The impact of the Large Magellanic Cloud on dark matter direct detection signals

We study the effect of the Large Magellanic Cloud (LMC) on the dark matter (DM) distribution in the Solar neighborhood, utilizing the Auriga magneto-hydrodynamical simulations of Milky Way (MW) analogues that have an LMC-like system. We extract the local DM velocity distribution at different times during the orbit of the LMC around the MW in the simulations. As found in previous idealized simulations of the MW-LMC system, we find that the DM particles in the Solar neighborhood originating from the LMC analogue dominate the high speed tail of the local DM speed distribution. Furthermore, the native DM particles of the MW in the Solar region are boosted to higher speeds as a result of a response to the LMC's motion. We simulate the signals expected in near future xenon, germanium, and silicon direct detection experiments, considering DM interactions with target nuclei or electrons. We find that the presence of the LMC causes a considerable shift in the expected direct detection exclusion limits towards smaller cross sections and DM masses, with the effect being more prominent for low mass DM. Hence, our study shows, for the first time, that the LMC's influence on the local DM distribution is significant even in fully cosmological MW analogues

Avaliação da presença de ácaros em cereais armazenados na grande São Paulo

Microscopic examinations of 160 samples of cereals (rice, beans, wheat corn, oats, peas and sorghum), 40% provided by Instituto Adolfo Lutz and collected from large distributors as COBAL, CIBRAZEM, PETROPACK, CEAGESP and DECOM, and 60% acquired at many small retailers, realized upon receipt and after 42 days incubation at 25°C and 70% relative humidity showed that 49% of the samples presented primary stored food mites. Of the infested samples, 48% had Tyrophagus putrescentiae (Schrank), 17.5% Aleuroglyphus ovatus (Troupeau), 6.8% Glycyphagus domesticus (DeGeer) , 4.37% Chortoglyphus arcuatus (Troupeau), 3.8% Suidasia pontifica Oudemans, 3.12% Blomia tropicalis Bronswijck, Cock & Oshima, 1.25% Histiostoma sp. and 0.6% Dermatophagoides pteronyssinus (Trouessart). Secondary mites were also present, mainly Tarsonemus sp. , Cheyletus malaccensis Oudemans and Blattosocius dentriticus (Berlese). Samples originating from the large distributors, when infested, had much fewer mites than those from the small retailers where the cereals remain over much longer periods before they are sold out and replaced. The presence of mites in samples after 42 days of incubation when their examination upon receipt was negative for these pests does not preclude the presence of mite eggs. Sitophilus oryzae (L.) (Insecta, Coleoptera) was common in rice, corn and wheat samples.O exame microscópico de 160 amostras de cereais (arroz, feijão, trigo, milho, a veia, ervilha e sorgo), 40% fornecidas pelo Instituto Adolfo Lutz e provenientes de distribuidores como COBAL, CIBRAZEM, PETROPACK, CEAGESP, DECOM e do 2º Exército, e 60% adquiridas em mercadinhos e armazéns na Grande São Paulo, feito no ato e após 42 dias de incubação a 25°C e 70% UR revelou que 49% das amostras apresentavam populações de ácaros primários de alimentos armazenados. Destas, 48% revelaram a presença de Tyrophagus putrescentiae (Schrank), 17,5% Aleuroglyphus ovatus (Troupeau), 6,8% Glycyphagus domesticus (DeGeer), 4,37% Chortoglyphus arcuatus (Troupeau), 3,8% Suidasia pontifica Oudemans, 3,12% Blomia tropicallis Bronswijck, Cook & Oshima, 1,25% Histiostoma sp. e Dermatophagoides pteronyssinus (Trouessart). Ácaros secundários também foram encontra dos destacando-se Tarsonemus sp., Cheyletus malaccensis Oudemans e Blattisocius dentriticus (Berlese), entre outros. As amostras originárias dos grandes distribuidores apresentavam bem menos ácaros do que aquelas dos pequenos armazéns onde a rotatividade de estoque é bem menor. O resultado positivo para ácaros de amostras mantidas em incubador por 42 dias quando seu exame no ato não os revelou, mostra que o simples exame de uma amostra de cereal num dado momento não exclui a hipótese dele estar contaminado por ovos de ácaros primários de alimentos. Dentre os insetos, o mais frequente foi o gorgulho Sitophilus orizae (L.) presente em amostras de arroz, milho e trigo

Unidad Experimental Demostrativa con fines educativos y de extensión.

La cátedra de Introducción a la Producción Animal cuenta con una Unidad Experimental Demostrativa  (UED) con fines educativos, de investigación y extensión. Ubicada entre las Facultades de Ciencias Agrarias y Forestales y de  Ciencias Veterinarias, en la ciudad de La Plata (34º 52´LS 57º 58´LO15 msnm), goza del privilegio de posibilitar la articulación con el alumnado, comunidad educativa en general, productores e institutos de investigación aledaños. Consiste en un conejar de 40 reproductores y en un hato caprino de 30 cabras. Esta ofrece a los estudiantes la oportunidad de profundizar temas específicos de la asignatura y participar de operaciones prácticas vinculadas a la disciplina. La UED cumple, en este sentido, un rol importante en la metodología de enseñanza-aprendizaje de la Zootecnia, acercando a los estudiantes a dos especies diferentes: caprinos, como representantes de los rumiantes, y conejos, como monogástricos de transición. Durante el desarrollo del curso los alumnos van aprendiendo diferentes labores y técnicas de manejo de ambas producciones (controles de peso, condición corporal, cronometría dentaria, administración de medicamentos, seguimiento productivo de las conejas, principales características de conformación externa de las diferentes razas caprinas, etc.). En ambos casos, pueden extrapolarse metodologías de manejo a otras especies de interés zootécnico. Como complemento de éstas actividades curriculares obligatorias, tanto el conejar como el hato caprino, contribuyen a incrementar la oferta de actividades optativas (pasantías y ayudantías) requeridas por el plan de estudios para completar la formación de grado. En cuanto a las líneas de investigación  y formación de posgrado la UED provee el sustento experimental a tres tesistas doctorales del área de Nutrición Animal, uno de ellos en la producción caprina y los otros en producción cunícola. Los resultados obtenidos sistemáticamente han podido transferirse a productores de la zona, aportando fundamentalmente herramientas de manejo en áreas sensibles de ambas producciones como la reproducción y la alimentación. En Cunicultura se ha difundido el manejo reproductivo intensivo, promoviendo intervalos entre partos de 35 días, mayor productividad y menor peso relativo de la alimentación de las madres en el balance económico del establecimiento. En producción caprina, actualmente se desarrollan líneas de investigación relacionadas con nutrición, efecto fisiológico de diversas dietas y su respuesta en la calidad de los productos obtenidos (composición de la leche caprina). En el ámbito de la extensión, se brinda el servicio a laboratorios e institutos, de provisión de material vivo y animales para experimentación, alojamiento, seguimiento y mantenimiento de los mismos.

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results