods and data sets used for the assembly of this new version of the SOCAT data collection and compares these with those used for earlier versions of the data collection (Pfeil et al., 2013; Sabine et al., 2013; Bakker et al., 2014). Individual data set files, included in the synthesis product, can be downloaded here: doi:10.1594/PANGAEA.849770. The gridded products are available here: doi:10.3334/CDIAC/OTG.SOCAT_V3_GRID

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

An update to the Surface Ocean CO₂ Atlas (SOCAT version 2)

The Surface Ocean CO₂ Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO₂ (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3 million to 10.1 million surface water fCO₂ values) and extended data coverage (from 1968–2007 to 1968–2011). The quality control criteria, while identical in both versions, have been applied more strictly in version 2 than in version 1. The SOCAT website (http://www.socat.info/) has links to quality control comments, metadata, individual data set files, and synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longerterm variation, as well as initialisation or validation of ocean carbon models and coupled climate-carbon models