Tecnología y tipología del torques de Sintra (Lisboa, Portugal). Un adorno de oro del Bronce Atlántico compuesto por los tipos Sagrajas-Berzocana y Villena-Estremoz

Not available<br><br>[es] El estudio del torques de Sintra (Lisboa) ha revelado detalles tecnológicos y tipológicos que indican una mezcla de dos tipos bien conocidos durante el Bronce Final Atlántico de la Península Ibérica: Sagrajas-Berzocana y Villena-Estremoz. Esta combinación refuerza la tesis según la cual ambas tradiciones orfebres coexistieron durante un tiempo. El torques está formado por distintos elementos fabricados con técnicas avanzadas, como la fusión adicional además de una variante de la cera perdida que requiere la utilización del torno. Se pone de relieve la importancia de la investigación tecnológica en los estudios sobre tipología y cronología de objetos metálicos.
 
 [fr] Sur la technologie et la typologie du collier de Sintra (Lisbonne, Portugal) - Un oeuvre d'orfèvrerie du Bronze Final Atlantique composé des types Sagrajas-Berzocana et Villena-Estremoz.
 
 L'étude du collier de Sintra (Lisbonne) a revélé des détails technologiques et typologiques indiquant une combinaison de deux types bien connus dans le Bronze Final Atlantique de la Péninsule Ibérique : Sagrajas-Berzocana et VilIena-Estremoz. Cette combinaison renforce la thèse selon laquelle les deux traditions d'orfèvrerie ont coexisté partiellement dans le temps. Le collier est constitué de différents éléments fabriqués avec des techniques avançees, comme la fonte additionnelle ainsi qu'une version élaborée de la cire perdue faisant appel au tour. L'importance des recherches technologiques pour la typologie et chronologie des objects métalliques est mise en évidence

Tecnología y tipología del torques de Sintra (Lisboa, Portugal). Un adorno de oro del Bronce Atlántico compuesto por los tipos Sagrajas-Berzocana y Villena-Estremoz

Not available[es] El estudio del torques de Sintra (Lisboa) ha revelado detalles tecnológicos y tipológicos que indican una mezcla de dos tipos bien conocidos durante el Bronce Final Atlántico de la Península Ibérica: Sagrajas-Berzocana y Villena-Estremoz. Esta combinación refuerza la tesis según la cual ambas tradiciones orfebres coexistieron durante un tiempo. El torques está formado por distintos elementos fabricados con técnicas avanzadas, como la fusión adicional además de una variante de la cera perdida que requiere la utilización del torno. Se pone de relieve la importancia de la investigación tecnológica en los estudios sobre tipología y cronología de objetos metálicos. [fr] Sur la technologie et la typologie du collier de Sintra (Lisbonne, Portugal) - Un oeuvre d'orfèvrerie du Bronze Final Atlantique composé des types Sagrajas-Berzocana et Villena-Estremoz. L'étude du collier de Sintra (Lisbonne) a revélé des détails technologiques et typologiques indiquant une combinaison de deux types bien connus dans le Bronze Final Atlantique de la Péninsule Ibérique : Sagrajas-Berzocana et VilIena-Estremoz. Cette combinaison renforce la thèse selon laquelle les deux traditions d'orfèvrerie ont coexisté partiellement dans le temps. Le collier est constitué de différents éléments fabriqués avec des techniques avançees, comme la fonte additionnelle ainsi qu'une version élaborée de la cire perdue faisant appel au tour. L'importance des recherches technologiques pour la typologie et chronologie des objects métalliques est mise en évidence

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible.

To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we adopted a symptom-to-circuit approach in the Fmr1-knockout (Fmr1-/-) mouse model of Fragile X syndrome. Using a go/no-go task and in vivo two-photon calcium imaging, we find that impaired visual discrimination in Fmr1-/- mice correlates with marked deficits in orientation tuning of principal neurons and with a decrease in the activity of parvalbumin interneurons in primary visual cortex. Restoring visually evoked activity in parvalbumin cells in Fmr1-/- mice with a chemogenetic strategy using designer receptors exclusively activated by designer drugs was sufficient to rescue their behavioral performance. Strikingly, human subjects with Fragile X syndrome exhibit impairments in visual discrimination similar to those in Fmr1-/- mice. These results suggest that manipulating inhibition may help sensory processing in Fragile X syndrome

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements