Tree-Network Overrun Model Associated with Pilots’ Actions and Flight Operational Procedures

The runway excursions are defined as the exit of an aircraft from the surface of the runway. These excursions can take place at takeoff or at landing and consist of two types of events: veer off and overrun. This last one, which occurs when the aircraft exceeds the limits at the end of the runway, is the event of interest in the current study. This chapter aims to present an accident model with a new approach in aeronautical systems, based on the tasks of the pilots related to the operational procedures necessary for the approach and landing, in order to obtain the chain of events that lead to this type of accident. Thus, the tree-network overrun model (TNO model) was proposed, unlike most traditional models, which consider only the hardware failures or which do not satisfactorily explain the interrelationship between the factors influencing the operator. The proposed model is developed in a fault tree and transformed into a Bayesian network up to the level of the basic elements. The results showed the qualitative model of the main tasks performed by the pilots and their relation to the accident. It has also been suggested how to find and estimate the probability of factors that can impact on each of the tasks

Gestão de conflitos na escola em tempos de pandemia

A pandemia, causada pela COVID-19, gerou inúmeras mudanças de ordem estrutural nas escolas de todo o país. Com o objetivo de compreender quais ações relacionadas aos conflitos decorrentes destas mudanças foram realizadas pela equipe gestora de uma escola particular da cidade de São José dos Campos, interior de São Paulo, esta pesquisa de abordagem qualitativa teve como procedimento metodológico o estudo de campo e a revisão sistemática dos dados. O corpus desta pesquisa baseou-se nas avaliações de 28 professores dos diversos segmentos da escola, concernentes aos efeitos desta gestão. Por meio desta investigação, verificou-se que, apesar da atuação moderada por parte dos gestores nas questões de conflito, quando houve, levou os professores a adquirirem aperfeiçoamento, tanto de ordem pessoal, quanto profissional, bem como de suas práticas pedagógicas em mais de 91% dos casos. Considera-se importante que as instituições de ensino cogitem estruturar e capacitar uma equipe de profissionais que pensem em estratégias para a resolução dos conflitos que possam vir a surgir no âmbito escolar, com o objetivo de promover a motivação do trabalho em equipe e um ambiente mais positivamente produtivo

Análise de fatores humanos e organizacionais relacionados ao procedimento de frenagem de aeronaves em condições ambientais desfavoráveis / Analysis of human and organizational factors related to aircraft braking procedure in unfavorable environmental conditions

Este artigo identifica e prioriza os principais fatores contribuintes relacionados ao procedimento de frenagem que ocorrem durante pouso de aeronaves comerciais de médio e grande porte. A literatura disponível e a pesquisa com especialistas indicam que as condições adversas durante o procedimento de frenagem ocorre principalmente quando há condições ambientais desfavoráveis e/ou quando a pista do aeroporto é desfavorável ao pouso. Com o objetivo de identificar os principais fatores humanos, organizacionais, aeroportuários e ambientais que influenciam o procedimento de frenagem, foram analisados os relatórios de acidentes e incidentes da base de dados do National Transportation Safety Board (NTSB) entre 2005 e 2015. Os fatores identificados foram analisados utilizando um modelo de acidente e priorizados de acordo com a probabilidade de ocorrência obtida através da Rede Bayesiana. Assim, os resultados obtidos permitem a seleção dos fatores que devem ser priorizados pelos órgãos competentes, a fim de colaborar com a gestão da segurança no transporte aéreo e reduzir as excursões de pista durante o procedimento de pouso dessas aeronaves. A metodologia utilizada e os resultados encontrados são as principais contribuições deste estudo

Use of a flap based on the superior lateral genicular artery to cover lower limb injuries: case reports

The knee is one of the main joints in the human body, and due to its conformation and functionality, it is easily susceptible to injuries. Surgical reconstruction of injuries around the knee and proximal region of the leg represents a major challenge due to the exposure of osteoarticular, tendinomuscular and neurovascular structures and has been performed using various muscle and musculocutaneous flaps. Other flaps are also described for treating these lesions, although less frequently in the literature, such as the cutaneous flap based on the pedicle of the superior lateral genicular artery. Next, It presents a report of five cases of patients who were victims of motorcycle accidents in which the lesion was covered around the knee and proximal region of the leg using a skin flap based on the pedicle of the superior lateral genicular artery, in which good coverage of lesions, high flap survival rate, good clinical and aesthetic results. The use of the superior lateral genicular artery presents aesthetic advantages since the color and texture of the flap are similar to those of the knee region and provide a better quality appearance, in addition to not causing joint mobility problems

Inhibition of IL-10 Production by Maternal Antibodies against Group B Streptococcus GAPDH Confers Immunity to Offspring by Favoring Neutrophil Recruitment

Group B Streptococcus (GBS) is the leading cause of neonatal pneumonia, septicemia, and meningitis. We have previously shown that in adult mice GBS glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an extracellular virulence factor that induces production of the immunosuppressive cytokine interleukin-10 (IL-10) by the host early upon bacterial infection. Here, we investigate whether immunity to neonatal GBS infection could be achieved through maternal vaccination against bacterial GAPDH. Female BALB/c mice were immunized with rGAPDH and the progeny was infected with a lethal inoculum of GBS strains. Neonatal mice born from mothers immunized with rGAPDH were protected against infection with GBS strains, including the ST-17 highly virulent clone. A similar protective effect was observed in newborns passively immunized with anti-rGAPDH IgG antibodies, or F(ab')2 fragments, indicating that protection achieved with rGAPDH vaccination is independent of opsonophagocytic killing of bacteria. Protection against lethal GBS infection through rGAPDH maternal vaccination was due to neutralization of IL-10 production soon after infection. Consequently, IL-10 deficient (IL-10−/−) mice pups were as resistant to GBS infection as pups born from vaccinated mothers. We observed that protection was correlated with increased neutrophil trafficking to infected organs. Thus, anti-rGAPDH or anti-IL-10R treatment of mice pups before GBS infection resulted in increased neutrophil numbers and lower bacterial load in infected organs, as compared to newborn mice treated with the respective control antibodies. We showed that mothers immunized with rGAPDH produce neutralizing antibodies that are sufficient to decrease IL-10 production and induce neutrophil recruitment into infected tissues in newborn mice. These results uncover a novel mechanism for GBS virulence in a neonatal host that could be neutralized by vaccination or immunotherapy. As GBS GAPDH is a structurally conserved enzyme that is metabolically essential for bacterial growth in media containing glucose as the sole carbon source (i.e., the blood), this protein constitutes a powerful candidate for the development of a human vaccine against this pathogen

A evolução clínica do paciente portador de abscesso pulmonar: Clinical evolution of patients with lung abscess

Atualmente, com a era da antibioticoterapia e demais meios terapêuticos, o abscesso pulmonar decaiu em termos de morbimortalidade, mas ainda permanece como um desafio em termos diagnósticos e manejo clínico. O abscesso pulmonar corresponde a uma cavidade com pus no pulmão, envolvido por tecido inflamado e geralmente oriunda de uma infecção. O artigo objetivou descrever de modo narrativo a evolução clínica do portador de abscesso pulmonar, ressaltando os principais dados para a compreensão deste fenômeno. Um abscesso pulmonar é causado principalmente por bactérias existentes na boca ou garganta, a qual são aspiradas até os pulmões. A sintomatologia é inespecífica, abordando fadiga, inapetência, sudorese noturna, febre, perda ponderal e tosse com expectoração. O quadro clínico geralmente necessita do complemento de exames de imagem, principalmente a radiografia torácica para diagnóstic

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Measurement of exclusive Upsilon photoproduction from protons in pPb collisions at root sNN=5.02 Tev

An Erratum to this article was published on 20 April 2022: https://doi.org/10.1140/epjc/s10052-022-10276-2The exclusive photoproduction of (nS) meson states from protons, (nS) p (with n = 1, 2, 3), is studied in ultraperipheral pPb collisions at a centre-of-mass energy per nucleon pair of The measurement is performed using the decay mode, with data collected by the CMS experiment corresponding to an integrated luminosity of 32.6 nb(-1). Differential cross sections as functions of the nS) transverse momentum squared and rapidity y, are presented. The 1S) photoproduction cross section is extracted in the rapidity range < 2.2, which corresponds to photon-proton centre-of-mass energies in the range 91 W < 826 GeV. The data are compared to theoretical predictions based on perturbative quantum chromodynamics and to previous measurements.Peer reviewe

Search for high-mass resonances in dilepton final states in proton-proton collisions at root s=13 TeV

A search is presented for new high-mass resonances decaying into electron or muon pairs. The search uses proton-proton collision data at a centre-of-mass energy of 13TeV collected by the CMS experiment at the LHC in 2016, corresponding to an integrated luminosity of 36 fb(-1). Observations are in agreement with standard model expectations. Upper limits on the product of a new resonance production cross section and branching fraction to dileptons are calculated in a model-independent manner. This permits the interpretation of the limits in models predicting a narrow dielectron or dimuon resonance. A scan of different intrinsic width hypotheses is performed. Limits are set on the masses of various hypothetical particles. For the Z(SSM)' (Z(psi)') particle, which arises in the sequential standard model (superstring-inspired model), a lower mass limit of 4.50 (3.90) TeV is set at 95% confidence level. The lightest Kaluza-Klein graviton arising in the Randall-Sundrum model of extra dimensions, with coupling parameters k/(M) over bar (Pl) of 0.01, 0.05, and 0.10, is excluded at 95% con fi dence level below 2.10, 3.65, and 4.25TeV, respectively. In a simpli fi ed model of dark matter production via a vector or axial vector mediator, limits at 95% con fi dence level are obtained on the masses of the dark matter particle and its mediator.Peer reviewe