75 research outputs found
Association of HIV infection with distribution and viral load of HPV types in Kenya: a survey with 820 female sex workers
- Author
- AK Chaturvedi
- Annalene Nel
- B Armitage
- B Auvert
- C Ng'andwe
- CB Woodman
- CE Depuydt
- Christophe E Depuydt
- Davy Vanden Broeck
- DD Davey
- DM Parkin
- DN Dames
- EM de Villiers
- GM Clifford
- GM Clifford
- GM Clifford
- GP Yeoh
- H De Vuyst
- H De Vuyst
- H De Vuyst
- HD Strickler
- HD Strickler
- International Agency for Research on Cancer
- J del Amo
- J Fontaine
- JC Smith
- JE Levi
- JM Palefsky
- JM Palefsky
- JM Palefsky
- John-Paul Bogers
- JS Mandelblatt
- JS Smith
- K Ishi
- KF Schulz
- Kishor Mandaliya
- KL Dunkle
- KL Wallin
- L Dal Maso
- LA Juarez-Figueroa
- M Odida
- M Temmerman
- Marleen Temmerman
- Matthew F Chersich
- MF Chersich
- MP Hawken
- N Munoz
- N Munoz
- N Munoz
- NS De Carvalho
- Patricia Claeys
- PR Ulin
- PV Chin-Hong
- R Chatterjee
- RD Burk
- RS McClelland
- S Luchters
- SC Thomsen
- Stanley MF Luchters
- V Bouvard
- W Bosire
- WHO
- WHO
- Wim Delva
- WL Kirungi
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>Human papillomavirus (HPV) and HIV are each responsible for a considerable burden of disease. Interactions between these infections pose substantial public health challenges, especially where HIV prevalence is high and HPV vaccine coverage low.</p> <p>Methods</p> <p>Between July 2005 and January 2006, a cross-sectional community-based survey in Mombasa, Kenya, enrolled female sex workers using snowball sampling. After interview and a gynaecological examination, blood and cervical cytology samples were taken. Quantitative real-time PCR detected HPV types and viral load measures. Prevalence of high-risk HPV was compared between HIV-infected and -uninfected women, and in women with abnormal cervical cytology, measured using conventional Pap smears.</p> <p>Results</p> <p>Median age of the 820 participants was 28 years (inter-quartile range [IQR] = 24-36 years). One third of women were HIV infected (283/803; 35.2%) and these women were y more likely to have abnormal cervical cytology than HIV-negative women (27%, 73/269, versus 8%, 42/503; <it>P </it>< 0.001). Of HIV-infected women, 73.3% had high-risk HPV (200/273) and 35.5% had HPV 16 and/or 18 (97/273). Corresponding figures for HIV-negative women were 45.5% (229/503) and 15.7% (79/503). After adjusting for age, number of children and condom use, high-risk HPV was 3.6 fold more common in HIV-infected women (95%CI = 2.6-5.1). Prevalence of all 15 of the high-risk HPV types measured was higher among HIV-infected women, between 1.4 and 5.5 fold. Median total HPV viral load was 881 copies/cell in HIV-infected women (IQR = 33-12,110 copies/cell) and 48 copies/cell in HIV-uninfected women (IQR = 6-756 copies/cell; <it>P </it>< 0.001). HPV 16 and/or HPV 18 were identified in 42.7% of LSIL (32/75) and 42.3% of HSIL (11/26) lesions (<it>P </it>= 0.98). High-risk HPV types other than 16 and 18 were common in LSIL (74.7%; 56/75) and HSIL (84.6%; 22/26); even higher among HIV-infected women.</p> <p>Conclusions</p> <p>HIV-infected sex workers had almost four-fold higher prevalence of high-risk HPV, raised viral load and more precancerous lesions. HPV 16 and HPV 18, preventable with current vaccines, were associated with cervical disease, though other high-risk types were commoner. HIV-infected sex workers likely contribute disproportionately to HPV transmission dynamics in the general population. Current efforts to prevent HIV and HPV are inadequate. New interventions are required and improved implementation of existing strategies.</p
Highlights From the Annual Meeting of the American Epilepsy Society 2022
- Author
- Alexander Allyson L
- Andrade Danielle M
- Arevalo-Astrada Miguel
- Auer Nancy
- Bainbridge Jacquelyn L
- Bartolomei Fabrice
- Baxendale Sallie A
- Becker Danielle A
- Berg Anne T
- Bernasconi Andrea
- Bernasconi Neda
- Bernhardt Boris
- Bhatnagar Shivani
- Bluemcke Ingmar
- Blumenfeld Hal
- Buchanan Gordon F
- Burdette David E
- Burneo Jorge G
- Busch Robyn M
- Chauvel Patrick
- Chin Jeannie
- Clifford Lisa
- Conner Kelly R
- Conway Jeannine
- Cook Mark J
- Diaz-Arastia Ramon
- Drees Cornelia
- French Jacqueline A
- Ganguly Taneeta Mindy
- Gelfand Michael A
- Glauser Tracy A
- Gleichgerrcht Ezequiel
- Goldman Alica M
- Gonzalez-Martinez Jorge
- Gotman Jean
- Grinspan Zachary
- Guilfoyle Shanna
- Gupta Gita
- Hammer Michael
- Hartman Adam L
- Hentges Katie
- Hogan R Edward
- Huh Linda
- Hyslop Ann
- Jobst Barbara
- Jobst Barbara
- Josephson Colin B
- Kelley Sarah A
- Knupp Kelly
- Koepp Matthias
- Kothare Sanjeev
- Krook-Magnuson Esther
- Kwasa Jasmine
- La Vega-Talbott Maite
- Lam Alice D
- Lee Jong Woo
- Lowenstein Daniel H
- Maturu Sarita
- Mayor Luis Carlos
- McDonald Carrie
- McKee Heather R
- McKhann Guy M
- Meador Kimford J
- Mefford Heather C
- Michael Elizabeth H
- Mikati Mohamad A
- Millichap John J
- Mitchell James W
- Myers Leah S
- Naritoku Dean
- Neville Kerri L
- Noebels Jeffrey
- O'Brien Terence J
- Oluigbo Chima O
- Patel Anup D
- Pavlova Milena K
- Paz Jeanne T
- Pennell Page B
- Perry M Scott
- Perucca Piero
- Pitkaenen Asla
- Plueger Madona
- Pugh Mary Jo
- Quigg Mark
- Reddy Shilpa B
- Reynolds Tamara S
- Rubinos Clio
- Ryan Christopher
- Sajatovic Martha
- Santana-Gomez Cesar
- Schommer Linsday
- Schuele Stephan
- Shellhaas Renee A
- Shrey Daniel W
- Singh Rani K
- Sperling Michael R
- Suleman Saher
- Templer Jessica W
- Thom Maria
- Trinka Eugen
- Valencia Ignacio
- Varadkar Sophia M
- Velez-Ruiz Naymee
- Veliskova Jana
- Voskobiynyk Yuliya
- Wagner Janelle L
- Wagnon Jacy L
- Waller Claire
- Waller Jill
- Wang Zhong Irene
- Welborn Michelle W
- Wirrell Elaine
- Publication venue
- SAGE PUBLICATIONS INC
- Publication date
- 16/08/2023
- Field of study
With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health professionals gathered to learn a variety of topics about epilepsy. The program was carefully tailored to meet the needs of professionals with different interests and career stages. This article summarizes the different symposia presented at the meeting. Basic science lectures addressed the primary elements of seizure generation and pathophysiology of epilepsy in different disease states. Scientists congregated to learn about anti-seizure medications, mechanisms of action, and new tools to treat epilepsy including surgery and neurostimulation. Some symposia were also dedicated to discuss epilepsy comorbidities and practical issues regarding epilepsy care. An increasing number of patient advocates discussing their stories were intertwined within scientific activities. Many smaller group sessions targeted more specific topics to encourage member participation, including Special Interest Groups, Investigator, and Skills Workshops. Special lectures included the renown Hoyer and Lombroso, an ILAE/IBE joint session, a spotlight on the impact of Dobbs v. Jackson on reproductive health in epilepsy, and a joint session with the NAEC on coding and reimbursement policies. The hot topics symposium was focused on traumatic brain injury and post-traumatic epilepsy. A balanced collaboration with the industry allowed presentations of the latest pharmaceutical and engineering advances in satellite symposia
Genetic Variants For Head Size Share Genes and Pathways With Cancer
- Author
- Adams Hieab H H
- Amod Alyssa R
- Andersson Sture
- Atkins Joshua R
- Avinun Reut
- Aygün Nil
- Beiser Alexa S
- Beyer Frauke
- Bis Joshua C
- Bos Daniel
- Bowden Donald W
- Brunner Han G
- Bryan R Nick
- Bülow Robin
- Cairns Murray J
- Calhoun Vince D
- Carrion-Castillo Amaia
- Caspers Svenja
- Catheline Gwenaëlle
- Cecil Charlotte A M
- Cheung Ching-Lung
- Cichon Sven
- Crivello Fabrice
- Dalvie Shareefa
- Dartigues Jean-François
- Debette Stéphanie
- DeCarli Charles
- Duperron Marie-Gabrielle
- Enlund-Cerullo Maria
- Evans Tavia E
- Ford Judith M
- Fornage Myriam
- Franke Barbara
- Freedman Barry I
- Friedrich Nele
- Grabe Hans J
- Green Melissa J
- Hariri Ahmad R
- Haworth Simon
- Helmer Catherine
- Hoffmann Per
- Homuth Georg
- Hostettler Isabel C
- Houlden Henry
- Hsu Fang-Chi
- Håberg Asta K
- Ikram M Arfan
- Ikram M Kamran
- Jack Clifford R
- Jahanshad Neda
- Jian Xueqiu
- Jockwitz Christiane
- Kamatani Yoichiro
- Knodt Annchen R
- Knol Maria J
- Koudstaal Peter J
- Kämpe Anders
- Lam Max
- Lamballais Sander
- Launer Lenore J
- Le Grand Quentin
- Lewis Cora E
- Li Gloria H Y
- Li Shuo
- Liang Dan
- Lim Keane
- Longstreth W T
- Macciardi Fabio
- Matsuda Fumihiko
- Mazoyer Bernard
- Medland Sarah E
- Mishra Aniket
- Miyamoto Susumu
- Moebus Susanne
- Mosley Thomas H
- Muetzel Ryan
- Mäkitie Outi
- Mühleisen Thomas W
- Nagata Manabu
- Nakahara Soichiro
- Palmer Nicholette D
- Patel Yash
- Paus Tomas
- Pausova Zdenka
- Pawlak Mikolaj A
- Poot Raymond A
- Preda Adrian
- Quidé Yann
- Reay William R
- Reinbold Céline S
- Roshchupkin Gennady V
- Sargurupremraj Muralidharan
- Satizabal Claudia L
- Schmidt Reinhold
- Scholz Markus
- Schreiner Pamela J
- Seshadri Sudha
- Setoh Kazuya
- Shapland Chin Yang
- Shin Jean
- Sidney Stephen
- Sim Kang
- St Pourcain Beate
- Stein Dan J
- Stein Jason L
- Tabara Yasuharu
- Teumer Alexander
- Teunissen Mariël W A
- Thompson Paul M
- Tsuchida Ami
- Uhlmann Anne
- van Dam-Nolen Dianne H K
- van der Auwera Sandra
- van der Lugt Aad
- van Erp Theo G M
- Vernooij Meike W
- Villringer Arno
- Werring David J
- White Tonya
- Windham B Gwen
- Witte A Veronica
- Wittfeld Katharina
- Yang Qiong
- Yoshida Kazumichi
- Publication venue
- DigitalCommons@TMC
- Publication date
- 03/05/2024
- Field of study
The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer
A review of the infection-associated cancers in North African countries
- Author
- A Bahadi
- A Benouda
- A Elzouki
- A Jemal
- A Jemal
- A Sbai
- A Zohoun
- AB Rickinson
- AM Ismail
- AS Dhrif
- AS Felix
- Asta Försti
- B Kassimi El
- BH Meldal
- BJ Feng
- C Frank
- C Martel de
- D Forman
- D Lavanchy
- D Parkin
- DL Lamm
- DM Parkin
- EM Lehman
- ET Chang
- F Amarir
- F Bray
- F DeWolfe Miller
- F Donato
- F Khelifa
- F Mégraud
- F Roudot-Thoraval
- FX Bosch
- FX Bosch
- G Clifford
- G De-The
- H Errihani
- H Khaled
- H Lahlaoui
- H Triki
- H Zur Hausen
- HA Elasifer
- Helicobacter and Cancer Collaborative Group
- I Gouda
- I Lahlou Amine
- I Sebaie El
- IA Khaled
- IG Gasim
- J Guerra
- J Heikel
- JF Perz
- JM Palefsky
- JM Walboomers
- JP Gisbert
- K Boulaajaj
- K Djeriri
- K Harzallah
- K Hemminki
- K Matsuo
- K Siai
- KB Mansour
- L Bruni
- L Dal Maso
- Loubna Mazini
- M Andreoni
- M Chiaramonte
- M Hamdi Cherif
- M Mseddi
- M Obtel
- MA Daw
- MA Mohammad
- MA Salem
- Meriem Khyatti
- MM Sherif
- Mohammed Attaleb
- N Ben Alaya Bouafif
- N Hannachi
- N Hannachi
- N Missaoui
- O Bahri
- OA Wasfi
- P Steinmann
- PV Chin-Hong
- R Belbaraka
- R Dhanasekaran
- R Zanetti
- RD Trimbitas
- Roxana-Delia Trimbitas
- S Alaoui Boukhris
- S Benjelloun
- S Benjelloun
- S Ezzikouri
- S Mejri
- S Rouabhia
- S Sekkat
- S Vaccarella
- SD Lee
- SM Olama
- SN Lu
- T Khoby El
- W Blattner
- WA Alashek
- Wafaa Mohamed Hussein
- Wagida A. Anwar
- WHO
- X Zhou
- YA Mohamoud
- YH Huang
- Z Ayed
- Z Bodalal
- ZN Said
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Almeida Marcio A. A.
- Alnaes Dag
- Alvim Marina K. M.
- Ames David
- Amlien Inge K.
- Anderson Tim J.
- Andersson Micael
- Andreassen Ole A.
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J.
- Artiges Eric
- Ashley-Koch Allison
- Assareh Amelia A.
- Atkins Joshua R.
- Ayesa-Arriola Rosa
- Bastin Mark E.
- Baune Bernhard T.
- Beckham Jean C.
- Belger Aysenil
- Bernard Manon
- Bis Joshua C.
- Blangero John
- Boomsma Dorret I.
- Bralten Janita
- Brandt Christine L.
- Brodaty Henry
- Brouwer Rachel M.
- Brown Gregory G.
- Brunner Han G.
- Buckner Randy L.
- Buimer Elizabeth E. L.
- Buitelaar Jan K.
- Bulow Robin
- Burger Christian
- Bustillo Juan R.
- Cahn Wiepke
- Cairns Murray J.
- Calhoun Vince
- Cannon Dara M.
- Carr Vaughan J.
- Caseras Xavier
- Caspers Svenja
- Cavalleri Gianpiero L.
- Cendes Fernando
- Chakravarty Mallar
- Chen Qiang
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Colodro-Conde Lucia
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crespo-Facorro Benedicto
- Curran Joanne E.
- Dale Anders M.
- Dalrymple-Alford John C.
- Dalvie Shareefa
- Dannlowski Udo
- Davies Gareth E.
- de Araujo Tania K.
- de Geus Eco J. C.
- de Zubicaray Greig I.
- de Zwarte Sonja M. C.
- Deary Ian J.
- Debette Stephanie
- Decarli Charles
- Degenhardt Franziska
- Delanty Norman
- den Braber Anouk
- Dennis Michelle F.
- Depondt Chantal
- Desrivieres Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doherty Colin P.
- Dohm Katharina
- Donohoe Gary
- Ehrlich Stefan
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espeseth Thomas
- Espiritu Ryan
- Fan Chun Chieh
- Fedko Iryna O.
- Fernandez Guillen
- Fisher Simon E.
- Flor Herta
- Foley Sonya F.
- Ford Judith M.
- Fornage Myriam
- Forstner Andreas J.
- Francks Clyde
- Franke Barbara
- Fukunaga Masaki
- Garijo Daniel
- Garrett Melanie E.
- Ge Tian
- Giddaluru Sudheer
- Gil Yolanda
- Glahn David C.
- Goldman Aaron L.
- Gollub Randy L.
- Gowland Penny A.
- Grabe Hans J.
- Grasby Katrina L.
- Green Melissa J.
- Green Robert C.
- Groenewold Nynke A.
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gurholt Tiril P.
- Gutman Boris A.
- Haberg Asta K.
- Hansell Narelle K.
- Hariri Ahmad R.
- Harris Mathew A.
- Harrison Marc B.
- Hartman Catharina A.
- Hashimoto Ryota
- Haswell Courtney C.
- Hauser Michael
- Hausler Alexander N.
- Heindel Walter
- Heinz Andreas
- Henskens Frans A.
- Herms Stefan
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hillegers Manon H. J.
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U.
- Holleran Laurena
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hong L. Elliot
- Hoogman Martine
- Hopkins William D.
- Hosten Norbert
- Hottenga Jouke-Jan
- Ikeda Masashi
- Ikram M. Arfan
- Jack Clifford R.
- Jahanshad Neda
- Jang MiHyun
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E.
- Jernigan Terry L.
- Jia Tianye
- Jockwitz Christiane
- Jonsson Erik G.
- Kahn Rene S.
- Kanai Ryota
- Karama Sherif
- Kasperaviciute Dalia
- Kaufmann Tobias
- Kelly Sinead
- Kennedy Martin A.
- Kikuchi Masataka
- Kimbrel Nathan A.
- Kircher Tilo T. J.
- Klein Marieke
- Knapp Michael
- Knodt Annchen R.
- Kochunov Peter
- Kolskar Knut
- Koops Sanne
- Kramer Bernd
- Krug Axel
- Kwok John B. J.
- Lam Max
- Lancaster Thomas M.
- Launer Lenore
- Le Hellard Stephanie
- Lee Phil H.
- Lett Tristram A.
- Lewis Lindsay B.
- Lim Kelvin O.
- Lind Penelope A.
- Longstreth W. T.
- Loohuis Loes M. Olde
- Lopes-Cendes Iscia
- Lopez Oscar L.
- Loughland Carmel M.
- Luciano Michelle
- Luykx Jurjen J.
- Macciardi Fabio
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Martinot Marie-Laure Paillere
- Mathalon Daniel H.
- Mather Karen A.
- Mathias Samuel R.
- Mattay Venkata S.
- Matthews Sarah
- Mazoyer Bernard
- McDonald Colm
- McEwen Sarah C.
- McMahon Katie L.
- McMahon Mary Agnes B.
- Medland Sarah E.
- Melle Ingrid
- Melzer Tracy R.
- Meyer-Lindenberg Andreas
- Michie Patricia T.
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Moreira Jose C. V.
- Morey Rajendra A.
- Morris Derek W.
- Mosley Thomas H.
- Mota Nina R.
- Mowry Bryan
- Mueller Bryon A.
- Mueller-Myhsok Bertram
- Muhleisen Thomas W.
- Najt Pablo
- Nakahara Soichiro
- Nauck Matthias
- Nhat Trung Doan
- Nho Kwangsik
- Noethen Markus M.
- Nordvik Jan E.
- Nyberg Lars
- O'Leary Daniel S.
- Oosterlaan Jaap
- Opel Nils
- Ophoff Roel A.
- Orfanos Dimitri Papadopoulos
- Painter Jodie N.
- Pantelis Christos
- Paus Tomas
- Pausova Zdenka
- Pearson John F.
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Pitcher Toni L.
- Pizzagalli Fabrizio
- Pol Hilleke E. Hulshoff
- Polderman Tinca J. C.
- Posthuma Danielle
- Preda Adrian
- Putz Benno
- Quide Yann
- Quinlan Erin B.
- Ragothaman Anjanibhargavi
- Rashid Faisal M.
- Rasser Paul E.
- Ratnakar Varun
- Reay William R.
- Redlich Ronny
- Reinbold Celine S.
- Reppermund Simone
- Repple Jonathan
- Richard Genevieve
- Riedel Brandalyn C.
- Rietschel Marcella
- Risacher Shannon L.
- Rocha Cristiane S.
- Roffman Joshua L.
- Roshchupkin Gennady V.
- Rowland Laura M.
- Sachdev Perminder S.
- Salminen Lauren
- Samann Philipp G.
- Saremi Arvin
- Satizabal Claudia L.
- Saykin Andrew J.
- Schall Ulrich
- Schlag Fenja
- Schmaal Lianne
- Schmidt Reinhold
- Schofield Peter R.
- Schumann Gunter
- Scott Rodney J.
- Secolin Rodrigo
- Seshadri Sudha
- Shapland Chin Yang
- Shatokhina Natalia
- Shen Li
- Shin Jean
- Shumskaya Elena
- Sim Kang
- Sisodiya Sanjay M.
- Smoller Jordan W.
- Sommer Iris E.
- Sonderby Ida E.
- Sprooten Emma
- St Pourcain Beate
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Strike Lachlan T.
- Tansey Katherine E.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomopoulos Sophia I.
- Thompson Paul M.
- Toga Arthur W.
- Tooney Paul A.
- Tordesillas-Gutierrez Diana
- Torres Fabio R.
- Trollor Julian N.
- Turner Jessica A.
- Uhlmann Anne
- Vallerga Costanza L.
- van der Meer Dennis
- Van der Wee Nic J. A.
- van Donkelaar Marjolein M. J.
- van Eijk Liza
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Rooij Daan
- Van Son Jaqueline Mayoral
- van Tol Marie-Jose
- van't Ent Dennis
- Veldink Jan H.
- Veltman Dick J.
- Verhoef Ellen
- Volzke Henry
- Voyvodic James T.
- Walter Henrik
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Wardlaw Joanna M.
- Weber Bernd
- Weinberger Daniel R.
- Wen Wei
- Westlye Lars T.
- Whelan Christopher D.
- Whelan Robert
- White Tonya
- Witt Stephanie H.
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wright Margaret J.
- Wu Jing Qin
- Yamamori Hidenaga
- Yang Qiong
- Yasuda Clarissa L.
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H.
- Zsembik Leo C. P.
- Zwiers Marcel P.
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Global economic burden of unmet surgical need for appendicitis
- Author
- Aahlin E. K.
- Aamer A.
- Aaniana K.
- Ababneh A.
- Abaliksta T.
- Abantanga F.
- Abbas M.
- Abbasy J.
- Abbo O.
- Abbouch M.
- Abd-Elmawla M.
- Abd-Elrasoul Y.
- Abdallah E.
- Abdel-Aty A.
- Abdel-Hameed N.
- Abdel-Kader S. M.
- Abdel-Wahab N. Y. E.
- Abdelaal A.
- Abdelaty M.
- Abdelazeam A. R.
- Abdelazim G.
- Abdelaziz M. A.
- Abdelbadeai K.
- Abdelfatah A.
- AbdelFattah I.
- Abdelgelil A.
- Abdelghany S.
- Abdelhady S.
- Abdelhamed R.
- Abdelhamid A.
- Abdelhaq A.
- Abdelkader M.
- Abdelkader O.
- Abdelkareem A.
- Abdelkhalek M.
- Abdelmageed E.
- Abdelmotaleb I.
- Abdelraheim M.
- Abdelraouf A. M.
- Abdelrouf D. M.
- Abdelshafy M.
- Abdelshakour M.
- Abdrabou A. K.
- Abdul-Latif S.
- Abdulaziz H.
- Abdulbagi O.
- Abdulgawad M.
- Abdulhakeem E. M.
- Abdullah M. A.
- Abdullah N.
- Abdullah N. A. N.
- Abdullahi L.
- Abdurrazzaaq A.
- Abebe N. S.
- Abebe N. S.
- Abem O. E.
- Abiola O.
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- Ziubryte G.
- Zohair A.
- Zuber M.
- Zulkifli A.
- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
- Author
- Antonio A. Ornellas
- Bernard HU
- Bezerra AL
- Bezerra AL
- Bezerra AL
- Boshart M
- Chan PK
- Clifford GM
- de Villiers EM
- Depasquale I
- Dillner J
- Eduardo W. Chin
- Franceschi S
- Geipert N
- Gregoire L
- Gregoire L
- Heideman DA
- Jacobs MV
- Kayes O
- Lont AP
- Lont AP
- Manos MM
- Marcos A. Scheiner
- Maria H. Ornellas
- Maria J. Andrada-Serpa
- McCance DJ
- Mercia M. Campos
- Micali G
- Muñoz N
- Nasca MR
- Nasca MR
- Noel JC
- Parkin DM
- Parkin DM
- Picconi MA
- Pietrzak P
- Powell J
- Prowse DM
- Qu W
- Remmerbach TW
- Rubin MA
- Rubin MA
- Seixas AL
- zur Hausen H
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
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- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
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- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
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- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
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- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
- DeMarco Kathryn
- den Braber Anouk
- Dennis Michelle F
- Depondt Chantal
- Desrivieres Sylvane
- Desrivières Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
- Dohm Katharina
- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
- Dooley Eoin
- Doraiswamy P Murali
- Drost Dick
- Duara Ranjan
- Dubow Jordan S
- Dunlop Becky
- Egebjerg Jan
- Ehrlich Stefan
- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espay Alberto
- Espay Kristy
- Espeseth Thomas
- Espiritu Ryan
- Faber Kelley
- Factor Stewart
- Fan Chun Chieh
- Fargher Kristin
- Farlow Martin R
- Fatica Parianne
- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernández Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
- Fillmer Ariane
- Finger Elizabeth
- Fisher Simon E
- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
- Flor Herta
- Flor Herta
- Foley Sonya F
- Fontaine Deborah
- Fontoura Paulo
- Ford Judith M
- Fornage Myriam
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- Foroud Tatiana
- Foroud Tatiana M
- Forstner Andreas J
- Foster Eric
- Foster Norm
- Fox Nick
- Francks Clyde
- Frank Richard
- Frank Samuel
- Franke Barbara
- Franklin Erin
- Franz Carol E
- Frasier Mark
- Frouin Vincent
- Fröhner Juliane
- Fukunaga Masaki
- Gaikwad Mrunalini
- Galasko Douglas
- Garavan Hugh
- Garijo Daniel
- Garrett Melanie E
- Gauss Katharina
- Ge Tian
- Geldmacher David
- Gessert Devon
- Ghanbari Mohsen
- Giddaluru Sudheer
- Gigliotti Christina
- Gil Yolanda
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- Glahn David C
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- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
- Green Robert C
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- Greig-Custo Maria T
- Griffith Randall
- Grimmer Yvonne
- Groenewold Nynke A
- Grossman Hillel
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
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- Harlan Sherry
- Harless Kelly
- Harris Mat
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- Harrison Marc B
- Hart David
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- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
- Hauser Robert
- Hawkins Keith A
- Hefti Franz
- Heidebrink Judith L
- Heindel Walter
- Heinz Andreas
- Heinz Andreas
- Heinzen Erin L
- Henskens Frans A
- Hergesheimer Lindsey
- Herms Stefan
- Hernando Raymundo
- Herring Scott
- Heslenfeld Dirk J
- Hetelle Joel
- Hewitt David L
- Heyn Chris Chinthaka
- Hibar Derrek P
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- Himali Jayandra J
- Ho Beng-Choon
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- Hofer Edith
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- Hoffmann Wolfgang U
- Hofman Albert
- Hogarth Penelope
- Hohmann Sarah
- Holleran Laurena
- Holmes Avram J
- Holsboer Florian
- Holtzman David
- Homuth Georg
- Hong L Elliot
- Honig Lawrence S
- Hoogman Martine
- Hopkins William D
- Hosein Chris
- Hosten Norbert
- Hottenga Jouke-Jan
- Hsiao John
- Hsiung Ging-Yuek Robin
- Hu Shu-Ching
- Hulshoff Pol Hilleke E
- Hunter Christine
- Hynes Mary L
- Häusler Alexander N
- Håberg Asta K
- Ihlenfeld Albrecht
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Arfan
- Ing Alex
- Initiative Alzheimer’s Disease Neuroimaging
- Initiative Parkinson’s Progression Markers
- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
- Ismail M Saleem
- Ittermann Bernd
- Jack Clifford R
- Jack Clifford R
- Jagust William
- Jahanshad Neda
- James Angela
- James Olga
- James Raymond
- Jang MiHyun
- Jankovic Joseph
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E
- Jennings Danna
- Jernigan Terry L
- Jia Tianye
- Jia Tianye
- Jian Xueqiu
- Jiang Jiyang
- Jicha Greg
- Jimenez Gustavo
- Jockwitz Christiane
- Johnson Kathleen
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- Kaye Jeffrey A
- Kelly Sinead
- Keltz Melanie
- Kennedy Martin A
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- Khachaturian Zaven
- Kieburtz Karl
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- Kikuchi Masataka
- Killiany Ronald
- Kim Sungeun
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- Kircher Tilo T J
- Kittur Smita
- Kiyasova Vera
- Klein Marieke
- Knapp Michael
- Knodt Annchen R
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- Kolskår Knut
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- Yamamori Hidenaga
- Yanez Beatriz
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- Yang Qiong
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- Yeh Randy
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- Zamrini Edward
- Zare Habil
- Zaremba Dario
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- Zhu Alyssa H
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- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
ICAR: endoscopic skull‐base surgery
- Author
- Aaron G
- Aaron GP
- Abergel A
- Abouaf L
- Abrishamkar S
- Acioly MA
- Acioly MA
- Acuna RT
- Adams AS
- Adappa ND
- Aferzon M
- Agaimy A
- Agarwal A
- Aggarwal A
- Agrawal D
- Ahmed OH
- Aihara M
- Akagami R
- Alahmadi H
- Albu S
- Albu S
- Albu S
- Alexander A
- Alimohamadi M
- Almefty R
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almond MC
- Alobaid A
- Alobid I
- Alobid I
- Alos L
- AlQahtani A
- Altay T
- Alvarez FL
- Alves MV
- Al‐Mamgani A
- Al‐Mefty O
- Al‐Sheibani S
- Amano K
- Amdur RJ
- Amelot A
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
- Amichetti M
- Amin SM
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- Anderson RL
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- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
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- Adham W
- Adhitama N
- Adil M
- Adisa AO
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- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
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- Aglan A
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- Aguilera M
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- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
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- Ahmed H
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- Ahmed LAM
- Ahmed S
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- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
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- Al-Faifi JJ
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- Alada M
- Alahmady O
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- Alaloul E
- Alamin S
- Alamoudi M
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- Albiety A
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- Aldalaq A
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- Alexander P
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- Alexandre C
- Alfarsi MA
- Alghamdi A
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- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
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- Ali A
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- Ali CDM
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- Ali FM
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- Ali SAWEW
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- Ali THA
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- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
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- Aljboor K
- Aljiffry M
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- Aljohani E
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- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
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- Allam Y
- Allegri A
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- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
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- Alser OH
- Alshareef R
- Altaf A
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- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
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- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
- Asal M
- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
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- Augestad KM
- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
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- Balkan AZA
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- Balmaceda R
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- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
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- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
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- Bassit KA
- Basso SMM
- Basson S
- Batt J
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- Beamon M
- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
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- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
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- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
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- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
- Blanco R
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- Blencowe N
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- Bliksoen M
- Blower E
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- Bray LD
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- Breitenstein S
- Breslin R
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- Brown D
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- Brown J
- Browning DRL
- Brunoni B
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- Bugaev N
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- Burns H
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- Cabala Chiong JA
- Cacurri A
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- Caliman C
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- Campagnaro T
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- Cheung YHE
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- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
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- Chiu SMY
- Choi J
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- Chong BFHK
- Chong CL
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- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
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- Del Basso C
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- Delforge X
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- Dempster E
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- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
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- Dick L
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- Din F
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- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
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- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
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- Driscoll A
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- du Plooy F
- Du Toit F
- Duane T
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- Duhoranenayo D
- Duinhouwer L
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- Ebrahim OS
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- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
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- Fairfield C
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- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
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- Faraz A
- Fares M
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- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
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- Firwana A
- Fitsum A
- Fitzgerald JE
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- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
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- Forno W
- Fouad A
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- Fourcade L
- Fowler AJ
- Fozard T
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- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
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- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
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- Galiqi G
- Galleano R
- Gallo G
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- Galvez CP
- Gamal D
- Gamal E
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- Gamal S
- Gamaly E
- Gamil D
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- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
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- Germanos S
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- Gerosa A
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- Grizhja B
- Grobler DC
- Grosos C
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- Guevara Torres S
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- Gunawan R
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- Halicioglu I
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- Hashim A
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- Hassaan A
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- Hassanein AB
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- Ibraheem HI
- Ibrahem AA
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- Ibrahim A
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- Ibrahim I
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- Kasputyte S
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- Korkolis D
- Kosai NR
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- Kotecha D
- Koto MZ
- Kotobi H
- Koumpa F
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- Mohamed M
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- Mohamed O
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- Mohammad A
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- Montoya Botero JA
- Montrimaite M
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- Sakr A
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- Samaraweera DI
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- Sammarco G
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
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