Towards an empirical analysis of justice in ecosystem governance

The 2010 Nagoya Protocol under the Convention on Biological Diversity and recent changes in the policies of major international conservation organizations highlight current interest in revisiting the moral case for conservation. Concerns with equity and human rights challenge well-established notions of justice centered on human responsibility toward nature, the common good or the rights of future generations. This review introduces an empirical approach to the analysis of justice and shows how conservation scientists can apply it to ecosystem services-based governance (or in short, ecosystem governance). It identifies dominant notions of justice and points out their compatibility with utilitarian theories of justice. It then discusses the limited appropriateness of these notions in many contexts in which conservation takes place in the Global South and explores how technical components of ecosystem governance influence the realization of the notions in practice. The review highlights the need for conservation scientists and managers to analyze the justice of ecosystem governance in addition to their effectiveness and efficiency. Justice offers a more encompassing perspective than equity for the empirical analysis of conservation governance

Sowing the seeds of sustainable rural livelihoods? An assessment of Participatory Forest Management through REDD+ in Tanzania

Participatory forest management (PFM) initiatives have emerged worldwide for a range of aims including to improve forest governance, enhance resource conservation and to increase rural people’s access to and benefits from forest resources. Some of these initiatives have also received climate finance support to enhance their impact on mitigation. However, their effects on forest governance and livelihoods are complex and remain poorly studied. In this article, we address this gap by analysing governance and livelihood changes in a PFM initiative in Tanzania that has received funding as a REDD+ pilot site. Based on qualitative governance analysis and quantitative livelihood panel data (2011–2014) that compares villages and households within and outside the project, we find that improvements to forest governance are substantial in project villages compared to control villages, while changes in income have been important but statistically insignificant, and driven by a regional sesame cash crop boom unrelated to enhanced forestry revenues. Focusing on whether PFM had enhanced other wealth indicators including household conditions and durable assets, our analysis shows again no significant differences between participant and control villages, although the participant villages do have, on average, a greater level of durable assets. Overall, our findings are positive regarding forest governance improvements but inconclusive regarding livelihood effects, which at least in the short term seem to benefit more from agricultural intensification than forestry activities, whose benefits might become more apparent over a longer time period. In conclusion we emphasize the need for moving towards longer term monitoring efforts, improving understandings of local dynamics of change, particularly at a regional rather than community level, and defining the most appropriate outcome variables and cost-effective systems of data collection or optimization of existing datasets if we are to better capture the complex impacts of PFM initiatives worldwide

Transgenic Overexpression of LARGE Induces α-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle

BACKGROUND: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of α-dystroglycan. Overexpression of LARGE induces hyperglycosylation of α-dystroglycan in both wild type and in cells from dystroglycanopathy patients, irrespective of their primary gene defect, restoring functional glycosylation. Viral delivery of LARGE to skeletal muscle in animal models of dystroglycanopathy has identical effects in vivo, suggesting that the restoration of functional glycosylation could have therapeutic applications in these disorders. Pharmacological strategies to upregulate Large expression are also being explored. METHODOLOGY/PRINCIPAL FINDINGS: In order to asses the safety and efficacy of long term LARGE over-expression in vivo, we have generated four mouse lines expressing a human LARGE transgene. On observation, LARGE transgenic mice were indistinguishable from the wild type littermates. Tissue analysis from young mice of all four lines showed a variable pattern of transgene expression: highest in skeletal and cardiac muscles, and lower in brain, kidney and liver. Transgene expression in striated muscles correlated with α-dystroglycan hyperglycosylation, as determined by immunoreactivity to antibody IIH6 and increased laminin binding on an overlay assay. Other components of the dystroglycan complex and extracellular matrix ligands were normally expressed, and general muscle histology was indistinguishable from wild type controls. Further detailed muscle physiological analysis demonstrated a loss of force in response to eccentric exercise in the older, but not in the younger mice, suggesting this deficit developed over time. However this remained a subclinical feature as no pathology was observed in older mice in any muscles including the diaphragm, which is sensitive to mechanical load-induced damage. CONCLUSIONS/SIGNIFICANCE: This work shows that potential therapies in the dystroglycanopathies based on LARGE upregulation and α-dystroglycan hyperglycosylation in muscle should be safe

The impact of parents' mental health on parent-baby interaction: A prospective study

The aims of the current study were to examine the effect of fathers’ and mothers’ pre and postnatal mental health on mother–infant and father–infant interactions. Mental health was broadly defined to include anxiety, depression and PTSD. A community sample of 44 mothers and 40 fathers from 45 families completed questionnaire measures of mental health in late pregnancy and three months postpartum. Mother–infant and father–infant interactions were observed and videoed three months postpartum and analysed using the CARE-index. Results showed that prenatal mental health, in particular anxiety, was associated with parent–infant interactions to a greater extent than postnatal mental health. Fathers’ prenatal symptoms were associated with higher paternal unresponsiveness and infant passivity whilst fathers’ postnatal symptoms were associated with higher levels of infant difficulty in the father–baby interaction. The results also indicated that mothers and fathers interaction with their babies were similar, both on average and within the couples, with 34% being inept or at risk. These findings highlight the need for early detection and prevention of both mental health and parent–infant relationship problems in fathers as well as mothers. However, further prospective and longitudinal studies are needed to understand the influences of parental mental health on the parent–infant interactions further. Also it should be noted that the mental health scores were low in this sample, which may reflect the sample characteristics. Future studies therefore would benefit from focusing on more vulnerable groups of parents

Molecular mechanisms and phenotypic variation in RYR1-related congenital myopathies

Dominant mutations in the skeletal muscle ryanodine receptor (RYR1) gene are well-recognized causes of both malignant hyperthermia susceptibility (MHS) and central core disease (CCD). More recently, recessive RYR1 mutations have been described in few congenital myopathy patients with variable pathology, including multi-minicores. Although a clinical overlap between patients with dominant and recessive RYR1 mutations exists, in most cases with recessive mutations the pattern of muscle weakness is remarkably different from that observed in dominant CCD. In order to characterize the spectrum of congenital myopathies associated with RYR1 mutations, we have investigated a cohort of 44 patients from 28 families with clinical and/or histopathological features suggestive of RYR1 involvement. We have identified 25 RYR1 mutations, 9 of them novel, including 12 dominant and 13 recessive mutations. With only one exception, dominant mutations were associated with a CCD phenotype, prominent cores and predominantly occurred in the RYR1 C-terminal exons 101 and 102. In contrast, the 13 recessive RYR1 mutations were distributed evenly along the entire RYR1 gene and were associated with a wide range of clinico-pathological phenotypes. Protein expression studies in nine cases suggested a correlation between specific mutations, RyR1 protein levels and resulting phenotype: in particular, whilst patients with dominant or recessive mutations associated with typical CCD phenotypes appeared to have normal RyR1 expression, individuals with more generalized weakness, multi-minicores and external ophthalmoplegia had a pronounced depletion of the RyR1 protein. The phenomenon of protein depletion was observed in some patients compound heterozygous for recessive mutations at the genomic level and silenced another allele in skeletal muscle, providing additional information on the mechanism of disease in these patients. Our data represent the most extensive study of RYR1-related myopathies and indicate complex genotype-phenotype correlations associated with mutations differentially affecting assembly and function of the RyR1 calcium release channe

Messiness of forest governance:How technical approaches suppress politics in REDD+ and conservation projects

Reduction of Emissions from Deforestation and Forest Degradation (REDD+) was originally conceived to address the global problem of climate change by reducing deforestation and forest degradation at national and subnational levels in developing countries. Since its inception, REDD+ proponents have increasingly had to adapt global ideas to local demands, as the rollout process was met with on-the-ground realities, including suspicion and protest. As is typical in aid or ‘development’ projects conceived in the global North, most of the solutions advanced to improve REDD+ tend to focus on addressing issues of justice (or ‘fairness’) in distributive terms, rather than addressing more inherently political objections to REDD+ such as those based on rights or social justice. Using data collected from over 700 interviews in five countries with both REDD+ and non-REDD+ cases, we argue that the failure to incorporate political notions of justice into conservation projects such as REDD+ results in ‘messiness’ within governance systems, which is a symptom of injustice and illegitimacy. We find that, first, conservation, payment for ecosystem services, and REDD+ project proponents viewed problems through a technical rather than political lens, leading to solutions that focused on procedures, such as ‘benefit distribution.’ Second, focusing on the technical aspects of interventions came at the expense of political solutions such as the representation of local people's concerns and recognition of their rights. Third, the lack of attention to representation and recognition justices resulted in illegitimacy. This led to messiness in the governance systems, which was often addressed in technical terms, thereby perpetuating the problem. If messiness is not appreciated and addressed from appropriate notions of justice, projects such as REDD+ are destined to fail

Women, wellbeing and Wildlife Management Areas in Tanzania

Community-based wildlife management claims pro-poor, gender-sensitive outcomes. However, intersectional political ecology predicts adverse impacts on marginalised people. Our large-scale quantitative approach draws out common patterns and differentiated ways women are affected by Tanzania’s Wildlife Management Areas (WMAs). This first large-scale, rigorous evaluation studies WMA impacts on livelihoods and wellbeing of 937 married women in 42 villages across six WMAs and matched controls in Northern and Southern Tanzania. While WMAs bring community infrastructure benefits, most women have limited political participation, and experience resource use restrictions and fear of wildlife attacks. Wealth and region are important determinants, with the poorest worst impacted

Linking notions of justice and project outcomes in carbon offset forestry projects: Insights from a comparative study in Uganda

Over the last 20 years, Uganda has emerged as a testing ground for the various modes of carbon forestry used in Africa. Carbon forestry initiatives in Uganda raise questions of justice, given that people with comparatively negligible carbon footprints are affected by land use changes initiated by the desire of wealthy people, firms, and countries to reduce their more extensive carbon footprints. This paper examines the notions of justice local people express in relation to two contrasting carbon forestry projects in Uganda, the Mount Elgon Uganda Wildlife Authority – Forests Absorbing Carbon Emissions (UWA-FACE) project and Trees for Global Benefit (TFGB). UWA-FACE closed down its initial operations at Mount Elgon after 10 years as a result of deep controversies and negative international publicity, whereas TFGB is regarded by many as an exemplary design for smallholder carbon forestry in Africa. Our approach builds upon an emerging strand in the literature, of empirical analyses of local people’s notions of justice related to environmental interventions. The main contribution of the paper is to examine how people’s notions of justice have influenced divergent project outcomes in these cases. In particular, we highlight the relative success of TFGB in the way it meets people’s primarily distributional concerns, apparently without significantly challenging prevalent expectations of recognition or procedural justice. In contrast, we illuminate how controversy across the range of justice dimensions in UWA-FACE at Mount Elgon ultimately led to the project’s decline. This paper therefore explores how attention to notions of justice can contribute to a fuller understanding of the reactions of people to carbon forestry projects, as well as the pathways and ultimate outcomes of such interventions

The role of celebrities in mediating distant suffering

How effective are celebrities, not just in helping to draw attention to distant suffering, but in actually regulating spectators’ mediated experiences of the lives of distant strangers? What function does the perceived authenticity of a celebrity play in their role as mediator? This article seeks to address such questions by analysing the results of an audience study involving two phases of focus groups separated by a two-month diary study. The results show that celebrities certainly help to shape our mediated experiences of distant suffering – but not always in the ways and to the extent we might expect. What is clear is that celebrities are generally ineffective in cultivating a cosmopolitan engagement with distant suffering

Vascular endothelial growth factor prevents G93A-SOD1-induced motor neuron degeneration

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder characterized by selective loss of motor neurons (MNs). Twenty percent of familial ALS cases are associated with mutations in Cu 2+ /Zn 2+ superoxide dismutase (SOD1). To specifically understand the cellular mechanisms underlying mutant SOD1 toxicity, we have established an in vitro model of ALS using rat primary MN cultures transfected with an adenoviral vector encoding a mutant SOD1, G93A-SOD1. Transfected cells undergo axonal degeneration and alterations in biochemical responses characteristic of cell death such as activation of caspase-3. Vascular endothelial growth factor (VEGF) is an angiogenic and neuroprotective growth factor that can increase axonal outgrowth, block neuronal apoptosis, and promote neurogenesis. Decreased VEGF gene expression in mice results in a phenotype similar to that seen in patients with ALS, thus linking loss of VEGF to the pathogenesis of MN degeneration. Decreased neurotrophic signals prior to and during disease progression may increase MN susceptibility to mutant SOD1-induced toxicity. In this study, we demonstrate a decrease in VEGF and VEGFR2 levels in the spinal cord of G93A-SOD1 ALS mice. Furthermore, in isolated MN cultures, VEGF alleviates the effects of G93A-SOD1 toxicity and neuroprotection involves phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling. Overall, these studies validate the usefulness of VEGF as a potential therapeutic factor for the treatment of ALS and give valuable insight into the responsible signaling pathways and mechanisms involved. © 2009 Wiley Periodicals, Inc. Develop Neurobiol, 2009Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64297/1/20747_ftp.pd