Correlations between meteorological parameters and prostate cancer

<p>Abstract</p> <p>Background</p> <p>There exists a north-south pattern to the distribution of prostate cancer in the U.S., with the north having higher rates than the south. The current hypothesis for the spatial pattern of this disease is low vitamin D levels in individuals living at northerly latitudes; however, this explanation only partially explains the spatial distribution in the incidence of this cancer. Using a U.S. county-level ecological study design, we provide evidence that other meteorological parameters further explain the variation in prostate cancer across the U.S.</p> <p>Results</p> <p>In general, the colder the temperature and the drier the climate in a county, the higher the incidence of prostate cancer, even after controlling for shortwave radiation, age, race, snowfall, premature mortality from heart disease, unemployment rate, and pesticide use. Further, in counties with high average annual snowfall (>75 cm/yr) the amount of land used to grow crops (a proxy for pesticide use) was positively correlated with the incidence of prostate cancer.</p> <p>Conclusion</p> <p>The trends found in this USA study suggest prostate cancer may be partially correlated with meteorological factors. The patterns observed were consistent with what we would expect given the effects of climate on the deposition, absorption, and degradation of persistent organic pollutants including pesticides. Some of these pollutants are known endocrine disruptors and have been associated with prostate cancer.</p

Estrogen receptor positive breast cancers and their association with environmental factors

<p>Abstract</p> <p>Background</p> <p>Epidemiological studies to assess risk factors for breast cancer often do not differentiate between different types of breast cancers. We applied a general linear model to determine whether data from the Surveillance, Epidemiology, and End Results Program on annual county level age-adjusted incidence rates of breast cancer with and without estrogen receptors (ER+ and ER-) were associated with environmental pollutants.</p> <p>Results</p> <p>Our final model explained approximately 38% of the variation in the rate of ER+ breast cancer. In contrast, we were only able to explain 14% of the variation in the rate of ER- breast cancer with the same set of environmental variables. Only ER+ breast cancers were positively associated with the EPA's estimated risk of cancer based on toxic air emissions and the proportion of agricultural land in a county. Meteorological variables, including short wave radiation, temperature, precipitation, and water vapor pressure, were also significantly associated with the rate of ER+ breast cancer, after controlling for age, race, premature mortality from heart disease, and unemployment rate.</p> <p>Conclusions</p> <p>Our findings were consistent with what we expected, given the fact that many of the commonly used pesticides and air pollutants included in the EPA cancer risk score are classified as endocrine disruptors and ER+ breast cancers respond more strongly to estrogen than ER- breast cancers. The findings of this study suggest that ER+ and ER- breast cancers have different risk factors, which should be taken into consideration in future studies that seek to understand environmental risk factors for breast cancer.</p

Increasing boys' and girls' intention to avoid teenage pregnancy: a cluster randomised control feasibility trial of an interactive video drama based intervention in post-primary schools in Northern Ireland

Background: Adolescent men have a vital yet neglected role in reducing unintended teenage pregnancy (UTP). There is a need for gender-sensitive educational interventions. Objectives: To determine the value and feasibility of conducting an effectiveness trial of the If I Were Jack Relationship and Sexuality Education (RSE) intervention in a convenience quota sample of post-primary schools in Northern Ireland. Secondary objectives were to assess acceptability to schools, pupils (male/female, aged 14–15 years) and parents/guardians; to identify optimal delivery structures and systems; to establish participation rates and reach, including equality of engagement of different socioeconomic and religious types; to assess trial recruitment and retention rates; to assess variation in normal RSE practice; to refine survey instruments; to assess differences in outcomes for male and female pupils; to identify potential effect sizes that might be detected in an effectiveness trial and estimate appropriate sample size for that trial; and to identify costs of delivery and pilot methods for assessing cost-effectiveness. Design: Cluster randomised Phase II feasibility trial with an embedded process and economic evaluation. Intervention: A teacher-delivered classroom-based RSE resource – an interactive video drama (IVD) with classroom materials, teacher training and an information session for parents – to immerse young people in a hypothetical scenario of Jack, a teenager whose girlfriend is unintentionally pregnant. It addresses gender inequalities in RSE by focusing on young men and is designed to increase intentions to avoid UTP by encouraging young people to delay sexual intercourse and to use contraception consistently in sexual relationships. Main outcome measures: Abstinence from sexual intercourse (delaying initiation of sex or returning to abstinence) or avoidance of unprotected sexual intercourse (consistent correct use of contraception). Secondary outcomes included Knowledge, Attitudes, Skills and Intentions. Results: The intervention proved acceptable to schools, pupils and parents, as evidenced through positive process evaluation. One minor refinement to the parental component was required, namely the replacement of the teacher-led face-to-face information session for parents by online videos designed to deliver the intervention to parents/guardians into their home. School recruitment was successful (target 25%, achieved 38%). No school dropped out. Pupil retention was successful (target 85%, achieved 93%). The between-group difference in incidence of unprotected sex of 1.3% (95% confidence interval 0.55% to 2.2%) by 9 months demonstrated an effect size consistent with those reported to have had meaningful impact on UTP rates (resulting in an achievable sample size of 66 schools at Phase III). Survey instruments showed high acceptability and reliability of measures (Cronbach’s alpha: 0.5–0.7). Economic evaluation at Phase III is feasible because it was possible to (1) identify costs of delivering If I Were Jack (mean cost per pupil, including training of teachers, was calculated as £13.66); and (2) develop a framework for assessing cost-effectiveness. Conclusion: Trial methods were appropriate, and recruitment and retention of schools and pupils was satisfactory, successfully demonstrating all criteria for progression to a main trial. The perceived value of culture- and gender-sensitive public health interventions has been highlighted. Future work: Progression to a Phase III effectiveness trial. Trial registration: Current Controlled Trials ISRCTN99459996. Funding: This project was funded by the NIHR Public Health Research programme and will be published in full in Public Health Research; Vol. 5, No. 1. See the NIHR Journals Library website for further project information

The worldwide marine radiocarbon reservoir effect: definitions, mechanisms, and prospects

When a carbon reservoir has a lower radiocarbon content than the atmosphere, this is referred to as a reservoir effect. This is expressed as an offset between the radiocarbon ages of samples from the two reservoirs at a single point in time. The marine reservoir effect (MRE) has been a major concern in the radiocarbon community, as it introduces an additional source of error that is often difficult to accurately quantify. For this reason, researchers are often reluctant to date marine material where they have another option. The influence of this phenomenon makes the study of the MRE important for a broad range of applications. The advent of Accelerator Mass Spectrometry (AMS) has reduced sample size requirements and increased measurement precision, in turn increasing the number of studies seeking to measure marine samples. These studies rely on overcoming the influence of the MRE on marine radiocarbon dates through the worldwide quantification of the local parameter ΔR, that is, the local variation from the global average MRE. Furthermore, the strong dependence on ocean dynamics makes the MRE a useful indicator for changes in oceanic circulation, carbon exchange between reservoirs, and the fate of atmospheric CO2, all of which impact Earth's climate. This article explores data from the Marine Reservoir Database and reviews the place of natural radiocarbon in oceanic records, focusing on key questions (e.g., changes in ocean dynamics) that have been answered by MRE studies and on their application to different subjects

Isotopic evidence for dietary diversity at the mediaeval Islamic necropolis of Can Fonoll (10th to 13th centuries CE), Ibiza, Spain

The diet of the population interred at the Islamic necropolis of Can Fonoll, Ibiza, Spain, which was in use between the 10th and 13th centuries AD, is reconstructed from the carbon (δ13C) and nitrogen (δ15N) stable isotope ratios of bone collagen from 112 individuals. The mean ± sd (1σ) δ13C (− 19.0 ± 1.3‰) and δ15N (10.3 ± 0.8‰) values of the Can Fonoll population indicate a diet based largely on terrestrial C3 resources. However, the wide range of both δ13C (− 20.6‰ to − 8.6‰) and δ15N (7.0‰ to 12.1‰) values attested at Can Fonoll indicate significant variation in individual diet. The elevated δ13C values of a small proportion of the individuals buried at Can Fonoll are consistent with the consumption of a large proportion of, or dependence on, C4 resources, such as millet. Comparison of the δ13C and δ15N values of the Can Fonoll population with those of other mediaeval populations from the Balearic Islands and mainland Spain highlights a wide range of stable isotope values, which reflects not only significant differences in diet but also points to widespread mobility within the Mediterranean Basin

The Relationship Between Female Adolescent Self- Esteem, Decision Making and Contraceptive Behavior

Context Adolescence is a period of transition that involves biological, cognitive, psychological and social changes. During the vulnerable transition period of adolescence, decisions relating to contraception may occur. The purpose of this study was to examine the relationship between female adolescent self-esteem, decision making and contraceptive behavior. Understanding the relationship between female adolescent self-esteem, decision-making and contraceptive behavior has contributed to the knowledge base about female contraceptive behavior. Gaining further insight into these relationships will help health care professionals provide counseling and health care to female adolescents. Methods Using a descriptive cross sectional survey design, data were collected from a convenience sample of 98 female adolescents aged 14-17 who came to 5 different clinics in Hawaii for health care. Along with a brief demographic questionnaire, global self­ esteem was measured by Rosenberg's SelfEsteem Scale (Rosenberg, 1965), decision­ making was measured by the Flinders Adolescent Decision Making Questionnaire (Mann, Harmoni, Power, Beswick & Ormond, 1988) and sexual activity and contraception use was measured by a Sexual History and Contraceptive Use Questionnaire developed for this study. The conceptual framework for this study was Janis and Mann's (1977) conflict theory of decision-making. Descriptive statistics, logistic regression and correlations were used to analyze associations and correlations between age, global self esteem, decision self esteem, decision coping (vigilant and maladaptive) and contraceptive use for sexually active female adolescents. Results No significant associations or correlations were found between age, global self-esteem, decision self esteem, decision coping (vigilance) and their decision to use contraception in sexually active adolescent females. There was, however, significant negative correlation (p<.OS) between maladaptive decision-making and contraceptive use in sexually active female adolescents. This suggests that sexually active adolescent females with higher maladaptive scores are less likely to use contraception. There was also significant association (p<.OS) between maladaptive decision-making in contraceptive use and sexually active female adolescents. For every one unit increase on the maladaptive scale, the odds of using contraception were estimated to decrease by 7% meaning those who scored higher on the maladaptive scale were less competent or poor decision makers and less likely to use contraception. Conclusions Adolescents who score higher on the maladaptive decision-making scale are less competent in decision-making and are less likely to use contraception. Interventions focused on improving decision-making skills and stimulating thinking around not only sexual issues, but also relationship and communication in adolescent issues, may facilitate more competent decision-making

Measuring variability in prehistoric stone construction on Rapa Nui, Chile

Thesis (M.A.)--University of Hawaii at Manoa, 2005.Includes bibliographical references (leaves 143-155).viii, 155 leaves, bound ill., maps 29 c

Expanding on incremental dentin methodology to investigate childhood and infant feeding practices on Taumako (southeast Solomon Islands)

Though many ethnohistoric sources in the tropical Pacific recount chiefly feasting events, few describe childhood feeding practices despite the impact childhood under-nutrition may have had on morbidity and early mortality. Bioarchaeological investigation of the Namu burial ground (circa 750–300 BP) on the island of Taumako (southeast Solomon Islands) provides a direct means of understanding prehistoric life on a Polynesian Outlier in the south western Pacific. We investigate infant and childhood (0–10 years) feeding behavior in prehistoric Taumako by creating δ13Ccollagen, δ15Ncollagen, and δ13Ccarbonate profiles from 20 individuals using horizontal dentin sections of permanent first molars. The high-resolution data created using novel sample preparation offers insight into childhood diet in the absence of documentary evidence, incrementally sampling δ13Ccollagen and δ15Ncollagen but also expanding on the method to provide carbonate data from the same sequential dentin samples. The individuals who died in adolescence have significantly lower δ15Ncollagen values in early life than those who died in adulthood, which may suggest a link between diet, nutritional health, and morbidity. There were no significant differences in isotope values between social status groups, suggesting shared childhood experiences regarding types of foods consumed. Longitudinal assessment of δ13Ccollagen and δ15Ncollagen shows a strong relationship between the two values, likely a result of the typical tropical Pacific diet consisting largely of high protein marine foods that overshadows low protein terrestrial foods. This highlights the utility of δ13Ccarbonate in order to more effectively investigate consumption of low protein foodtypes in this region

Multiproxy isotopic analyses of human skeletal material from Rapa Nui: Evaluating the evidence from carbonates, bulk collagen, and amino acids

Abstract Objectives Stable isotope ratio analysis of bulk bone collagen dominates research into past diet; however, bone carbonate and compound specific isotope analyses (CSIA) of amino acids provide alternative, yet complementary, lines of evidence toward that same research goal. Together they inform on different aspects of diet, allowing greater certainty in reconstructions. Here we present new data on carbonate isotopes for Rapa Nui and reevaluate prehistoric diet in the context of these new and previously published bulk collagen and CSIA data. Materials and methods We analyzed carbon isotopes in bone carbonate from 28 prehistoric human teeth from Rapa Nui. These represent a subset of material examined previously for carbon and nitrogen isotope ratios in bulk collagen. We then reevaluate prehistoric diet in light of these and other published data. In addition, we analyzed carbon and nitrogen isotope ratios in 28 modern plant specimens from Rapa Nui to better approximate the isotopic value of the terrestrial endmember. Results Bulk data suggest a predominantly terrestrial diet, with the amount of marine sources incorporated varying though time. While previously argued to reveal greater amounts of marine consumption, reanalysis of recently published CSIA data suggests this result may relate to the proportion of carbon assimilated rather than consumed. Utilizing models incorporating concentration dependence for estimating dietary proportions results in much lower estimates of marine consumption, in line with findings of the bulk data. Discussion While these data indicate a larger focus on terrestrial resources, limitations in all forms of analysis make it difficult to determine exact dietary contributions in this mixed system. Better understanding of the complex physiological processes governing isotopic routing and fractionation, and knowledge of appropriate isotopic endmember values are needed to advance this research

Dataset for Relationship Between Plant and Soil Isotopes and Climate in a Sagebrush-Steppe Ecosystem of Southern Idaho

The overarching goal of this study is to better understand the relationship between plant carbon (C) and nitrogen (N) isotopic signatures and climate in a sagebrush-steppe ecosystem. Additionally, this study seeks to a) determine how plant isotopic data in the sampled ecosystem compare with global patterns with respect to broader climate gradients; and b) evaluate any additional effects on plant isotopic compositions due to soil attributes (chemical, physical). Climatic effects on C and N isotopes were analyzed by examining plant and soil samples across a climatic gradient within the Reynolds Creek Critical Zone Observatory (RCCZO) (comprised of the USDA ARS Reynolds Creek Experimental Watershed) located in the Owyhee Mountains in southwestern Idaho. Sampling focused on two subwatersheds (Johnston Draw and Whiskey Hills) in July 2015. Soil cores were obtained from both plant and interplant spaces, with a total of 480 samples (120 cores at 4 depth intervals). Samples of plants (n=120) present at each core location were collected at the same time soils were obtained to allow for evaluating relationships between soil and plant processes. At each plant location, samples consist of sagebrush foliar tissue, while samples from interplant plots often consisted of a mixture of grasses and forbs. Soil data include soil moisture, gravimetric water content, soil organic matter, stable carbon and nitrogen isotopes, percent carbon and nitrogen, initial/final/potential nitrate concentration, initial/final/potential ammonium concentration, net nitrification rate, potential net nitrification rate, net mineralization rate, potential net mineralization rate, and pH. Note: the majority of extractions for ammonium concentrations were contaminated so ammonium (and thus mineralization) data is largely unavailable for this study. Plant data includes stable carbon and nitrogen isotopes and percent carbon and nitrogen for sagebrush foliar tissues (perennial leaves only)