Действие оксиэтилированных алкил- и изононилфенолов на параметры рецепторного связывания в подостром токсикологическом опыте

The influence of oxyethylized alkyl and isononilphenols on parameters of receptor binding in subacute toxicological experiment There was studied the influence of neonols AF 9-12 and AFS 9-6 KM on parameters of receptor binding of adrenaline, serotonin, dopamine and glucocorticoid receptors of cerebral cortex in subacute toxicological experiment on white rats of Wistar population, which were exposed to 45 days feeding in dozes 1/100 and 1/1000 DL50. The revealed alterations in α1-adrenoreceptors were characterized by the increase of affinity to ligand and decrease of number of this type receptors. There was observed the increase of number of highly affinal and the decrease of low affinal pool of β-adrenoreceptors in experimental groups of animals. The parameters of binding of serotonin receptors of second type were characterized by the decrease of affinity of binding with ligand. In animals of experimental groups affinity of D2-receptors to the marked ligand in cortex changed in comparison with control. Xenobiotics increased the presence of glucocorticoid receptors in cerebral cortex.В работе изучено влияние неонолов марок АФ 9-12 и АФС 9-6 КМ на параметры рецепторного связывания адреналиновых, серотониновых, дофаминовых и глюкокортикоидных рецепторов синаптосом коры головного мозга в условиях подострого токсикологического эксперимента на белых крысах популяции Вистар, которым перорально вводились ксенобиотики в дозах 1/100 и 1/1000 DL50 при ежедневной затравке в течение 45 суток. Обнаруженные изменения со стороны α1-адренорецепторов характеризовались увеличением сродства к лиганду и уменьшением количества данного типа рецепторов. Отмечалось увеличение количества высокоаффинного и снижение низкоаффинного пула β-адренорецепторов в опытных группах животных. Параметры связывания серотониновых рецепторов второго типа характеризовались снижением сродства связывания с лигандом. У животных экспериментальных групп нарушалось сродство D2-рецепторов к меченому лиганду в коре головного мозга сравнительно с контролем. Ксенобиотики в той или иной степени приводили, в зависимости от дозы воздействия, к повышению содержания глюкокортикоидных рецепторов в коре головного мозга

Динамика содержания ионов натрия и калия в крови и органах животных в условиях стрессорного воздействия ксенобиотиков

There was investigated the content of sodium and potassium in the heart, liver, kidneys, adrenal glands, spleen, blood serum of pubertal rats (male) of WAG line which have been exposed to peroral impact of new groups of xenobiotics – neonols AF 9-12 and AFS 9-6 KM in subacute toxicological experiment during 45 days. There was revealed that under the action of oxyethylized derivatives of phenols in doses 1/10 and 1/100 DL50 the content of sodium and potassium in animal organs decreased and in blood plasma increased. This indicates disturbance of organism adaptation to injurious impact of toxic substances. The dose 1/1000 DL50 is not active.В работе исследовано содержание макроэлементов натрия и калия в сердце, печени, почках, надпочечниках, селезёнке, сыворотке крови половозрелых крыс (самцов) линии WAG, подвергавшихся пероральному воздействию новых групп ксенобиотиков – неонолов марок АФ 9-12 и АФС 9-6 КМ в подостром токсикологическом опыте в течение 45 суток. Выявлено, что под действием оксиэтилированных производных фенолов в дозах 1/10 и 1/100 DL50 содержание макроэлементов натрия и калия снижается в органах животных и повышается в плазме крови. Это свидетельствует о нарушении адаптации организма к вредному воздействию токсических веществ. Доза 1/1000 DL50 не действующая

Effects of plasma heating on the magnitude and distribution of plasma flows in the helical divertor of the Uragan-3M torsatron

Recently, a strong up-down asymmetry in the poloidal distributions of diverted plasma flows has been observed in the l = 3/m = 9 Uragan-3M torsatron, in many features similar to what have been observed in the l = 2 Heliotron E heliotron/torsatron. With this asymmetry, the predominant outflow of the diverted plasma is directed with the ion toroidal drift. On this basis, the asymmetry can be related to the space non-uniformity of the charged particle loss. In the work reported, the magnitude of divertor flow in U-3M and the vertical asymmetry in its distribution are studied as functions of the heating parameter P/, P being the power absorbed in the plasma, and are juxtaposed with corresponding P-related changes in the density and fast ion content in the plasma. As P/ increases, an increase of fast ion content and of particle loss, on the one hand, and an increase of divertor flow magnitude and of vertical asymmetry of the flow, on the other hand, are observed. A mutual accordance between these processes validates the hypothesis on a dominating role of fast particle loss in formation of vertical asymmetry of divertor flows in helical devices

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters

Measurement of the inclusive isolated prompt photon cross-section in pp collisions at sqrt(s)= 7 TeV using 35 pb-1 of ATLAS data

A measurement of the differential cross-section for the inclusive production of isolated prompt photons in pp collisions at a center-of-mass energy sqrt(s) = 7 TeV is presented. The measurement covers the pseudorapidity ranges |eta|<1.37 and 1.52<=|eta|<2.37 in the transverse energy range 45<=E_T<400GeV. The results are based on an integrated luminosity of 35 pb-1, collected with the ATLAS detector at the LHC. The yields of the signal photons are measured using a data-driven technique, based on the observed distribution of the hadronic energy in a narrow cone around the photon candidate and the photon selection criteria. The results are compared with next-to-leading order perturbative QCD calculations and found to be in good agreement over four orders of magnitude in cross-section.Comment: 7 pages plus author list (18 pages total), 2 figures, 4 tables, final version published in Physics Letters

Measurement of D*+/- meson production in jets from pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

This paper reports a measurement of D*+/- meson production in jets from proton-proton collisions at a center-of-mass energy of sqrt(s) = 7 TeV at the CERN Large Hadron Collider. The measurement is based on a data sample recorded with the ATLAS detector with an integrated luminosity of 0.30 pb^-1 for jets with transverse momentum between 25 and 70 GeV in the pseudorapidity range |eta| < 2.5. D*+/- mesons found in jets are fully reconstructed in the decay chain: D*+ -> D0pi+, D0 -> K-pi+, and its charge conjugate. The production rate is found to be N(D*+/-)/N(jet) = 0.025 +/- 0.001(stat.) +/- 0.004(syst.) for D*+/- mesons that carry a fraction z of the jet momentum in the range 0.3 < z < 1. Monte Carlo predictions fail to describe the data at small values of z, and this is most marked at low jet transverse momentum.Comment: 10 pages plus author list (22 pages total), 5 figures, 1 table, matches published version in Physical Review

Search for scalar top quark pair production in natural gauge mediated supersymmetry models with the ATLAS detector in pp collisions at sqrt(s) = 7 TeV

The results of a search for pair production of the lighter scalar partners of top quarks in 2.05 fb-1 of pp collisions at sqrt(s) =7 TeV using the ATLAS experiment at the LHC are reported. Scalar top quarks are searched for in events with two same flavour opposite-sign leptons (electrons or muons) with invariant mass consistent with the Z boson mass, large missing transverse momentum and jets in the final state. At least one of the jets is identified as originating from a b-quark. No excess over Standard Model expectations is found. The results are interpreted in the framework of R-parity conserving, gauge mediated Supersymmetry breaking `natural' scenarios, where the neutralino is the next-to-lightest supersymmetric particle. Scalar top quark masses up to 310 GeV are excluded for the lightest neutralino mass between 115 GeV and 230 GeV at 95% confidence level, reaching an exclusion of the scalar top quark mass of 330 GeV for the lightest neutralino mass of 190 GeV. Scalar top quark masses below 240 GeV are excluded for all values of the lightest neutralino mass above the Z boson mass.Comment: 7 pages plus author list (20 pages total), 4 figures, 1 table, matches published PLB versio

Measurement of the production cross section of prompt j/psi mesons in association with a W (+/-) boson in pp collisions root s=7 TeV with the ATLAS detector

The process pp → W±J/ψ provides a powerful probe of the production mechanism of charmonium in hadronic collisions, and is also sensitive to multiple parton interactions in the colliding protons. Using the 2011 ATLAS dataset of 4.5 fb-1 of p s = 7TeV pp collisions at the LHC, the first observation is made of the production of W± + prompt J/ events in hadronic collisions, using W± → μ and J/ψ → μ+μ-. A yield of 27.4±7.5 -6.5 W± + prompt J/ψ events is observed, with a statistical significance of 5.1. The production rate as a ratio to the inclusive W± boson production rate is measured, and the double parton scattering contribution to the cross section is estimated. Copyright CERN, for the benefit of the ATLAS Collaboration