Detection of a glitch in the pulsar J1709-4429

We report the detection of a glitch event in the pulsar J1709$-$4429 (also known as B1706$-$44) during regular monitoring observations with the Molonglo Observatory Synthesis Telescope (UTMOST). The glitch was found during timing operations, in which we regularly observe over 400 pulsars with up to daily cadence, while commensally searching for Rotating Radio Transients, pulsars, and FRBs. With a fractional size of $\Delta\nu/\nu \approx 52.4 \times10^{-9}$, the glitch reported here is by far the smallest known for this pulsar, attesting to the efficacy of glitch searches with high cadence using UTMOST.Comment: 3 pages, 1 figur

Current results and future prospects from PSR J1757-1854, a highly-relativistic double neutron star binary

Pulsars, rapidly-rotating highly-magnetised neutron stars, can serve as useful laboratories for probing aspects of fundamental physics. Binary pulsars, especially those in tight binary systems with massive, compact companions, are useful in testing different theories of gravity, the current paradigm being General Relativity (GR). Additionally, binary pulsars can also be utilised to explore other areas of fundamental physics, such as the behaviour of matter at ultra-high densities and the neutron star moment of inertia. A standout example is PSR J1757-1854, a 21.5-ms pulsar in a highly-eccentric (e=0.61), 4.4-hr orbit around a neutron star companion. This pulsar exhibits some of the most extreme relativistic parameters ever observed in a binary pulsar, reaching a maximum line-of-sight acceleration of close to 700 m/s/s and displaying among the strongest relativistic effects due to gravitational wave damping. To date, five post-Keplerian parameters have been measured in PSR J1757-1854, allowing for three independent tests of gravity to be conducted (of which GR passes all three) and for the component neutron star masses to be separated. The extreme properties of this system (particularly its high eccentricity) are expected to allow for future measurements of Lense-Thirring precession effects (allow for a measurement of the neutron star moment of inertia) and the relativistic deformation of the orbit, both of which remain almost completely unexplored by other binary systems. Although first discovered by the Parkes Radio Telescope in 2016 as part of the High Time Resolution Universe Southern Galactic Plane survey, it is ongoing observations with the Green Bank Telescope (GBT) which have provided the backbone of PSR J1757-1854’s continuing study. The large-bandwidth, high-precision observations afforded by the GBT played a fundamental role in delivering the science derived from the pulsar so far, and will be critical in allowing it to reach its full scientific potential going forward. In this talk I will provide a progress report on the ongoing timing of the system, including a review of the latest mass measurements and gravity tests, with an emphasis towards the future science which this pulsar will make possible

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts