68 research outputs found
Simulating Globular Clusters in Dark Matter Subhalos
A cosmological zoom-in simulation that develops into a Milky Way-like halo begins at redshift 7. The initial dark matter distribution is seeded with dense star clusters of median mass 5 × 105 M o˙, placed in the largest subhalos present, which have a median peak circular velocity of 25 km s-1. Three simulations are initialized using the same dark matter distribution with the star clusters starting on approximately circular orbits having initial median radii 6.8, 0.14 kpc, and, at the exact center of the subhalos. The simulations are evolved to the current epoch at which time the median galactic orbital radii of the three sets of clusters are 30, 5, and 16 kpc, with the clusters losing about 2%, 50%, and 15% of their mass, respectively. Clusters beginning at small orbital radii have so much tidal forcing that they are often not in equilibrium. Clusters that start at larger subhalo radii have a velocity dispersion that declines smoothly to ≃20% of the central value at ≃20 half-mass radii. The clusters that begin in the subhalo centers can show a rise in velocity dispersion beyond 3-5 half-mass radii. That is, the clusters that form without local dark matter always have stellar-mass-dominated kinematics at all radii, whereas about 25% of the clusters that begin in subhalo centers have remnant local dark matter
Mass-to-Light Ratios of Galaxy Groups from Weak Lensing
We present the findings of our weak lensing study of a sample of 116 CNOC2
galaxy groups. The lensing signal is used to estimate the mass-to-light ratio
of these galaxy groups. The best fit isothermal sphere model to our lensing
data has an Einstein radius of 0.88"+/-0.12", which corresponds to a
shear-weighted velocity dispersion of 245+/-18 km/s. The mean mass-to-light
ratio within 1 h^-1 Mpc is 185+/-28 h times solar in the B-band and is
independent of radius from the group center.
The signal-to-noise ratio of the shear measurement is sufficient to split the
sample into subsets of "poor" and "rich" galaxy groups. The poor galaxy groups
were found to have an average velocity dispersion of 193+/-38 km/s and a
mass-to-light ratio of 134+/-26 h times solar in the B-band, while the rich
galaxy groups have a velocity dispersion of 270+/-39 km/s and a mass-to-light
ratio of 278+/-42 h times solar in the B-band, similar to the mass-to-light
ratio of clusters. This steep increase in the mass-to-light ratio as a function
of mass, suggests that the mass scale of ~10^13 solar masses is where the
transition between the actively star-forming field environment and the
passively-evolving cluster environment occurs. This is the first such detection
from weak lensing.Comment: Accepted for publication in ApJ 6 pages, 6 figures, uses emulateap
The Next Generation Virgo Cluster Survey - Infrared (NGVS-IR): I. A new Near-UV/Optical/Near-IR Globular Cluster selection tool
The NGVS-IR project (Next Generation Virgo Survey - Infrared) is a contiguous
near-infrared imaging survey of the Virgo cluster of galaxies. It complements
the optical wide-field survey of Virgo (NGVS). The current state of NGVS-IR
consists of Ks-band imaging of 4 deg^2 centered on M87, and J and Ks-band
imaging of 16 deg^2 covering the region between M49 and M87. In this paper, we
present the observations of the central 4 deg^2 centered on Virgo's core
region. The data were acquired with WIRCam on the Canada-France-Hawaii
Telescope and the total integration time was 41 hours distributed in 34
contiguous tiles. A survey-specific strategy was designed to account for
extended galaxies while still measuring accurate sky brightness within the
survey area. The average 5\sigma limiting magnitude is Ks=24.4 AB mag and the
50% completeness limit is Ks=23.75 AB mag for point source detections, when
using only images with better than 0.7" seeing (median seeing 0.54"). Star
clusters are marginally resolved in these image stacks, and Virgo galaxies with
\mu_Ks=24.4 AB mag arcsec^-2 are detected. Combining the Ks data with optical
and ultraviolet data, we build the uiK color-color diagram which allows a very
clean color-based selection of globular clusters in Virgo. This diagnostic plot
will provide reliable globular cluster candidates for spectroscopic follow-up
campaigns needed to continue the exploration of Virgo's photometric and
kinematic sub-structures, and will help the design of future searches for
globular clusters in extragalactic systems. Equipped with this powerful new
tool, future NGVS-IR investigations based on the uiK diagram will address the
mapping and analysis of extended structures and compact stellar systems in and
around Virgo galaxies.Comment: 23 pages, 18 figures. Accepted for publication in ApJ
Exploring the Diversity of Groups at 0.1<z<0.8 with X-ray and Optically Selected Samples
We present the global group properties of two samples of galaxy groups
containing 39 high quality X-ray selected systems and 38 optically
(spectroscopically) selected systems in coincident spatial regions at
0.12<z<0.79. Only nine optical systems are associable with X-ray systems. We
discuss the confusion inherent in the matching of both galaxies to extended
X-ray emission and of X-ray emission to already identified optical systems.
Extensive spectroscopy has been obtained and the resultant redshift catalog and
group membership are provided here. X-ray, dynamical, and total stellar masses
of the groups are also derived and presented. We explore the effects of
applying three different kinds of radial cut to our systems: a constant cut of
1 Mpc and two r200 cuts, one based on the velocity dispersion of the system and
the other on the X-ray emission. We find that an X-ray based r200 results in
less scatter in scaling relations and less dynamical complexity as evidenced by
results of the Anderson-Darling and Dressler-Schectman tests, indicating that
this radius tends to isolate the virialized part of the system. The constant
and velocity dispersion based cuts can overestimate membership and can work to
inflate velocity dispersion and dynamical and stellar mass. We find Lx-sigma
and Mstellar-Lx scaling relations for X-ray and optically selected systems are
not dissimilar. The mean fraction of mass found in stars for our systems is
approximately 0.014 with a logarithmic standard deviation of 0.398 dex. We also
define and investigate a sample of groups which are X-ray underluminous given
the total group stellar mass. For these systems the fraction of stellar mass
contributed by the most massive galaxy is typically lower than that found for
the total population of groups implying that there may be less IGM contributed
from the most massive member in these systems. (Abridged)Comment: Accepted for publication in the Astrophysical Journal (ApJ). 27
pages, 14 figures, 12 table
The Carnegie Supernova Project: First Near-Infrared Hubble Diagram to z~0.7
The Carnegie Supernova Project (CSP) is designed to measure the luminosity
distance for Type Ia supernovae (SNe Ia) as a function of redshift, and to set
observational constraints on the dark energy contribution to the total energy
content of the Universe. The CSP differs from other projects to date in its
goal of providing an I-band {rest-frame} Hubble diagram. Here we present the
first results from near-infrared (NIR) observations obtained using the Magellan
Baade telescope for SNe Ia with 0.1 < z < 0.7. We combine these results with
those from the low-redshift CSP at z <0.1 (Folatelli et al. 2009). We present
light curves and an I-band Hubble diagram for this first sample of 35 SNe Ia
and we compare these data to 21 new SNe Ia at low redshift. These data support
the conclusion that the expansion of the Universe is accelerating. When
combined with independent results from baryon acoustic oscillations (Eisenstein
et al. 2005), these data yield Omega_m = 0.27 +/- 0.0 (statistical), and
Omega_DE = 0.76 +/- 0.13 (statistical) +/- 0.09 (systematic), for the matter
and dark energy densities, respectively. If we parameterize the data in terms
of an equation of state, w, assume a flat geometry, and combine with baryon
acoustic oscillations, we find that w = -1.05 +/- 0.13 (statistical) +/- 0.09
(systematic). The largest source of systematic uncertainty on w arises from
uncertainties in the photometric calibration, signaling the importance of
securing more accurate photometric calibrations for future supernova cosmology
programs. Finally, we conclude that either the dust affecting the luminosities
of SNe Ia has a different extinction law (R_V = 1.8) than that in the Milky Way
(where R_V = 3.1), or that there is an additional intrinsic color term with
luminosity for SNe Ia independent of the decline rate.Comment: 44 pages, 23 figures, 9 tables; Accepted for publication in the
Astrophysical Journa
Conformational Altered p53 as an Early Marker of Oxidative Stress in Alzheimer's Disease
In order to study oxidative stress in peripheral cells of Alzheimer's disease (AD) patients, immortalized lymphocytes derived from two peculiar cohorts of patients, referring to early onset AD (EOSAD) and subjects harboured AD related mutation (ADmut), were used. Oxidative stress was evaluated measuring i) the typical oxidative markers, such as HNE Michel adducts, 3 Nitro-Tyrosine residues and protein carbonyl on protein extracts, ii) and the antioxidant capacity, following the enzymatic kinetic of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRD). We found that the signs of oxidative stress, measured as oxidative marker levels, were evident only in ADmut but not in EOSAD patients. However, oxidative imbalance in EOSAD as well as ADmut lymphocytes was underlined by a reduced SOD activity and GRD activity in both pathological groups in comparison with cells derived from healthy subjects. Furthermore, a redox modulated p53 protein was found conformational altered in both EOSAD and ADmut B lymphocytes in comparison with control cells. This conformational altered p53 isoform, named “unfolded p53”, was recognized by the use of two specific conformational anti-p53 antibodies. Immunoprecipitation experiments, performed with the monoclonal antibodies PAb1620 (that recognizes p53wt) and PAb240 (that is direct towards unfolded p53), and followed by the immunoblotting with anti-4-hydroxynonenal (HNE) and anti- 3-nitrotyrosine (3NT) antibodies, showed a preferential increase of nitrated tyrosine residues in unfolded p53 isoform comparing to p53 wt protein, in both ADmut and EOSAD. In addition, a correlation between unfolded p53 and SOD activity was further found. Thus this study suggests that ROS/RNS contributed to change of p53 tertiary structure and that unfolded p53 can be considered as an early marker of oxidative imbalance in these patients
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling
J. Kaprio, A. Palotie, A. Raevuori-Helkamaa ja S. Ripatti ovat työryhmän Eating Disorders Working Group of the Psychiatric Genomics Consortium jäseniä. Erratum in: Sci Rep. 2017 Aug 21;7(1):8379, doi: 10.1038/s41598-017-06409-3We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that approached genome-wide significance (rs929626 in EBF1 (Early B-Cell Factor 1); P = 2.04 x 10(-7); OR = 0.7; 95% confidence interval (CI) = 0.61-0.8) with independent replication (P = 0.04), suggesting a variant-mediated dysregulation of leptin signaling may play a role in AN. Multiple SNPs in LD with the variant support the nominal association. This demonstrates that although the clinical and etiologic heterogeneity of AN is universally recognized, further careful sub-typing of cases may provide more precise genomic signals. In this study, through a refinement of the phenotype spectrum of AN, we present a replicable GWAS signal that is nominally associated with AN, highlighting a potentially important candidate locus for further investigation.Peer reviewe
Recommended from our members
A genome-wide association study of anorexia nervosa
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2,907 cases with AN from 14 countries (15 sites) and 14,860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery datasets. Seventy-six (72 independent) SNPs were taken forward for in silico (two datasets) or de novo (13 datasets) replication genotyping in 2,677 independent AN cases and 8,629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication datasets comprised 5,551 AN cases and 21,080 controls. AN subtype analyses (1,606 AN restricting; 1,445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01×10−7) in SOX2OT and rs17030795 (P=5.84×10−6) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76×10−6) between CUL3 and FAM124B and rs1886797 (P=8.05×10−6) near SPATA13. Comparing discovery to replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P= 4×10−6), strongly suggesting that true findings exist but that our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field
- …