La voce delle immagini

A Palazzo Grassi, Caroline Bourgeois delinea un percorso di ampio respiro che abbraccia tutta la (seppur breve) storia della videoarte

Nuovi paesaggi e nuove prospettive per i territori abitati in tempo di crisi: la rigenerazione del PEEP “Circus” a Venezia attraverso gli spazi aperti

Il paper s’interroga su come rimettere in moto alcuni processi di trasformazione urbana che si sono fermati a causa della scarsità di risorse, il cui precipitato si è materializzato in vuoti urbani, servizi non offerti, processi di coesione interrotti. Tale approccio presuppone un duplice spostamento del punto di vista, nella distanza del punto d’osservazione, perché i quartieri pubblici presi in considerazione si inseriscono nel funzionamento di una porzione di territorio più ampia; e nell’oggetto osservato, rivolgendo l’attenzione non solo allo spazio “fisico” ma anche a quello abitato e delle politiche. Il caso studio del PEEP Circus di Venezia s’inserisce nel contesto tipico dei territori dispersi del Nord-Est, nel quale l'introduzione di edilizia residenziale pubblica ha seguito le stesse regole di quella privata. Nonostante siano state portate avanti alcune operazioni di miglioramento sia fisico che sociale da parte dell’amministrazione locale, è mancato un coordinamento dei diversi tipi di azione. Ne è risultato che lo spazio aperto collettivo del Circus continua a rimanere vuoto, presa di distanza, sociale oltre che fisica, da parte dei suoi abitanti

Medicalización global, TDAH y niñeces. un estudio en medios de comunicación de 7 países

The aim is to analyze research results in seven countries in Asia, America,Europe and Oceania, to know which social actors are represented in the media on ADHD, inwhat ways and with what effects. We support the argument in three axes: ADHD as aparadigmatic example of the medicalization of children's mental health; ADHD in childhood asa global diagnosis; and the media as a relevant non-medical actor in the globalization of ADHDdiagnosis. A corpus of 28 pieces of specific bibliography (books, book chapters and scientificarticles) was formed. We consider the contributions of the medicalization of society as atheoretical-conceptual reference. The multiplicity of media discourses about ADHD inchildren, and the articulation of non-medical social actors in the processes of globalmedicalization of ADHD are discuss.O objetivo é analisar os resultados da pesquisa em sete países da Ásia, América, Europa e Oceania, para saber quais atores sociais estão representados na mídia sobre TDAH, de que forma e com quais efeitos. Apoiamos o argumento em três eixos: TDAH como exemplo paradigmático da medicalização da saúde mental das crianças; TDAH na infância como diagnóstico global; e a mídia como um ator não médico relevante na globalização do diagnóstico de TDAH. Foi formado um corpus de 28 peças de bibliografia específica (livros, capítulos de livros e artigos científicos). Tomamos como referência teórico-conceitual as contribuições da corrente da medicalização da sociedade. Discute a multiplicidade de discursos midiáticas sobre TDAH em crianças, e sobre a articulação de atores sociais não médicos nos processos de medicalização global do TDAH.El objetivo es analizar resultados de investigaciones en siete países de Asia, América, Europa y Oceanía, para conocer qué actores sociales aparecen representados en los medios de comunicación sobre el TDAH, de qué maneras y con qué efectos. Sustentamos la argumentación en tres ejes: el TDAH como ejemplo paradigmático de la medicalización de la salud mental infantil; el TDAH en la infancia como diagnóstico global; y los medios de comunicación como actor no médico relevante en la globalización del diagnóstico de TDAH. Se conformó un corpus de 28 piezas de bibliografía específica (libros, capítulos de libros y artículos científicos). Tomamos como referencia teórico-conceptual los aportes de la corriente de la medicalización de la sociedad. Se discute acerca de la multiplicidad de discursos mediáticos acerca del TDAH en las niñeces, y sobre la articulación de actores sociales no médicos en los procesos de medicalización global del TDAH.Fil: Bianchi, Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; ArgentinaFil: Oberti, Milagros. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; ArgentinaFil: Faraone, Silvia Adriana. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; ArgentinaFil: Torricelli, Flavia Claudia. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Instituto de Investigaciones "Gino Germani"; Argentin

Chapter Archeological findings of ancient harbor in the pilot site of Interreg Adrion APPRODI project in Ortona (Ch, Abruzzo), central Adriatic Sea

The Interreg Adrion ‘APPRODI’ project aims at a qualitative change in the nature of tourism demand with a transnational approach and at increasing visibility of destinations. the project will allow to create the conditions for development of cultural tourism, even underwater, increasing and enhancing the historical and archaeological resources. The dive samplings allowed to find an important archaeological heritage in the seabeds in front of Ortona coast, testifying to the presence of an ancient port and maritime traffic

Antioxidant and Antisenescence Effects of Bergamot Juice

Aging is one of the main risk factor for the onset of cardiovascular diseases; one of the possible explanations could be linked to the age-associated overproduction of free radicals. This increase of oxidative stress can be overcome with a high intake of food antioxidants. In this context, a number of studies have been addressed to assess the antiaging potential of natural antioxidant compounds. Recently, it has been shown that the juice of bergamot (Citrus bergamia Risso et Poiteau), a fruit mostly produced in the Ionian coastal areas of Southern Italy (Calabria), is a valuable source of health-promoting constituents with, among other, antioxidant properties. In order to investigate the potential antiaging effects of this Mediterranean natural antioxidant source, bergamot juices of three different cultivars ("fantastico," "femminello," and "castagnaro") were herein characterized by the mean of high-performance liquid chromatography-photodiode array-electrospray ionization-tandem mass spectrometry. Then, juices were investigated for the evaluation of total polyphenolic and flavonoid contents, cell-free model antioxidant activities, and in vitro antiaging properties on two different cellular models of induced myocardial senescence. The best performing juice was also assessed in vivo. The phytochemical profiles confirmed that juices were rich in flavonoids, both flavone and flavanone glycosides. In addition, two limonoid glycosides were also identified in all cultivars. Each cultivar showed different phenolic and flavonoid contents. In tube results showed the juice robust antioxidant activities that correlate with their phenolic and flavonoid contents. Moreover, for the first time, the ability of juice to counteract the chemical-induced senescence was here demonstrated in both cellular models. Lastly, the in vivo data obtained from mouse hearts evidenced an increase in transcription of genes involved in antiaging and antioxidant responses. The overall results suggest that bergamot juice exerts antioxidant and antisenescence effects, making it useful for nutraceutical purposes

Course and Lethality of SARS-CoV2 Epidemic in Nursing Homes after Vaccination in Florence, Italy

Evidence on the effectiveness of SARS-CoV-2 vaccines in nursing home (NHs) residents is limited. We examined the impact of the BNT162b2 mRNA SARS-CoV-2 vaccine on the course of the epidemic in NHs in the Florence Health District, Italy, before and after vaccination. Moreover, we assessed survival and hospitalization by vaccination status in SARS-CoV-2-positive cases occurring during the post-vaccination period. We calculated the weekly infection rates during the pre-vaccination (1 October–26 December 2020) and post-vaccination period (27 December 2020–31 March 2021). Cox analysis was used to analyze survival by vaccination status. The study involved 3730 residents (mean age 84, 69% female). Weekly infection rates fluctuated during the pre-vaccination period (1.8%–6.5%) and dropped to zero during the post-vaccination period. Nine unvaccinated (UN), 56 partially vaccinated (PV) and 35 fully vaccinated (FV) residents tested SARS-CoV-2+ during the post-vaccination period. FV showed significantly lower hospitalization and mortality rates than PV and UV (hospitalization: FV 3%, PV 14%, UV 33%; mortality: FV 6%, PV 18%, UV 56%). The death risk was 84% and 96% lower in PV (HR 0.157, 95%CI 0.049–0.491) and FV (HR 0.037, 95%CI 0.006–0.223) versus UV. SARS-CoV-2 vaccination was followed by a marked decline in infection rates and was associated with lower morbidity and mortality among infected NH residents

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders