Developmental simulation of the adult cranial morphology of australopithecus sediba.

The type specimen of Australopithecus sediba (MH1) is a late juvenile, prompting some commentators to suggest that had it lived to adulthood its morphology would have changed sufficiently so as to render hypotheses regarding its phylogenetic relations suspect. Considering the potentially critical position of this species with regard to the origins of the genus Homo, a deeper understanding of this change is especially vital. As an empirical response to this critique, a developmental simulation of the MH1 cranium was carried out using geometric morphometric techniques to extrapolate adult morphology using extant male and female chimpanzees, gorillas and humans by modelling remaining development. Multivariate comparisons of the simulated adult A. sediba crania with other early hominin taxa indicate that subsequent cranial development primarily reflects development of secondary sexual characteristics and would not likely be substantial enough to alter suggested morphological affinities of A. sediba. This study also illustrates the importance of separating developmental vectors by sex when estimating ontogenetic change. Results of the ontogenetic projections concur with those from mandible morphology, and jointly affirm the taxonomic validity of A. sediba.Andrew W. Mellon Foundation and National Geographic Society.NCS201

Superconductivity and Charge Density Wave in a Quasi-One-Dimensional Spin Gap System

We consider a model of spin-gapped chains weakly coupled by Josephson and Coulomb interactions. Combining such non-perturbative methods as bosonization and Bethe ansatz to treat the intra-chain interactions with the Random Phase Approximation for the inter-chain couplings and the first corrections to this, we investigate the phase diagram of this model. The phase diagram shows both charge density wave ordering and superconductivity. These phases are seperated by a line of critical points which exhibits an approximate an SU(2) symmetry. We consider the effects of a magnetic field on the system. We apply the theory to the material Sr_2 Ca_12 Cu_24 O_41 and suggest further experiments.Comment: 14 pages, 7 figure; submitted to PRB; Revised with new version: references added; section on the flux state remove

Thermodynamics of Trapped Imbalanced Fermi Gases at Unitarity

We present a theory for the low-temperature properties of a resonantly interacting Fermi mixture in a trap, that goes beyond the local-density approximation. The theory corresponds essentially to a Landau-Ginzburg-like approach that includes self-energy effects to account for the strong interactions at unitarity. We show diagrammatically how these self-energy effects arise from fluctuations in the superfluid order parameter. Gradient terms of the order parameter are included to account for inhomogeneities. This approach incorporates the state-of-the-art knowledge of the homogeneous mixture with a population imbalance exactly and gives good agreement with the experimental density profiles of Shin et al. [Nature 451, 689 (2008)]. This allows us to calculate the universal surface tension of the interface between the equal-density superfluid and the partially polarized normal state of the mixture. We also discuss the possibility of a metastable state to explain the deformation of the superfluid core that is seen in the experiment of Partridge et al. [Science 311, 503 (2006)].Comment: 26 pages, 7 figures, contribution to Lecture Notes in Physics "BCS-BEC crossover and the Unitary Fermi Gas" edited by W. Zwerge

Mixing time of critical Ising model on trees is polynomial in the height

In the heat-bath Glauber dynamics for the Ising model on the lattice, physicists believe that the spectral gap of the continuous-time chain exhibits the following behavior. For some critical inverse-temperature $\beta_c$, the inverse-gap is bounded for $\beta < \beta_c$, polynomial in the surface area for $\beta = \beta_c$ and exponential in it for $\beta > \beta_c$. This has been proved for $\Z^2$ except at criticality. So far, the only underlying geometry where the critical behavior has been confirmed is the complete graph. Recently, the dynamics for the Ising model on a regular tree, also known as the Bethe lattice, has been intensively studied. The facts that the inverse-gap is bounded for $\beta \beta_c$ were established, where $\beta_c$ is the critical spin-glass parameter, and the tree-height $h$ plays the role of the surface area. In this work, we complete the picture for the inverse-gap of the Ising model on the $b$-ary tree, by showing that it is indeed polynomial in $h$ at criticality. The degree of our polynomial bound does not depend on $b$, and furthermore, this result holds under any boundary condition. We also obtain analogous bounds for the mixing-time of the chain. In addition, we study the near critical behavior, and show that for $\beta > \beta_c$, the inverse-gap and mixing-time are both $\exp[\Theta((\beta-\beta_c) h)]$.Comment: 53 pages; 3 figure

Effective Actions and Phase Fluctuations in d-wave Superconductors

We study effective actions for order parameter fluctuations at low temperature in layered d-wave superconductors such as the cuprates. The order parameter lives on the bonds of a square lattice and has two amplitude and two phase modes associated with it. The low frequency spectral weights for amplitude and relative phase fluctuations is determined and found to be subdominant to quasiparticle contributions. The Goldstone phase mode and its coupling to density fluctuations in charged systems is treated in a gauge-invariant manner. The Gaussian phase action is used to study both the $c$-axis Josephson plasmon and the more conventional in-plane plasmon in the cuprates. We go beyond the Gaussian theory by deriving a coarse-grained quantum XY model, which incorporates important cutoff effects overlooked in previous studies. A variational analysis of this effective model shows that in the cuprates, quantum effects of phase fluctuations are important in reducing the zero temperature superfluid stiffness, but thermal effects are small for $T << T_c$.Comment: Some numerical estimates corrected and figures changed. to appear in PRB, Sept.1 (2000

Trends in characteristics and outcomes among US adults hospitalised with COVID-19 throughout 2020: An observational cohort study

Objectives To examine the temporal patterns of patient characteristics, treatments used and outcomes associated with COVID-19 in patients who were hospitalised for the disease between January and 15 November 2020. Design Observational cohort study. Setting COVID-19 subset of the Optum deidentified electronic health records, including more than 1.8 million patients from across the USA. Participants There were 51 510 hospitalised patients who met the COVID-19 definition, with 37 617 in the laboratory positive cohort and 13 893 in the clinical cohort. Primary and secondary outcome measures Incident acute clinical outcomes, including in-hospital all-cause mortality. Results Respectively, 48% and 49% of the laboratory positive and clinical cohorts were women. The 50- 65 age group was the median age group for both cohorts. The use of antivirals and dexamethasone increased over time, fivefold and twofold, respectively, while the use of hydroxychloroquine declined by 98%. Among adult patients in the laboratory positive cohort, absolute age/sex standardised incidence proportion for in-hospital death changed by -0.036 per month (95% CI -0.042 to -0.031) from March to June 2020, but remained fairly flat from June to November, 2020 (0.001 (95% CI -0.001 to 0.003), 17.5% (660 deaths /3986 persons) in March and 10.2% (580/5137) in October); in the clinical cohort, the corresponding changes were -0.024 (95% CI -0.032 to -0.015) and 0.011 (95% CI 0.007 0.014), respectively (14.8% (175/1252) in March, 15.3% (189/1203) in October). Declines in the cumulative incidence of most acute clinical outcomes were observed in the laboratory positive cohort, but not for the clinical cohort. Conclusion The incidence of adverse clinical outcomes remains high among COVID-19 patients with clinical diagnosis only. Patients with COVID-19 entering the hospital are at elevated risk of adverse outcomes

Measurement of the cross section for isolated-photon plus jet production in pp collisions at √s=13 TeV using the ATLAS detector

The dynamics of isolated-photon production in association with a jet in proton–proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb−1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon–jet invariant mass and the scattering angle in the photon–jet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements

A search for resonances decaying into a Higgs boson and a new particle X in the XH → qqbb final state with the ATLAS detector

A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb−1 of proton–proton collision data at collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle X is assumed to decay to a pair of light quarks, and the fully hadronic final state is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the resonance

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele