Dileptons and Direct Photons at SPS

The study of dilepton and direct photon emission was one of the main topics of the experimental program at the SPS devoted to the search of signals for QGP formation. Three generations of experiments, Helios-3, NA38/NA50, CERES and NA60 measured e+e- or mu+mu- production in various colliding systems and at different energies. While lepton pair production in p-A collisions was found to be reasonably well described by the expected sources, all experiments observed in nuclear collisions an excess of the yield above the extrapolation from p-A. As a result of this joint experimental effort we have currently a large amount of information characterizing this excess: its mass spectrum over the full range from 0.2 GeV/c^2 up to the J/psi, its transverse momentum spectra including their mass dependence, its angular distributions, its dependence on collision centrality over the complete range etc. Putting together all this information leads to the conclusion that what we observe is the long-sought thermal radiation from the fireball.Comment: 8 pages, 6 figures - To appear in the conference proceedings for Quark Matter 2009, March 30 - April 4, Knoxville, Tennesse

Effects of a Novel GPR55 Antagonist on the Arachidonic Acid Cascade in LPS-Activated Primary Microglial Cells

Neuroinflammation is a crucial process to maintain homeostasis in the central nervous system (CNS). However, chronic neuroinflammation is detrimental, and it is described in the pathogenesis of CNS disorders, including Alzheimer’s disease (AD) and depression. This process is characterized by the activation of immune cells, mainly microglia. The role of the orphan G-protein-coupled receptor 55 (GPR55) in inflammation has been reported in different models. However, its role in neuroinflammation in respect to the arachidonic acid (AA) cascade in activated microglia is still lacking of comprehension. Therefore, we synthesized a novel GPR55 antagonist (KIT 10, 0.1–25 µM) and tested its effects on the AA cascade in lipopolysaccharide (LPS, 10 ng / mL)-treated primary rat microglia using Western blot and EIAs. We show here that KIT 10 potently prevented the release of prostaglandin $E_{2}$ ($PGE_{2}$), reduced microsomal $PGE_{2}$ synthase (mPGES-1) and cyclooxygenase-2 (COX-2) synthesis, and inhibited the phosphorylation of Ikappa B-alpha (IκB-α), a crucial upstream step of the inflammation-related nuclear factor-kappaB (NF-κB) signaling pathway. However, no effects were observed on COX-1 and -2 activities and mitogen-activated kinases (MAPK). In summary, the novel GPR55 receptor antagonist KIT 10 reduces neuroinflammatory parameters in microglia by inhibiting the COX-2/$PGE_{2}$ pathway. Further experiments are necessary to better elucidate its effects and mechanisms. Nevertheless, the modulation of inflammation by GPR55 might be a new therapeutic option to treat CNS disorders with a neuroinflammatory background such as AD or depression

Gauged Inflation

We propose a model for cosmic inflation which is based on an effective description of strongly interacting, nonsupersymmetric matter within the framework of dynamical Abelian projection and centerization. The underlying gauge symmetry is assumed to be $SU(N+1)$ with $N \gg 1$. Appealing to a thermodynamical treatment, the ground-state structure of the model is classically determined by a potential for the inflaton field (dynamical monopole condensate) which allows for nontrivially BPS saturated and thereby stable solutions. For $T<M_P$ this leads to decoupling of gravity from the inflaton dynamics. The ground state dynamics implies a heat capacity for the vacuum leading to inflation for temperatures comparable to the mass scale $M$ of the potential. The dynamics has an attractor property. In contrast to the usual slow-roll paradigm we have $m\gg H$ during inflation. As a consequence, density perturbations generated from the inflaton are irrelevant for the formation of large-scale structure, and the model has to be supplemented with an inflaton independent mechanism for the generation of spatial curvature perturbations. Within a small fraction of the Hubble time inflation is terminated by a transition of the theory to its center symmetric phase. The spontaneously broken $Z_{N+1}$ symmetry stabilizes relic vector bosons in the epochs following inflation. These heavy relics contribute to the cold dark matter of the universe and potentially originate the UHECRs beyond the GZK bound.Comment: 23 pages, 4 figures, subsection added, revision of text, to app. in PR

Third Generation Familons, B Factories, and Neutrino Cosmology

We study the physics of spontaneously broken family symmetries acting on the third generation. Massless familons (or Majorons) $f$ associated with such broken symmetries are motivated especially by cosmological scenarios with decaying tau neutrinos. We first note that, in marked contrast with the case for the first two generations, constraints on third generation familon couplings are poor, and are, in fact, non-existent at present in the hadronic sector. We derive new bounds from $B^0$--$\bar{B}^0$ mixing, $B^0 \to l^+ l'^-$, $b\to s\nu\bar{\nu}$, and astrophysics. The resulting constraints on familon decay constants are still much weaker than those for the first and second generation. We then discuss the promising prospects for significant improvements from searches for $\tau\to l f$, $B\to (\pi, K) f$, and $b\to (d,s) f$ with the current CLEO, ARGUS, and LEP data. Finally, we note that future constraints from CLEO III and the $B$ factories will probe decay constants beyond 10^8 GeV, well within regions of parameter space favored by proposed scenarios in neutrino cosmology.Comment: ReVTeX, 33 pages, 6 figures, notation improved, references added, revised to conform to pubished versio

Environmental filtering drives assembly of diatom communities over evolutionary time‐scales

Aim Ecological communities are structured through the interplay of deterministic assembly processes such as competition and environmental filtering. Whereas the drivers of spatial community structure are frequently studied in extant communities, little is known about the relative importance of assembly processes in response to environmental factors over evolutionary time-scales. Here, we use an integrative framework to unravel community assembly processes since the inception of a long-lived lake ecosystem. Location Lake Ohrid. Time period From lake formation 1.36 million years ago to the present. Major taxa studied Planktonic diatoms. Methods We constructed a dated phylogeny of extant and extinct diatoms and collected trait data for 380 fossil communities to quantify phylogenetic community structure and functional richness and to determine the relative importance of deterministic assembly processes over time. We then used regression analysis to correlate the phylogenetic community structure with palaeoenvironmental and intrinsic biological predictors and to identify primary drivers of assembly processes. Results Our results suggest a dense packing of niche space with higher species richness and co-occurrence of closely related species. There are only two short episodes in the very recent past dominated by distantly related taxa. We found distinct changes in phylogenetic community structure upon speciation or extinction events and an increase in mean community relatedness over time. Main conclusions Our finding of closely related co-occurring species implies environmental filtering as the primary assembly mechanism, with a minor but increasingly important role of competition towards the present, driven by evolutionary dynamics. Such an increase in the relative contribution of competition to the assembly of communities in relation to the aging of an insular ecosystem, together with a denser packing of morphospace in the early phase of system ontogeny is compatible with ecological predictions according to the theory of island biogeography

Electromagnetic Probes

A review is presented of dilepton and real photon measurements in relativistic heavy ion collisions over a very broad energy range from the low energies of the BEVALAC up to the highest energies available at RHIC. The dileptons cover the invariant mass range \mll = 0 - 2.5 GeV/c$^2$, i.e. the continuum at low and intermediate masses and the light vector mesons, $\rho, \omega, \phi$. The review includes also measurements of the light vector mesons in elementary reactions.Comment: To be published in Landolt-Boernstein Volume 1-23A; 40 pages, 24 figures. Final version updated with small changes to the text, updated references and updated figure

Nature's Swiss Army Knives: Ovipositor Structure Mirrors Ecology in a Multitrophic Fig Wasp Community

Resource partitioning is facilitated by adaptations along niche dimensions that range from morphology to behaviour. The exploitation of hidden resources may require specially adapted morphological or sensory tools for resource location and utilisation. Differences in tool diversity and complexity can determine not only how many species can utilize these hidden resources but also how they do so.The sclerotisation, gross morphology and ultrastructure of the ovipositors of a seven-member community of parasitic wasps comprising of gallers and parasitoids developing within the globular syconia (closed inflorescences) of Ficus racemosa (Moraceae) was investigated. These wasps also differ in their parasitism mode (external versus internal oviposition) and their timing of oviposition into the expanding syconium during its development. The number and diversity of sensilla, as well as ovipositor teeth, increased from internally ovipositing to externally ovipositing species and from gallers to parasitoids. The extent of sclerotisation of the ovipositor tip matched the force required to penetrate the syconium at the time of oviposition of each species. The internally ovipositing pollinator had only one type of sensillum and a single notch on the ovipositor tip. Externally ovipositing species had multiple sensilla types and teeth on their ovipositors. Chemosensilla were most concentrated at ovipositor tips while mechanoreceptors were more widely distributed, facilitating the precise location of hidden hosts in these wasps which lack larval host-seeking behaviour. Ovipositor traits of one parasitoid differed from those of its syntopic galler congeners and clustered with those of parasitoids within a different wasp subfamily. Thus ovipositor tools can show lability based on adaptive necessity, and are not constrained by phylogeny.Ovipositor structure mirrored the increasingly complex trophic ecology and requirements for host accessibility in this parasite community. Ovipositor structure could be a useful surrogate for predicting the biology of parasites in other communities

Framework and baseline examination of the German National Cohort (NAKO)

The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection and prevention of disease. Specifically, NAKO is designed to identify novel and better characterize established risk and protection factors for the development of cardiovascular diseases, cancer, diabetes, neurodegenerative and psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases in a random sample of the general population. Between 2014 and 2019, a total of 205,415 men and women aged 19–74 years were recruited and examined in 18 study centres in Germany. The baseline assessment included a face-to-face interview, self-administered questionnaires and a wide range of biomedical examinations. Biomaterials were collected from all participants including serum, EDTA plasma, buffy coats, RNA and erythrocytes, urine, saliva, nasal swabs and stool. In 56,971 participants, an intensified examination programme was implemented. Whole-body 3T magnetic resonance imaging was performed in 30,861 participants on dedicated scanners. NAKO collects follow-up information on incident diseases through a combination of active follow-up using self-report via written questionnaires at 2–3 year intervals and passive follow-up via record linkages. All study participants are invited for re-examinations at the study centres in 4–5 year intervals. Thereby, longitudinal information on changes in risk factor profiles and in vascular, cardiac, metabolic, neurocognitive, pulmonary and sensory function is collected. NAKO is a major resource for population-based epidemiology to identify new and tailored strategies for early detection, prediction, prevention and treatment of major diseases for the next 30 years. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10654-022-00890-5

Risk to human health related to the presence of perfluoroalkyl substances in food

Acknowledgements: The Panel wishes to thank the following for their support provided to this scientific output as Hearing experts: Klaus Abraham, Esben Budtz-Jørgensen, Tony Fletcher, Philippe Grandjean, Hans Mielke and Hans Rumke and EFSA staff members: Davide Arcella, Marco Binaglia, Petra Gergelova, Elena Rovesti and Marijke Schutte. The Panel wishes to acknowledge all European competent institutions, Member State bodies and other organisations that provided data for this scientific output. The Panel would also like to thank the following authors and co-authors for providing additional information in relation to their respective studies: Berit Granum, Margie M Peden-Adams, Thomas Webster.Peer reviewedPublisher PD

One size doesn’t fit all: time to revisit patient-reported outcome measures (PROMs) in paediatric ophthalmology?

The purpose of this article is to summarise methodological challenges and opportunities in the development and application of patient reported outcome measures (PROMs) for the rare and complex population of children with visually impairing disorders. Following a literature review on development and application of PROMs in children in general, including those with disabilities and or/chronic condition, we identified and discuss here 5 key issues that are specific to children with visual impairment: (1) the conflation between theoretically distinct vision-related constructs and outcomes, (2) the importance of developmentally appropriate approaches to design and application of PROMs, (3) feasibility of standard questionnaire formats and administration for children with different levels of visual impairment, (4) feasibility and nature of self-reporting by visually impaired children, and (5) epidemiological, statistical and ethical considerations. There is an established need for vision-specific age-appropriate PROMs for use in paediatric ophthalmology, but there are significant practical and methodological challenges in developing and applying appropriate measures. Further understanding of the characteristics and needs of visually impaired children as questionnaire respondents is necessary for development of quality PROMs and their meaningful application in clinical practice and research