Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by thetype A receptor (EDNRA). This action may play a significant role in the etiology of hypertension.There are different works that shows an association between certain polymorphisms of endothelinaxis and clinical phenotype of hypertension. We describe the genetic variability +138/ex1Short Research ArticleLassen et al.; BJMMR, 11(7): 1-8, 2016; Article no.BJMMR.205202insertion/deletion (I/D) adenosine (A) in the ET-1 gene and polymorphism thymidine/cytosine (T/C)His323His in the EDNRA gene associated at the clinical variability in hypertensive patients.Study Design: Observational, transversal and analytical study.Place and Duration of Study: Hypertension Service at the Internal Medicine Department ofCórdoba Hospital, and Biochemical and Molecular Biology Department in School of Medicine,National University of Cordoba, Argentine. Patients considered hypertensive between April 2009and April 2010.Methodology: Were assessed 136 patients serum lipid profiles, renal and hepatic functions andwere taken Thoracic X-rays, electrocardiograms, and echocardiographs. DNA extracted fromcirculating leukocyte were used to analyze the polymorphisms of genes by PCR-RFLP.Results: For the polymorphisms of Receptor A from Endothelin -1 studied the presence ofcytosine homozygous genotype was less frequent in males (P = .02). For both genders, the samegenotype was associated to low plasma alkaline phosphatase activity and cholesterol levels. Thepresence of thymidine nucleotide allele correlated with plasma alkaline phosphatase activity andcholesterol levels. The Thymidine allele correlated with the degree of cardiovascular compromise(r = 0.54, P= .002). For the genetic variant in the ET-1 gene, the homozygous adenine deletionwas associated to normal plasma levels of glutamate/pyruvate transaminase enzyme activity, uricacid concentration, cholesterol, and Low Density Lipoprotein in hypertensive subjects withoutclinical risk.Conclusion: We observed a gender-specific protective effect for EDNRA gene variations, thesubjects that carried the TT genotype presented more aggressive symptomatology. These resultsshow an association between plasmatic biochemical parameters, the clinical condition, andpolymorphisms in the endothelin axis genes.Fil: Lassen, Oscar. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; ArgentinaFil: Herrera, Jimena María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Dotto, Gladys. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; ArgentinaFil: Ojeda, Silvia. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Garutti, Alicia. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; ArgentinaFil: Bertolotto, Patricia Isolina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Tabares, Sandra. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Bioquímica y Biología Molecular; ArgentinaFil: Sembaj, Adela. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Bioquímica y Biología Molecular; Argentin

Infección por hongos filamentosos en pacientes quemados: estudio retrospectivo.

Antecedentes: Las infecciones son las complicaciones más frecuentes en los pacientes quemados. Los hongos filamentosos ocupan un lugar incierto dentro de las estadísticas nosocomiales; existen escasos datos sobre la prevalencia de las mismas, los agentes causales y el desenlace de los que las padecen. Objetivos: El objetivo fue evaluar  prevalencia de la infección por hongos filamentosos (IHF) en pacientes internados en la unidad terapia intensiva de quemados (UTIQ), revisar algunas características clínicas, epidemiológicas, microbiológicas y evolución de estos pacientes;  conocer  la frecuencia y distribución de las especies fúngicas aisladas.Materiales y métodos: Estudio retrospectivo y descriptivo. Se incluyeron todos los individuos que ingresaron a la terapia intensiva de pacientes quemados (2012-2015), con cultivo positivo para hongos filamentosos en biopsias de piel y escaras.Resultados: Un total de 168 de pacientes ingresaron en la unidad intensiva de quemados  en un período de 3 años. El 17% desarrolló IHF (29/168) y el 90% fueron grandes quemados.  Se recuperaron 29 hongos filamentosos (93% de exámenes microscópicos positivos): Aspergillus spp (24%), Fusarium spp (14%), Mucor spp (3%) y diversos géneros de hongos negros (58%).  El 95% presentó entre 1 y 4 infecciones bacterianas además de la infección fúngica en piel. El 24% de los pacientes con IHF falleció. La causa de la muerte fue shock cardiogénico irreversible con falla multiorgánica.Conclusiones: La infección por hongos filamentosos se presentó en el 17% de los pacientes quemados. Los principales hongos causantes de infección  fúngica fueron dematiáceos. La mortalidad entre los pacientes fue del 24%,  siendo Fusarium el hongo  hallado en el mayor número de muertes (50%)

Estudio comparativo de características clínicas, bioquímicas y genéticas entre pacientes chagásicos y no chagásicos: asociación entre polimorfismos genéticos y variables marcadoras de riesgo cardiovascular

6 p.En la Enfermedad de Chagas (EC), la presencia del Trypanosoma cruzi (T.cruzi) es un factor determinante en la evolución hacia el deterioro de la función cardiaca. Para contrarrestar la infección, el huésped activa un conjunto de mecanismos de defensa (inmune e inflamatorio) que persisten en el tiempo. Podríamos atribuir parte de la responsabilidad de la variabilidad en la expresión de síntomas y evolución de la EC a características genéticas de cada individuo que permiten que se pongan en marcha mecanismos moleculares adaptativos del huésped, para sobrellevar la función cardiaca con normalidad y no poner en riesgo la vida [1,2]. Diversos trabajos han observado asociación entre polimorfismos de un solo nucleótido (SNPs) de diferentes factores en diferentes cardiomiopatías [3,4]. En este sentido poco se conoce de lo que sucede con la fisiopatogenia de la Cardiomiopatía Chagásica Cronica. Nos propusimos identificar polimorfismos en el gen de la SOD-Mn (superóxido dismutasa dependiente de Manganeso) en el gen de Endotelina 1- y su receptor A y asociar la variabilidad génica a características clínicas y/o bioquímicas en individuos con y sin infección con T.cruzi.Fil: Lassen, Oscar. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Departamento de Semiología UAMI N° 3. Hospital Córdoba. Consultorio de Chagas e hipertensión; Argentina.Fil: Dotto, Gladys. Hospital Córdoba. Laboratorio Central; Argentina.Fil: Ojeda, Silvia. Universidad Nacional de Córdoba. Facultad de Matemáticas, Astronomía y Física. Argentina.Fil: Garutti, Alicia. Hospital Córdoba. Laboratorio Central; Argentina.Fil: Bertolotto, Patricia. Universidad Nacional de Córdoba. Facultad de Matemáticas, Astronomía y Fisca; Argentina.Fil: Tabares, Sandra. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina.Fil: Gallerano, Rafael. Universidad Nacional de Córdoba. Escuela de Ciencias Médicas. Departamenteo de Semiología UAMI 3. Hospital Córdoba. Consultorio de Chagas e hipertensión; Argentina.Fil: Sembaj, Adela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina.Bioquímica y Biología Molecula

Хирургическое лечение холециститов и их осложнений

ЖЕЛЧНОКАМЕННАЯ БОЛЕЗНЬЖЕЛЧНЫХ ПУТЕЙ БОЛЕЗНИПЕЧЕНИ БОЛЕЗНИХИРУРГИЯ ЖЕЛЧНЫХ ПУТЕЙХИРУРГИЯ ПЕЧЕНИХОЛЕЦИСТИТКурс лекций включает в себя 8 лекций, посвященных анатомическим сведениям о желчевыводящих путях, этиопатогенезу острого и хронического холецистита. Освещены современные методы диагностики заболевания желчевыводящих путей, приведена клиническая картина различных форм острого холецистита, включая поражения желчевыводящих путей, хирургическая тактика, способы хирургических вмешательств, ошибки в хирургии желчевыводящих путей, постхолецистэктомический синдром

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass