Evaluación de híbridos y clones de cacao en rendimiento y calidad para la zona marginal baja cafetera bajo sistema agroforestal: proyecto

La información que se reúne en este Informe abarca un periodo cercano a los 20 afias a partir de 1986, recopilando los resultados y experiencias de varios experimentos y ensayos que se realizaron en cacao en la línea del Manejo del Recurso Genético Proyecto "Evaluación de híbridos y clones de cacao por producción, rendimiento y calidad, bajo un sistema agroforestal para la Zona Central Cafetera de Colombia" dentro del Convenio que CORPOICA Regional Nueve mantuvo en forma recurrente con la Casa Luker.Cacao-Theobroma caca

Informe de actividades de investigación en cacao, tomate de árbol y morera 1994 y I semestre 1995

Haciendo referencia al Proyecto de "Evaluación de clones e híbridos", la investigación a la fecha, en sus tres experimentos mas avanzados demuestra que existen algunos materiales híbridos, de cacao que sobresalen por su rendimiento tales como: SC6 x (ICS 39 x SPA9) con 2.588 Kg/ha, Se 40 x les 6 con 2.458. entre -loa--6-y 7 años de edad En el experimento que se realiza en la finca Finca Tres puertas a 4 años de edad están sobresaliendo el híbrido, ET 96 x IMC 67 con 1.208 y el IMC 67 x ICS 6 con 947 Kg En cuanto a clones, los materiales más recomendables son el TSH 565, IMC 67 y TSH 792.Cacao-Theobroma cacaoTomate-Solanum lycopersicu

Assessing the risk of cardiovascular events in patients receiving immune checkpoint inhibitors

Funding Information: This article is part of the CLARIFY project, supported by the European Union Horizon 2020 Research and Innovation Program under grant agreement number 875160. Publisher Copyright: Copyright © 2022 Torrente, Blanco, Franco, Garitaonaindia, Calvo, Collazo-Lorduy, Gutiérrez, Sánchez, González-del-Alba, Hernández, Méndez, Cantos, Núñez, Sousa and Provencio.Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, despite their excellent therapeutic effect, these medications typically result in a broad spectrum of toxicity reactions. Immune-related cardiotoxicity is uncommon but can be potentially fatal, and its true incidence is underestimated in clinical trials. The aim of this study is to assess the incidence and identify risk factors for developing a cardiac event in patients treated with ICIs. Methods: We conducted a single-institution retrospective study, including patients treated with ICIs in our center. The main outcomes were cardiac events (CE) and cardiovascular death. Results: A total of 378 patients were analyzed. The incidence of CE was 16.7%, during a median follow-up of 50.5 months. The multivariable analysis showed that age, a history of arrhythmia or ischemic heart disease, and prior immune-related adverse events were significantly associated with CE. Conclusion: CE during ICI treatment are more common than currently appreciated. A complete initial cardiovascular evaluation is recommended, especially in high-risk patients, being necessary a multidisciplinary approach of a specialized cardio-oncology team.publishersversionpublishe

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements