A Qualitative Study of Teachers\u27 Perceptions of Staff Development in Three Public Northeast Tennessee Elementary School Districts.

This study serves as an insight into teachersÆ perceptions of their staff development experiences. With the constraints under the No Child Behind Act, teachers, schools, and school systems are faced with the challenge of meeting extremely high standards with students. Although standards such as these expectations have never been met, it remains that teachers are faced with attempting this task. Teachers shared their perceptions of the staff development experiences they have received. Student achievement and its relationship to staff development was explored. Teachers discussed perceived factors that influenced staff development training. Also, included in the study was teachers\u27 perceptions of the need for staff development with proven applications. A qualitative research method utilized interviews from 25 veteran and apprentice elementary teachers ranging in experience from two years to thirty plus years of service in the educational profession. All interviews were recorded, transcribed, and transferred to the NUDIST program. This allowed all transcripts to be coded and analyzed. This process allowed themes to emerge from the data. This study could be of interest to school systems into the insights and needs of apprentice and veteran teachers. The results of these data could assist school districts with information to evaluate their current staff development programs and determine if changes should be made

Development of a clinical teaching evaluation and feedback tool for faculty

Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics. Sigma-2 receptors, recently identified as TMEM97, have been implicated in cancer and neurodegenerative disease. Structurally distinct sigma-2 receptor ligands induce cell death in tumor cells, linking sigma-2 receptors to apoptotic pathways. Recently, we reported that sigma-2 receptors can also stimulate glycolytic hallmarks, effects consistent with a prosurvival function and upregulation in cancer cells. Both apoptotic and metabolically stimulative effects were observed with compounds related to the canonical sigma-2 antagonist SN79. Here we investigate a series of 6-substituted SN79 analogs to assess the structural determinants governing these divergent effects. Substitutions on the benzoxazolone ring of the core SN79 structure resulted in high-affinity sigma-2 receptor ligands (Ki 5 0.56–17.9 nM), with replacement of the heterocyclic oxygen by N-methyl (producing N-methylbenzimidazolones) generally decreasing sigma-1 affinity and a sulfur substitution (producing benzothiazolones) imparting high affinity at both subtypes, lowering subtype selectivity. Substitution at the 6-position with COCH3, NO2, NH2, or F resulted in ligands that were not cytotoxic. Five of these ligands induced an increase in metabolic activity, as measured by increased reduction of MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetra-zolium bromide) in human SK-N-SH neuroblastoma cells, further supporting a role for sigma-2 receptors in metabolism. Substitution with 6-isothiocyanate resulted in ligands that were sigma-2 selective and that irreversibly bound to the sigma-2 receptor, but not to the sigma-1 receptor. These ligands induced cell death upon both acute and continuous treatment (EC50 5 7.6–32.8 mM), suggesting that irreversible receptor binding plays a role in cytotoxicity. These ligands will be useful for further study of these divergent roles of sigma-2 receptors

A homogeneous aa index: 1. secular variation

Originally complied for 1868-1967 and subsequently continued so that it now covers 150 years, the aa index has become a vital resource for studying space climate change. However, there have been debates about the inter-calibration of data from the different stations. In addition, the effects of secular change in the geomagnetic field have not previously been allowed for. As a result, the components of the “classical” aa index for the southern and northern hemispheres (aaS and aaN) have drifted apart. We here separately correct both aaS and aaN for both these effects using the same method as used to generate the classic aa values but allowing {\delta}, the minimum angular separation of each station from a nominal auroral oval, to vary as calculated using the IGRF-12 and gufm1 models of the intrinsic geomagnetic field. Our approach is to correct the quantized aK-values for each station, originally scaled on the assumption that {\delta} values are constant, with time-dependent scale factors that allow for the drift in {\delta}. This requires revisiting the intercalibration of successive stations used in making the aaS and aaN composites. These intercalibrations are defined using independent data and daily averages from 11 years before and after each station change and it is shown that they depend on the time of year. This procedure produces new homogenized hemispheric aa indices, aaHS and aaHN, which show centennial-scale changes that are in very close agreement. Calibration problems with the classic aa index are shown to have arisen from drifts in {\delta} combined with simpler corrections which gave an incorrect temporal variation and underestimate the rise in aa during the 20th century by about 15%

A homogeneous aa index: 2. hemispheric asymmetries and the equinoctial variation

Paper 1 [Lockwood et al., 2018] generated annual means of a new version of the aa geomagnetic activity index which includes corrections for secular drift in the geographic coordinates of the auroral oval, thereby resolving the difference between the centennial-scale change in the northern and southern hemisphere indices, aaN and aaS. However, other hemispheric asymmetries in the aa index remain: in particular, the distributions of 3-hourly aaN and aaS values are different and the correlation between them is not high on this timescale (r = 0.66). In the present paper, a location-dependant station sensitivity model is developed using the am index (derived from a much more extensive network of stations in both hemispheres) and used to reduce the difference between the hemispheric aa indices and improve their correlation (to r = 0.79) by generating corrected 3-hourly hemispheric indices, aaHN and aaHS, which also include the secular drift corrections detailed in Paper 1. These are combined into a new, “homogeneous” aa index, aaH. It is shown that aaH, unlike aa, reveals the “equinoctial”-like time-of-day/time-of-year pattern that is found for the am index

Extending the Planetary Mass Function to Earth Mass by Microlensing at Moderately High Magnification

A measurement by microlensing of the planetary mass function of planets with masses ranging from 5M_E to 10M_J and orbital radii from 0.5 to 10 AU was reported recently. A strategy for extending the mass range down to (1-3)M_E is proposed here. This entails monitoring the peaks of a few tens of microlensing events with moderately high magnifications with 1-2m class telescopes. Planets of a few Earth masses are found to produce deviations of ~ 5% to the peaks of microlensing light curves with durations ~ (0.7-3)hr in events with magnification ~ 100 if the projected separation of the planet lies in the annular region (0.85-1.2)r_E. Similar deviations are produced by Earth mass planets in the annular region (0.95-1.05)r_E. It is possible that sub-Earths could be detected very close to the Einstein ring if they are sufficiently abundant, and also planetary systems with more than one low mass planet.Comment: 12 pages, 20 figures (in press) MNRAS (2013

Allogeneic Hematopoietic Stem Cell Transplantation Following the Use of Hypomethylating Agents among Patients with Relapsed or Refractory AML: Findings from an International Retrospective Study

Abstract Patients with primary refractory or relapsed acute myeloid leukemia (RR-AML) have very poor prognosis. Due to limited treatment options, some patients are treated with hypomethylating agents (HMAs) due to their tolerability. Little is known about the role of allogeneic hematopoietic stem cell transplantation (HSCT) following HMA therapy in this setting. We retrospectively analyzed an international cohort of 655 RR-AML patients who received HMA therapy to study patterns and outcomes with HSCT. Only 37 patients (5.6%) patients underwent HSCT after HMA therapy. The conditioning regimen was myeloablative in 57% and nonmyeloablative in 43%. Patients received matched unrelated donor, matched sibling, haploidentical and mismatched unrelated HSCT in 56%, 24%, 16% and 4% of cases, respectively. Acute GvHD and chronic GvHD were observed in 40% and 17% of patients. While the median OS for the entire cohort of patients was 15.3 months (95% CI 9.5 – 21.7 months), OS reached 29.7 months (95% CI 7.01 – not-reached) for patients who achieved a complete remission (CR) to HMA and no intervening therapies between HMA therapy and HSCT. Our study suggests that HMA therapy can effectively bridge some patients with RR-AML to HSCT

Identification of novel epithelial ovarian cancer loci in women of African ancestry.

Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10-6 ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1). For HGSOC, we identified six loci with suggestive evidence of association including rs37792 (132 kb 5' of follistatin [FST]), rs57403204 (81 kb 3' of MAGEC1), rs79079890 (LOC105376360 intronic), rs66459581 (5 kb 5' of PRPSAP1), rs116046250 (GABRG3 intronic) and rs192876988 (32 kb 3' of GK2). Among the identified variants, two are near genes known to regulate hormones and diseases of the ovary (AKR1C3 and FST), and two are linked to cancer (AKR1C3 and MAGEC1). In follow-up studies of the 10 identified variants, the GK2 region SNP, rs192876988, showed an inverse association with EOC in European ancestry women (p = 0.002), increased risk of ER positive breast cancer in African ancestry women (p = 0.027) and decreased expression of GK2 in HGSOC tissue from African ancestry women (p = 0.004). A European ancestry-derived polygenic risk score showed positive associations with EOC and HGSOC in women of African ancestry suggesting shared genetic architecture. Our investigation presents evidence of variants for EOC shared among European and African ancestry women and identifies novel EOC risk loci in women of African ancestry

Pravastatin for early-onset pre-eclampsia:a randomised, blinded, placebo-controlled trial

Objective: Women with pre-eclampsia have elevated circulating levels of soluble fms-like tyrosine kinase-1 (sFlt-1). Statins can reduce sFlt-1 from cultured cells and improve pregnancy outcome in animals with a pre-eclampsia-like syndrome. We investigated the effect of pravastatin on plasma sFlt-1 levels during pre-eclampsia. Design: Blinded (clinician and participant), proof of principle, placebo-controlled trial. Setting: Fifteen UK maternity units. Population: We used a minimisation algorithm to assign 62 women with early-onset pre-eclampsia (24 +0–31 +6 weeks of gestation) to receive pravastatin 40 mg daily (n = 30) or matched placebo (n = 32), from randomisation to childbirth. Primary outcome: Difference in mean plasma sFlt-1 levels over the first 3 days following randomisation. Results: The difference in the mean maternal plasma sFlt-1 levels over the first 3 days after randomisation between the pravastatin (n = 27) and placebo (n = 29) groups was 292 pg/ml (95% CI −1175 to 592; P = 0.5), and over days 1–14 was 48 pg/ml (95% CI −1009 to 913; P = 0.9). Women who received pravastatin had a similar length of pregnancy following randomisation compared with those who received placebo (hazard ratio 0.84; 95% CI 0.50–1.40; P = 0.6). The median time from randomisation to childbirth was 9 days [interquartile range (IQR) 5–14 days] for the pravastatin group and 7 days (IQR 4–11 days) for the placebo group. There were three perinatal deaths in the placebo-treated group and no deaths or serious adverse events attributable to pravastatin. Conclusions: We found no evidence that pravastatin lowered maternal plasma sFlt-1 levels once early-onset pre-eclampsia had developed. Pravastatin appears to have no adverse perinatal effects. Tweetable abstract: Pravastatin does not improve maternal plasma sFlt-1 or placental growth factor levels following a diagnosis of early preterm pre-eclampsia #clinicaltrial finds

Nutrition for the ageing brain: towards evidence for an optimal diet

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline